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surface wave inversion with unknown number of soil layers based on a hybrid learning procedure of deep learning and genetic algorithm

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 345-358页

作者： Zan Zhou Thomas Man-Hoi lok Wan-Huan Zhou Department of Civil and Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina

surface wave inversion is a key step in the application of surface waves to soil velocity ***,a common practice for the process of inversion is that the number of soil layers is assumed to be known before using heuristic search algorithms to compute the shear wave velocity profile or the number of soil layers is considered as an optimization ***,an improper selection of the number of layers may lead to an incorrect shear wave velocity *** this study,a deep learning and genetic algorithm hybrid learning procedure is proposed to perform the surface wave inversion without the need to assume the number of soil ***,a deep neural network is adapted to learn from a large number of synthetic dispersion curves for inferring the layer ***,the shear-wave velocity profile is determined by a genetic algorithm with the known layer *** applying this procedure to both simulated and real-world cases,the results indicate that the proposed method is reliable and efficient for surface wave inversion.

关键词： surface wave inversion analysis shear-wave velocity profile deep neural network genetic algorithm

spreadsheet quality assurance:a literature review

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Frontiers of Computer science 2024年第2期18卷 61-82页

作者： Pak-lok POON Man Fai LAU Yuen Tak YU sau-Fun TANG school of Engineering and Technology Central Queensland UniversityMelbourne 3000Australia Department of Computing Technologies Swinburne University of TechnologyHawthorn 3122Australia Department of Computer science City University of Hong KongHong Kong SAR 999077China The Royal Victorian Eye and Ear Hospital East Melbourne 3002Australia

spreadsheets are very common for information processing to support decision making by both professional developers and non-technical end ***,business intelligence and artificial intelligence are increasingly popular in the industry nowadays,where spreadsheets have been used as,or integrated into,intelligent or expert systems in various application ***,it has been repeatedly reported that faults often exist in operational spreadsheets,which could severely compromise the quality of conclusions and decisions based on the *** a view to systematically examining this problem via survey of existing work,we have conducted a comprehensive literature review on the quality issues and related techniques of spreadsheets over a 35.5-year period(from January 1987 to June 2022)for target journals and a 10.5-year period(from January 2012 to June 2022)for target *** other findings,two major ones are:(a)spreadsheet quality is best addressed throughout the whole spreadsheet life cycle,rather than just focusing on a few specific stages of the life cycle.(b)Relatively more studies focus on spreadsheet testing and debugging(related to fault detection and removal)when compared with spreadsheet specification,modeling,and design(related to development).As prevention is better than cure,more research should be performed on the early stages of the spreadsheet life *** by our comprehensive review,we have identified the major research gaps as well as highlighted key research directions for future work in the area.

关键词： decision support system end-user computing end-user programming Excel spreadsheet

A path planning algorithm for a crop monitoring fixed-wing unmanned aerial system

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维普期刊数据库

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science China(Information sciences) 2024年第8期67卷 5-23页

作者： Longhao QIAN Yi lok LO Hugh Hong-tao LIU Institute of Aerospace studies University of Toronto Department of Mechanical Engineering The University of Hong Kong

With the growing demand for automation in agriculture, industries increasingly rely on drones to perform crop monitoring and surveillance. In this regard, fixed-wing unmanned aerial systems(UAss)are viable platforms for scanning a large crop field, given their payload capacity and range. To achieve maximum coverage without landing for battery replacement, an algorithm for producing a minimal required energy survey path is essential. Hence, an energy-aware coverage path planning algorithm is proposed *** constraints for a fixed-wing UAs to fly at low altitudes while achieving full coverage of the crop field are first analyzed. Then, the full path is decomposed into straight-line and U-turn primitives. Finally, an algorithm to calculate a combination of straight-line segments and U-turns is proposed to obtain the path with minimum required energy consumption. The genetic algorithm is used to efficiently determine the order of the straight-line paths to traverse. Case studies show that the proposed algorithm can produce planning results for a convex-polygon-shaped crop field.

关键词： aerial survey energy minimization fixed-wing UAs genetic algorithm path planning

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ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 721-722页

作者： Hiu Chuen lok Glenda M.Halliday Woojin scott Kim Brain and Mind Centre&school of Medical sciences The University of SydneySydneyNSWAustralia

ATP-binding cassette(ABC)transporters are ubiquitous membrane-bound proteins that are responsible for the translocation of a broad spectrum of substrates across cellular membranes,including lipids,amino acids,nucleosides,sugars,and ***,ABC transporters are highly expressed in the *** their functions in the brain still need to be elucidated,several members are implicated in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease(AD),Parkinson’s disease(PD),and frontotemporal *** this perspective,we will review current knowledge of ABC transporters in the central nervous system in terms of physiological functions and pathology in ***,we will explore the possibilities of ABC transporters as potential targets in the development of therapeutics for neurodegenerative diseases.

关键词： sugar degenerative diseases

FE65:a hub for neurodevelopment

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Neural Regeneration Research 2024年第9期19卷 1883-1884页

作者： Yuqi Zhai Laura lok-Haang Ng Dennis Dik-Long Chau Kwok-Fai Lau school of Life sciences Faculty of ScienceThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during ***65 belongs to the FE65 protein *** family is comprised of three memb... 详细信息

关键词： family development partner

Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi Tanaka Hyung-lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRIsPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

适当的患者教育可以改进中国农村丙型肝炎患者的疾病知识及对抗病毒治疗的接受程度

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中华肝脏病杂志 2018年第11期26卷 824-828页

作者：杨明饶慧瑛封波 El izabeth Wu 魏来 anna s. lok 北京大学人民医院北京大学肝病研究所丙型肝炎和肝病免疫治疗北京市重点实验室 100044 美国密歇根大学医学院胃肠及肝病科 48109

目的评估丙型肝炎教育对中国农村慢性丙型肝炎（CHC）患者疾病知识和抗病毒治疗接受程度的影响。方法河北省某县CHC项目的农村患者接受HCV教育，包括医生给予讲座和随后进行的互动式讨论，并完成教育前后测试。结果总共纳入151例CHC患... 详细信息

目的评估丙型肝炎教育对中国农村慢性丙型肝炎（CHC）患者疾病知识和抗病毒治疗接受程度的影响。方法河北省某县CHC项目的农村患者接受HCV教育，包括医生给予讲座和随后进行的互动式讨论，并完成教育前后测试。结果总共纳入151例CHC患者。平均年龄为57．3岁，50．3％为男性，51．0％患者的受教育程度为小学或文盲，76．2％的家庭月收入低于3000元。98.0％的患者将其基线丙型肝炎知识定义为“无”或“只有一点”。多因素分析显示，年龄和家庭收入与基线知识总分相关。教育后，患者知识总分的平均分（范围：0-28分）从13．1升至23．0（P〈0．001），题目回答正确患者的平均百分比从46．8％升至82．1％（P〈0．001），患者对抗病毒治疗的接受程度从33．9％升至65．6％（P〈0．001）。结论虽然中国农村患者的受教育程度较低，按患者选择的方式进行的丙型肝炎教育可以显著改善患者的疾病知识和抗病毒治疗的接受程度。

关键词：肝炎病毒,丙型预防传播治疗阻碍

AAsLD慢性乙型肝炎临床指南(2007)精粹

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AASLD慢性乙型肝炎临床指南(2007)精粹

慢性乙型肝炎患者的乙型肝炎表面抗原会消失吗?——西方观点

中国医师协会感染科医师分会成立大会暨首届感染科医师论坛

作者： anna s.F.lok Brian J.Mc Mahon

美国肝病研究协会(AAsLD)关于《慢性乙型肝炎的临床实践指南》(《指南》) 最近再次更新,并经 AAsLD 批准,代表学会立场,刊登于 Hepatology 2007年第2 期(lok As,McMahon ***,2007,45:507-539)。《指南》更新遵循既往原

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cnki会议

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中国医学前沿杂志（电子版） 2013年第7期5卷 19-20页

作者： anna s.lok 美国密歇根大学安娜堡48109

乙肝表面抗原（HBsAg）发现迄今已有50年历史，随着研究的进展，人们对HBsAg的认识越来越深入。那么，HBsAg会消失吗？HBsAg消失后患者的预后会有何变化？

关键词： HBsAg CHB 自发清除 HBeAg 乙型