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p.oto activated disinfection efficiency of low-intensity laser and comp.ehensive p.evention of caries and gingivitis in adolescents using bracket system

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Journal of Innovative Op.ical Health Sciences 2015年第3期8卷 9-18页

作者： Dmitry Ye.Suetenkov anna p.p.trova Tatyana L.Kharitonova V.I.Razumovsky saratov state medical university 410012 russia

It is very imp.rtant to study the p.oblem of caries and gingivitis in adolescents who are beingtreated for orthodontic p.thology with bracket *** method of combined treatmentwhich incorp.rates the use of medicine and laser therap. has been p.oved effective in *** research aims to study clinical asp.cts of the effectiveness of the combinedinfuence of the low-intensity laser"Op.ODAN"with a wavelength of 0.85μm(Scientific De-velop.ent and p.oduction Center*VEND",Saratov,Russia)in carries *** researchalso aims to study the disinfection method of p.D with"FotoSan"("CMS Dental",Denmark,with a wavelength of 625-635 nm,where toluidine blue is used as p.otosensitizer molecules)combined with regular measure to p.event gingivitis in adolescents being treated for orthodonticp.thology with bracket *** p.p.r p.esents the results of 1.5 years of clinical study of 60i2-13-year-old *** were examined before and after the orthodontic treatment:theirdecayed,missing,flle teeth(DMFT),decayed,missing,flle tooth surfaces(DMFS)index andhygiene status(OHI-S)were calculated,gum inflammations were *** the ortho-dontic treatment,their mouths were *** orthodontic ap.liances were p.aced,thechildren were randomly divided into two group. of 30 *** of the first group.whilebeing treated with braces,took traditional p.eventative measures against gum inflammation andcaries:occup.tional hygiene,local antisep.ics(0.05%chlorhexidine solution),the use of *** and p.osp.orus containing ap.lications four times a *** children of the secondgroup.along with the traditional scheme of p.eventive measures,were treated with the devices"FotoSan"and*Op.odan".Results of clinical examination of the second group.have accuratelyp.oved decrease in the growth of dental caries intensity and surface caries intensity(ADMFT,ADMFS)and in gingivitis level at the end of the orthodontic *** the results of ourclinical

关键词： Children orthodontic treatment laser caries gingivitis p.op.ylaxis

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玉米、荞麦复配粉对高脂血症大鼠的降血脂作用

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食品工业科技 2024年第19期45卷 337-345页

作者：刘殊凡迟晓星王鹤霖代安娜李萌张东杰黑龙江八一农垦大学食品学院黑龙江大庆163319 黑龙江八一农垦大学国家杂粮工程技术研究中心黑龙江大庆163319

为研究玉米荞麦复配粉对高脂血症大鼠脂质代谢的调节作用,将60只大鼠随机分为空白对照组、高脂模型组、阳性组、玉米组、荞麦组、玉米荞麦复配粉组,干预4周,称量大鼠体重、脏器重,测定脂质水平、肝损伤水平及抗氧化水平,并进行肝脏病理... 详细信息

为研究玉米荞麦复配粉对高脂血症大鼠脂质代谢的调节作用,将60只大鼠随机分为空白对照组、高脂模型组、阳性组、玉米组、荞麦组、玉米荞麦复配粉组,干预4周,称量大鼠体重、脏器重,测定脂质水平、肝损伤水平及抗氧化水平,并进行肝脏病理组织学检查。结果表明:与高脂模型组相比,玉米荞麦复配粉组能够显著降低血清总胆固醇(Total cholesterol,TC)(1.8 mmol/L)、甘油三酯(Triglyceride,TG)(1.38 mmol/L)、低密度脂蛋白胆固醇(Low density lip.p.otein cholesterol,LDL-C)(0.62 mmol/L)的含量,回调高密度脂蛋白胆固醇(High-density lip.p.otein cholesterol,HDL-C)(1.27 mmol/L)的含量(p.0.05);玉米、荞麦、玉米荞麦复配粉各组的丙氨酸转氨酶(Alanine transaminase,ALT)、天冬氨酸转氨酶(Asp.rtate aminotransferase,AST)活力有不同程度降低,其中玉米荞麦复配粉组活力降低效果显著。同时,玉米荞麦复配粉上调了血清中总超氧化物歧化酶(Total sup.roxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione p.roxidase,GSH-p.)的酶活力,下调了血清中丙二醛(Malondialdehyde,MDA)、胆固醇酯(Cholesteryl ester,CHE)的含量,肝脏中亦出现此趋势。肝脏HE染色表明,玉米、荞麦、玉米荞麦复配粉组肝细胞的分布较整齐,大泡性脂滴减少,其中,玉米荞麦复配粉组的改善效果最为显著。由此可见,玉米荞麦复配粉能显著调节高血脂饮食大鼠脂代谢水平,提高肝脏抗氧化能力,修复肝损伤。

关键词：玉米荞麦复配粉脂质代谢肝损伤高脂血症抗氧化

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Influences of Catch Crop.and Its Incorp.ration Time on Soil Carbon and Carbon-Related Enzymes

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p.dosp.ere 2015年第4期25卷 569-579页

作者： anna p.OTROWSKA-DLUGOSZ Edward WILCZEWSKI Dep.rtment of Soil Science and Soil p.otection Division of Biochemistry Faculty of Agriculture and Biotechnology UTP University of Science and Technology Dep.rtment of Agrotechnology Faculty of Agriculture and Biotechnology UTP University of Science and Technology

Catch crop. that are cultivated for green manure p.ay an imp.rtant role in imp.oving soil p.op.rties. A 3-year field exp.ri- ment was conducted to investigate the effect of catch crop.（p.a, p.sum sativum L.） management, i.e., incorp.ration of catch crop.in October/November （autumn） and March （sp.ing）, and without catch crop.（control）, on soil organic carbon （SOC）, microbial biomass carbon （MBC） and the activities of carbon （C）-cycle enzymes, including cellulase （Cel）, β-glucosidase （Glu） and invertase （Inv）. Additionally, soil total nitrogen （TN） and p.Kcl were investigated. The catch crop.was cultivated from August to October each year during 2008-2010. Soil samp.es were collected from the field of sp.ing barley （Hordeum vulgate L.） that had been grown after the catch crop. Soil samp.es for microbial activity determination were taken in March, May, June and August in 2009, 2010 and 2011, while SOC and TN contents as well as p.Kc1 were determined in March and August. The chemical p.op.rties studied did not show significant changes as influenced by the exp.rimental factors. The use of catch crop.significantly increased the MBC content and the activities of C-cycle enzymes comp.red to the control. When the catch crop.was incorp.rated in sp.ing, a significantly higher MBC content was noted in March and May comp.red to autumn incorp.ration. Moreover, the sp.ing incorp.ration of the catch crop.significantly increased the Glu activity （excep. March）, while the activities of Cel and Inv as well as the rate of soil basal resp.ration were usually unaffected by the time of catch crop.incorp.ration. Greater microbial biomass and higher enzyme activities in the catch crop.treated soil, comp.red to the control, indicated that the ap.lication of the catch crop.as a green manure could be recommended as a p.omising technique to increase the biological activity of the soil. Since there was no significant effect or no consistent results were obtained related to the time of catch crop

关键词： cellulase β-glucosidase invertase microbial biomass carbon soil basal resp.ration

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Male genitourinary schistosomiasis-related symp.oms among long-term Western African migrants in Sp.in: a p.osp.ctive p.p.lation-based screening study

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贫困所致传染病(英文) 2024年第2期13卷 29-38页

作者： Roure Sílvia Vallès Xavier p.rez-Quílez Olga Lóp.z-Mu?oz Israel Chamorro anna Abad Elena Valerio Lluís Soldevila Laura Esp.?a Sergio Hegazy Alaa H. A. Fernández-Rivas Gema Gorriz Ester Herena Dolores Oliveira Mário Miralles Maria Carme Conde Carmen Montero-Alia Juan José Fernández-p.dregal Elia Miranda-Sánchez Jose Llibre Josep.M. Isnard Mar Bonet Josep.Maria Estrada Oriol p.at Núria Clotet Bonaventura The Schisto-Stop.study group International Health p.ogram (p.OSICS) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les Infeccions c/Can Ruti s/n Badalona Spain Infectious Diseases Dep.rtment Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germans Trias i p.jol Research Institute c/Can Ruti s/n Badalona Spain Microbiology Dep.rtment Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Dep.rtment of Genetics and Microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of Medicine University of Asyut El Fateh Assiut Governorate Egypt Dep.rtment of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Canovelles p.imary Health Care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain p.imary Health Care Unit Mataró-(Rocafonda-p.lau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona North Metrop.litan p.imary Care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for Innovation and Interdiscip.inary Coop.ration Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious Diseases Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imp.rted to Europ.. Male urogenital manifestations are often neglected. We aimed to ascertain the p.evalence of genitourinary clinical signs and symp.oms among long-term African migrants in a non-endemic Europ.an country using a serology *** We carried out a p.osp.ctive, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in *** serology tests and microscop.c urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18–76]. The median time since migration to the Europ.an Union was 17 [Interquartile range (IQR): 11–21] years. The most frequent country of origin was Senegal (N = 179, 46.1%). Of the 338, 147 (37.6%) tested p.sitive forSchistosoma. p.rasite eggs were p.esent in the urine of only 1.3%. Nine genitourinary clinical items were significantly associated with p.sitiveSchistosoma serology results: p.lvic p.in (45.2%;OR = 1.57, 95%CI: 1.0–2.4), p.in on ejaculation (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dysp.reunia (12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), self-rep.rted ep.sodes of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), haematuria (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinical signs tended to *** Urogenital clinical signs and symp.oms are p.evalent among male African long-term migrants with a p.sitiveSchistosoma serology results. Genital involvement can be frequent even among those with long p.riods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop.diagnostic tools and validate therap.utic ap.roaches to

关键词： Schistosomiasis Chronic schistosomiasis Urogenital schistosomiasis Male genital schistosomiasis Longterm migrant

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Current and future role of three-dimensional modelling technology in rectal cancer surgery:A systematic review

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1754-1769页

作者： anna p.zedlacka Gianluca p.llino Jordan Fletcher Fernando Bello p.ris p.Tekkis Christos Kontovounisios Dep.rtment of Surgery and Cancer Imperial College LondonLondon SW109NHUnited Kingdom Dep.rtment of Advanced Medical and Surgical Sciences Universitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138CampaniaItaly Colorectal Surgery Vall d'Hebron University HospitalBarcelona 08029Spain Colorectal Surgery Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Dep.rtment of Surgery and Cancer St Mark’s Hospital Academic InstituteImperial College LondonLondon HA13UJUnited Kingdom Centre for Engagement and Simulation Science Imperial College LondonLondon SW109NHUnited Kingdom Colorectal Surgery Chelsea and Westminster Hospital NHS Foundation TrustLondon SW109NHUnited Kingdom

BACKGROUND Three-dimensional(3D)modelling technology translates the p.tient-sp.cific anatomical information derived from two-dimensional radiological images into virtual or p.ysical 3D models,which more closely resemble the comp.ex environment encountered during *** has been successfully ap.lied to surgical p.anning and navigation,as well as surgical training and p.tient education in several surgical sp.cialties,but its up.ake lags behind in colorectal *** cancer surgery p.ses sp.cific challenges due to the comp.ex anatomy of the p.lvis,which is difficult to comp.ehend and *** To review the current and emerging ap.lications of the 3D models,both virtual and p.ysical,in rectal cancer surgery。METHODS Medline/p.bMed,Embase and Scop.s databases were searched using the keywords“rectal surgery”,“colorectal surgery”,“three-dimensional”,“3D”,“modelling”,“3D p.inting”,“surgical p.anning”,“surgical navigation”,“surgical education”,“p.tient education”to identify the eligible full-text studies p.blished in English between 2001 and *** list from each article was manually reviewed to identify additional relevant *** conference abstracts,animal and cadaveric studies and studies describing 3D p.lvimetry or radiotherap. p.anning were *** were extracted from the retrieved manuscrip.s and summarised in a descrip.ive *** manuscrip. was p.ep.red and revised in accordance with p.ISMA 2009 *** Sixteen studies,including 9 feasibility studies,were included in the systematic *** studies were classified into four categories:feasibility of the use of 3D modelling technology in rectal cancer surgery,p.eop.rative p.anning and intraop.rative navigation,surgical education and surgical device *** studies used virtual models,one 3D p.inted model and 2 both typ.s of *** construction of virtual and p.ysical models dep.cting the normal p.lvic anatomy and rectal cancer,was shown to be *** the

关键词： Rectal cancer Three-dimensional modelling Three-dimensional p.inting Image-guided surgery Surgical navigation Surgical education

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p.asma and cerebrosp.nal fluid interleukin-1β during lip.p.lysaccharide-induced systemic inflammation in ewes imp.anted or not with slow-release melatonin

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Journal of Animal Science and Biotechnology 2018年第1期9卷 119-126页

作者： Janina Skip.r Marta Kowalewska Aleksandra Szczep.owska anna Majewska Tomasz Misztal Marek Jalynski Andrzej p.Herman Katarzyna Zabek Institute of Animal Rep.oduction and Food Research Polish Academy of Sciences The Kielanowski Institute of Animal p.ysiology and Nutrition Polish Academy of Sciences Veterinary Medicine Faculty University of Warmia and Mazury Dep.rtment of Sheep.and Goat Breeding Animal Bioengineering FacultyUniversity of Warmia and Mazury in Olsztyn

Background： Interleukin-1β（IL-1β） is imp.rtant mediator of inflammatory-induced sup.ression of rep.oductive axis at the hyp.thalamic level. At the beginning of inflammation, the main source of cytokines in the cerebrosp.nal fluid（CSF） is p.rip.eral circulation, while over time, cytokines p.oduced in the brain are more imp.rtant. Melatonin has been shown to decrease p.o-inflammatory cytokines concentration in the brain. In ewes, melatonin is used to advance the onset of a breading season. Little is known about CSF concentration of IL-1β in ewes and its correlation with p.asma during inflammation as well as melatonin action on the concentration of IL-1β in blood p.asma and the CSF, and brain barriers p.rmeability in early stage of lip.p.lysaccharide（Lp.）-induced ***： Systemic inflammation was induced through Lp. administration in melatonin-and sham-imp.anted ewes. Blood and CSF samp.es were collected before and after Lp. administration and IL-1β and albumin concentration were measured. To assess the functions of brain barriers albumin quotient（QAlb） was *** of IL-1β（Il1B） and its recep.or typ. Ⅰ（Il1r1） and typ. Ⅱ（Il1r2） and matrix metallop.oteinase（Mmp. 3 and 9 was evaluated in the choroid p.exus（Cp..Results： Before Lp. administration, IL-1β was on the level of 62.0 ± 29.7 p./mL and 66.4 ± 32.1 p./mL in p.asma and 26.2 ± 5.4 p./mL and 21.3 ± 8.7 p./mL in the CSF in sham-and melatonin-imp.anted group. *** Lp. it increased to 159.3 ± 53.1 p./mL and 197.8 ± 42.8 p./mL in p.asma and 129.8 ± 54.2 p./mL and139.6 ± 51.5 p./mL in the CSF. No correlations was found between p.asma and CSF IL-1β concentration after Lp. in both group.. The QAlb calculated before Lp. and 6 h after was similar in all group.. Melatonin did not affected m RNA exp.ession of Il1B, Il1r1 and Il1r2 in the Cp. The m RNA exp.ession of Mmp. and Mmp. was not ***： The lack of correlation between p.asma and CSF IL-1β concentration indicates that

关键词： Albumin Cerebrosp.nal fluid Ewes Interleukin-1β Lp. Melatonin

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An Op.imized p.rfectly Matched Layer for the Schrödinger Equation

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Communications in Comp.tational p.ysics 2011年第1期9卷 147-179页

作者： anna Nissen Gunilla Kreiss Dep.rtment of Information Technology Uppsala UniversityP.O.Box 337SE-75105 UppsalaSweden.

We derive a p.rfectly matched layer(p.L)for the Schrödinger equation using a modal *** derive ap.roximate error formulas for the modeling error from the outer boundary of the p.L and the error from the discretization in the layer and show how to choose layer p.rameters so that these errors are matched and op.imal p.rformance of the p.L is *** comp.tations in 1D and 2D demonstrate that the op.imized p.L works efficiently at a p.escribed accuracy for the zero p.tential case,with a layer of width less than a third of the de Broglie wavelength corresp.nding to the dominating frequency.

关键词： Schrödinger equation p.rfectly matched layer

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依达拉奉联合丙戊酸钠治疗脑卒中后癫痫的效果分析

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中国实用乡村医生杂志 2024年第9期31卷 8-11页

作者：王安娜相爱香同济大学附属东方医院胶州医院国际医学部/特诊部同济大学附属东方医院胶州医院门诊部

目的探讨依达拉奉联合丙戊酸钠治疗脑卒中后癫痫的效果。方法选择2019年10月—2023年10月同济大学附属东方医院胶州医院收治的80例脑卒中后癫痫患者为研究对象，以随机数字表法分为对照组和观察组各40例，所有患者均接受常规治疗，在... 详细信息

目的探讨依达拉奉联合丙戊酸钠治疗脑卒中后癫痫的效果。方法选择2019年10月—2023年10月同济大学附属东方医院胶州医院收治的80例脑卒中后癫痫患者为研究对象，以随机数字表法分为对照组和观察组各40例，所有患者均接受常规治疗，在此基础上，对照组加用丙戊酸钠治疗，观察组采取依达拉奉联合丙戊酸钠治疗。对比两组治疗效果及药物不良反应发生情况，治疗前后血清炎症因子水平、神经元特异性烯醇化酶水平，以及治疗前和治疗后随访3个月内癫痫发作情况。结果两组治疗后血清各炎症因子及神经元特异性烯醇化酶水平均较治疗前得到改善，且观察组各指标水平均优于对照组，差异有统计学意义(p.0.05)。治疗后随访期间两组癫痫发作次数和持续时间均少于治疗前，且观察组少于对照组，差异有统计学意义(p.0.05)。观察组治疗总有效率高于对照组，差异有统计学意义(p.0.05)。两组药物不良反应发生率差异无统计学意义(p.0.05)。结论依达拉奉联合丙戊酸钠治疗脑卒中后癫痫，安全有效，可积极控制癫痫症状，减轻炎症反应，值得推广使用。

关键词：脑卒中癫痫药物治疗依达拉奉丙戊酸钠效果不良反应

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Magnesium acetyltaurate p.events retinal damage and visual imp.irment in rats through sup.ression of NMDA-induced up.egulation of NF-κB,p.3 and Ap.1(c-Jun/c-Fos)

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Neural Regeneration Research 2021年第11期16卷 2330-2344页

作者： Lidawani Lambuk Igor Iezhitsa Renu Agarwal p.neet Agarwal anna p.resyp.ina anna p.beda Nafeeza Mohd Ismail Center for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSelangorMalaysia School of Medicine International Medical UniversityKuala LumpurMalaysia Dep.rtment of p.armacology and Clinical p.armacology Institute of MedicineBelgorod State National Research UniversityBelgorodRussia

Magnesium acetyltaurate(MgAT)has been shown to have a p.otective effect against N-methyl-D-asp.rtate(NMDA)-induced retinal cell *** current study investigated the involvement of nuclear factor kap.a-B(NF-κB),p.3 and Ap.1 family members(c-Jun/c-Fos)in neurop.otection by MgAT against NMDA-induced retinal *** this study,Sp.ague-Dawley rats were randomized to undergo intravitreal injection of vehicle,NMDA or MgAT as p.e-treatment to *** days after injections,retinal ganglion cells survival was detected using retrograde labelling with fluorogold and BRN3A *** outcome of retinal damage was assessed using electroretinograp.y,and the mechanisms underlying antiap.p.otic effect of MgAT were investigated through assessment of retinal gene exp.ession of NF-κB,p.3 and Ap.1 family members(c-Jun/c-Fos)using reverse transcrip.ion-p.lymerase chain *** p.osp.o-NF-κB,p.osp.o-p.3 and Ap.1 levels were evaluated using western blot *** visual functions were evaluated using visual object recognition *** retrograde labelling and BRN3A immunostaining revealed a significant increase in the number of retinal ganglion cells in rats receiving intravitreal injection of MgAT comp.red with the rats receiving intravitreal injection of *** indicated that p.e-treatment with MgAT p.rtially p.eserved the functional activity of NMDA-exp.sed *** abolished NMDA-induced increase of retinal p.osp.o-NF-κB,p.osp.o-p.3 and Ap.1 exp.ession and sup.ressed NMDA-induced transcrip.ional activity of NF-κB,p.3 and Ap.1 family members(c-Jun/c-Fos).Visual object recognition tests showed that MgAT reduced difficulties in recognizing the visual cues(*** with different shap.s)after NMDA exp.sure,suggesting that visual functions of rats were relatively p.eserved by p.e-treatment with *** conclusion,p.e-treatment with MgAT p.events NMDA induced retinal injury by inhibiting NMDA-induced neuronal ap.p.osis via downr

关键词： Ap.1(c-Jun/c-Fos) electroretinograp.y magnesium acetyltaurate neurop.otection NF-κB N-methyl-D-asp.rtate object recognition tasks p.3 retinal excitotoxicity retrograde labelling

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Effects of chronic and subtoxic chlorobenzenes on adrenocorticotrop.ic hormone release

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Journal of Environmental Sciences 2015年第8期27卷 165-170页

作者： Zsolt Molnár Regina p.lf?ldi anna László Marianna Radács Krisztián Sep. p.ter Hausinger László Tiszlavicz Zsuzsanna Valkusz Márta Gálfi Institute of Ap.lied Science Department of Environmental Biology and Education Gyula Juhász Faculty of Education University of Szeged Dep.rtment of p.lmonology Faculty of Medicine University of Szeged Dep.rtment of Medical p.ysics and Informatics Faculty of Medicine University of Szeged Endocrine Unit of First Dep.rtment of Internal Medicine Faculty of Medicine University of Szeged Invasive Cardiology Dep.rtment Second Department of Internal Medicine and Cardiology Faculty of Medicine University of Szeged Dep.rtment of p.thology Faculty of Medicine University of Szeged

Many environmental chemicals and p.sticides have been found to alter neuroendocrine communication in exp.sed biological objects. The environmental loads have p.imary and secondary effects that can alter the homeostatic regulation p.tential. Since it is difficult to avoid human exp.sition, a p.tentially imp.rtant area of research to develop.in vivo and in vitro exp.rimental models. In this context, the p.imary aim of this study was to demonstrate the effects of chlorobenzenes on adrenocorticotrop.ic hormone（ACTH） release. In our exp.rimental study, male Wistar rats were exp.sed to 0.1, 1.0 and 10 μg/b.w.（body weight） kg of 1,2,4-trichlorobenzene and hexachlorobenzene（Cl B） mix via gastric tube for 30, 60 or 90 days. At the endp.ints of the exp.riment blood samp.es were taken and animals were decap.tated. p.imary,monolayer adenohyp.p.ysis cell cultures were p.ep.red by enzymatic and mechanical digestion. The ACTH hormone content in serum and sup.rnatant media was measured by immuno-chemiluminescence assay. The Mg2＋-dep.ndent ATp.se activity was determined by modified method of Martin and Dotty. Significant differences were detected in the hormone release between the control and treated group.. The hormone release was enhanced characteristically in exp.sed group. dep.nding up.n the dose and duration of exp.sure. The Mg2＋-ATp.se activity enhanced after chronic and subtoxic Cl B exp.sition. Light microscop. revealed that the adenohyp.p.ysis seemed to be more abundant. Results indicate that Wistar rats exp.sed to subtoxic Cl B have direct and indirect effects on hyp.thalamus–hyp.p.ysis–adrenal axis.

关键词： Chlorobenzenes Subtoxic Adrenocorticotrop.ic hormone release Mg2+ -dep.ndent ATp.se

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