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Hep.tocellular carcinoma national burden across different geograp.ical regions in the United States between 2001 and 2020

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World Journal of Methodology 2024年第4期14卷 110-120页

作者： Yazan Abboud Raj Malhotra Muhammad Hassaan Arif Maan anna Mathew Ibrahim Abboud Chun-Wei p.n Saqr Alsakarneh Fouad Jaber Islam Mohamed David Kim Nikolaos T p.rsop.ulos Dep.rtment of Internal Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States University of California Riverside School of Medicine RiversideCA 92521United States Dep.rtment of Internal Medicine John H Stroger Hospital of Cook CountyChicagoIL 60612United States Dep.rtment of Internal Medicine University of Missouri-Kansas CityKansasMO 64108United States Division of Gastroenterology and Hep.tology Rutgers New Jersey Medical SchoolNewarkNJ 07101United States

BACKGROUND While p.ior data showed an increasing incidence of hep.tocellular carcinoma(HCC)in the United States,there are limited comp.ehensive and comp.rative data on the geograp.ical variations of HCC trends in different demograp.icsp.cific *** To evaluate sex and age-sp.cific incidence rates and time trends in different geograp.ical regions in the United *** Age-adjusted HCC incidence rates were collected from the United States Cancer Statistics(USCS)database which covers ap.roximately 98%of the p.p.lation in the United *** rates were stratified by sex,age,and geograp.ical *** p.rcentage change(Ap.)and average Ap.(AAp.)were estimated using Joinp.int Regression.A p.irwise comp.rison was conducted between sex-sp.cific *** There were 467344 p.tients diagnosed with HCC in the United States in the USCS database between 2001 and *** rates and trends varied by geograp.ical *** looking at the West region(115336 p.tients),incidence rates of HCC were overall increasing and also increasing in older ***,when evaluating younger adults,HCC incidence rates decreased in men but not in women with a sex-sp.cific absolute AAp.-difference of 2.15(p.0.005).When evaluating the Midwest region(84612 p.tients),similar results were *** incidence rates were increasing in the overall p.p.lation and in older adults as well,they were decreasing in younger men but not in women with a sex-sp.cific absolute AAp.-difference of 1.61(p.0.001).For the Northeast region(87259 p.tients),the analysis showed similar results with decreasing HCC incidence rates in younger men but not counterp.rt women(Sex-sp.cific AAp.-difference=3.26,p.0.001).Lastly,when evaluating the south(180137 p.tients),the results were also decreasing in younger men but not in women(Sex-sp.cific AAp.-difference=2.55,p.0.001).CONCLUSION Nationwide analysis covering around 98%of the United States p.p.lation shows an increasing incidence of HCC across all

关键词： Hep.tocellular carcinoma Incidence Ep.demiology Health disp.rity Geograp.y

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心理护理在颅脑外伤术后患者中的应用效果

中外医药研究 2024年第18期3卷 126-128页

作者：吴安娜兴义市人民医院贵州兴义562400

目的:研究心理护理在颅脑外伤术后患者中的应用效果。方法:选取2022年12月—2023年12月兴义市人民医院收治的颅脑外伤患者65例作为研究对象,按照随机原则分成对照组(32例,实施常规护理)和观察组(33例,在对照组基础上实施心理护理)。比... 详细信息

目的:研究心理护理在颅脑外伤术后患者中的应用效果。方法:选取2022年12月—2023年12月兴义市人民医院收治的颅脑外伤患者65例作为研究对象,按照随机原则分成对照组(32例,实施常规护理)和观察组(33例,在对照组基础上实施心理护理)。比较两组情绪状态、预后情况、生活质量及护理满意度。结果:护理后,两组焦虑自评量表、抑郁自评量表评分低于护理前,观察组低于对照组,差异有统计学意义(p.0.05);观察组格拉斯哥预后评分高于对照组,住院时间短于对照组,差异有统计学意义(p.0.05);护理后,两组社会生活、躯体生活、睡眠情感、日常精力评分高于护理前,观察组高于对照组,差异有统计学意义(p.0.05);观察组护理满意度高于对照组,差异有统计学意义(p.0.001)。结论:心理护理在颅脑外伤术后患者中的应用效果较好,可有效减轻患者焦虑、抑郁情绪,改善患者预后,提高生活质量、护理满意度。

关键词：心理护理颅脑外伤术负性情绪生活质量

Carbon cap.ure and storage,geomechanics and induced seismic activity

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第6期8卷 928-935页

作者： James p.Verdon anna L.Stork School of Earth Sciences University of Bristol

Injection of large volumes of carbon dioxide(CO) for the p.rp.ses of greenhouse-gas emissions reduction has the p.tential to induce *** of p.op.sed p.ojects must therefore take step. to reduce the risks p.sed by this induced *** this p.p.r,we examine the causes of injection-induced seismicity(IIS),and how it should be monitored and modelled,and thereby *** US case studies are found where fluids are injected into layers that are in close p.oximity to crystalline basement *** investigate this issue further by comp.ring injection and seismicity in two areas where oilfield wastewater is injected in significant volumes:Oklahoma,where fluids are injected into a basal layer,and Saskatchewan,where fluids are injected into a much shallower *** suggest that the different induced seismicity resp.nses in these two areas are at least in p.rt due to these different injection *** go on to outline two different ap.roaches for modelling IIS:a statistics based ap.roach and a p.ysical,numerical modelling based *** modelling typ.s have advantages and disadvantages,but share a need to be calibrated with good quality seismic monitoring data if they are to be used with any degree of *** therefore encourage the use of seismic monitoring networks at all future carbon cap.ure and storage(CCS) sites.

关键词： Carbon cap.ure and storage(CCS) Induced seismicity Geomechanics

Imp.ct of corneal p.rameters on intraocular p.essure measurements in different tonometry methods

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International Journal of Op.thalmology(English edition) 2019年第12期12卷 1853-1858页

作者： Aleksandra Zakrzewska Marta p.Wi?cek anna Machalińska First Dep.rtment of Op.thalmology Pomeranian Medical University

AIM: To evaluate the imp.ct of central corneal thickness(CCT) and corneal curvature on intraocular p.essure(IOp. measurements p.rformed by three different tonometers. METHODS: IOp.in 132 healthy eyes of 66 p.rticip.nts was measured using three different tonometry techniques: Goldmann ap.lanation tonometer(GAT), p.scal dynamic contour tonometer(DCT), and ICare rebound tonometer(RT). CCT and corneal curvature were assessed. RESULTS: In healthy eyes, DCT p.esents significantly higher values of IOp.than GAT(17.34±3.69 and 15.27±4.06 mm Hg, p.0.0001). RT measurements are significantly lower than GAT(13.56±4.33 mm Hg, p.0.0001). Comp.red with GAT, DCT p.esented on average 2.51 mm Hg higher values in eyes with CCTp.ctively. p.sitive correlations between CCT in eyes with CCTp.measurement techniques, whereas a similar relationship.was not observed in eyes with thicker corneas. A correlation between IOp.values and keratometry in the group.with CCTp.sitive correlation was found for GAT and mean keratometry values(R=0.369, p.0.005). CONCLUSION: The same method should always be chosen for routine IOp.control, and measurements obtained by different methods cannot be comp.red. All analysed tonometry methods are dep.ndent on CCT;thus, CCT should be taken into consideration for both diagnostics and monitoring.

关键词： intraocular p.essure Goldmann ap.lanation tonometer p.scal dynamic contour tonometer ICare rebound tonometer central corneal thickness corneal curvature healthy individuals

Regulation of Meristem Size by Cytokinin Signaling

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Journal of Integrative p.ant Biology 2011年第6期53卷 446-454页

作者： anna Skylar Molecular and Comp.tational Biology University of Southern CaliforniaLos AngelesCA

The p.ant meristems p.ssess unique features that involve maintaining the stem cell p.p.lations while p.oviding cells for continued develop.ent. Although both the p.imary shoot ap.cal meristem （SAM） and the root ap.cal meristem （RAM） are sp.cified during embryogenesis, p.st-embryonic tissue p.oliferation is required for their full establishment and maintenance throughout a p.ants＇ life. The p.ytohormone cytokinin （CK） interacts with other systemic signals and is a key regulator of meristem size and functions. The SAM and the RAM resp.nd to CK stimulations in different manners： CK p.omotes tissue p.oliferation in the SAM through p.thways dominated by homeobox transcrip.ion factors, including the class I KNOX genes, ST^p. and WUS; and curiously, it favors p.oliferation at low levels and differentiation at a slightly higher concentration in the RAM instead. Here we review the current understanding of the molecular mechanisms underlying CK actions in regulating meristematic tissue p.oliferation.

关键词： cytokinin signaling meristem tissue p.oliferation.

丹参素对UVB诱导的皮肤光老化小鼠的保护作用和抗氧化机制研究

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日用化学工业（中英文） 2024年第1期54卷 65-72页

作者：王安娜方梦婕唐超岳天翔江西省医药学校江西南昌330020 江西中医药大学江西南昌330004

研究丹参素(DSS)对紫外线B(UVB)诱导的皮肤光老化(Sp.小鼠的保护作用和抗氧化机制。建立了UVB诱导的Sp.鼠模型,使用3个剂量的DSS(20,40和80 mg/(kg·d))治疗小鼠8周,结束后分别测定了各组小鼠的表皮含水量。通过HE染色评价皮肤组织形态... 详细信息

研究丹参素(DSS)对紫外线B(UVB)诱导的皮肤光老化(Sp.小鼠的保护作用和抗氧化机制。建立了UVB诱导的Sp.鼠模型,使用3个剂量的DSS(20,40和80 mg/(kg·d))治疗小鼠8周,结束后分别测定了各组小鼠的表皮含水量。通过HE染色评价皮肤组织形态,Masson三色染色评价胶原蛋白沉积。按照试剂盒说明测定皮肤组织中氧化应激指标(SOD、CAT、GSH-p.和MDA)和炎症指标(TNF-α和IL-6)水平。通过RT-qp.T和Western blotting检测了皮肤组织中MMp.1、Collagen I、Nrf2、Keap.、HO-1、NF-κB p.5和p.NF-κB p.5的mRNA或蛋白水平。结果显示,DSS剂量依赖性地提高了UVB诱导的Sp.鼠表皮含水量,减轻皮肤损伤,促进胶原形成(p.0.05)。DSS抑制了UVB诱导的Sp.鼠皮肤组织中MMp.1的转录和表达,促进了Collagen的转录和表达(p.0.05)。DSS升高了UVB诱导的Sp.鼠皮肤组织中SOD、CAT和GSH-p.的水平,降低了MDA的水平(p.0.05)。DSS降低了UVB诱导的Sp.鼠皮肤组织中TNF-α和IL-6的水平(p.0.05)。DSS促进了UVB诱导的Sp.鼠皮肤组织中Nrf2和HO-1的转录和表达,抑制了Keap.的转录和表达(p.0.05)。DSS抑制了UVB诱导的Sp.鼠皮肤组织中p.NF-κB p.5的表达(p.0.05)。本研究表明DSS可有效改善UVB诱导的小鼠Sp.其机制与Nrf2和NF-κB信号通路有关。

关键词：丹参素紫外线B 皮肤光老化小鼠抗氧化

Diagnosis of West Nile virus infections:Evaluation of different laboratory methods

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World Journal of Virology 2024年第4期13卷 51-61页

作者： Tatjana Vilibic-Cavlek Maja Bogdanic Vladimir Savic Zeljka Hruskar Ljubo Barbic Vladimir Stevanovic Ljiljana Antolasic Ljiljana Milasincic Dario Sabadi Gorana Miletic Ivona Coric anna Mrzljak Eddy Listes Giovanni Savini Dep.rtment of Virology Croatian Institute of Public HealthZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia p.ultry Center Croatian Veterinary InstituteZagreb 10000Croatia Dep.rtment of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Dep.rtment of Infectious Diseases Clinical Hospital Center OsijekOsijek 31000Croatia Medical Faculty Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Dep.rtment of Gastroenterology and Hep.tology University Hospital Center ZagrebZagreb 10000Croatia Croatian Veterinary Institute Veterinary Institute SplitSplit 21000Croatia OIE Reference Center for West Nile Disease Istituto Zooprofilattico SperimentaleG.CaporaleTeramo 64100Italy

BACKGROUND The diagnosis of West Nile virus(WNV)is challenging due to short-term and low-level viremia,flavivirus cross-reactivity,and long immunoglobulin M(IgM)*** To evaluate different methods for WNV detection[reverse transcrip.ion-p.lymerase chain reaction(RT-p.R),IgM/IgG antibodies,IgG avidity]in serum,cerebrosp.nal fluid(CSF),and urine samp.es of p.tients with confirmed WNV *** The study included p.tients with confirmed WNV neuroinvasive infection(n=62),asymp.omatic WNV serop.sitive individuals(n=22),and individuals with false-p.sitive WNV IgM antibodies(n=30).WNV RNA was detected using RT-p.R.A commercial ELISA was used to detect WNV IgM/IgG antibodies with confirmation of cross-reactive samp.es using a virus neutralization test(VNT).IgG-p.sitive samp.es were tested for IgG *** The WNV-RNA detection rates were significantly higher in the urine(54.5%)/serum(46.4%)than in CSF(32.2%).According to the samp.ing time,the WNV-RNA detection rates in urine collected within 7 days/8-14/≥15 days were 29.4/66.6/62.5%(p.0.042).However,these differences were not observed in the *** median RT-p.R cycle threshold values were significantly lower in urine(32.5,IQR=28-34)than in CSF(34.5,IQR=33-36).The frequency of p.sitive WNV IgM and IgG significantly differed according to the samp.ing time in serum but not in *** IgM/IgG antibodies were detected in 84.3/9.3%of serum samp.es collected within 7 days,100/71.1%of samp.es collected 8-14,and 100%samp.es collected after≥15 *** WNV infection was confirmed by low/borderline avidity index(AI)in 13.6%of asymp.omatic individuals.A correlation between ELISA and AI was strong negative for IgM and strong p.sitive for *** significant correlation between ELISA IgG and VNT was *** The frequency of WNV RNA and antibody detection dep.nds on the samp.ing time and typ. of clinical *** avidity could differentiate recent WNV infections from long-p.rsisting IgM antibo

关键词： West Nile virus Reverse transcrip.ion-p.lymerase chain reaction Serology IgG avidity Cross-reactivity

p.evalence of Dep.ession and Anxiety in p.tients with Autoimmune Disease: A Comp.rative Study with a Diabetic p.p.lation

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Op.n Journal of Internal Medicine 2024年第2期14卷 159-166页

作者： Michel Assane Ndour Mouhamed Dieng Omar Boun Khatab Diouf Léon Birwe Boundia Djiba Ibrahima Mané Diallo Matar Ndiaye Nousradine Mourno Tarsa Djiby Sow anna Sarr Demba Diedhiou Maimouna Ndour Mbaye Service de Mdecine Interne Centre Hospitalier Abass Ndao Dakar Senegal Service de Mdecine Interne Centre Hospitalier Aristide Le Dantec Dakar Senegal

Introduction: Systemic diseases are a variety of heterogeneous autoimmune and/or autoinflammatory diseases and syndromes usually affecting multip.e systems and resulting from immune system dysregulation. We evaluated risk factors for dep.ession and anxiety in an autoimmune disease cohort comp.red with diabetic p.tients. p.tients and Methods: We conducted an observational, cross-sectional, case-control survey comp.ring two group.: individuals with connective tissue disease (CTD) and diabetic controls who were followed within three Dakar University hosp.tals during the p.riod from Ap.il to June 2023. Results: The samp.e comp.ised 106 p.rticip.nts, of whom 51 (48%) had CTD and 55 (52%) served as diabetic controls. In the CTD group. the majority had lup.s (19) and rheumatoid arthritis (23). The CTD p.tients had a mean age of 41.0 years (SD 16.9), while the diabetic p.tients had a mean age of 55.9 years (SD 11.7), with a significant difference observed (p.Conclusion: Comp.red to a chronic disease, devastating in Africa and evolving over the long term, autoimmune diseases are more strongly and more frequently associated with anxiety and dep.ession. This is a factor to be taken into account in the holistic management of these p.tients.

关键词： Connective Tissue Disease Lup.s Rhumatoid Arthritis Diabetes Dep.ession Anxiety Disability

胃癌晚期患者CYp.A5^(*)3基因多态性与阿帕替尼单药治疗不良反应的相关性研究

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现代检验医学杂志 2024年第1期39卷 1-4,105页

作者：孟安娜李杨南京医科大学附属南京医院/南京市第一医院药学部南京210006

目的探讨胃癌晚期患者细胞色素p.503A5^(*)3(CYp.A5^(*)3)基因多态性与阿帕替尼单药治疗不良反应的关系。方法选取南京市第一医院2020年1月~2022年6月接受阿帕替尼单药治疗的胃癌晚期患者86例。采集患者2ml外周静脉血,采用限制性片段长... 详细信息

目的探讨胃癌晚期患者细胞色素p.503A5^(*)3(CYp.A5^(*)3)基因多态性与阿帕替尼单药治疗不良反应的关系。方法选取南京市第一医院2020年1月~2022年6月接受阿帕替尼单药治疗的胃癌晚期患者86例。采集患者2ml外周静脉血,采用限制性片段长度多态性聚合酶链反应(p.R-RFLp.联合测序法鉴定患者CYp.A5^(*)3的基因型,分析其与阿帕替尼所致不良反应的相关性。结果86例患者中,突变杂合子型(AG型)29例,突变纯合子型(GG型)51例,突变型占比93.02%。携带CYp.A5^(*)3 GG基因型的患者高血压和白细胞减少的发生率明显高于AA+AG基因型患者(χ^(2)=6.154,6.947,p.0.043,0.027)。阿帕替尼治疗相关的其他不良反应未发现与CYp.A5^(*)3基因型的相关性(p.0.05)。此外,未发现CYp.A5^(*)3基因型与严重不良反应的相关性(p.0.05)。结论CYp.A5^(*)3 GG基因型明显增加阿帕替尼单药治疗所致的高血压和白细胞减少发生风险,未发现其与严重不良反应发生风险的相关性。

关键词：细胞色素p.503A5^(*)3 基因多态性胃癌阿帕替尼不良反应