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Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure

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World Journal of Gastroenterology 2010年第18期16卷 2227-2234页

作者： Taru Kantola Suvi Mklin anna-maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi Department of Anesthesiology and Intensive Care Medicine Surgical Hospital of Helsinki Helsinki University Hospital Finnish Office for Health Technology Assessment at the National Institute for Health and Welfare Finland Helsinki and Uusimaa Hospita Group Group Administration Department of Health Economics University of HelsinkiDepartment of Public Health and Finnish Office for Health Technology AssessmentPO Box 4100014 University of Helsinki Department of Surgery Transplantation and Liver Surgery ClinicHelsinki University Hospital Transplantation and Liver Surgery Clinic Helsinki University Hospital

AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to *** were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver *** 3-year outcomes and number of liver transplantations were *** direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control *** health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) *** HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was ***:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish *** to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 *** incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was ***:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone.

关键词： Albumin dialysis Cost-efficiency Healthrelated quality of life Quality-adjusted life year

Role of radiotherapy in the management of hepatocellular carcinoma:A systematic review

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World Journal of Hepatology 2015年第1期7卷 101-112页

作者： maria-Aggeliki Kalogeridi anna Zygogianni George Kyrgias John Kouvaris Sofia Chatziioannou Nikolaos Kelekis Vassilis Kouloulias Radiotherapy Department Larissa University Hospital41110 LarisaGreece 1~(st) Radiology Department Radiotherapy UnitAretaieion University Hospital11528 AthensGreece 2~(nd) Radiology Department Radiotherapy UnitAttikon University Hospital12642 AthensGreece

Many patients with hepatocellular carcinoma(HCC) present with advanced disease,not amenable to curative therapies such as surgery,transplantation or radiofrequency ablation. Treatment options for this group of patients include transarterial chemoembolization(TACE) and radiation therapy. Especially TACE,delivering a highly concentrated dose of chemotherapy to tumor cells while minimizing systemic toxicity of chemotherapy,has given favorable results on local control and survival. Radiotherapy,as a therapeutic modality of internal radiation therapy with radioisotopes,has also achieved efficacious tumor control in advanced disease. On the contrary,the role of external beam radiotherapy for HCC has been limited in the past,due to the low tolerance of surrounding normal liver parenchyma. However,technological innovations in the field of radiotherapy treatment planning and delivery,have provided the means of delivering radical doses to the tumor,while sparing normal tissues. Advanced and highly conformal radiotherapy approaches such as stereotactic body radiotherapy and proton therapy,evaluated for efficacy and safety for HCC,report encouraging results. In this review,we present the role of radiotherapy in hepatocellular carcinoma patients not suitable for radical treatment.

关键词： Hepatocellular carcinoma Radiotherapy Radio-embolization Hyperthermia Review

WNT/β-catenin signaling in hepatocellular carcinoma:The aberrant activation,pathogenic roles,and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 727-746页

作者： anna Gajos-Michniewicz Malgorzata Czyz Department of Molecular Biology of Cancer Medical University of LodzLodz 92-215Poland

Hepatocellular carcinoma(HCC)is a liver cancer,highly heterogeneous both at the histopathological and molecular *** arises from hepatocytes as the result of the accumulation of numerous genomic alterations in various signaling pathways,including canonical WNT/β-catenin,AKT/mTOR,MAPK pathways as well as signaling associated with telomere maintenance,p53/cell cycle regulation,epigenetic modifiers,and oxidative *** role of WNT/β-catenin signaling in liver homeostasis and regeneration is well established,whereas in development and progression of HCC is extensively ***,we review recent advances in our understanding of how WNT/β-catenin signaling facilitates the HCC development,acquisition of stemness features,metastasis,and resistance to *** outline genetic and epigenetic alterations that lead to activated WNT/β-catenin signaling in *** discuss the pivotal roles of CTNNB1 mutations,aberrantly expressed non-coding RNAs and complexity of crosstalk between WNT/β-catenin signaling and other signaling pathways as challenging or advantageous aspects of therapy development and molecular stratification of HCC patients for treatment.

关键词： Cancer stem cells CTNNB1 mutations Liver cancer Non-coding RNA Tumor heterogeneity

Flutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries

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Journal of Animal Science and Biotechnology 2019年第3期10卷 618-632页

作者： Katarzyna Knapczyk-Stwora anna Nynca Renata E.Ciereszko Lukasz Paukszto Jan P.Jastrzebski Elzbieta Czaja Patrycja Witek Marek Koziorowski maria Slomczynska Department of Endocrinology Institute of Zoology and Biomedical ResearchJagiellonian University in KrakowGronostajowa 9 Street30-387 KrakowPoland Laboratory of Molecular Diagnostics Faculty of Biology and BiotechnologyUniversity of Warmia and Mazury in OlsztynOlsztynPoland Department of Animal Anatomy and Physiology Faculty of Biology and BiotechnologyUniversity of Warmia and Mazury in OlsztynOlsztynPoland Department of Plant Physiology Genetics and BiotechnologyFaculty of Biology and BiotechnologyUniversity of Warmia and Mazury in OlsztynOlsztynPoland Department of Physiology and Reproduction of Animals University of RzeszowRzeszowPoland

Background: Androgens are involved in the regulation of ovarian development during fetal/neonatal *** chemicals displaying anti-androgenic activities may affect multiple signal transduction pathways by blocking endogenous androgen *** aim of the current study was to examine effects of the anti-androgen flutamide on the expression of coding transcripts and long non-coding RNAs(lncRNAs) in neonatal porcine *** employing RNA-Seq technology we aimed to extend our understanding of the role of androgens in neonatal folliculogenesis and examine the impact of the anti-androgen flutamide on ovarian ***: Piglets were subcutaneously injected with flutamide(50 mg/kg BW) or corn oil(controls) between postnatal days 1 and 10(n = 3/group).Ovaries were excised from the 11-day-old piglets and total cellular RNAs were isolated and ***: Flutamide-treated piglet ovaries showed 280 differentially expressed genes(DEGs;P-adjusted < 0.05 and log2 fold change ≥1.0) and 98 differentially expressed lncRNAs(DELs;P-adjusted < 0.05 and log2 FC ≥ 1.0).The DEGs were assigned to GO term,covering biological processes,molecular functions and cellular components,which linked the DEGs to functions associated with cellular transport,cell divisions and *** addition,STRING software demonstrated strongest interactions between genes related to cell *** between DEGs and DELs were also found,revealing that a majority of the genes targeted by the flutamide-affected lncRNAs were associated with intracellular transport and cell ***: Our results suggest that neonatal exposure of pigs to flutamide alters the expression of genes involved in ovarian cell proliferation,ovarian steroidogenesis and oocyte fertilization,which in turn may affect female reproduction in adult life.

关键词： Flutamide LncRNA Ovary Pig RNA-Seq Transcriptome

Production and characterization of bioaerosols for model validation in spacecraft environment

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Journal of Environmental Sciences 2018年第7期30卷 227-238页

作者： Anniina Salmela Eero Kokkonen Ilpo Kulmala anna-maria Veijalainen Rob van Houdt Natalie Leys Audrey Berthier Ilyin Viacheslav Sergey Kharin Julia Morozova Alexander Tikhomirov Pertti Pasanen Department of Environmental and Biological Sciences University of Eastern Finland PO Box 1627 FI-70211 Kuopio Finland VTT Ltd PO Box 1300 FI-33100 Tampere Finland Microbiology Unit Belgian Nuclear Research Centre B-2400 Mol Belgium Institut de Medecine et de Physiologie Spatiales BP 74404 F-31405 Toulouse Cedex France Institute of Bio-Medical Problems 76-A Khorosheu Skoye shosse RU-123007 Moscow Russia Institute of Biophysics SB RAS Akademgorodok Krasnoyarsk RU-660036 Russia

This study aimed to evaluate the suitability of two bioaerosol generation systems（dry and wet generation） for the aerosolization of microorganisms isolated from the International Space Station, and to calibrate the produced bioaerosols to fulfill the requirements of computational fluid dynamics model（CFD） validation. Concentration, stability, size distribution, agglomeration of generated bioaerosol and deposition of bioaerosols were analyzed. In addition, the dispersion of non-viable particles in the air was *** proved that wet generation from microbial suspensions could be used for the production of well-calibrated and stabile bioaerosols for model validation. For the simulation of the natural release of fungal spores, a dry generation method should be used. This study showed that the used CFD model simulated the spread of non-viable particles fairly well. The mathematical deposition model by Lai and Nazaroff could be used to estimate the deposition velocities of bioaerosols on surfaces, although it somewhat underestimated the measured deposition velocities.

关键词： Bioaerosol Modeling CFD Spacecraft Fungi Bacteria

Global epigenetic changes during somatic cell reprogramming to iPS cells

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Journal of Molecular Cell Biology 2011年第6期3卷 341-350页

作者： anna Mattout Alva Biran Eran Meshorer Department of Genetics Institute of Life SciencesThe Hebrew University of JerusalemJerusalem 91904Israel

Embryonic stem cells(ESCs)exhibit unique chromatin features,including a permissive transcriptional program and an open,decondensed chromatin *** pluripotent stem cells(iPSCs),which are very similar to ESCs,hold great promise for therapy and basic ***,the mechanisms by which reprogramming occurs and the chromatin organization that underlies the reprogramming process are largely *** we characterize and compare the epigenetic landscapes of partially and fully reprogrammed iPSCs to mouse embryonic fibroblasts(MEFs)and ESCs,which serves as a standard for *** immuno-fluorescence and biochemical fractionations,we analyzed the levels and distribution of a battery of histone modifications(H3ac,H4ac,H4K5ac,H3K9ac,H3K27ac,H3K4me3,H3K36me2,H3K9me3,H3K27me3,and gH2AX),as well as HP1a and lamin *** find that fully reprogrammed iPSCs are epigenetically identical to ESCs,and that partially reprogrammed iPSCs are closer to ***,combining both time-course reprogramming experiments and data from the partially reprogrammed iPSCs,we find that heterochromatin reorganization precedes Nanog expression and active histone ***,these data delineate the global epigenetic state of iPSCs in conjunction with their pluripotent state,and demonstrate that heterochromatin precedes euchromatin in reorganization during reprogramming.

关键词： chromatin pluripotency reprogramming iPSCs ESCs histone modifications epigenetics

Key changes across valley floors in mountain areas affected by different levels of human impact: a case study of the Ochotnica river catchment in the Polish Carpathians

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Journal of Mountain Science 2024年第11期21卷 3567-3583页

作者： Agata GOŁĄB anna MICHNO Doctoral School of Exact and Natural Sciences Jagiellonian UniversityProf.St.Łojasiewicza St 11Cracow 30348Poland Faculty of Geography and Geology Jagiellonian UniveristyGronostajowa St 3Cracow 30387Poland

The goal of this paper was to present knowledge on changes in the morphodynamic structure of the Ochotnica River(Polish Carpathians)and transformations within its active river zone since the end of the 19th *** study used a set of archival and contemporary cartographic materials and the results of three-fold field mapping of the morphodynamic structure of the *** and indirect human interference with the natural environment of the catchment and the fluvial system was taken into account in the *** of changes in the morphodynamic structure of the Ochotnica and its active river zone since the end of the 19th century indicated significant changes in the development trend of the *** contemporary structure of the Ochotnica is more complex than in the *** has been a fragmentation of the riverbed into sections with different morphodynamic *** proportion of erosive sections has increased,which explains the reduced in the width of the active river zone of the *** average width of the active river zone of the river between 1861 and 2022 has changed from 80 m to 18 *** impact has been identified as the main reason for the changes in the morphodynamic structure of the riverbed and its active river ***,only the unregulated sect ion is characterised by free lateral migration of the riverbed and the widest active river zone(~28 m).

关键词： Active river zone Channel changes Mountain river Human impact

Crystal structure and thermal expansion of perovskites containing uranium(VI) and rare-earth elements

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Journal of Rare Earths 2009年第1期27卷 4-11页

作者： Aleksandr Knyazev anna Ershova Nikolai Chernorukov Nizhny Novgorod State University

By the method of high-temperature reactions in solid phase, compounds with the general formula MⅡ（AⅢ2/3U1/3）O3（MⅡ=Sr, AⅢ=Sc, In;MⅡ=Ba, AⅢ=Sc, In, Y, Nd-Lu） were *** structures（space groups Fm 3 m and Pnma） were refined by the Rietveld method and morphotropic transition in Ba（Ln2/3U1/3）O3 on the border of Gd-Tb was *** means of high-temperature X-ray diffraction, phase transitions were studied and thermal expansion coefficients were determined.

关键词： perovskite uranium X-ray diffraction Rietveld structure thermal expansion rare earths

Surface coal mine permit application for successful reclamation, semi-arid shortgrass prairie （Wyoming, USA）

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International Journal of Coal Science & Technology 2018年第1期5卷 8-17页

作者： anna Krzyszowska Waitkus Environmental Consulting 80 Eagle Nest LaramieWY 82070 USA

Approximately 40% of USA coal originates in an ecologically sensitive area of semi-arid shortgrass prairie in Wyoming. Before a surface coal mine can begin operation in the USA, it must secure a mining permit and comply with regulations and performance standards under the USA Surface Mining Control and Reclamation Act （SMCRA）, other federal environmental acts, and state programs. The Wyoming Department of Environmental Quality （WDEQ）/Land Quality Division （LQD） administers Wyoming＇s coal regulatory program. The permit application and bonding process for the largest surface coal mine permit in the USA, North Antelope Rochelle Mine （NARM） located in short grassland prairie in the northeast Wyoming, is discussed. The permit application process begins with the collection of baseline environ- mental data that characterizes premining conditions of the permit area. The permit application includes adjudication information, baseline information, mine and operation plans, and reclamation plans. Fulfillment of permit commitments and requirements of rules and regulations are inspected monthly by the LQD＇ s representative in the field. Before a mine permit is issued, the mine operator must submit a reclamation bond to secure the performance of reclamation obligations that is later revised annually. In Wyoming, four reclamation bond release phases indicate the completion of various stages of the reclamatikon process. NARM＇s specific bond release verification cirteria, performance standards, and field verificatoins of bond release phases are discussed. The Bond Release Geodatabase （a GIS/GPS approach） was developed for this mine to monitor progress in meeting criteria and performance standards for incremental bond release. The Bond Release Geodatabase significantly reduces the time needed to track bond release progress, reach agreement between operator and regulator, and improve the state inspector＇s ability to assess reclamation adequacy and progress.

关键词： Surface coal mine permitting Bonding Reclamation GIS/GPS geodatabase USA rules and regulations Inspections