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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen muhammad m Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y mansour mohamad Abdalkader michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura mechtouff michel Piotin Fabricio Oliveira Lima Francisco mont'Alverne Wazim Izzath Nobuyuki Sakai mahmoud mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami anna m cervantes-arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile melanie Walker malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan michael Chen monika Killer-Oberpfalzer Vitor mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC magalhaes Raghid Kikano Santiago Ortega-Gutierrez mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa markus möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri anna Luisa Kuhn Gianmarco Bernava Paolo machi Daniel G Abud Octavio m Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P mehta Naoto Kimura mamoru murakami Jin Soo Lee Ji man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve m Cordina Hong Gee Roh Ken Wong Juan F Arenillas mario martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca m Luis Silva Teddy Y Wu Simon John Alex Brehm marios Psychogios William J mack matthew Tenser Tatemi Todaka miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri michael Kelly Lissa Peeling Yuichi murayama Hugh Stephen Winters Johnny Wong mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 march-31 may 2020.The prior 1-year control period(1 march-31 may 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pmbolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,pm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of Clinical Oncology 2024年第2期15卷 195-207页

作者： Angeles C Tecalco-Cruz Karen H medina-Abreu Enrique Oropeza-martínez Jesus Zepeda-cervantes AleidaVázquez-macías marina macías-Silva Posgrado en Ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Colegio de Ciencias y Humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología Celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of cancer.The deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer progression.In particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γsignaling.In this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in LUAD.Interestingly,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus 2.In addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

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Expectations and Level of Satisfaction of the Patient with Parkinson’s Disease Undergoing Deep Brain Stimulation Surgery at the National Institute of Neurology and Neurosurgery

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Advances in Parkinson's Disease 2024年第1期13卷 1-7页

作者： Paola Bazán-Rodríguez Eduardo Ichikawa-Escamilla Etienne Reséndiz-Henríquez Carlos E. martínez-Cortés Amin cervantes-Arriaga mayela Rodríguez-Violante Lisette Bazán-Rodríguez Laboratorio de Enfermedades Neurodegenerativas en el Instituto Nacional de Neurología y Neurocirugía manuel Velasco Suarez Ciudad de México México Laboratorio de Enfermedades Neurodegenerativas en el Instituto Nacional de Neurología y Neurocirugía manuel Velasco Suarez Ciudad de México México. Unidad Periférica para el Estudio de la Neuroinflamación en Patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de México México

Background: Deep brain stimulation (DBS) is an established treatment for patients with advanced Parkinson’s disease (PD). Reports show continued patient satisfaction after surgery despite not maintaining clinical improvement as measured by evolution scales. Objectives: The present study sought to explore expectations and level of satisfaction in patients after DBS surgery with a semi-structured questionnaire and subsequent correlation with functional scales, Quality of Life (QoL), and motor and non-motor symptoms. methods: We performed descriptive statistics to represent demographic data, Wilcoxon rank tests to determine significant differences, and Spearman correlation between the applied scales. Results: We evaluated 20 patients with a history of DBS surgery. 45% were female, with a mean age of 55.7 ± 14.15 years, a mean disease duration of 13.42 ± 8.3 years, and a mean time after surgery of 3.18 ± 1.86 years. Patients reported surgery meeting expectations in 85.5% and continued satisfaction in 92%. These two variables showed a significant correlation. Conclusions: This sample of patients remained satisfied after DBS surgery, although we found no differences in motor and non-motor clinimetric scales. Further studies are needed to confirm the importance of assessing quality of life in patients with DBS.

关键词： Parkinson’s Disease Quality of Life Deep Brain Stimulation Patient Satisfaction

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Cell-specific pathways recruited for symbiotic nodulation in the medicago truncatula legume

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molecular Plant 2022年第12期15卷 1868-1888页

作者： Sergio Alan cervantes-Pérez Sandra Thibivilliers Carole Laffont Andrew D.Farmer Florian Frugier marc Libault Department of Agronomy and Horticulture Center for Plant Science InnovationUniversity of Nebraska-LincolnLincolnNE 68503USA Single Cell Genomics Core Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA Institute of Plant Sciences Paris-Saclay(IPS2) UniversitéParis-SaclayCNRSINRAEUniversitéParis-CitéUniversitéd’Evry91190 Gif-sur-YvetteFrance National Center for Genome Resources Santa FeNM 87505USA

medicago truncatula is a model legume species that has been studied for decades to understand the symbiotic relationship between legumes and soil bacteria collectively named rhizobia.This symbiosis called nodulation is initiated in roots with the infection of root hair cells by the bacteria,as well as the initiation of nodule primordia from root cortical,endodermal,and pericycle cells,leading to the development of a new root organ,the nodule,where bacteria fix and assimilate the atmospheric dinitrogen for the benefit of the plant.Here,we report the isolation and use of the nuclei from mock and rhizobia-inoculated roots for the single nuclei RNA-seq(sNucRNA-seq)profiling to gain a deeper understanding of early responses to rhizobial infection in medicago roots.A gene expression map of the medicago root was generated,comprising 25 clusters,which were annotated as specific cell types using 119 medicago marker genes and orthologs to Arabidopsis cell-type marker genes.A focus on root hair,cortex,endodermis,and pericycle cell types,showing the strongest differential regulation in response to a short-term(48 h)rhizobium inoculation,revealed not only known genes and functional pathways,validating the sNucRNA-seq approach,but also numerous novel genes and pathways,allowing a comprehensive analysis of early root symbiotic responses at a cell type-specific level.

关键词： medicago root single-cell transcriptomic rhizobium nodule initiation root hair cells cortical cells

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Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade:A single-center experience

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World Journal of Gastroenterology 2022年第40期28卷 5881-5892页

作者： Eduardo cervantes-Alvarez mario Vilatoba Nathaly Limon-de la Rosa Osvely mendez-Guerrero David Kershenobich Aldo Torre Nalu Navarro-Alvarez PECEm Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico City 14080Mexico Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Department of Trasplant Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Department of molecular Biology Universidad Panamericana School of MedicineMexico City 03920Mexico Department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States

BACKGROUND Liver transplantation for the most critically ill remains controversial;however,it is currently the only curative treatment option.AIm To assess immediate posttransplant outcomes and compare the short(1 year)and long-term(6 years)posttransplant survival among cirrhotic patients stratified by disease severity.mETHODS We included cirrhotic patients undergoing liver transplantation between 2015 and 2019 and categorized them into compensated cirrhosis(CC),decompensated cirrhosis(DC),and acute-on-chronic liver failure(ACLF).ACLF was further divided into severity grades.Our primary outcomes of interest were total days of intensive care unit(ICU)and hospital stay,development of complications and posttransplant survival at 1 and 6 years.RESULTS 235 patients underwent liver transplantation(CC=11,DC=129 and ACLF=95).Patients with ACLF had a significantly longer hospital stay[8.0(6.0-13.0)vs CC,6.0(3.0-7.0),and DC 7.0(4.5-10.0);P=0.01]and developed more infection-related complications[47(49.5%),vs CC,1(9.1%)and DC,38(29.5%);Pmilar among groups(P=0.60 and P=0.90,respectively).ACLF patients stratified according to ACLF grade[ACLF-1 n=40(42.1%),ACLF-2 n=33(34.7%)and ACLF-3 n=22(23.2%)],had similar ICU and hospital stay length(P=0.68,P=0.54),as well as comparable frequencies of overall and infectious posttransplant complications(P=0.58,P=0.80).There was no survival difference between ACLF grades at 1 year and 6 years(P=0.40 and P=0.15).CONCLUSION Patients may benefit from liver transplantation regardless of the cirrhosis stage.ACLF patients have a longer hospital stay and frequency of infectious complications;however,excellent,and comparable 1 and 6-year survival rates support their enlisting and transplantation including those with ACLF-3.

关键词： Liver transplantation Acute-on-chronic liver failure Prognosis Survival analysis Critical care

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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1584-1606页

作者： Rodolfo Daniel cervantes-Villagrana Damaris Albores-García Alberto Rafael cervantes-Villagrana Sara Judit García-Acevez Department of Pharmacology Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)07360 Mexico CityMexico Department of Environmental Health Sciences Florida International University(FIU)MiamiFlorida 33199USA Laboratorio de investigación en Terapéutica Experimental Unidad Académica de Ciencias QuímicasÁrea de Ciencias de la SaludUniversidad Autónoma de Zacatecas(UAZ)ZacatecasMéxico Dirección de Proyectos e Investigación Grupo Diagnóstico Médico Proa06400 CDMX CuauhtémocMéxico

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and dissemination.Besides the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and leukocytes.The neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor cells.Strikingly,tumor-associated nerve fibers can guide cancer cell dissemination.moreover,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(mDSCs),and m2 macrophages,to the tumor microenvironment.These leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic effect.Furthermore,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTLA-4 plasma membrane proteins.Altogether,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer cells.Inspired by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced neurogenesis.Here we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based therapies.Small molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis.

关键词： PD1 therapies invasion

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Effects of a blend of Saccharomyces cerevisiae-based direct-fed microbial and fermentation products on plasma carbonylmetabolome and fecal bacterial community of beef steers

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Journal of Animal Science and Biotechnology 2020年第2期11卷 504-513页

作者： James A.Adeyemi Sunday O.Peters marcos De Donato Andres Pech cervantes Ibukun m.Ogunade College of Agriculture Communitiesand the EnvironmentKentucky State UniversityFrankfortKY 40601USA Department of Animal Science Berry CollegeMount BerryGA 30149USA Tecnologico de monterrey Escuela de Ingenieria y CienciasQueretaroMexico Agricultural Research Station Fort Valley State UniversityFort ValleyGA 31030USA

Background:Previous studies have evaluated the metabolic status of animals fed direct-fed microbial(DFm)using enzyme-based assays which are time-consuming and limited to a few metabolites.In addition,little emphasis has been placed on investigating the effects of DFm on hindgut microbiota.We examined the effects of dietary supplementation of a blend of Saccharomyces cerevisiae-based DFm and fermentation products on the plasma concentrations of carbonyl-containing metabolites via a metabolomics approach,and fecal bacterial community,via 16S rRNA gene sequencing,of beef steers during a 42-day receiving period.Forty newly weaned steers were randomly assigned to receive a basal diet with no additive(CON;n=20)or a basal diet supplemented with 19 g of Commence™(PROB;n=20)for a 42-day period.Commence™(PmI,Arden Hills,mN)is a blend of 6.2×1011 cfu/g of S.cerevisiae,3.5×1010 cfu/g of a mixture of Enterococcus lactis,Bacillus subtilis,Enterococcus faecium,and Lactobacillus casei,and the fermentation products of these aforementioned microorganisms and those of Aspergillus oryzae and Aspergillus niger.On d 0 and 40,rectal fecal samples were collected randomly from 10 steers from each treatment group.On d 42,blood was collected for plasma preparation.Results:A total number of 812 plasma metabolites were detected.Up to 305 metabolites[fold change(FC)≥1.5,FDR≤0.01]including glucose,hippuric acid,and 5-hydroxykynurenamine were increased by PROB supplementation,whereas 199 metabolites(FC≤0.63,FDR≤0.01)including acetoacetate were reduced.Supplementation of PROB increased(P≤0.05)the relative abundance of Prevotellaceae UCG-003,megasphaera,Dorea,Acetitomaculum,and Blautia.In contrast,the relative abundance of Elusimicrobium,moheibacter,Stenotrophomonas,Comamonas,and uncultured bacterium belonging to family p-2534-18B5 gut group(phylum Bacteroidetes)were reduced(P≤0.05).Conclusions:The results of this study demonstrated that supplementation of PROB altered both the plasma carbonyl metabolome towards increased glucose concentration su

关键词： Beef steer Carbonyl Fecal bacteria Lactate-utilizing bacteria Plasma metabolomics

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Evaluating physical changes of iron oxide nanoparticles due to surface modification with oleic acid

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Chinese Physics B 2020年第10期29卷 186-194页

作者： S Rosales N Casillas A Topete O cervantes G González J A Paz m E Cano Centro Universitario de Ciencias Exactas e Ingenienas Universidad de GuadalajaraBlvd.Marcelino Garcia Burragan 1421C.P.44430GuadalajaraJaliscoMexico Centro Universitario de la Cienegu Universidad de GuadalajaraAv.Universidad 1115C.P.47820OcotlanJaliscoMexico Centro Universitario de Ciencias de In Salud Universidad de Guadalajara.Sierra Mojada 950C.P.44340GuadalajaraJaliscoMexico

The physical characterization of a colloidal system of superficially modified magnetic nanoparticles (mNPs) is presented. The system consists of oleic acid-coated iron oxide nanoparticles (OAmNP) suspended in water. A structural analysis is carried out by using standard physical techniques to determine the diameter and shape of the mNPs and also the width of the coating shell. The colloidal stability and the polydispersity index of this ferrofluid are determined by using Zeta potential measurements. Additionally, the magnetic characterization is conducted by obtaining the DC magnetization loops, and the blocking temperatures are determined according to the ZFC–FC protocol. Finally, the values of power absorption density P of the ferrofluid are estimated by using a magneto-calorimetric procedure in a wide range of magnetic field amplitude H and frequency f. The experimental results exhibit spherical-like shape of OAmNP with (20 ± 4) nm in diameter. Due to the use of coating process, the parameters of the magnetization loops and the blocking temperatures are significantly modified. Hence, while the uncoated mNPs show a blocking state of the magnetization, the OAmNP are superparamagnetic above room temperature (300 K). Furthermore, the reached dependence P versus f and P versus H of the ferrofluid with coated mNPs are clearly fitted to linear and quadratic correlations, respectively, showing their accordance with the linear response theory.

关键词： nanoparticles ferrofluid magnetic hyperthermia functionalization

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Caerulin-induced pancreatitis in rats: Histological and genetic expression changes from acute phase to recuperation

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World Journal of Gastroenterology 2006年第25期12卷 3999-4003页

作者： Javier magaa-Gómez Guillermo López-cervantes Ana maría Calderón de la Barca Departamento de Nutrición Centro de Investigación en Alimentación y Desarrollo A.C. HermosilloSonoraMéxicoDepartamento de Patología Hospital Infantil del Estado de SonoraHermosilloSonoraMéxicoDepartamento de Nutrición Centro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico

瞄准：为了学习组织学、联系胰腺炎的蛋白质 mRNA 累积，在老鼠从导致 caerulin 的胰腺炎的尖锐阶段胰改变到恢复。方法：尖锐胰腺炎被 caerulein 在男 Wistar 老鼠导致并且列在后面在上面为 90 d 由组织学并且胰的 mRNA 分析。胰在 0 ... 详细信息

瞄准：为了学习组织学、联系胰腺炎的蛋白质 mRNA 累积，在老鼠从导致 caerulin 的胰腺炎的尖锐阶段胰改变到恢复。方法：尖锐胰腺炎被 caerulein 在男 Wistar 老鼠导致并且列在后面在上面为 90 d 由组织学并且胰的 mRNA 分析。胰在 0 点被把， 9， 24 h 并且 3， 5， 15， 30， 60， 90 d 正式就职以后。浮肿(E) ， polymorphonuclear neutrophil (PmN ) 渗入，细胞质的空泡形成(V) ，酶原小粒弄空(ZD ) 和腺泡组织的破坏(广告) 是评估的用显微镜。联系胰腺炎的蛋白质(奶头) 和 L13A mRNAs 的累积被即时 PCR 确定。结果：主要组织学的变化出现在为 PmN 渗入和细胞质的 V 正式就职以后的 9 h 在为 E 和 ZD 的 24 h 和 3 d 分别地。所有参数在 5 d 以后被恢复，除了推迟了超过 30 d 的 ZD。主要广告在 15 d 以后被观察，值在 30 d 以后回到了正常。同样到组织学的变化， PAP mRNA 的累积在 24 h 与最高的累积在 9 h 被增加，差别消失在 5 d 以后。结论：从尖锐阶段发生到胰的胰腺炎，新生和重新区别的恢复并且奶头表示是只胰腺炎的尖锐回答。

关键词：雨蛙肽胰腺炎组织遗传疾病

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Experimental investigations of transient pressure variations in a high head model Francis turbine during start-up and shutdown

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Journal of Hydrodynamics 2014年第2期26卷 277-290页

作者： TRIVEDI Chirag cervantes michel J. GANDHI B.K. OLE DAHLHAUG G. Division of Fluid and Experimental mechanics Department of Engineering Sciences and Mathematics Lule? University of Technology Department of mechanical and Industrial Engineering Indian Institute of Technology Water Power Laboratory Department of Energy and Process Engineering Norwegian University of Science and Technology

Penetration of the power generated using wind and solar energy to electrical grid network causing several incidents of the grid tripping, power outage, and frequency drooping. This has increased restart （star-stop） cycles of the hydroelectric turbines significantly since grid connected hydroelectric turbines are widely used to manage critical conditions of the grid. Each cycle induces significant stresses due to unsteady pressure loading on the runner blades. The presented work investigates the pressure loading to a high head （ He = 377 m, De = 1.78 m） Francis turbine during start-stop. The measurements were carried out on a scaled model turbine （Hm = 12.5 m, Dm = 0.349 m）. Total four operating points were considered. At each operating point, three schemes of guide vanes opening and three schemes of guide vanes closing were investigated. The results show that total head variation is up to 9% during start-stop of the turbine. On the runner blade, the maximum pressure amplitudes are about 14 kPa and 16 kPa from the instantaneous mean value of 121 kPa during rapid start-up and shutdown, respectively, which are about 1.5 times larger than that of the slow start-up and shutdown. moreover, the maximum pressure fluctuations are given at the blade trailing edge.

关键词： Francis turbine pressure fluctuations start-up shutdown transient

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