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Acta Pharmaceutica Sinica B 2021年第12期11卷 3756-3767页

作者： Regina D.Schnegelberger Anna L.Lang Gavin E.Arteel Juliane I.Beier Department of Pharmacology&Chemical Biology University of PittsburghPittsburghPA 15213USA Department of Neurology University of Miami Miller School of MedicineMiamiFL 33136USA Department of Medicine Division of GastroenterologyHepatology&NutritionUniversity of PittsburghPittsburghPA 15213USA Pittsburgh liver Research Center University of PittsburghPittsburghPA 15213USA Department of Environmental&Occupational Health University of PittsburghPittsburghPA 15213USA

Occupational and environmental exposures to industrial chemicals are well known to cause hepatotoxicity and liver injury.However,despite extensive evidence showing that exposure can lead to disease,current research approaches and regulatory policies fail to address the possibility that subtle changes caused by low level exposure to chemicals may also enhance preexisting conditions.In recent years,the conceptual understanding of the contribution of environmental chemicals to liver disease has progressed significantly.Mitochondria are often target of toxicity of environmental toxicants resulting in multisystem disorders involving different cells,tissues,and organs.Here,we review persistent maladaptive changes to mitochondria in response to environmental toxicant exposure as a mechanism of hepatotoxicity.With better understanding of the mechanism(s) and risk factors that mediate the initiation and progression of toxicant-induced liver disease,rational targeted therapy can be developed to better predict risk,as well as to treat or prevent this disease.

关键词： Organochlorines Metals Persistent organic pollutants TASH liver disease Hepatotoxicity Mitochondrial maladaptation Mitohormesis

经颈静脉肝内门体静脉分流术后肾功能改变及其与生存情况的关系:单中心经验

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Gastroenterology Report 2021年第4期9卷 306-312,I0001,I0002页

作者： Min lang Angela l.lang Brian Q.Tsui Weiping Wang Brian K.Erly Bo Shen Baljendra Kapoor Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Anesthesia Critical Careand Pain ManagementMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Radiology UCLA Medical CenterLos AngelesCAUSA Department of Radiology Mayo ClinicJacksonvilleFLUSA Colorado School of Public Health AuroraColoradoUSA The Inflammatory Bowel Disease Center at Columbia Columbia University Irving Medical CenterNew YorkNYUSA Division of Vascular and Interventional Radiology Imaging InstituteCleveland ClinicClevelandOHUSA

背景:经颈静脉肝内门体静脉分流术(TIPS)对于肾功能的影响以及TIPS之后血肌酐(Cr)水平与病死率的关系仍然不明。本研究旨在评估TIPS对肾功能的影响,以及TIPS治疗后Cr水平与死亡风险的关系。方法:2004-2017年间接受TIPS治疗的593例患者... 详细信息

背景:经颈静脉肝内门体静脉分流术(TIPS)对于肾功能的影响以及TIPS之后血肌酐(Cr)水平与病死率的关系仍然不明。本研究旨在评估TIPS对肾功能的影响,以及TIPS治疗后Cr水平与死亡风险的关系。方法:2004-2017年间接受TIPS治疗的593例患者被纳入研究。收集TIPS术前7天内(T0)以及术后12天(T1)、512天(T2)、1540天(T3)的Cr水平。采用多变量线性回归和Cox比例风险模型评估TIPS后Cr水平对1年死亡率的预测价值。结果:593例患者中,127例(21.4%)基础Cr水平升高(≥1.5 mg/dl;平均2.51˘1.49 mg/dl),466例(78.6%)基础Cr水平正常(l;平均0.92˘0.26 mg/dl)。TIPS术前Cr水平升高的患者TIPS之后Cr水平显著降低(0.60 mg/dl),而TIPS术前Cr水平正常的患者TIPS之后Cr水平无明显变化(l)。全组患者TIPS之后30天、90天及1年死亡率分别为13%、20%和32%。静脉曲张出血、T0 Cr高水平及T3高Cr水平是1年死亡率的独立危险因素。结论:对于基础肾功能不全的患者,TIPS可改善其肾功能。TIPS之后Cr水平是1年死亡风险的有效预测指标。

关键词： Cox比例风险模型静脉曲张出血经颈静脉肝内门体静脉分流术死亡风险 TIPS 肾功能不全

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不要抛弃你的现有网络

软件 2009年第2期30卷 22-23页

作者： Trevor l.lang 辛磊夫 HMS工业网络

诸如限制开关和接近传感器这样的设备未来也不会装配以太网,所以这里要介绍的就是如何将它们和以太网连接起来。

关键词：网络接近传感器以太网

Co-occurrence based texture synthesis

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Computational Visual Media 2022年第2期8卷 289-302页

作者： anna Darzi Itai lang Ashutosh Taklikar Hadar Averbuch-Elor Shai Avidan Tel Aviv University Tel Aviv 6997801Israel Cornell-Tech Cornell UniversityNYCNY10044USA

As image generation techniques mature,there is a growing interest in explainable representations that are easy to understand and intuitive to manipulate.In this work,we turn to co-occurrence statistics,which have long been used for texture analysis,to learn a controllable texture synthesis model.We propose a fully convolutional generative adversarial network,conditioned locally on co-occurrence statistics,to generate arbitrarily large images while having local,interpretable control over texture appearance.To encourage fidelity to the input condition,we introduce a novel differentiable co-occurrence loss that is integrated seamlessly into our framework in an end-to-end fashion.We demonstrate that our solution offers a stable,intuitive,and interpretable latent representation for texture synthesis,which can be used to generate smooth texture morphs between different textures.We further show an interactive texture tool that allows a user to adjust local characteristics of the synthesized texture by directly using the co-occurrence values.

关键词： co-occurrence texture synthesis deep learning generative adversarial networks(GANs)

Can the growing of transgenic maize threaten protected lepidoptera in Europe?

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Insect Science 2021年第4期28卷 1159-1168页

作者： Gábor l.lövei Andreas lang Marco Ferrante Victor Bacle Department of Agroecology Aarhus UniversitySlagelseDenmark Institute of Applied Ecology Fujian Agricultural and Forestry UniversityFuzhouChina Buro lang Zell im WiesentalGermany Department of Environmental Geosciences University of BaselBaselSwitzerland Centre for Ecology Evolution and Environmental ChangesAzorean Biodiversity GroupFaculty of Agricultural and Environmental SciencesUniversity of the AzoresAngra do HeroismoPortugal la Painerie Preaux du PerchePerche en NoceFrance

We evaluated whether protected European butterflies can potentially be at risk if transgenic maize is extensively grown in Central Europe.We explored potential consequences of both insect resistant(IR)and herbicide resistant(HR)transgenic maize.IR maize can produce pollen that is toxic to lepidopteran larvae,and this puts butterfly species at possible risk if the presence of young larvae coincides with maize flowering,during which large quantities of maize pollen can be deposited on vegetation.By considering the timing of maize flowering in Europe and the phenology of the protected lepidoptera species,we found that 31 species had at least one generation where 50%of the larval stage overlapped with maize flowering,and 69 species for which first instar larvae were present during maize pollen shedding.HR maize allows high concentration herbicide treatments on fields without seasonal limitation,which can drastically reduce weed densities.In cases where such weed species are host plants for protected butterflies,reduced host plant/food availability can result,causing population decreases.By using published information,we first identified the important weed species in major maize-growing European countries.Subsequently,we checked whether the host plants of protected lepidoptera included species that are common maize weeds.We identified 140 protected species having food plants that are common weeds in one or more of the major European maize-growing countries.If HR maize is grown in Europe,there is a potential hazard that their food plants will seriously decline,causing a subsequent decline of these protected species.

关键词： butterflies conservation environmental risk food plants GM crop pollen toxicity

The mechanism and function of active DNA demethylation in plants

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Journal of Integrative Plant Biology 2020年第1期62卷 148-159页

作者： Ruie liu Zhaobo lang Shanghai Center for Plant Stress Biology and National Key Laboratory of Plant Molecular Genetics Center of Excellence in Molecular Plant Sciences the Chinese Academy of Sciences

DNA methylation is a conserved and important epigenetic mark in both mammals and plants.DNA methylation can be dynamically established,maintained,and removed through different pathways.In plants,active DNA demethylation is initiated by the RElEASE OF SIlENCING 1(ROS1)family of bifunctional DNA glycosylases/lyases.Accumulating evidence suggests that DNA demethylation is important in many processes in plants.In this review,we summarize recent studies on the enzymes and regulatory factors that have been identified in the DNA demethylation pathway.We also review the functions of active DNA demethylation in plant development as well as biotic and abiotic stress responses.Finally,we highlight those aspects of DNA demethylation that require additional research.

关键词： removed maintained initiated

Subcellular localization of Rho GTPases: implications for axon regeneration

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Neural Regeneration Research 2015年第7期10卷 1032-1033页

作者： Di anna l.Hynds Department of Biology Texas Woman's University

Damage to neurons in the central nervous system often leads to a permanent loss of function due to several factors,including reduced capacity of axons to regenerate and an environment that inhibits axon regeneration because of disruption of myelin and the formation of a growth-refractory glial scar around the injury（Yoon and Tuszynski,2012）.

关键词： Rho Subcellular localization of Rho GTPases GTPase

Embracing oligodendrocyte diversity in the context of perinatal injury

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Neural Regeneration Research 2017年第10期12卷 1575-1585页

作者： Jessie Newville lauren l.Jantzie lee anna Cunningham Department of Neurosciences University of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Pediatrics University of New Mexico Health Sciences CenterAlbuquerqueNMUSA

Emerging evidence is fueling a new appreciation of oligodendrocyte diversity that is overturning the traditional view that oligodendrocytes are a homogenous cell population.Oligodendrocytes of distinct origins,maturational stages,and regional locations may differ in their functional capacity or susceptibility to injury.One of the most unique qualities of the oligodendrocyte is its ability to produce myelin.Myelin abnormalities have been ascribed to a remarkable array of perinatal brain injuries,with concomitant oligodendrocyte dysregulation.Within this review,we discuss new insights into the diversity of the oligodendrocyte lineage and highlight their relevance in paradigms of perinatal brain injury.Future therapeutic development will be informed by comprehensive knowledge of oligodendrocyte pathophysiology that considers the particular facets of heterogeneity that this lineage exhibits.

关键词： oligodendrogenesis oligodendrocyte progenitor cell myelination central nervous system development ontogenetic origin white matter white matter injury preterm birth glia macroglia

Grafting affects yield and phenolic prof ile of Solanum melongena l. landraces

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Journal of Integrative Agriculture 2016年第5期15卷 1017-1024页

作者： l Sabatino G Iapichino A Maggio E D’ anna M Bruno F D’ anna Department of Agricultural and Forest Sciences University of Palermo Department of Biological Chemical and Pharmaceutical Sciences and Technologies University of Palermo Regional Centres for Agricultural Technologies (Ce.R.T.A.) University of Foggia

The influence of grafting on agronomical and qualitative characteristics of four Sicilian eggplant landraces was investigated. Grafted and ungrafted plants were compared in the open field in the northern coast of Sicily. Solanum torvum seedlings were used as rootstock. Regardless of genotypes tested, grafting significantly increased total fruit production, marketable production, and number of marketable fruits, but did not affect weight of marketable fruits and waste production. landrace 2（Sciacca）, with black epidermal tissue and pyriform fruit shape, when grafted onto S. torvum not only gave a higher yield performance than ungrafted plants, but also showed a higher phenolic antioxidant content. landrace 4（Sicilia）, with black epidermal tissue and small cylindrical fruits also benefited, when grafted onto S. torvum, from a substantial increase in antioxidant fruit content. As consumers＇ demand for fruits and vegetables rich in compounds important for human health is steadily increasing, these landrace/rootstock combinations should deserve more attention by plant nurseries involved in grafted seedling production and interested in the valorization and conservation of eggplant biodiversity.

关键词： eggplant propagation technique yield polyphenols HPlC analysis

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求图中点度数的量子算法

中山大学学报（自然科学版）（中英文） 2024年第1期63卷 1-9页

作者：郎健翔李绿周中山大学计算机学院广东广州510006

本文探讨了图属性测试问题的量子加速:对于给定的图和整数k,图中是否存在一个度数为k的顶点?该问题的量子复杂度在邻接矩阵oracle模型下被证明为O(N√k),而其经典复杂度为Ω(N^(2)),其中N是图中顶点的数量.为了证明该结果,得出了一个技... 详细信息

本文探讨了图属性测试问题的量子加速:对于给定的图和整数k,图中是否存在一个度数为k的顶点?该问题的量子复杂度在邻接矩阵oracle模型下被证明为O(N√k),而其经典复杂度为Ω(N^(2)),其中N是图中顶点的数量.为了证明该结果,得出了一个技术性结论,即对于给定的函数g:[N]→{0,1}和整数k,存在一个量子算法可以在O(√Nk)次查询内判定|{x:g(x)=1}|是否等于k.文中的结果基于量子奇异值变换(QSVT)和有误差输入的量子搜索技术.

关键词：量子奇异值变换量子算法图属性测试