Environmental toxicant-induced maladaptive mitochondrial changes:A potential unifying mechanism in fatty liver disease?

作     者：Regina D.Schnegelberger Anna L.Lang Gavin E.Arteel Juliane I.Beier Regina D.Schnegelberger;Anna L.Lang;Gavin E.Arteel;Juliane I.Beier

作者机构：Department of Pharmacology&Chemical BiologyUniversity of PittsburghPittsburghPA 15213USA Department of NeurologyUniversity of Miami Miller School of MedicineMiamiFL 33136USA Department of MedicineDivision of GastroenterologyHepatology&NutritionUniversity of PittsburghPittsburghPA 15213USA Pittsburgh Liver Research CenterUniversity of PittsburghPittsburghPA 15213USA Department of Environmental&Occupational HealthUniversity of PittsburghPittsburghPA 15213USA 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第12期

页      面：3756-3767页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 0713[理学-生态学] 10[医学] 

基　　金：funded by awards from the National Institutes of Health: K01 DK096042  R03 DK107912  R21 ES031531  P30DK120531 and P20GM113226  USA。 

主　　题：Organochlorines Metals Persistent organic pollutants TASH Liver disease Hepatotoxicity Mitochondrial maladaptation Mitohormesis 

摘      要：Occupational and environmental exposures to industrial chemicals are well known to cause hepatotoxicity and liver injury.However,despite extensive evidence showing that exposure can lead to disease,current research approaches and regulatory policies fail to address the possibility that subtle changes caused by low level exposure to chemicals may also enhance preexisting conditions.In recent years,the conceptual understanding of the contribution of environmental chemicals to liver disease has progressed significantly.Mitochondria are often target of toxicity of environmental toxicants resulting in multisystem disorders involving different cells,tissues,and organs.Here,we review persistent maladaptive changes to mitochondria in response to environmental toxicant exposure as a mechanism of hepatotoxicity.With better understanding of the mechanism(s) and risk factors that mediate the initiation and progression of toxicant-induced liver disease,rational targeted therapy can be developed to better predict risk,as well as to treat or prevent this disease.