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A tale of two tails:asymmetry in Great Grey Shrike(Lanius excubitor)

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Avian Research 2018年第1期9卷 19-26页

作者： Reuven Yosef anna maria Kubicka Martin Brandsma Piotr Tryjanowski Ben-Gurion University of the Negev-Eilat Campus RO.Box 27288106 EilatIsrael. Institute of Zoology Poznan University of Life SciencesWojska Polskiego 71 C60-625 Poznari Poland. Noordwolde The Netherlands

Background: Asymmetry in the wild is a controversial, and to date, unresolved *** asymmetry(FA) is the developmental instability(intra-individual variation) while, directional asymmetry(DA) expresses the asymmetry of the population ***: We analysed 63 Great Grey Shrike(Lanius excubitor) skins at the Naturalis Biodiversity Center, Leiden, the *** black markings on the tails were digitized in order to evaluate the symmetry of the two sides of each *** helped understand if nutritional condition affected ***: ANOVA revealed no significant differences in size of the tail between sexes(F = 1.67, p > 0.05).However, there was significant difference in the shape of the black area in feathers between the sexes(F = 2.14, p < 0.05), and males had more elongated and slender black ***, DA was observed only in males, but FA was noted in both *** correlation showed no significant association between FA score and tail features in both the ***, in females, we observed a negative significant correlation between the number of fault and growth *** shape of the black area in the tail displayed no statistically significant association with the tail features in both sexes although growth bars influenced tail shape more than the number of fault ***: We concluded that the characteristics discovered by us need to also be checked in the field and if they can be used to sex ***, chromatic manipulative studies are require to verify if DA influences sexual selection in the Great Grey Shrike.

关键词： Lanius excubitor Ptilochronology Geometric morphometrics Fluctuating Directional asymmetry

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Positive frequency of autoantibodies in multiple sclerosis patients Are they associated with therapy?

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Neural Regeneration Research 2010年第4期5卷 257-260页

作者： Gerardo Iuliano Luigi Cinquanta anna maria Ferruzzi Rosa Napoletano Azienda Ospedaliera Ospedali Riuniti di SalernoU.O.NeurologiaCentro Provinciale Sclerosi Multipla Azienda Ospedaliera Ospedali Riuniti di SalernoU.O.Laboratorio Patologia Clinica Azienda Ospedaliera Ospedali Riuniti di Salerno

BACKGROUND： Humoral autoimmunity in patients with multiple sclerosis is often asymptomatic and transient during interferon therapy. OBJECTIVE： To analyze the frequency of positivity to autoantibodies in multiple sclerosis patients and to clarify whether it is modified by immunomodulating therapy. DESIGN： A retrospective *** AND SE＇rrlNG： The study was performed at the Multiple Sclerosis Center, Department of Neurosciences, Salerno Hospital, Italy, between 2005 and 2007. PARTICIPANTS： A total of 169 multiple sclerosis patients were included, 57 males and 112 females Individuals were mainly outpatients and were usually tested yearly for autoantibodies. Patients with previous immunological diseases were excluded from statistical evaluation. METHODS： The frequency of positivity was calculated in patients grouped for gender, multiple sclerosis clinical parameters, magnetic resonance imaging features and disease modifying therapy. A total of 113 patients were treated with beta interferons. MAIN OUTCOME MEASURES： Frequency of positivity to any autoantibody. Prevalences and incidences were ***： The overall prevalence of autoantibodies within 3 years was 47.3%. In multiple sclerosis patients who were untreated or treated with drugs other than interferons, the prevalence was higher, and greater positivity to autoantibodies was seen in patients treated with interferons [odds ratio （95% confidence interval）, 2.87 （1.5 - 5.2）, P 〈 0.05 - 0.01]. Multiple regression analysis showed a significant association of the positivity to autoantibodies with interferon therapy, rather than gender, relapse or magnetic resonance imaging. CONCLUSION： Interferon therapy is associated with significantly higher frequency of autoantibodies in patients with multiple sclerosis. The differences among the therapies are not influenced by other variables such as gender or clinical pattern.

关键词： multiple sclerosis autoimmunity autoantibodies immunomodulation interferon

A practical approach to the diagnosis of autoimmune pancreatitis

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World Journal of Gastroenterology 2011年第16期17卷 2076-2079页

作者： Luca Frulloni Antonio Amodio anna maria Katsotourchi Italo Vantini Department of Medicine University of Verona Cattedra di Gastroenterologia Policlinico GB Rossi

Autoimmune pancreatitis is a disease characterized by specific pathological features,different from those of other forms of pancreatitis,that responds dramatically to steroid *** pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging,mimicking pancreatic ***,the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic *** in the presence of a pancreatic mass the probability of tumour is much higher than that of pancreatitis,the physician should be aware that in focal autoimmune pancreatitis the first step before using steroids is to exclude pancreatic *** this review,we briefly analyse the strategies to be followed for a correct diagnosis of autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis Therapy Diagnosis

In vivo interspecific pollination success between Pinus radiata,P. maximinoi, P. oocarpa and P. tecunumanii

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Journal of Forestry Research 2019年第3期30卷 817-826页

作者： Hannel Ham anna-maria Botha Arnulf Kanzler Ben du Toit Department of Forest and Wood Science Stellenbosch UniversityPrivate Bag X1Stellenbosch 7602South Africa Genetics Department Stellenbosch University Private Bag X1Stellenbosch 7602South Africa Sappi Forest Research P.O. Box 473Howick 3290South Africa

The objective of the study was to investigate in vivo interspecific pollination success between Pinus radiata, P. maximinoi, P. oocarpa and P. tecunumanii. Pinus radiata was control pollinated with pollen lots of P. maximinoi, P. oocarpa and P. tecunumanii in a P. radiata seed orchard at Karatara (Southern Cape, South Africa). Pollination success was determined by counting the number of visible ovules, pollen grains inside and outside P. radiata ovules, as well as pollen tubes visible inside P. radiata ovules. Conelets were harvested and studied at eight time intervals, including 24 h after pollination, and weekly for 7 weeks after pollination. Histology studies with a standard fixation-dehydration-embedding sequence and paraffin wax method were used to determine the number of visible pollen grains inside versus outside the ovules and number of pollen tubes. Results indicated that pollen grains did sift through the cone scales within 24 h after pollination. However, P. radiata differed significantly (time by type of cross interaction) from the other three hybrid combinations in terms of number of visible ovules, visible pollen grains inside and outside of the ovules as well as pollen tubes, confirming limited interspecific hybridisation success. Future studies need to determine the percentage of fertile ovules in cross combination as a tool in predicting pollination success.

关键词： Pollen tubes Pollen grains Hybridization Reproductive barriers Pinus radiata

Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief review

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 238-252页

作者： anna Khlyustova Cédric Labay Zdenko Machala maria-Pau Ginebra Cristina Canal Biomaterials Biomechanics and Tissue Engineering GroupDepartment of Materials Science and MetallurgyUniversitat Politecnica de CatalunyaBarcelona 08019Spain Research centre in Multiscale Science and Engineering Universitat Politecnica de CatalunyaBarcelona 08019Spain Faculty of Mathematics Physics and InformaticsComenius UniversityBratislava 84248Slovakia

Reactive oxygen and nitrogen species (RONS) are among the key factors in plasma medicine. They are generated by atmospheric plasmas in biological fluids, living tissues and in a variety of liquids. This ability of plasmas to create a delicate mix of RONS in liquids has been used to design remote or indirect treatments for oncological therapy by treating biological fluids by plasmas and putting them in contact with the tumour;Documented effects include selective cancer cell toxicity, even though the exact mechanisms involved are still under investigation. However, the "right" dose for suitable therapeutical activity is crucial and still under debate. The wide variety of plasma sources hampers comparisons. This review focuses on atmospheric pressure plasma jets as the most studied plasma devices in plasma medicine and compiles the conditions employed to generate RONS in relevant liquids and the concentration ranges obtained. The concentrations of H2O2, NO2^-, NO3^- and short-lived oxygen species are compared critically to provide a useful overview for the reader.

关键词： atmospheric plasma jets liquids ROS RNS plasma-dose

Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer

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World Journal of Gastrointestinal Oncology 2019年第2期11卷 117-138页

作者： anna maria Berghella anna Aureli Angelica Canossi Tiziana Del Beato Alessia Colanardi Patrizia Pellegrini Istituto di Farmacologia Traslazionale Consiglio Nazionale delle Ricerche

BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical *** To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer *** A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze *** study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a *** Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxid

关键词： Aging and cancer biomarker Cancer personalized treatments Oxidation and immune biomarkers Trx1/CD30 target KIRs and FcγR polymorphisms Th cytokines Aging and disease Cancer-related mechanisms

Botulinum toxin for chronic anal fissure after biliopancreatic diversion for morbid obesity

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World Journal of Gastroenterology 2012年第10期18卷 1021-1027页

作者： Serafino Vanella Giuseppe Brisinda Gaia Marniga anna Crocco Giuseppe Bianco Giorgio maria Department of Surgery Catholic School of Medicine University Hospital "Agostino Gemelli"

AIM: To study the effect of botulinum toxin in patients with chronic anal fissure after biliopancreatic diversion (BPD) for severe obesity. METHODS: Fifty-nine symptomatic adults with chronic anal fissure developed after BPD were enrolled in an open label study. The outcome was evaluated clinically and by comparing the pressure of the anal sphincters before and after treatment. All data were analyzed in univariate and multivariate analysis. RESULTS: Two months after treatment, 65.4% of the patients had a healing scar. Only one patient had mild incontinence to flatus that lasted 3 wk after treatment, but this disappeared spontaneously. In the multivariate analysis of the data, two registered months after the treatment, sex (P = 0.01), baseline resting anal pressure (P = 0.02) and resting anal pressure 2 mo after treatment (P < 0.0001) were significantly related to healing ***: Botulinum toxin, despite worse results than in non-obese individuals, appears the best alternative to surgery for this group of patients with a high risk of incontinence.

关键词： Botulinum toxin Anal diseases Anal fis- sure Severe obesity Bariatric surgery Biliopancreatic diversion

FUNCTIONAL NEAR-INFRARED SPECTROSCOPY-BASED ASSESSMENT OF ATTENTION IMPAIRMENTS AFTER TRAUMATIC BRAIN INJURY

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 251-260页

作者： anna C.MERZAGORA maria T.SCHULTHEIS BANU ONARAL MELTEM IZZETOGLU School of Biomedical Engineering Science and Health Systems Drexel University PhiladelphiaPAUSA Department of Psychology Drexel University PhiladelphiaPAUSA

A frequent consequence of traumatic brain injury(TBI)is cognitive impairment,which results in significant disruption of an individual's everyday *** date,most clinical rehabilitation interventions still rely on behavioral observation,with little or no quantitative information about physiological changes produced at the brain *** brain imaging has been extensively used in the study of cognitive impairments following ***,its applications to rehabilitation have been *** is due in part to the expensive or invasive nature of these *** objective of this study is to apply functional near-infrared spectroscopy(fNIR)to the assessment of attention impairments following *** provides a localized measure of prefrontal hemodynamic activation,which is susceptible to TBI,and it does so in a noninvasive,affordable and wearable way,thus partially overcoming the limitations of other *** included 5 TBI subjects and 11 healthy *** activation measurements were collected during a target categorization *** differences were found in the hemodynamic response between healthy and TBI *** particular,the elicited responses exhibited reduced amplitude in the TBI ***,the results providefirst evidence of the ability of fNIR to reveal differences between TBI and healthy subjects in an attention *** is therefore a promising neuroimaging technique in thefield of *** use of fNIR in neurorehabilitation applications would benefit from its noninvasiveness and cost-effectiveness and the neurophysiological information obtained through the evaluation of the hemodynamic activation could provide invaluable information to guide the choice of intervention.

关键词： fNIR attention traumatic brain injury NIRS TBI