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Evaluation of Mast Cells in Dermal versus Subcutaneous Hemangiomas and Hemangiosarcomas in Dogs

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Open Journal of Veterinary Medicine 2012年第2期2卷 60-65页

作者： Katherine A. Barber Kim M. Newkirk ann reed Robert L. Donnell College of Veterinary Medicine University of Tennessee Knoxville USA Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville USA Research Computing Support Office of Information Technology University of Tennessee Knoxville USA

This study investigated the role of mast cells in canine cutaneous vascular tumors, and is the first such study to distinguish between tumors arising in the dermis versus the subcutis. Mast cell numbers in canine cutaneous hemangiomas (HA) and hemangiosarcomas (HSA) were evaluated to identify a relationship between mast cells, tumor type (HA, HSA), histologic location (dermis, subcutis) and tumor recurrence. One hundred and sixty-seven biopsies from 148 dogs were evaluated. Using only one biopsy from each dog, mast cell counts (MCC) for each tumor (n = 148) were obtained by averaging the number of mast cells counted in ten 400× fields. A significant difference in mean MCC was found only between tumor types, with HA having more mast cells than HSA (4.2 ± 4.2 vs. 2.2 ± 2.6;p < 0.001). No significant difference in mean MCC existed between tumors that recurred and those that did not. There was no difference in recurrence rate between tumor type or histologic location. Our results indicate that benign HA contain more mast cells than malignant endothelial cell tumors, regardless of histologic location;whether this is a cause or effect relationship remains to be determined.

关键词： Canine Dermis Hemangioma Hemangiosarcoma Mast Cell Skin Subcutaneous

Predictive Models of Clinical Improvement in Rituximab-Treated Myositis Patients Using Clinical Features, Autoantibodies, and Biomarkers

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第3期5卷 68-80页

作者： Jeannette M. Olazagasti Cynthia S. Crowson Molly S. Hein Consuelo Lopez de Padilla Rohit Aggarwal Chester V. Oddis ann M. reed Division of Rheumatology Mayo Clinic Rochester MN USA Division of Health Sciences Research Mayo Clinic Rochester MN USA Division of Rheumatology University of Pittsburgh Pittsburgh PA USA Division of Rheumatology Department of Pediatrics Duke University School of Medicine Durham NC USA

Background: Response to rituximab so far is unpredictable in patients with refractory myositis. Predictive models of clinical improvement are developed using clinical, laboratory, and gene expression/cytokine/chemokine variables in rituximab-treated refractory myositis patients. Methods: We analyzed data for 200 myositis patients (76 with adult polymyositis (PM), 76 with adult dermatomyositis (DM), and 48 with juvenile (DM)) in the rituximab in myositis trial. Clinical improvement is defined as the change from baseline to 24 weeks in Physician Global Visual Analog Scale (VAS). We analyze the association of baseline variables with improvements: demographics, myositis subtype, clinical and laboratory parameters, autoantibody status, and interferon (IFN)- regulated chemokines. Multivariable linear regression models are developed by using stepwise variable selection methods. Results: A “base” multivariable model to predict improvement with clinical and laboratory variablesonly is built with modest predictive ability (adjusted R2 = 0.21). This model includes two significant factors at baseline: Physician Global VAS and Muscle Disease Activity VAS. A “final” multivariable model to predict improvement including non-standard laboratory measures is developed and demonstrated better predictive ability (adjusted R2 = 0.32). This model includes Physician Global VAS, IFN chemokine score and IL-2 levels. The “final” model explained 11% more variability than the “base” model. Conclusions: Changes in disease activity over time following treatment with rituximab in refractory myositis can be predicted. These models can be clinically useful to optimize treatment selection in myositis.

关键词： Myositis Rituximab Cytokines Chemokines

Radioecology: Why Bother?

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Journal of Environmental Protection 2014年第3期5卷 181-192页

作者： Emily Amanda Caffrey Mary Elizabeth Leonard Jonathan Bamberger Napier Delvan reed Neville Kathryn ann Higley Department of Nuclear Engineering and Radiation Health Physics Oregon State University Corvallis USA.

The importance of radioecology to the discussion of radioactive contamination is discussed here. This paper discusses the history of radioecology, alongside the most recent developments in the science. It describes the need for more environmental data, and explains where the gaps in current knowledge lie. The calculation of radiation dose to wildlife along with the complications in performing such calculations is discussed. The paper also tackles the difficult question of the implications of radioecology on nuclear waste management and site decommissioning policies. From the beginnings of the science to today, radioecology is poised to be an important field of study as humans continue to rely on ionizing radiation to improve their lives.

关键词： Radioecology Wildlife Dose Calculations Nuclear Waste Disposal Environmental Protection

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医学影像世界的人工智能:挑战与机遇

Science Bulletin 2023年第7期68卷 648-652页

作者：薛华丹胡歌洪楠 N.reed Dunnick 金征宇 Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking University People’s HospitalBeijing 100044China Department of Radiology University of MichiganAnn Arbor 48109USA

Medical imaging is involved in all processes of clinical *** 70%of diagnostic information originates from radiologic images,which also account for 90%of the digital data volume of a ***,the number of physicians has increased only modestly compared to the rapid growth in the number of medical *** China,data from medical imaging increases by 30%every year,whereas the number of radiologists increases by only 4%*** intelligence(AI),which is representative technology of the fourth industrial revolution,may alleviate the increasing pressure and job burnout,and further improve the diagnostic efficiency of radiology services[1].Despite the urgent and realistic demand for AI technology,many challenges remain in the development and translation of AI *** rate of the scientific translation of AI research into clinical applications is extremely ***,AI models that are applied in clinical settings exhibit unreliable performance and are often impractical[2].Therefore,radiologists may not have access to suitable medical imaging AI models to solve specific clinical *** paper analyzes and discusses this problem according to two aspects:the data sources and the AI algorithm(Fig.1).

关键词： spite 人工智能 annually

Strategies for PET imaging of the receptor for advanced glycation endproducts(RAGE)

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Journal of Pharmaceutical Analysis 2020年第5期10卷 452-465页

作者： Lindsey R.Drake Allen F.Brooks Jenelle Stauff Phillip S.Sherman Janna Arteaga Robert A.Koeppe Aimee reed Timothy J.Montavon Marc B.Skaddan Peter J.H.Scott Department of Radiology University of MichiganAnn ArborMI48109USA Department of Medicinal Chemistry University of MichiganAnn ArborMI48109USA AbbVie Process Chemistry North ChicagoIL60064USA AbbVie Centralized Medicinal Chemistry North ChicagoIL60064USA AbbVie Translational Imaging North ChicagoIL60064USA

The implication of the receptor for advanced glycation end-products(RAGE)in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory *** the context of investigating RAGE as a biomarker,there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography(PET)*** have synthesized potential small molecule radiotracers for both the intracellular([18F]InRAGER)and extracellular([18F]RAGER)domains of *** we report preclinical evaluation of both using in vitro(lead panel screens)and in vivo(rodent and nonhuman primate PET imaging)*** radiotracers have high affinity for RAGE and show good brain uptake,but suffer from off-target *** source of the off-target PET signal is not attributable to binding to melatonin receptors,but remains *** have also investigated use of lipopolysaccharide(LPS)-treated mice as a possible animal model with upregulated RAGE for evaluation of new imaging *** of the mouse brain sections revealed increases in RAGE in the male cohorts,but no difference in the female ***,it proves challenging to quantify the changes in RAGE due to off-target binding of the ***,they are appropriate lead scaffolds for future development of 2nd generation RAGE PET radiotracers because of their high affinity for the receptor and good CNS penetration.

关键词： RAGE Neuroimaging Positron emission tomography Radiochemistry Neuroinflammation

Management Procedures for Data Collected via Intelligent Transportation Systems

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Journal of Civil Engineering and Architecture 2015年第9期9卷 1069-1078页

作者： Qiang Hong Richard Wallace Eric Dennis Brian reed William Tansil Matt Smith Center for Automotive Research Ann Arbor 48108 USA Geospatial & Applied Technologies Group Parson Brinckerhoff Baltimore 21201 USA Michigan Department of Transportation Lansing 30050 USA

Addressing transportation planning, operation and investment challenges requires increasingly sophisticated data and information management strategies. ITS （intelligent transportation systems） and CV （connected vehicle） technologies represent a new approach to capturing and using needed transportation data in real time or near real time. In the case of Michigan, several ITS programs have been launched successfully, but independently of each other. The objective of this research is to evaluate and assess all important factors that will influence the collection, management and use of ITS data, and recommend strategies to develop integrated, dynamic and adaptive data management systems for state transportation agencies.

关键词： ITS connected vehicle technology transportation data management state transportation agency.

全美经济综合展望——2008年reed美国经济预测会议上各路专家的多方观点

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建筑玻璃与工业玻璃 2008年第2期28卷 21-24页

作者： ann Lallande 张雨丝（译）

经济学家们在reed举办的2008年建筑预测会议上对美国建筑业的经济情况给出的评论褒贬不一。该会议于2007年10月3日至4日在华盛顿特区举行。

关键词：经济预测美国专家展望经济情况经济学家建筑业华盛顿

New frontiers for the materials genome initiative

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npj Computational Materials 2019年第1期4卷 776-798页

作者： Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao Institute for Molecular Engineering University of ChicagoChicagoIL 60615USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA Materials Department and Materials Research Laboratory University of CaliforniaSanta BarbaraCA 93106USA Department of Materials Science and Engineering Cornell UniversityIthacaNY 14853USA Department of Physics Colorado School of MinesGoldenCO 80401USA Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Physics University of Texas at AustinAustinTX 78712USA Department of Polymer Science and Engineering University of MassachusettsAmherstMA 01003USA Institute of Condensed Matter and Nanosciences UniversitéCatholique de Louvain1348 Louvain-la-NeuveBelgium Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Department of Materials Design and Innovation University of Buffalo–The State University of New YorkBuffaloNY 14260-5030USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Department of Metallurgical and Materials Engineering Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and *** with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the *** May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and *** article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts.

关键词： utilize frontier accomplishment

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应用糖皮质激素治疗咽喉痛：临床实践指南

英国医学杂志中文版 2018年第6期21卷 346-352页

作者：卫红齐(译) 苏州大学附属第二医院耳鼻咽喉科

单剂量口服糖皮质激素在治疗急性咽喉痛中扮演着怎样的角色？依据BMJ快速推荐程序，使用GRADE框架。专家小组对糖皮质激素的使用做出了弱推荐。专家组根据2017年4月发表的一项大型随机试验所引发的相关系统性综述做出了这些推荐。该试... 详细信息

单剂量口服糖皮质激素在治疗急性咽喉痛中扮演着怎样的角色？依据BMJ快速推荐程序，使用GRADE框架。专家小组对糖皮质激素的使用做出了弱推荐。专家组根据2017年4月发表的一项大型随机试验所引发的相关系统性综述做出了这些推荐。该试验报告称，糖皮质激素提高了48小时疼痛完全缓解患者的比例。

关键词：糖皮质激素急性咽喉痛激素治疗临床实践指南应用单剂量口服系统性综述专家小组