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Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease

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Journal of Geriatric Cardiology 2016年第8期13卷 701-711页

作者： Giovanni Corsetti Evasio Pasini Tiziano m Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi Department of Clinical & Experimental Sciences Division of Human Anatomy & Physiopathology University of Brescia Brescia Italy 'S.maugeri Foundation ' IRCCS Cardiology Division Medical Centre of Lumezzane Brescia Italy Zena and michael A Wiener Cardiovascular Institute Mount Sinai Medical Center New York USA Center for Heart and Vessel Preclinical Studies St. John Hospital & Medical Center Wayne State University School of Medicine Detroit USA VA ann Arbor Health Care System University of Michigan Ann Arbor USA Department of Cardiovascular Surgery 'San Rocco' Hospital Ome Brescia Italy Department of Biotechnological and Applied Clinical Sciences University of L 'Aquila L 'Aquila Italy Division of Sport-Internal medicine Department of Clinical & Experimental Sciences University of Brescia Brescia Italy Department of Clinical Sciences and Community Health University of Milan Milan Italy

Background Klotho proteins （α- and β） are membrane-based circulating proteins that regulate cell metabolism, as well as the lifespan modulating activity of Fibroblast Growth Factors （FGFs）. Recent data has shown that higher plasma circulating Klotho levels reduce cardio- vascular risk, suggesting Klotho has a protective role in cardiovascular diseases. However, although so far it has been identified in various organs, it is unknown whether cardiomyocytes express Klotho and FGFs, and whether high cardiovascular risk could affect cardiac expres- sion ofKlotho, FGFs and other molecules. methods We selected 20 patients with an estimated 10-year high atherosclerotic cardiovascular disease and 10 age-matched control subjects with an estimated 10-year low risk undergone cardiac surgery for reasons other than coronary artery by-pass. In myocardial biopsies, we evaluated by immuno-histochemistry whether Klotho and FGFs were expressed in cardiomyo- cytes, and whether higher cardiovascular risk influenced the expression of other molecules involved in endoplasmic reticulum stress, oxida- tive stress, inflammation and fibrosis. Results Only cardiomyocytes of patients with a higher cardiovascular risk showed lower expression of Klotho, but higher expressions of FGFs. Furthermore, higher cardiovascular risk was associated with increased expression of oxidative and endoplasmic reticular stress, inflammation and fibrosis. Conclusions This study showed for the first time that Klotho proteins are ex- pressed in human cardiomyocytes and that cardiac expression of Klotho is down-regulated in higher cardiovascular risk patients, while expression of stress-related molecules were significantly increased.

关键词： Atherosclerotic disease Cardiomyocytes Cardiovascular risk Human heart Klotho

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and Security 2022年第3期1卷 28-42页

作者： Robert L.Vadas Jr. Robert m.Hughes Yeon Jae Bae min Jeong Baek Orestes Carlos Bello Gonzáles marcos Callisto Débora ReisdeCarvalho Kai Chen maria T.Ferreira Pablo Fierro Jon S.Harding Dana m.Infante C.J.Kleynhans Diego R.macedo Isabela martins Norman mercado Silva Nabor moya Susan J.Nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.Jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key Laboratory of marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias marinas y Limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(mmIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of mmIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)mmI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and mmI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI mmI Fish macroinvertebrates Algae Streams Rivers Lakes Wetlands Biological monitoring

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定量临床核心脏病学(第2部分):应用进展及新技术

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中华核医学与分子影像杂志 2022年第9期42卷 568-576页

作者： Piotr J.Slomka Jonathan B.moody Robert J.H.miller Jennifer m.Renaud Edward P.Ficaro Ernest V.Garcia 王丽(译) 杨敏福(审校) Department of Imaging(Division of Nuclear medicine) Medicineand Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA INVIA medical Imaging Solutions Ann ArborMI Department of Cardiac Sciences University of CalgaryCalgaryABCanada Division of Cardiology Department of Internal MedicineUniversity of MichiganAnn ArborMI Department of Radiology and Imaging Sciences Emory UniversityAtlantaGA 首都医科大学附属北京朝阳医院核医学科北京100020

定量分析已广泛用于核心脏病学图像的处理和解读、改进疾病诊断和危险分层。该文为继续教育文章(含2部分)的第2部分,将对新兴的定量分析工具的临床潜在应用进行综述,介绍机械运动同步性、心室功能、灌注和融合显像定量分析技术,对PET和S... 详细信息

定量分析已广泛用于核心脏病学图像的处理和解读、改进疾病诊断和危险分层。该文为继续教育文章(含2部分)的第2部分,将对新兴的定量分析工具的临床潜在应用进行综述,介绍机械运动同步性、心室功能、灌注和融合显像定量分析技术,对PET和SPECT评估心肌血流量的新方法进行讨论。心肌活性、微钙化定量检测及心脏结节病和心脏淀粉样变的定量评估亦在文中描述。人工智能在改善图像分析、提高疾病诊断效能和风险预测方面的潜在作用将在文末进行论述。上述新技术的临床潜在应用及优化实施方法将在文中重点阐述。

关键词：核心脏病学心肌血流量定量人工智能相位分析

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Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2

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Journal of microbiology and Immunology 2004年第4期2卷 272-277页

作者：杨建民 michael S FRIEDmAN Christopher m REYNOLDS marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J mULE Kevin T mCDONAGH Department of Hematology Changhai Hospital The Second Millitay Medical University Shanghai 200433 China Departments of Internal medicine Departments of Surgery Departments of Internal medicine University of Michigan Medical School Ann Arbor MI 48109 and De- partment of Chemical Immunology the Weizmann Institute of Science Israel

We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (mCF7) p185HER2 to assay for antigen specific im- mune responses. Both Cm+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2.

关键词： Gene therapy retrovirus Chimeric T-cell receptor Human peripheral T-lymphocytes Immunotherapy

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人m-07e白血病细胞凋亡过程中激活Caspase-3引起的Bcl-2蛋白酶解与Lyn^(p53/56)激酶失活相关(英文)

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中国实验血液学杂志 2000年第3期8卷 166-175页

作者：张学敏胡美茹兰雨于鸣 Ben D-m Chen 国家生物医学分析中心军事医学科学院基础医学研究所北京100850 Department of Internal medicine and Barbara Ann Karmanos Cancer InstitutesWayne State University School of Medicine

人巨核白血病细胞系m 0 7e的生长严格依赖于Gm CSF。在m 0 7e细胞 ,Gm CSF受体 (Gm CSFR)由两个亚基所组成 :低亲合力的配体特异的α亚基和一个磷酸化的 β亚基 ,后者与lynp53 56 酪氨酸蛋白激酶固定相连。本研究检测了lyn激酶在调节TGF... 详细信息

人巨核白血病细胞系m 0 7e的生长严格依赖于Gm CSF。在m 0 7e细胞 ,Gm CSF受体 (Gm CSFR)由两个亚基所组成 :低亲合力的配体特异的α亚基和一个磷酸化的 β亚基 ,后者与lynp53 56 酪氨酸蛋白激酶固定相连。本研究检测了lyn激酶在调节TGF β 1诱导的m 0 7e细胞凋亡过程中的作用。从培养液中去除rhGm CSF首先导致了lyn激酶活性受抑 ,接着发生细胞生长受阻和凋亡。m 0 7e细胞凋亡过程中伴随有大量Bcl 2和Bax蛋白分别被酶解为 2 2kD和 18kD的较小片段。应用特异性的抑制剂 ,发现上述Bcl 2蛋白的变化是循激活的caspase 3(CPP32 )途径发生的 ,后者在m 0 7e细胞中大量表达。Bax蛋白变化的机制尚不清楚。TGF β 1对rhGm CSF刺激的细胞生长具有抑制作用 ,促进m 0 7e细胞凋亡的机制与去除rhGm CSF所致相同 ,包括大量Bcl 2和Bax蛋白被特异酶解和lyn激酶失活。TGF β 1并不影响lyn蛋白和 β链的表达水平 ,也不阻止这两个信号传导元件的相互作用。研究结果表明 ,TGF β 1通过抑制Gm CSFR相关的lyn激酶活性而抑制m 0 7e细胞生长并促进凋亡发生。本实验还表明激活的CPP32对Bcl 2蛋白的酶解是与细胞凋亡发生相关的一个自然过程。

关键词： Bc1-2 lyn蛋白激酶细胞凋亡白血病

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野生向日葵种子萌发方法的比较

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种子 1986年第3期 71-74页

作者： J.m.chandler ,C.C.Jan ,杨竹平南京农业大学小麦品种研究室

种子休眠妨碍了向日葵种的研究及其在改良栽培向日葵（Helianthus annuus L.）的育种程序中的应用。测验了数种种子处理方法,测定其在打破许多野生向日葵种的强烈的种子休眠系统上的效率。第一个处理（称为完整处理）包括种子的机械多... 详细信息

种子休眠妨碍了向日葵种的研究及其在改良栽培向日葵（Helianthus annuus L.）的育种程序中的应用。测验了数种种子处理方法,测定其在打破许多野生向日葵种的强烈的种子休眠系统上的效率。第一个处理（称为完整处理）包括种子的机械多次划破、于100毫克/升赤霉酸液中浸泡1小时及去除种壳。其他处理是该程序的简化和三个应用赤霉酸和2-氯乙基-次磷酸的完整种子处理。结果表明:去除种壳和种皮的处理最为有效,使许多种（包括极难萌发的一年生沙漠种）的萌发率提高到90%以上,将多次划破的种子置于100毫克/升赤霉酸液中浸泡1小时能促进某些种的萌发。将完整种子置于100毫克/升赤霉酸液中浸泡1小时或于500毫克/升2-氯乙基-次磷酸液中浸泡1小时均不能促进萌发。完整种子置于100毫克/升或100毫克/升赤霉酸液中培养10天可促进萌发,但形成非正常苗,虽然完整处理复杂,但其萌发率高,且材料间变异最小,因而推荐完整处理作为最佳的方法。许多作物育种家都关注把野生向日葵种作为改良栽培向日葵（Helianthus annuus L.）的基因资源,但强烈的种子休眠系统妨碍了这些物种的利用。在所有的野生种中均存在不同强度的种子休眠系统,但在一年生沙漠种*** Heiser、*** Blake和***亚种fephrods（***）Heiser（Heiser等,1969）尤为强烈。这些旱生种作为耐旱基因资源具有特别重要的价值。据恶,某些多年生种的休眠也非常强烈（Heiser,1916）。为确保野生向日葵种子萌发良好,已应用了数种方法。Heiser等（1969）报道一般最有效的方法是将种子播种于盆内,每移出室外3周至1个月,使其置于不同温度（包括冻融）之下。这种方法可促进萌发,但极少超过50%,且对一年生旱生种无效。对旱生种也应用了其他方法,包括湿润和干燥交替、多次换水冲洗和浸泡种子,但萌发率极少达到10%。据研究（Kumar和sastry,1974、1975,Zimmerman,1977,Fick,1978,Harada,1982）,乙烯萌发混合物,2-氯乙基-次磷酸可促进刚收获的栽培向日葵种子的萌发,赤霉酸（GA3）和苯甲基腺嘌呤也有同样的效果（Kumar和sastry 1974,1975）,去除种壳也可促进萌发（Kumar和sastry 1974,1975,Harada,1982）。本研究的目的是比较野生向日葵种种子的几种萌发方法,从而确定一种简单又有效的程序。

关键词：赤霉酸种壳氯乙基次磷酸赤霉素向日葵种子亚种种皮种子处理

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Condition-Based Diagnostic Approach for Predicting the maintenance Requirements of machinery

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Engineering（科研） 2009年第3期1卷 177-187页

作者： C. I. UGECHI E. A. OGBONNAYA m. T. LILLY S. O. T. OGAJI S. D. PROBERT Department of marine Engineering Rivers State University of Science and TechnologyPort Harcourt Nigeria Department of mechanical Engineering Rivers State University of Science and Technology Port Harcourt Nigeria School of Engineering Cranfield University Bedfordshire U K

Wise maintenance-procedures are essential for achieving high industrial productivities and low energy expenditure. A major part of the energy used in any production process is expended during the maintenance of the employed equipment. To ensure plant reliability and equipment availability, a condition-based maintenance policy has been developed in this investigation. In particular, this project explored the use of vibration parameters in the diagnosis of equipment failure. A computer-based diagnostic tool employing an artificial neural-network (ann) was developed to analyse the ensuing machinery faults, their causes and consequences. For various categories of this type of machinery, a vibration-severity chart (ISO 12372 / BS 4675: 1971) appropriately colour coded according to defined mechanical faults, was used in training of the ann. The model was validated using data obtained from a centrifugal pump on full load and fed into the program written in Visual Basic. The results revealed that, for centrifugal pumps within 15 to 300kw power range, vibration-velocity amplitude of between 0.9 and 2.7mm/s was within acceptable limits. When the values rose to between 2.8 and 7.0mm/s, closer monitoring and improved understanding of the equipment condition was needed. The evolved diagnostic and prognostic model is applicable for other rotary equipment that is used within the same power limits.

关键词： Condition Based Diagnostic model Predictive maintenance machinery Centrifugal Pumps

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Storylines of family medicine Ⅸ:people and places—diverse populations and locations of care

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Family medicine and Community Health 2024年第S03期12卷 79-88页

作者： William B Ventres Leslie A Stone Emad R Abou-Arab Julio meza David S Buck Jerome W Crowder Jennifer Y C Edgoose Alexander Brown Ellen J Plumb Amber K Norris Jay J Allen Lauren E Giammar John E Wood Scott m Dickson G Austin Brown Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family medicine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community medicine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and Behavioral Sciences University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family medicine Residency ConcordNew HampshireUSA San Francisco VA medical Center San FranciscoCaliforniaUSA Duluth Family medicine Residency Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAmS Northeast Regional Campus Family medicine Residency Program JonesboroArkansasUSA Cascades East Family medicine Residency Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅸ:people and places—diverse populations and locations of care’,authors address the following themes:‘LGBTQIA+health in family medicine’,‘A family medicine approach to substance use disorders’,‘Shameless medicine for people experiencing homelessness’,“Difficult”encounters—finding the person behind the patient’,‘Attending to patients with medically unexplained symptoms’,‘making house calls and home visits’,‘Family physicians in the procedure room’,‘Robust rural family medicine’and‘Full-spectrum family medicine’.may readers appreciate the breadth of family medicine in these essays.

关键词： illustration family dimensions

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恒河猴实施粘弹物质小管切开术

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美国医学会眼科杂志（中文版） 2005年第3期17卷 F0003-F0003页

作者： Ernst R. Tamm Roberto G. Carassa Daniel m. Albert B＇ ann T. Gabelt Sarit Patel Carol A. Rasmussen Paul L. Kaufman 陆遥（译）

目的：在活体正常猴眼上观察粘弹物质小管切开术后的结构变化和房水外流情况。

关键词：粘弹物质切开术恒河猴房水外流结构变化

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Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections

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Open Journal of Immunology 2012年第1期2卷 25-39页

作者： Yu Qiao Brian m. Gray mohammed H. Sofi Laura D. Bauler Kathryn A. Eaton mary X. D. O’Riordan Cheong-Hee Chang Department of microbiology and Immunology University of Michigan Ann Arbor USA Unit for Lab Animal medicine Medical School University of Michigan Ann Arbor USA

We have reported a new innate-like CD4 T cell population that expresses cell surface makers of effector/memory cells and produce Th1 and Th2 cytokines immediately upon activation. Unlike conventional CD4 T cells that are selected by thymic epithelial cells, these CD4 T cells, named T-CD4 T cells, are selected by mHC class II expressing thymocytes. Previously, we showed that the presence of T-CD4 T cells protected mice from airway inflammation suggesting an immune regulatory role of T-CD4 T cells. To further understand the function of T-CD4 T cells, we investigated immune responses mediated by T-CD4 T cells during bacterial infection because the generation of antigen specific CD4 T cells contributes to clearance of infection and for the development of immune memory. The current study shows a suppressive effect of T-CD4 T cells on both CD8 and CD4 T cell-mediated immune responses during Listeria and Helicobacter infections. In the mouse model of Listeria monocytogenes infection, T-CD4 T cells resulted in decreasedfrequency of Listeria-specific CD8 T cells and the killing activity of them. Furthermore, mice with T-CD4 T cells developed poor immune memory, demonstrated by reduced expansion of antigen-specific T cells and high bacterial burden upon re-infection. Similarly, the presence of T-CD4 T cells suppressed the generation of antigen-specific CD4 T cells in Helicobacter pylori infected mice. Thus, our studies reveal a novel function of T-CD4 T cells in sup-pressing anti-bacterial immunity.

关键词： Bacterial Infection Innate-Like CD4 T Cells Immune Suppression

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