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Effects of left ventricular assist device on pulmonary functions and pulmonary hemodynamics:A meta-analysis

World Journal of Cardiology 2020年第11期12卷 550-558页

作者： Waqas Ullah Casey Meizinger Zain Ali ankur panchal Rehan Saeed Donald C Haas Eduardo Rame Department of Internal Medicine Abington Jefferson HealthAbingtonPA 19001United States Department of Internal Medicine University of PittsburghPittsburghPA 15213United States Department of Cardiology Abington Jefferson HealthAbingtonPA 19001United States Department of Cardiology Thomas Jefferson UniversityAbingtonPA 19001United States

BACKGROUND Given current evidence,the effect of left ventricular assist device(LVAD)implantation on pulmonary function tests remains *** To better understand the factors contributing to the changes seen on pulmonary function testing and the correlation with pulmonary hemodynamics after LVAD *** Electronic databases were queried to identify relevant *** summary effect size was estimated as a difference of overall means and standard deviation on a random-effects *** A total of four studies comprising 219 patients were *** overall mean forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and diffusion lung capacity of carbon monoxide(DLCO)after LVAD implantation were significantly lower by 0.23 L(95%CI:0.11-0.34,P=00002),0.18 L(95%CI:0.03-0.34,P=0.02),and 3.16 mmol/min(95%CI:2.17-4.14,P<0.00001),*** net post-LVAD mean value of the cardiac index was significantly higher by 0.49 L/min/m2(95%CI:0.31-0.66,P<0.00001)compared to pre-LVAD *** pulmonary capillary wedge pressure and pulmonary vascular resistance were significantly reduced after LVAD implantation by 8.56 mmHg(95%CI:3.78-13.35,P=0.0004),and 0.83 Woods U(95%CI:0.11-1.55,P=0.02),*** was no significant difference observed in the right atrial pressure after LVAD implantation(0.61 mmHg,95%CI:-2.00 to 3.32,P=0.65).Overall findings appear to be driven by studies using HeartMateII *** LVAD implantation might be associated with a significant reduction of the spirometric measures,including FEV1,FVC,and DLCO,and an overall improvement of pulmonary hemodynamics.

关键词： Pulmonary function tests Left ventricular assist device Spirometry Ventricular assist device

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Effect of pre-twinning and heat treatment on formability of AZX311 Mg alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 1154-1169页

作者： Mahesh panchal Lalit Kaushik Min-Seong Kim Ravi Kottan Renganayagalu Shi-Hoon Choi Jaiveer Singh Department of Mechanical Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Department of Metallurgical and Materials Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Energy Materials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang-roSeongbuk-guSeoul 02792Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National University255 Jungang-roSuncheonJeonnam 57922Republic of Korea

In this study,the effects of pre-strain-induced tensile twins(TTWs)and controlled heat treatment on the formability behavior of AZX311 Mg alloy sheets were investigated.A 4%compressive strain was applied to pre-strain the sheets using the in-plane compression(IPC)technique along the rolling direction(RD)to introduce *** pre-strained(PS)samples were subsequently heat-treated at 250℃,350℃,and 400℃ independently for 1 hr,and are termed as PSA1,PSA2,and PSA3,*** cupping tests were conducted to assess the formability of the sheet samples under different initial *** results showed that the PS sample heat-treated at 250℃ for 1hr exhibited a decrease in the Erichsen index(IE)compared to the as-rolled sample,whereas PSA2 and PSA3 samples showed an increase in IE *** analysis revealed that most of the TTWs generated through pre-twinning were stable at 250℃;however,the twin volume fraction reduced to 41%at 350℃ compared to the PS samples due to enhanced thermal activity at that ***,PSA2 samples showed severe grain coarsening in some areas of the sample,and the fraction of such grains increased in the PSA3 *** stretch formability(IE value)of PSA2 samples showed a 32.3%increase compared to the as-rolled ***,the analysis of the deformed specimen at failure under the Erichsen test indicated that considerable detwinning occurs in the PS and PSA1 samples,whereas dislocation slip activity dominates in the PSA2 and PSA3 samples during stretch *** from detwinning and dislocation slip,deformation twins were also observed in all samples after the Erichsen ***,this work highlights the importance of texture control and its underlying mechanisms via pre-twinning followed by heat treatment and their impact on the room temperature(RT)stretch formability of AZX311 Mg alloy sheets.

关键词： Mg alloys Pre-twinning Texture Formability EBSD.

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A Novel Approach to Breast Tumor Detection: Enhanced Speckle Reduction and Hybrid Classification in Ultrasound Imaging

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Computers, Materials & Continua 2024年第5期79卷 1875-1901页

作者： K.Umapathi S.Shobana Anand Nayyar Judith Justin R.Vanithamani Miguel Villagómez Galindo Mushtaq Ahmad Ansari Hitesh panchal Department of Biomedical Engineering KIT-Kalaignarkarunanidhi Institute of TechnologyCoimbatore641402India Graduate School Faculty of Information TechnologyDuy Tan UniversityDa Nang550000Viet Nam Department of Biomedical and Instrumentation Engineering Avinashilingam Institute for Home Science and Higher Education forWomenCoimbatore641043India UniversidadMichoacana de SanNicolás de HidalgoAvenida Francisco J.Múgica S/N Ciudad Universitaria MoreliaCP58030Mexico Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Mechanical Engineering Gujarat Technological UniveristyNigam NagarChandkhedaAhmedabadGujarat382424India

Breast cancer detection heavily relies on medical imaging, particularly ultrasound, for early diagnosis and effectivetreatment. This research addresses the challenges associated with computer-aided diagnosis (CAD) of breastcancer fromultrasound images. The primary challenge is accurately distinguishing between malignant and benigntumors, complicated by factors such as speckle noise, variable image quality, and the need for precise segmentationand classification. The main objective of the research paper is to develop an advanced methodology for breastultrasound image classification, focusing on speckle noise reduction, precise segmentation, feature extraction, andmachine learning-based classification. A unique approach is introduced that combines Enhanced Speckle ReducedAnisotropic Diffusion (SRAD) filters for speckle noise reduction, U-NET-based segmentation, Genetic Algorithm(GA)-based feature selection, and Random Forest and Bagging Tree classifiers, resulting in a novel and efficientmodel. To test and validate the hybrid model, rigorous experimentations were performed and results state thatthe proposed hybrid model achieved accuracy rate of 99.9%, outperforming other existing techniques, and alsosignificantly reducing computational time. This enhanced accuracy, along with improved sensitivity and specificity,makes the proposed hybrid model a valuable addition to CAD systems in breast cancer diagnosis, ultimatelyenhancing diagnostic accuracy in clinical applications.

关键词： Ultrasound images breast cancer tumor classification segmentation deep learning lesion detection

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Performance analysis of solar still with cow dung cakes and blue metal stones

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Frontiers in Energy 2015年第2期9卷 180-186页

作者： Hitesh N. panchal Mechanical Engineering Department Gujarat Power Engineering andResearch Institute Mevad 382710 India

The aims of this paper is to investigate the effects of various materials inside the solar still on the increase of the productivity of potable water. Here, blue metal stones and cow dung cakes were used as materials. To investigate their effect, three identical solar stills with an effective area of 1 m square made from locally available materials were tested in climate conditions of Mehsana （23°50＇ N 72° 23＇）. The first and second solar stills were filled with blue metal, stones and cow dung cakes, while the third one was taken as a reference which consisted of only blue paint at the basin. The experiments show that blue metal stones have the highest distillate output at daytime, followed by cow dung cakes solar still and reference solar still. On the other hand, the overall distillate output of blue metal stones and cow dung cakes at daytime as well as at night were 35% and 20% compared with that of reference solar still.

关键词： blue metal stones cow dung cakes distillateoutput solar still solar intensity

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Response of loose bonding on reflection and transmission of elastic waves at interface between elastic solid and micropolar porous cubic crystal

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Applied Mathematics and Mechanics(English Edition) 2010年第5期31卷 605-616页

作者： Rajneesh KUMAR Meenakshi panchal Department of Mathematics Kurukshetra University

The problem of reflection and transmission of plane periodic waves incident on the interface between the loosely bonded elastic solid and micropolar porous cubic crystal half spaces is investigated. This is done by assuming that the interface behaves like a dislocation, which preserves the continuity of traction while allowing a finite amount of slip. Amplitude ratios of various reflected and transmitted waves have been depicted graphically. Some special cases of interest have been deduced from the present investigation.

关键词： micropolar porous cubic crystal reflection coefficients transmission coefficients bonding parameter

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Mill tailings based composites as paste backfill in mines of U-bearing dolomitic limestone ore

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 310-322页

作者： Sandeep panchal Debasis Deb T.Sreenivas Department of Mining Engineering Indian Institute of Technology Mineral Processing Division Bhabha Atomic Research Centre

This paper elaborates on the development of paste backfill using mill tailings generated during the processing of a uranium ore deposit hosted in dolomitic limestone. The tailings have been characterized in terms of the physical, chemical and mineralogical properties. Time-dependent rheological behaviors and geotechnical properties of cemented paste backfill(CPB) are also determined. The studies show that the mill tailing has the potential to form paste and the CPB has adequate strength to provide support to mine pillars, roofs, and walls.

关键词： Mining engineering Uranium ore deposit Tailings Cemented paste backfill(CPB) Rheology Compressive strength

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Strategies for fitting accurate machine-learned inter-atomic potentials for solid electrolytes

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Materials Futures 2023年第1期2卷 145-156页

作者： Juefan Wang Abhishek A panchal Pieremanuele Canepa Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1117575Singapore Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4117585Singapore

Ion transport in materials is routinely probed through several experimental techniques,which introduce variability in reported ionic diffusivities and *** computational prediction of ionic diffusivities and conductivities helps in identifying good ionic conductors,and suitable solid electrolytes(SEs),thus establishing firm structure-property ***-learned potentials are an attractive strategy to extend the capabilities of accurate ab initio molecular dynamics(AIMD)to longer simulations for larger systems,enabling the study of ion transport at lower ***,machine-learned potentials being in their infancy,critical assessments of their predicting capabilities are ***,we identified the main factors controlling the quality of a machine-learning potential based on the moment tensor potential formulation,when applied to the properties of ion transport in ionic conductors,such as *** results underline the importance of high-quality and diverse training sets required to fit moment tensor *** highlight the importance of considering intrinsic defects which may occur in *** demonstrate the limitations posed by short-timescale and high-temperature AIMD simulations to predict the room-temperature properties of materials.

关键词： solid electrolytes solid-state batteries lithium-ion batteries ionic conductors machine-learning potentials molecular dynamics density functional theory

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Seismic behavior of variable frequency pendulum isolator

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Earthquake Engineering and Engineering Vibration 2008年第2期7卷 193-205页

作者： V. R. panchal R. S. Jangid Department of Civil Engineering Indian Institute of TechnologyBombayPowaiMumbai 400076India

Earthquake performance of a flexible one-story building isolated with a variable frequency pendulum isolator （VFPI） under near-fault and far-field ground motions is investigated. The frictional forces mobilized at the interface of the VFPI are assumed to be velocity dependent. The interaction between frictional forces of the VFPI in two horizontal directions is duly considered and coupled differential equations of motion of the isolated system in the incremental form are solved iteratively. The response of the system with bi-directional interaction is compared with those without interaction. In addition, the effects of velocity dependence on the response of the isolated system are also investigated. Moreover, a parametric study is carried out to critically examine the influence of important parameters on bi-directional interaction effects of the frictional forces of the VFPI. These parameters are： the superstructure time period, frequency variation factor （FVF） and friction coefficient of the VFPI. From the above investigations, it is observed that the dependence of the friction coefficient on relative velocity of the system does not have a noticeable effect on the peak response of the system isolated with VFPI, and that the bi-directional interaction of frictional forces of the VFPI is important and if neglected, isolator displacements will be underestimated and the superstructure acceleration and base shear will be overestimated.

关键词： base isolation bi-directional interaction superstructure flexibility near-fault ground motion friction coefficient far-field ground motion VFPI

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Healing promoting potentials of roots of Ficus benghalensis *** albino rats

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 921-924页

作者： Krishna Murti Upendra Kumar Mayank panchal Singhania University JhunjhunuRajastkanIndia College of Pharmacy AzamgarhUttar PradeshIndia Vidyabharti Trust College of Pharmacy UmrakhGujaratIndia

Objective:To screen the wound healing activity of aqueous and ethanolic extract of roots of Ficus ***:Both the extracts were evaluated for wound healing by three models ie. incision,excision and dead space *** incision and dead space the extracts were applied ilaily topically till the 10th post wounding days while in excision model it was till the complete epithelialization *** group were administered Povidone iodine ointment topically *** breaking strength,percentage of wound contraction,period of epithelialization,dry granulation weight and hydroxyproline content were ***:The result of the present study showed that both extracts were able to increase the breaking strength(incision model), decrease period of *** percentage wound contraction(excision model), increase hydroxyproline content(Dead space wound model) significantly compared with control group(P<0.05).Conclusions:Based on result we conclude that aqueous extract is more effective than ethanolic ***,it is needed more research to be carried out especially on toxicity studies of ethanolic extract.

关键词： Ficus benghalensis Incision Excision Dead Space Hydroxyproline estimation Phytochemical analysis Povidone iodine

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Exploring the mechanism of action bitter melon in the treatment ofbreast cancer by network pharmacology

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World Journal of Experimental Medicine 2023年第5期13卷 142-155页

作者： Kavan panchal Bhavya Nihalani Utsavi Oza Aarti panchal Bhumi Shah Pharmaceutical Chemistry L.J.Institute of PharmacyL J UniversityGujaratAhmedabad 382210India

BACKGROUND Bitter melon has been used to stop the growth of breast cancer(BRCA)***,the underlying mechanism is still *** To predict the therapeutic effect of bitter melon against BRCA using network pharmacology and to explore the underlying pharmacological *** The active ingredients of bitter melon and the related protein targets were taken from the Indian Medicinal Plants,Phytochemistry and Therapeutics and SuperPred databases,*** GeneCards database has been searched for BRCA-related *** an intersection of the drug’s targets and the disease’s objectives,prospective bitter melon anti-BRCA targets were *** ontology and kyoto encyclopedia of genes and genomes enrichment analyses were carried out to comprehend the biological roles of the target *** binding relationship between bitter melon’s active ingredients and the suggested target proteins was verified using molecular docking *** Three key substances,momordicoside K,kaempferol,and quercetin,were identified as being important in mediating the putative anti-BRCA effects of bitter melon through the active ingredient-anti-BRCA target network *** shock protein 90 AA,proto-oncogene tyrosine-protein kinase,and signal transducer and activator of transcription 3 were found to be the top three proteins in the proteinprotein interaction network *** several pathways implicated in the anti-BRCA strategy for an active component include phosphatidylinositol 3-kinase/protein kinase B signaling,transcriptional dysregulation,axon guidance,calcium signaling,focal adhesion,janus kinase-signal transducer and activator of transcription signaling,cyclic adenosine monophosphate signaling,mammalian CONCLUSION Overall,the integration of network pharmacology,molecular docking,and functional enrichment analyses shed light on potential mechanisms underlying bitter melon’s ability to fight BRCA,implicating active ingredients and protein ta

关键词： Bitter melon Momordica charantia Network pharmacology Molecular docking Breast cancer Indian Medicinal Plants,Phytochemistry and Therapeutics

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