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异麦芽酮糖的低血糖指数特性及健康功能

中国食物与营养 2023年第7期29卷 31-35页

作者： anke sentko Goh Peen Ern 邢青斌贝利优研究所德国奥布里海姆67283 贝利优研究所新加坡117684 中国疾病预防控制中心营养与健康所北京100050

目的:异麦芽酮糖是一种低血糖指数碳水化合物,GI值为32,它是一种独特的二糖,可以缓慢但完全地被消化吸收。方法:介绍了异麦芽酮糖的结构、来源及生产,综述了异麦芽酮糖在体内的代谢、低血糖指数特性及其健康功效。结果:异麦芽酮糖可以... 详细信息

目的:异麦芽酮糖是一种低血糖指数碳水化合物,GI值为32,它是一种独特的二糖,可以缓慢但完全地被消化吸收。方法:介绍了异麦芽酮糖的结构、来源及生产,综述了异麦芽酮糖在体内的代谢、低血糖指数特性及其健康功效。结果:异麦芽酮糖可以像蔗糖和淀粉一样被很好地消化和耐受,但水解速度更低,这有利于代谢健康。异麦芽酮糖的低血糖特性在30多个不同人群(包括儿童和成年人)的不同健康阶段(从健康人群到糖尿病患者)的临床试验中得到了一致的证明。含异麦芽酮糖的低血糖指数饮食不仅可以降低血糖反应,减少血糖波动,而且还有益于其他代谢过程,包括较高的脂肪氧化率、较低的腹部脂肪堆积,并支持体重管理。结论:异麦芽酮糖的低血糖指数特性对代谢健康有着积极的影响。

关键词：异麦芽酮糖持续能量缓释碳水化合物糖尿病血糖管理体重管理

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The emerging role of tranexamic acid and its principal target,plasminogen,in skeletal health

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2869-2884页

作者： Weixin Xie Antonia Donat Shan Jiang anke Baranowsky Johannes Keller Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-EppendorfHamburg 20246Germany

The worldwide burden of skeletal diseases such as osteoporosis,degenerative joint disease and impaired fracture healing is steadily *** acid(TXA),a plasminogen inhibitor and anti-fibrinolytic agent,is used to reduce bleeding with high effectiveness and safety in major surgical *** its widespread clinical application,the effects of TXA beyond anti-fibrinolysis have been noticed and prompted renewed interest in its *** clinical trials have characterized the effects of TXA on reducing postoperative infection rates and regulating immune responses in patients undergoing ***,several animal studies suggest potential therapeutic effects of TXA on skeletal diseases such as osteoporosis and fracture *** a direct effect of TXA on the differentiation and function of bone cells in vitro was shown,few mechanisms of action have been ***,we summarize recent findings of the effects of TXA on skeletal diseases and discuss the underlying plasminogen-dependent and-independent mechanisms related to bone metabolism and the immune *** furthermore discuss potential novel indications for TXA application as a treatment strategy for skeletal diseases.

关键词： Tranexamic acid Osteoporosis Osteoarthritis Fracture healing Bone metabolism Inflammation Plasminogen Fibrinolysis

Anisotropic phonon dynamics in Dirac semimetal PtTe2 thin films enabled by helicity-dependent ultrafast light excitation

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Light(Science & Applications) 2024年第9期13卷 1888-1897页

作者： Ziyang Li Yequan Chen anke Song Jinzhong Zhang Rong Zhang Zongzhi Zhang Xuefeng Wang Key Laboratory of Micro and Nano Photonic Structures(MOE) School of Information Science and TechnologyFudan UniversityShanghaiChina Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials State Key Laboratory of Spintronics Devices and TechnologiesSchool of Electronic Science and EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina Department of Physics School of Physics and Electronic ScienceEast China Normal UniversityShanghaiChina Department of Physics Xiamen UniversityXiamenChina

Coherent phonons have aroused considerable attention in condensed matter physics owing to their extraordinary capacity of reflecting and controlling the physical properties of ***,the investigation on the interaction between coherent phonons and other microscopic particles on the ultrafast timescale within topological systems continues to be an active and unresolved ***,we show the energy transfer of coherent optical phonons(COP)in Dirac semimetal PtTe2 thin films using ultrafast optical pump-probe ***,the helicitydependent light-driven anisotropic COP signals disclose their direct connection with the light-excited anisotropic spinpolarized electrons via an angular momentum ***,we observe the notable decreases in the COP oscillation frequency and the decay rate with increasing temperatures due to the anharmonic phonon-phonon scattering and electron-phonon scattering in the COP dissipation process,*** work paves the way for uncovering the coherent phonons in Dirac semimetals for the potential applications in optoelectronics and optospintronics.

关键词： spectroscopy. phonon Dirac

Multisensory Conflict Impairs Cortico-Muscular Network Connectivity and Postural Stability: Insights from Partial Directed Coherence Analysis

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Neuroscience Bulletin 2024年第1期40卷 79-89页

作者： Guozheng Wang Yi Yang Kangli Dong anke Hua Jian Wang Jun Liu Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310058China Taizhou Key Laboratory of Medical Devices and Advanced Materials Research Institute of Zhejiang University-TaizhouTaizhou 318000China Department of Sports Science College of EducationZhejiang UniversityHangzhou 310058China Center for Psychological Science Zhejiang UniversityHangzhou 310058China

Sensory conflict impacts postural control,yet its effect on cortico-muscular interaction remains *** aimed to investigate sensory conflict's influence on the cortico-muscular network and postural *** used a rotating platform and virtual reality to present subjects with congruent and incongruent sensory input,recorded EEG(electroencephalogram)and EMG(electromyogram)data,and constructed a directed connectivity *** results suggest that,compared to sensory congruence,during sensory conflict:(1)connectivity among the sensorimotor,visual,and posterior parietal cortex generally decreases,(2)cortical control over the muscles is weakened,(3)feedback from muscles to the cortex is strengthened,and(4)the range of body sway increases and its complexity *** results underline the intricate effects of sensory conflict on cortico-muscular *** the sensory conflict,the brain adaptively decreases the integration of conflicting *** this integrated information,cortical control over muscles may be lessened,whereas the muscle feedback may be enhanced in compensation.

关键词： Cortico-muscular interaction Postural control Virtual reality Electroencephalogram Electromyography Sensory integration

菊苣根纤维菊粉和低聚糖是经过科学验证的益生元

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食品安全导刊 2021年第19期 I0019-I0019页

作者： anke sentko 吴平恩贝利优研究所贝利优研究院

5月24日,中国营养学会(CNS)发布了《中国营养学会益生元与健康专家共识》(以下简称《共识》)——在国内首次对益生元做出定义。根据《共识》,益生元被定义为“一般不能被人体所消化吸收但可被人体微生物选择性利用,能够改善肠道微生物... 详细信息

5月24日,中国营养学会(CNS)发布了《中国营养学会益生元与健康专家共识》(以下简称《共识》)——在国内首次对益生元做出定义。根据《共识》,益生元被定义为“一般不能被人体所消化吸收但可被人体微生物选择性利用,能够改善肠道微生物组成和/或活性,从而有益于人体健康的食物成分”。

关键词：中国营养学会食物成分益生元科学验证消化吸收低聚糖人体健康菊粉

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Impact of preoperative chemotherapy on surgical results in 139 patients with locally advanced pancreatic cancer

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 460-471页

作者： Marvin Petrikowski Tim Fahlbusch anke Reinacher-Schick Giedre Kucinskaite Andrea Tannapfel Waldemar Uhl Orlin Belyaev Department of General and Visceral Surgery St.Josef-Hospital BochumRuhr-University BochumBochumGermany Department of Hematology and Oncology with Palliative Medicine St.Josef-Hospital BochumRuhr-University BochumBochumGermany Department of Radiology and Nuclear Medicine St.Josef-Hospital BochumRuhr-University BochumBochumGermany Institute of Pathology Ruhr-University BochumBochumGermany

Background:The establishment of preoperative chemotherapy(PCT)with FOLFIRINOX and gemcitabine/nab-paclitaxel in recent years has enabled resectability in many patients with initially locally advanced pancreatic cancer(LAPC).Nevertheless,information about the impact of PCT on surgical results is ***:All patients with initial LAPC who received surgery after chemotherapy at the high-volume centre for pancreatic surgery of ***-Hospital Bochum between 2015 and 2022 were included in this retrospective cohort ***:A total of 139 patients underwent surgery after pre-treatment with FOLFIRINOX(76.3%),gemcitabine/nab-paclitaxel(11.5%),both(5.8%)and other regimens(6.5%).Eighty-five tumors(61.2%)were resectable after PCT.R0 resection was achieved in 92.9%,R1 in 7.1%and R2 in 0%of ***-four tumors were still not resectable at the time of *** results of the patients did not show increased postoperative mortality and morbidity compared to the literature *** 30-day mortality was 1.4%.Rates for pancreas-specific complications[postoperative pancreatic fistula(POPF),delayed gastric emptying(DGE),postpancreatectomy hemorrhage(PPH),and others]were not *** occurred in 10.5%and DGE in 26.3%after *** distal pancreatectomy,POPF was detected in 37.5%and DGE in 12.5%.Median postoperative survival(31 vs.13 months)and overall survival after initial diagnosis(40 vs.20 months)were significantly longer in resected patients(P<0.001).Postoperative recurrence-free survival in resected patients amounted to 12 ***:This study underlines that PCT allows resectability of primarily unresectable patients with LAPC without increasing perioperative mortality and *** may lead to a significant prolongation of recurrence-free and overall survival in resected patients after PCT.

关键词： Pancreatic cancer preoperative chemotherapy(PCT) postoperative complications mortality overall survival

Advancing oxygen separation:insights from experimental and computational analysis of La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)(M=Cu,Zn)oxygen transport membranes

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 17-29页

作者： Guoxing Chen Wenmei Liu Marc Widenmeyer Xiao Yu Zhijun Zhao Songhak Yoon Ruijuan Yan Wenjie Xie Armin Feldhoff Gert Homm Emanuel Ionescu Maria Fyta anke Weidenkaff Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS Alzenau 63755Germany Electrochemistry Laboratory Paul Scherrer InstituteVilligen PSI 5232Switzerland Department of Materials and Earth Sciences Materials and ResourcesTechnical University of DarmstadtDarmstadt 64287Germany Institute of Physical Chemistry and Electrochemistry Leibniz University HannoverHannover 30167Germany Institute for Computational Physics University of StuttgartStuttgart 70569Germany Computational Biotechnology RWTH AachenAachen 52074Germany

In this study,perovskite-type La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)(M=Cu,Zn)powders were synthesized using a scalable reverse co-precipitation method,presenting them as novel materials for oxygen transport *** comprehensive study covered various aspects including oxygen permeability,crystal structure,conductivity,morphology,CO_(2) tolerance,and long-term regenerative durability with a focus on phase structure and *** membrane La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)exhibited high oxygen permeation fluxes,reaching up to 0.88 and 0.64 mL·min^(−1)·cm^(−2) under air/He and air/CO_(2) gradients at 1173 K,*** 1600 h of CO_(2) exposure,the perovskite structure remained intact,showcasing superior CO_(2) resistance.A combination of first principles simulations and experimental measurements was employed to deepen the understanding of Cu/Zn substitution effects on the structure,oxygen vacancy formation,and transport behavior of the *** findings underscore the potential of this highly CO_(2)-tolerant membrane for applications in high-temperature oxygen *** enhanced insights into the oxygen transport mechanism contribute to the advancement of next-generation membrane materials.

关键词： perovskite oxygen permeation membrane oxygennionsdiffusiono xygen vacancy formation energy energy barrier

Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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人工智能如何改变生物制药行业

流程工业 2024年第8期 16-18页

作者： anke Geipel-Kern 《流程工业》德文版

生物制药行业目前正经历着许多变化。该行业面临着巨大的创新压力,现在可持续性和生成式人工智能也被提上了日程。该行业如何应对这一切?在德国施蒂利亚州塞高城堡(Seggau Castle),Zeta公司又一次举行了研讨会,邀请了170名制药和生物技... 详细信息

生物制药行业目前正经历着许多变化。该行业面临着巨大的创新压力,现在可持续性和生成式人工智能也被提上了日程。该行业如何应对这一切?在德国施蒂利亚州塞高城堡(Seggau Castle),Zeta公司又一次举行了研讨会,邀请了170名制药和生物技术领域的专家前来参会,并就当前生物制药领域的热点话题进行了探讨。

关键词：生物制药可持续性生成式人工智能数字孪生智能化工厂

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