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Journal of Bionic Engineering 2016年第4期13卷 650-658页

作者： Zupeng Zhou Yubing Gong Daoguo Yang anke schmitz Helmut schmitz School of Mechanical and Electrical Engineering Guilin University of Electronic Technology Guilin 541004 China Institute of Zoology University of Bonn Poppelsdorfer Schloss D-53115 Bonn Germany

Acanthocnemus nigricans is an inconspicuous pyrophilous beetle that approaches forest fires. The beetle is equipped with a pair of unique infrared （IR） receptors on its prothorax that allows it to detect hot surfaces in flight. The IR receptor consists of a little disc bearing about 90 tiny sensilla on its anterior half. The disc sensilla are unique in insects and their functions are largely unknown. Using a 3D reconstruction of the head and thorax we performed case studies to reveal different position-dependent expositions of the IR receptors to incoming radiation~ Results show that the spatiotemporal pattern in which different sectors of the disc are exposed provides the beetle with unambiguous information about its current direction to an IR source. As a striking structural element, the disc sensilla contain an electron-dense rod connecting an outer peg to the inner sensory cell. Finite element simulations suggest that the rod serves as a heat conductor directing heat to the thermosensitive cell inside the disc. Thus the disc sensilla can be interpreted as discrete temperature reading points. The resulting pattern of stimulated/deactivated sensilla, therefore, could provide the flying beetle with spatiotemporal information about its current position relative to an IR source. Possible biomimetic perspectives of the findings are discussed.

关键词： infrared receptor pyrophilous insects fire detection insect sensillum

The emerging role of tranexamic acid and its principal target,plasminogen,in skeletal health

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2869-2884页

作者： Weixin Xie Antonia Donat Shan Jiang anke Baranowsky Johannes Keller Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-EppendorfHamburg 20246Germany

The worldwide burden of skeletal diseases such as osteoporosis,degenerative joint disease and impaired fracture healing is steadily *** acid(TXA),a plasminogen inhibitor and anti-fibrinolytic agent,is used to reduce bleeding with high effectiveness and safety in major surgical *** its widespread clinical application,the effects of TXA beyond anti-fibrinolysis have been noticed and prompted renewed interest in its *** clinical trials have characterized the effects of TXA on reducing postoperative infection rates and regulating immune responses in patients undergoing ***,several animal studies suggest potential therapeutic effects of TXA on skeletal diseases such as osteoporosis and fracture *** a direct effect of TXA on the differentiation and function of bone cells in vitro was shown,few mechanisms of action have been ***,we summarize recent findings of the effects of TXA on skeletal diseases and discuss the underlying plasminogen-dependent and-independent mechanisms related to bone metabolism and the immune *** furthermore discuss potential novel indications for TXA application as a treatment strategy for skeletal diseases.

关键词： Tranexamic acid Osteoporosis Osteoarthritis Fracture healing Bone metabolism Inflammation Plasminogen Fibrinolysis

Non-coding RNAs in exercise immunology:A systematic review

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Journal of Sport and Health Science 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsch Melina Heimer Boris schmitz Frank C.Mooren Department of Rehabilitation Sciences Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV Clinic Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflammation,and improved overall *** strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical *** combined approaches were used:(a)a systematic literature search for“ncRNA and exercise immunology”,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reactome database,combined with a systematic literature search for“ncRNA and exercise”.Literature searches were based on PubMed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exercise-based interventions in healthy *** duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qualitative *** studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also *** were analyzed using ordering tables that included exercise modality(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between *** criteria were defined as“validated”with 100%of≥3 independent studies showing identical direction of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistance exercise,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** endurance exer

关键词： Immune system Inflammation MicroRNA ncRNA Physical exercise

Multisensory Conflict Impairs Cortico-Muscular Network Connectivity and Postural Stability: Insights from Partial Directed Coherence Analysis

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Neuroscience Bulletin 2024年第1期40卷 79-89页

作者： Guozheng Wang Yi Yang Kangli Dong anke Hua Jian Wang Jun Liu Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310058China Taizhou Key Laboratory of Medical Devices and Advanced Materials Research Institute of Zhejiang University-TaizhouTaizhou 318000China Department of Sports Science College of EducationZhejiang UniversityHangzhou 310058China Center for Psychological Science Zhejiang UniversityHangzhou 310058China

Sensory conflict impacts postural control,yet its effect on cortico-muscular interaction remains *** aimed to investigate sensory conflict's influence on the cortico-muscular network and postural *** used a rotating platform and virtual reality to present subjects with congruent and incongruent sensory input,recorded EEG(electroencephalogram)and EMG(electromyogram)data,and constructed a directed connectivity *** results suggest that,compared to sensory congruence,during sensory conflict:(1)connectivity among the sensorimotor,visual,and posterior parietal cortex generally decreases,(2)cortical control over the muscles is weakened,(3)feedback from muscles to the cortex is strengthened,and(4)the range of body sway increases and its complexity *** results underline the intricate effects of sensory conflict on cortico-muscular *** the sensory conflict,the brain adaptively decreases the integration of conflicting *** this integrated information,cortical control over muscles may be lessened,whereas the muscle feedback may be enhanced in compensation.

关键词： Cortico-muscular interaction Postural control Virtual reality Electroencephalogram Electromyography Sensory integration

Advancing oxygen separation:insights from experimental and computational analysis of La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)(M=Cu,Zn)oxygen transport membranes

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 17-29页

作者： Guoxing Chen Wenmei Liu Marc Widenmeyer Xiao Yu Zhijun Zhao Songhak Yoon Ruijuan Yan Wenjie Xie Armin Feldhoff Gert Homm Emanuel Ionescu Maria Fyta anke Weidenkaff Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS Alzenau 63755Germany Electrochemistry Laboratory Paul Scherrer InstituteVilligen PSI 5232Switzerland Department of Materials and Earth Sciences Materials and ResourcesTechnical University of DarmstadtDarmstadt 64287Germany Institute of Physical Chemistry and Electrochemistry Leibniz University HannoverHannover 30167Germany Institute for Computational Physics University of StuttgartStuttgart 70569Germany Computational Biotechnology RWTH AachenAachen 52074Germany

In this study,perovskite-type La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)(M=Cu,Zn)powders were synthesized using a scalable reverse co-precipitation method,presenting them as novel materials for oxygen transport *** comprehensive study covered various aspects including oxygen permeability,crystal structure,conductivity,morphology,CO_(2) tolerance,and long-term regenerative durability with a focus on phase structure and *** membrane La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)exhibited high oxygen permeation fluxes,reaching up to 0.88 and 0.64 mL·min^(−1)·cm^(−2) under air/He and air/CO_(2) gradients at 1173 K,*** 1600 h of CO_(2) exposure,the perovskite structure remained intact,showcasing superior CO_(2) resistance.A combination of first principles simulations and experimental measurements was employed to deepen the understanding of Cu/Zn substitution effects on the structure,oxygen vacancy formation,and transport behavior of the *** findings underscore the potential of this highly CO_(2)-tolerant membrane for applications in high-temperature oxygen *** enhanced insights into the oxygen transport mechanism contribute to the advancement of next-generation membrane materials.

关键词： perovskite oxygen permeation membrane oxygennionsdiffusiono xygen vacancy formation energy energy barrier

Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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人工智能如何改变生物制药行业

流程工业 2024年第8期 16-18页

作者： anke Geipel-Kern 《流程工业》德文版

生物制药行业目前正经历着许多变化。该行业面临着巨大的创新压力,现在可持续性和生成式人工智能也被提上了日程。该行业如何应对这一切?在德国施蒂利亚州塞高城堡(Seggau Castle),Zeta公司又一次举行了研讨会,邀请了170名制药和生物技... 详细信息

生物制药行业目前正经历着许多变化。该行业面临着巨大的创新压力,现在可持续性和生成式人工智能也被提上了日程。该行业如何应对这一切?在德国施蒂利亚州塞高城堡(Seggau Castle),Zeta公司又一次举行了研讨会,邀请了170名制药和生物技术领域的专家前来参会,并就当前生物制药领域的热点话题进行了探讨。

关键词：生物制药可持续性生成式人工智能数字孪生智能化工厂

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输液袋无菌灌装的新方案

流程工业 2024年第4期 30-31页

作者： anke Geipel Kern 不详

安全、无菌地将含有活性成分的生物药品和新的基因和细胞疗法产品装入输液袋——这是制药行业的一项新挑战。正因如此,专家们在这一领域获得的进展都是非常重要的案例。近期,Harro Höfliger推出了新的输液袋无菌灌装方法,以期为制药企... 详细信息

安全、无菌地将含有活性成分的生物药品和新的基因和细胞疗法产品装入输液袋——这是制药行业的一项新挑战。正因如此,专家们在这一领域获得的进展都是非常重要的案例。近期,Harro Höfliger推出了新的输液袋无菌灌装方法,以期为制药企业提供更全面的无忧包装。

关键词：无菌灌装输液袋细胞和基因疗法

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全球氢能技术发展现状及未来展望

流程工业 2024年第5期 26-29,31页

作者： anke Geipel-Kern 《PROCESS》

氢能源的兴起标志着能源转型开启了新篇章,而DECHEMA德国化学工程及生物技术协会(以下简称“DECHEMA”)正处于这一变革的核心地带,其汇聚了该领域的广泛而深入的专业知识。PROCESS专访了DECHEMA的董事总经理Andreas F?rster与能源与气... 详细信息

氢能源的兴起标志着能源转型开启了新篇章,而DECHEMA德国化学工程及生物技术协会(以下简称“DECHEMA”)正处于这一变革的核心地带,其汇聚了该领域的广泛而深入的专业知识。PROCESS专访了DECHEMA的董事总经理Andreas F?rster与能源与气候部门的负责人Florian Ausfelder,深入探讨了氢能发展现状。

关键词：核心地带化学工程生物技术协会氢能源能源转型 DEC 专业知识现状及未来

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维多利亚时期欧洲盒式吊坠研究

中国宝玉石 2024年第3期 16-22页

作者：赵文瑄李耿 Fabian schmitz 中国地质大学(北京)珠宝学院北京100083 Rhein Main宝石咨询公司德国美因茨55118

欧洲盒式吊坠(Locket)是一种可以开合的存放纪念物的小容器,可以在其中保存照片或微绘画像等物品。它起源于多世纪以前,盛行于维多利亚时期,直至今日依旧被珠宝品牌使用其表现形式,可见影响之久。本文以维多利亚时期欧洲盒式吊坠为研究... 详细信息

欧洲盒式吊坠(Locket)是一种可以开合的存放纪念物的小容器,可以在其中保存照片或微绘画像等物品。它起源于多世纪以前,盛行于维多利亚时期,直至今日依旧被珠宝品牌使用其表现形式,可见影响之久。本文以维多利亚时期欧洲盒式吊坠为研究对象,从它的历史来源与发展、材料形制、工艺功能及文化价值四方面进行研究。其历史来源于古代护身符,盛行于维多利亚时期,延续至今。材料多使用金属、彩色宝玉石及有机宝石等,形制主要为各种几何形状。制作工艺有金属工艺、微型肖像工艺、琅工艺、卡梅奥工艺等。功能以实用装饰性与情感表达相结合为主。佩戴者通过盒式吊坠与所放物品联系之人进行情感沟通,具有心灵疗愈效果,为现代首饰设计提供创作思路。

关键词：欧洲盒式吊坠护身符情感价值