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Toxic Effects of Seed Methanolic Extracts of Endemic Albizia Species （Fabaceae） from Madagascar on Animals

Journal of Life Sciences 2014年第8期8卷 676-689页

作者： Hanitra Ranjana Randrianarivo anjarasoa ravo razafindrakoto Holy Christiane Ratsimanohatra Lovarintsoa Judicael Randriamampianina Clara Fredeline Rajemiarimoelisoa Lolona Ramamonjisoa David Ramanitrahasimbola Danielle Aurore Doll Rakoto Victor Louis Jeannoda Laboratory of Applied Biochemistry to Medical Sciences Fundamental and Applied Biochemistry Department Faculty of SciencesUniversity of Antananarivo PO Bo 906 Antananarivo 101 Madagascar Department of Pharmacy Faculty of Medicine PO Box 375 Antananarivo 101 Madagascar National Tree Seed Centre (SNGF) PO Box 5091 Antananarivo 101 Madagascar

In order to find natural compounds of interest such as pesticides and therapeutic molecules, toxicological properties of seed methanolic extracts （SME） of nine Malagasy Albizia species were investigated. Toxicity was assessed on living animals by intraperitoneal and oral route, and pharmacological effects on isolated organs. All SME induced various disorders in mice but the signs of the nervous system disturbs were the earliest and the most often observed. The main organ lesions, examined on histological sections, induced vasodilatation, inflammatory infiltrate of neutrophil polymorphonuclears and hemorrhagic areas. At low concentrations （until 20 p.g/mL）, A. masikororum and A. viridis provoked on isolated auricular a positive inotrope effect followed by a progressive inhibition of the contraction and a complete atrial arrhythmia. Besides, A. viridis and A. bernieri induced some hepatic functional impairment after a chronic treatment during one month. Albizia greveana with a LD50 of 1.13-2 mg/kg was the most toxic and Albizia bernieri the least one with a LD50 of 52 mg/kg. Alkaloids and/or saponins, the major chemical groups found by phytochemical screening on these extracts, could be responsible of their toxicity.

关键词： Albizia phytochemical screening toxicity pharmacological activity.

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Prevalence and risk distribution of schistosomiasis among adults in Madagascar:a cross-sectional study

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Infectious Diseases of Poverty 2023年第2期12卷 136-136页

作者： Sarah Katharina Gruninger Tahinamandranto Rasamoelina Rivo Andry Rakotoarivelo anjarasoa ravo razafindrakoto Zaraniaina Tahiry Rasolojaona Rodson Morin Rakotozafy Patrick Richard Soloniaina Njary Rakotozandrindrainy Pia Rausche Cheick Oumar Doumbia Anna Jaeger Alexandre Zerbo Heidrun von Thien Philipp Klein Govert van Dam Egbert Tannich Norbert Georg Schwarz Eva Lorenz Jürgen May Raphael Rakotozandrindrainy Daniela Fusco Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg Germany German Centre for Infection Research (DZIF) Hamburg-Borstel-Lübeck-Riems Germany Centre d’Infectiologie Charles Mérieux (CICM) University of Antananarivo Antananarivo Madagascar Department of Infectious Diseases University of Fianarantsoa Andrainjato Fianarantsoa Madagascar Department of Microbiology and Parasitology University of Antananarivo Antananarivo Madagascar University Clinical Research Centre (UCRC) University of Sciences Technics and Technologies of Bamako (USTTB) Bamako Mali Department of Parasitology Leiden University Medical Centre Leiden The Netherlands National Reference Centre for Tropical Pathogens (NRC) Hamburg Germany Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre of the Johannes Gutenberg University Mainz Mainz Germany Department of Tropical Medicine I University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany

Background The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals,including universal health coverage(UHC).Current control strategies focus on school-aged children,systematically neglecting *** aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of *** In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina,Tsiroanomandidy and Ankazomborona in Madagascar,we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult *** and multivariable logistic regression were performed to evaluate odd *** The highest prevalence of ***,*** and co-infection of both species was 59.5%,61.3%and 3.3%,in Andina and Ankazomborona *** prevalence was observed among males(52.4%)and main contributors to the family income(68.1%).Not working as a farmer and higher age were found to be protective factors for *** Our findings provide evidence that adults are a high-risk group for *** data suggests that,for ensuring basic health as a human right,current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific,holistic and integrated approaches.

关键词： Schistosomiasis Schistosoma haematobium Schistosoma mansoni Universal health coverage Madagascar

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Relationship between Mutations in DNA Sequences Loci Coding Pre-miRNAs and Genes Related to Biogenesis of SncRNAs with MiRNA Expression in Endometrial Carcinoma Tissues

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Journal of Environmental Science and Engineering(B) 2015年第7期4卷 372-379页

作者： Massimiliano Chetta Angela Cordella Giuseppina Bruno Maurizio Guida Alessandro Weisz Maria ravo Department of Medicine and SurgetT---Laboratory of Molecular Medicine and Genomics University of Salerno Baronissi 84081Salerno Italy Foundation Institute for Hospitalization and Scientific Care (IRCCS) SDN Naples 80143 Italy Department of Obstetrics and Gynecology "San Giovanni Di Dio Ruggi D'Aragona" University Hospital--Schola MedicaSalernitana Salerno 84131 Italy Department of Molecular Pathology and Medical "San Giovanni Di Dio Ruggi D'Aragona" University Hospital--Schola MedicaSalernitana Salerno 84131 Italy

Endometrial cancer （EC） is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but it may also originate in the lower uterine segment or spread in endometrium with necrosis and hemorrhage. The analysis was performed using a custom panel containing all DNA sequences loci coding pre-miRNAs and genes related to biogenesis and regulation of sncRNAs in normal and tumor tissues extracted from 6 unrelated patients with endometrial carcinoma. The identified variations were correlated with mature miRNAs differentially expressed in the same normal and tumor endometrial tissues. The comparison analysis confirmed the high degree of cellular and genetic intratumoral heterogeneity with a temporal and spatial miRNA expression distribution in association with genomic variants identified. The classification of specific DNA mutations, onto the loci identified, should be suitable to characterize possible instability genome regions and help classification of tumors to ameliorate the clinical management of patients affected by endometrial carcinoma.

关键词： Endometrial cancer pre-miRNAs sncRNA miRNA expression.

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Female genital schistosomiasis,human papilloma virus infection,and cervical cancer in rural Madagascar:a cross sectional study

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Infectious Diseases of Poverty 2023年第5期12卷 100-100页

作者： Jean-Marc Kutz Pia Rausche Tahinamandranto Rasamoelina Sonya Ratefiarisoa ravo razafindrakoto Philipp Klein Anna Jaeger Rivo Solotiana Rakotomalala Zoly Rakotomalala Bodo Sahondra Randrianasolo Sandrine McKay-Chopin Jürgen May Rapahel Rakotozandrindrainy Dewi Ismajani Puradiredja Elisa Sicuri Monika Hampl Eva Lorenz Tarik Gheit Rivo Andry Rakotoarivelo Daniela Fusco Department of Infectious Disease Epidemiology Bernhard-Nocht Institute for Tropical Medicine (BNITM) Hamburg Germany German Center for Infection Research (DZIF) Hamburg-Borstel-Lübeck-Riems Germany Centre Infectiologie Charles Mérieux (CICM) Antananarivo Madagascar Centre Hospitalier Universitaire (CHU) Androva Mahajanga Madagascar Association K’OLO VANONA Antananarivo Madagascar International Agency for Research on Cancer (IARC) Lyon France University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany University of Antananarivo Antananarivo Madagascar Barcelona Institute for Global Health (IS Global) Barcelona Spain Köln-Hohenlind Hospital Cologne Germany University of Fianarantsoa Fianarantsoa Madagascar

Background Women’s health in resource-limited settings can benefit from the integrated management of high-burden diseases,such as female genital schistosomiasis(FGS)and human papilloma virus(HPV)-related cervical *** schistosomiasis-endemic countries such as Madagascar,data on FGS and HPV prevalence are lacking as well as preventive measures for both *** study aims to estimate the prevalence of FGS and HPV in rural Madagascar,and to examine associated risk factors to identify opportunities for improving women’s *** After initial community outreach activities,interested women aged 18-49 years were recruited consecutively in 2021 at three primary health care centers in the district of *** was detected by *** images were double-blind reviewed by two independent specialists.A Luminex bead-based assay was performed on cervical vaginal lavage specimens for HPV ***(CPR)and adjusted prevalence ratios(APR)of associations between selected factors and FGS and HPV positivity were estimated using univariable and multivariable binary Poisson regression with 95%confidence intervals(CIs).Results Among 500 women enrolled,302 had complete information on FGS and HPV diagnosis,and were thus eligible for *** the sample,189(62.6%,95%CI:56.9-68.1)cases of FGS were detected.A total of 129 women(42.7%,95%CI:37.1-48.5)tested positive for *** total,80 women(26.5%,95%CI:21.6-31.8)tested positive for both *** association was observed between FGS and HPV positivity,while previous pregnancy(APR=0.65,95%CI:0.43-0.78)and older age(APR=0.59,95%CI:0.42-0.81)are showing a negative association with HPV infection compared to no previous pregnancy and younger age *** The results of the study show that FGS and HPV are highly prevalent in rural *** concurrent prevalence of these two conditions requires urgent adaptations of public health strategies to improve women’s health,such as integrated

关键词： Women’s health Female genital schistosomiasis Human papilloma virus Cervical cancer Public health Madagascar

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Management of Painful Bone Metastases: The Interaction between Radiation Therapy and Zoledronate

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Journal of Cancer Therapy 2011年第5期2卷 697-702页

作者： Rossella Di Franco Mariagrazia Calvanese Mariagrazia Cuomo Roberto Manzo Paola Murino Salvatore Cappabianca Vincenzo ravo 不详

Background: Advanced cancers frequently metastasize to bone, and the presence of bone metastases is the most common cause of cancer-related pain. Pain management requires a multidisciplinary approach that involves the use of analgesics, bisphosphonates, radiotherapy, chemotherapy, surgery. The aim of our study was to evaluate the enhancement of radiotherapy on painful bone metastases in patients treated also with bisphosphonates. Materials and Methods: We analyzed the differences in benefit on pain and on quality of life comparing two groups of treatment. The first group comprised 104 patients treated with Radiotherapy (RT), the second one included 50 patients treated with radiotherapy associated to zoledronic acid (RT + Z). All patients completed before, during and after treatment, a questionnaire that rated the grade of pain, the pharmacological type of analgesic therapy and patient’s performance status. For each patient a total score was calculated, from a minimum value of 0% to a maximum of 20%, then expressed as a percentage. Patients were classified as responder if at the follow-up reported a reduction of over 20% of the initial score, no-change if there was a reduction of between 0% and 20%, progression if there was an increasing of the score. Results: In the group RT + Z we found fewer patients that started radiation therapy with severe pain (16% vs 32%), no patient had pain of grade 10, and a higher proportion of asymptomatic patients (12% vs 4%) was observed. In the RT alone group a higher percentage of patients started treatment assuming strong opioid more than once a day (26% vs 24%) and a reduction in number of these patients was about 14% compared with the reduction of 23.6% observed in the group RT + Z. Furthermore an increased total score was calculated only in the 6% of patient belonged to group RT alone. Finally, in the group RT + Z responder patients are 52%, compared to 36% of the RT group, non-responder were 36% versus 60% in the RT. The risk of

关键词： Bone Metastases Radiotherapy Zoledronate

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Predictability and Management of OARs Toxicity in Patients with Prostate Cancer Treated with High-Dose Radiotherapy

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Journal of Cancer Therapy 2013年第10期4卷 1452-1458页

作者： Vincenzo ravo Domenico Borrelli Sara Falivene Rossella Di Franco Matteo Muto Angela Argenone Valentina Borzillo Fabrizio Cammarota Paolo Muto Radiotherapy Emicenter Naples Italy Radiotherapy of Second University of Naples Naples Italy Radiotherapy Unit Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale”—IRCCS Naples Italy

Aim: To evaluate the predictability of toxicity analyzing the dose-volume histograms (DVHs) and to verify the effectiveness of preventive measures limiting side toxicity considering the evolution of the radiation techniques for prostate cancer treatment. Materials and Methods: 208 patients with localized prostate cancer were treated with exclusive radiotherapy until 73.8 Gy (group A) or 79.2 Gy (group B) with the dose escalation technique. Preventive measures to minimize the side effects were recommended in group B. Results: The assessment of genitourinary toxicity was similar while gastrointestinal toxicity was better in group B. Valuating the treatment plans, we found that most of the patients developing toxicity had “borderline” DVHs. Conclusion: Our analysis led to the establishment of a protocol for the management of patients with “border-line” DVH.

关键词： Toxicity Radiotherapy Prostate Cancer Prevention

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Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第1期4卷 16-23页

作者： Rossella Di Franco Vincenzo ravo Sara Falivene Angela Argenone Valentina Borzillo Francesca Maria Giugliano Elena Sammarco Matteo Muto Salvatore Cappabianca Paolo Muto Radiation Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori-Fondazione “Giovanni Pascale” IRCCS Naples Italy Radiation Oncology Muto-Onlus Foundation of Naples Casavatore Naples Italy Radiation Oncology Second University of Naples Naples Italy U.O.S. of Dermatology P.O. Ascalesi Naples Italy

Introduction: Skin toxicity is a frequent side effect of radio and chemo-treatments in patients treated for breast cancer after conservative surgery. The aim of this paper is to report our experience in the management of skin toxicity evaluating radiotherapy planning and using preventive local aids. Materials and Methods: We have observed 300 patients undergoing radiotherapy. All received the prescription of a prophylactic moisturizing cream. Skin toxicity was valuated according to Acute Radiation Morbidity Scoring Criteria of the RTOG. Moreover, in a subgroup of 100 patients, we correlated the study of breast volume and features of treatment plans, with the addition of topic prophylactic treatment, using an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?). In another subgroup, 100 patients were subjected to corneometry assessing numerically skin hydration before, during and after radiotherapy. Results: In all patients, we related skin toxicity and the type of cream used. All patients completed the radiotherapy treatment, and G4 cutaneous toxicity was not observed in any of them. In patients treated with topic treatment and therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?), the protective effect of (Ixor?) is more detected in patients with PTV (Planning Target Volume) <500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes. The values of corneometry allow us to evaluate the moisturizing effect for products used, and identify cases of skin toxicity in a first phase. Conclusions: Our study confirms the value of moisturizers in the prevention and resolution of radiotherapy-induced skin damage. An instrumental assessment of skin hydration with corneometry can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree.

关键词： Skin Toxicity Prevention and Treatment Radiotherapy

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