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Gastric intestinal metaplasia development in African American predominant United States population

World Journal of Gastrointestinal Endoscopy 2022年第10期14卷 597-607页

作者： Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand anjani kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho Department of Internal Medicine MedStar Washington Hospital CenterWashingtonDC 20010United States Department of Internal Medicine Georgetown University School of MedicineWashingtonDC 20007United States Department of Gastroenterology and Hepatology INOVA Medical SystemLeesburgVA 20176United States

BACKGROUND Gastric cancer significantly contributes to cancer mortality *** intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric *** natural history of GIM formation and progression over time is not fully ***,there are no clear guidelines on GIM surveillance or management in the United *** To investigate factors associated with GIM development over time in African American-predominant study *** This is a retrospective longitudinal study in a single tertiary hospital in Washington *** retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December *** included in the study had undergone two or more EGDswith gastric *** with no GIM at baseline were followed up until they developed GIM or until the last available *** criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy *** study population was divided into two groups based on GIM *** and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(***)status on the GIM *** Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)*** gender difference was obse

关键词： Gastric intestinal metaplasia Gastric cancer Helicobacter pylori Retrospective longitudinal study Esophagogastroduodenoscopy African American population

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The general class of Bianchi cosmological models with viscous fluid and particle creation in Brans-Dicke theory

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Research in Astronomy and Astrophysics 2014年第5期14卷 533-552页

作者： Raghavendra Chaubey anjani Kumar Shukla DST-Centre for Interdisciplinary Mathematical Sciences Faculty of Science Banaras Hindu University Varanasi India

This paper deals with the general class of Bianchi cosmological models with bulk viscosity and particle creation described by full causal thermodynamics in Brans-Dicke theory. We discuss three types of average scale-factor solutions for the general class of Bianchi cosmological models by using a special law for the deceler- ation parameter which is linear in time with a negative slope. The exact solutions to the corresponding field equations are obtained in quadrature form and solutions to the Einstein field equations are obtained for three different physically viable cosmologies. All the physical parameters are calculated and discussed in each model.

关键词： cosmology theory

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A Thorough Investigation on Image Forgery Detection

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1489-1528页

作者： anjani Kumar Rai Subodh Srivastava Department of Electronics&Communication Engineering NITPatnaIndia

Image forging is the alteration of a digital image to conceal some of the necessary or helpful *** cannot be easy to distinguish themodified region fromthe original image in *** demand for authenticity and the integrity of the image drive the detection of a fabricated *** have been cases of ownership infringements or fraudulent actions by counterfeiting multimedia files,including re-sampling or *** work presents a high-level view of the forensics of digital images and their possible detection *** work presents a thorough analysis of digital image forgery detection techniques with their steps and *** methods have identified forgery and its type and compared it with state of the *** work will help us to find the best forgery detection technique based on the different *** also shows the current issues in other methods,which can help researchers find future scope for further research in this field.

关键词： Forgery detection digital forgery image forgery localization image segmentation image forensics multimedia security

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Reframing Palliative Care:An East-West Integrative Palliative Care Model

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Chinese Journal of Integrative Medicine 2021年第10期27卷 723-728页

作者： S.anjani D.Mattai Ka-Kit P.Hui Department of Medicine David Geffen School of MedicineUniversity of California Los AngelesCaliforniaUSA Center for East-West Medicine Department of MedicineDavid Geffen School of MedicineUniversity of California Los AngelesCaliforniaUSA

Convergence of principles of palliative care and integrative medicine has led to the introduction of the new practice of integrative palliative care in which integrative therapies(including mind-body modalities,traditional Chinese medicine,Ayurveda,and dietary supplements)are used to provide symptom management for patients who are dying or experiencing the sequelae of serious illness and its *** propose an East-West Integrative palliative care model using non-drug therapies,such as acupuncture,diet,exercise,and stress management that shift the paradigm from suppressing the symptoms of illness to addressing both the root cause of the symptoms and the imbalance and declining homeostatic reserve that perpetuate these *** whole-person model expands the reach of palliative care,prolonging a better quality of life and allowing the patient to maintain as many activities as possible by preventing symptoms and improving *** this approach we reframe the dialogue such that patients are"living better"rather than"dying better"when faced with serious illness or *** this article,we provide an overview of the principles of palliative care,integrative medicine,and the novel area of integrative palliative care,and propose an East-West integrative palliative care model that incorporates and broadens the scope of these existing approaches.

关键词： person-centered model palliative care integrative medicine traditional Chinese medicine acupuncture symptom management cost-effectiveness reframing healthcare

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Metabolic engineering and genome editing strategies for enhanced lipid production in microalgae

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BIOCELL 2024年第8期48卷 1181-1195页

作者： anjani DEVI CHINTAGUNTA SAMUDRALA PRASHANT JEEVAN KUMAR NUNE SATYA SAMPATH KUMAR Department of Biotechnology Vignan’s Foundation ScienceTechnology and ResearchVadlamudiAndhra Pradesh522213India ICAR-Directorate of Floricultural Research Pune412307India

Depleting global petroleum reserves and skyrocketing prices coupled with succinct supply have been a grave concern,which needs alternative sources to conventional *** microalgae have been explored for enhanced lipid production,leading towards biodiesel *** microalgae have short life cycles,require less labor,and space,and are easy to scale ***,the primary source of lipids needed to produce biodiesel,is accumulated by most *** article focuses on different types of oleaginous microalgae,which can be used as a feedstock to produce *** biosynthesis in microalgae occurs through fatty acid synthesis and TAG synthesis ***-depth discussions are held regarding other efficient methods for enhancing fatty acid and TAG synthesis,regulating TAG biosynthesis bypass methods,blocking competing pathways,multigene approach,and genome *** most potential targets for gene transformation are hypothesized to be a malic enzyme and diacylglycerol acyltransferase while lowering phosphoenolpyruvate carboxylase activity is reported to be advantageous for lipid synthesis.

关键词： Oleaginous microalgae Biodiesel TAG synthesis Metabolic engineering Genome editing

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Performance Enhancement of Adaptive Neural Networks Based on Learning Rate

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Computers, Materials & Continua 2023年第1期74卷 2005-2019页

作者： Swaleha Zubair anjani Kumar Singha Nitish Pathak Neelam Sharma Shabana Urooj Samia Rabeh Larguech Department of Computer Science Aligarh Muslim UniversityAligarh202002Uttar PradeshIndia Department of Information Technology Bhagwan Parshuram Institute of Technology(BPIT)GGSIPUNew Delhi110089India Department of Computer Science and Engineering Maharaja Agrasen Institute of Technology(MAIT)GGSIPUNew DelhiIndia Department of Electrical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Deep learning is the process of determining parameters that reduce the cost function derived from the *** optimization in neural networks at the time is known as the optimal *** solve optimization,it initialize the parameters during the optimization *** should be no variation in the cost function parameters at the global *** momentum technique is a parameters optimization approach;however,it has difficulties stopping the parameter when the cost function value fulfills the global minimum(non-stop problem).Moreover,existing approaches use techniques;the learning rate is reduced during the iteration *** techniques are monotonically reducing at a steady rate over time;our goal is to make the learning rate *** present a method for determining the best parameters that adjust the learning rate in response to the cost function *** a result,after the cost function has been optimized,the process of the rate Schedule is *** approach is shown to ensure convergence to the optimal *** indicates that our strategy minimizes the cost function(or effective learning).The momentum approach is used in the proposed *** solve the Momentum approach non-stop problem,we use the cost function of the parameter in our proposed *** a result,this learning technique reduces the quantity of the parameter due to the impact of the cost function *** verify that the learning works to test the strategy,we employed proof of convergence and empirical tests using current methods and the results are obtained using Python.

关键词： Deep learning optimization convergence stochastic gradient methods

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An updated review on phenocopies of primary immunodeficiency diseases

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Genes & Diseases 2020年第1期7卷 12-25页

作者： Ankita Singh Ankur K.Jindal Vibhu Joshi Gummadi anjani Amit Rawat Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Primary immunodeficiency diseases(PIDs)refer to a heterogenous group of disorders characterized clinically by increased susceptibility to infections,autoimmunity and increased risk of *** group of disorders present with clinical manifestations similar to PIDs with known genetic defects but have either no genetic defect or have a somatic mutation and thus have been labelled as“Phenocopies of PIDs”.These diseases have been further subdivided into those associated with somatic mutations and those associated with presence of auto-antibodies against various *** this review,we provide an update on clinical manifestations,diagnosis and management of these diseases.

关键词： Anti-cytokine antibodies Phenocopies Primary immunodeficiency diseases Somatic mutations

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Injectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs

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Bioactive Materials 2023年第5期23卷 551-562页

作者： Jeffrey Luo anjani Darai Thanapat Pongkulapa Brian Conley Letao Yang Inbo Han Ki-Bum Lee Department of Chemistry and Chemical Biology RutgersThe State University of New JerseyPiscatawayNJ08854USA Department of Neurosurgery CHA University School of MedicineCHA Bundang Medical Center59 Yaptap-roBundang-guSeongnam-siGyeonggi-do13496Republic of Korea

Intervertebral disc(IVD)degeneration is a leading cause of back pain and precursor to more severe conditions,including disc herniation and spinal *** traditional growth factor therapies(e.g.,TGFβ)are effective at transiently reversing degenerated disc by stimulation of matrix synthesis,it is increasingly accepted that bioscaffolds are required for sustained,complete IVD *** scaffolds(e.g.,metal/polymer composites,non-mammalian biopolymers)can be improved in one or more IVD regeneration demands:biodegradability,noninvasive injection,recapitulated healthy IVD biomechanics,predictable crosslinking,and matrix repair *** meet these demands,tetrazine-norbornene bioorthogonal ligation was combined with gelatin to create an injectable bioorthogonal hydrogel(BIOGEL).The liquid hydrogel precursors remain free-flowing across a wide range of temperatures and crosslink into a robust hydrogel after 5-10 min,allowing a human operator to easily inject the therapeutic constructs into degenerated ***,BIOGEL encapsulation of TGFβpotentiated histological repair(e.g.,tissue architecture and matrix synthesis)and functional recovery(e.g.,high water retention by promoting the matrix synthesis and reduced pain)in an in vivo rat IVD degeneration/nucleotomy *** BIOGEL procedure readily integrates into existing nucleotomy procedures,indicating that clinical adoption should proceed with minimal *** bioorthogonal crosslinking is essentially non-reactive towards biomolecules,our developed material platform can be extended to other payloads and degenerative injuries.

关键词： Bioorthogonal chemistry Growth factor Injectable hydrogel Intervertebral disc degeneration Tissue engineering

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Design of ANN Based Non-Linear Network Using Interconnection of Parallel Processor

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Computer Systems Science & Engineering 2023年第9期46卷 3491-3508页

作者： anjani Kumar Singha Swaleha Zubair Areej Malibari Nitish Pathak Shabana Urooj Neelam Sharma Department of Computer Science Aligarh Muslim UniversityAligarh202002India Department of Industrial and Systems Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Technology Bhagwan Parshuram Institute of Technology(BPIT)GGSIPUNew Delhi110078India Department of Electrical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Artificial Intelligence&Machine Learning Maharaja Agrasen Institute of Technology(MAIT)GGSIPUNew Delhi110086India

Suspicious mass traffic constantly evolves,making network behaviour tracing and structure more *** networks yield promising results by considering a sufficient number of processing elements with strong interconnections between *** offer efficient computational Hopfield neural networks models and optimization constraints used by undergoing a good amount of parallelism to yield optimal *** neural network(ANN)offers optimal solutions in classifying and clustering the various reels of data,and the results obtained purely depend on identifying a *** this research work,the design of optimized applications is presented in an organized *** addition,this research work examines theoretical approaches to achieving optimized results using *** mainly focuses on designing *** optimizing design approach of neural networks analyzes the internal process of the neural *** in developing the network are based on the interconnections among the hidden nodes and their learning *** methodology is proven best for nonlinear resource allocation problems with a suitable design and complex *** ANN proposed here considers more or less 46k nodes hidden inside 49 million connections employed on full-fledged parallel *** proposed ANN offered optimal results in real-world application problems,and the results were obtained using MATLAB.

关键词： Artificial neural network(ANN) multiprocessor hidden node nonlinear optimization parallel processing

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Recent advances in chronic granulomatous disease

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Genes & Diseases 2020年第1期7卷 84-92页

作者： Gummadi anjani Pandiarajan Vignesh Vibhu Joshi Jitendra Kumar Shandilya Dharmagat Bhattarai Jyoti Sharma Amit Rawat Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Chronic granulomatous disease(CGD)is an inherited defect of phagocyte function due to defective NADPH *** with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals and are prone to recurrent bacterial and fungal *** complications are also noted in CGD such as colitis,non-infective granulomas causing gastrointestinal or urinary tract obstruction,hemophagocytic lymphohistiocytosis,and *** on toll-like receptor pathways and neutrophil extracellular traps in CGD have shed light on the role of NADPH oxidase in the innate immunity and pathogenesis of infections in *** reports also indicate a reduction of memory B cells and defective production of functional antibodies in *** the exact mechanisms for non-infective inflammatory complications in CGD are not yet clear,studies on efferocytosis and defective autophagy with inflammasome activation have made a substantial contribution to our understanding of the pathogenesis of inflammation in *** also discuss the clinical and molecular features of p40phox defects and a newer genetic defect,*** phenotypes of X-linked carriers of CYBB are also discussed.

关键词： Chronic granulomatous disease Colitis EROS Genetics Infections Inflammation p40phox

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