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Assessment of Glycosaminoglycan Content of Lumbar Intervertebral Discs in Patients with Radiculopathy

International Journal of Clinical medicine 2019年第4期10卷 259-269页

作者： Sophie Heüveldop Florian Fichter anja müller-lutz markus Konieczny markus Eichner Hans-J&ouml rg Wittsack Christoph Schleich Department of Diagnostic and Interventional Radiology Medical Faculty University of Düsseldorf Düsseldorf Germany Department of Orthopedics Medical Faculty University of Düsseldorf Düsseldorf Germany

Objective: To assess glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVDs) in patients with radiculopathy compared with healthy volunteers with glycosaminoglycan chemical exchange saturation transfer (gagCEST). methods: The lumbar spines of 15 patients with radiculopathy (9 women, 6 men;mean age 45 years;range: 19 - 80 years) and 13 healthy controls (10 women, 3 men;mean age 29 years;range: 19 - 38 years) without lumbar back pain or previous spine surgery were examined at a 3 Tesla (T) magnetic resonance imaging (mRI) scanner in this prospective study. The mRI protocol included standard morphological, sagittal, and transverse T2-weighted (T2w) images of the five lumbar IVDs (L1-S1) to assess Pfirrmann score and to detect disc disorders according to the Combined Task Force classification. To analyze biochemically the lumbar IVDs, a gagCEST sequence was applied to measure the GAG content of the nucleus pulposus (NP) and annulus fibrosus (AF). Results: Patients with radiculopathy indicated significantly lower gagCEST values in NP than healthy volunteers (2.82% ±3.12% vs. 4.09% ±2.25%, P = 0.017). The GAG content of AF showed no significant difference between volunteers and patients (2.66% ±2.01% vs. 1.92% ±2.56%;P = 0.175). Conclusions. Patients with radiculopathy presented with lower GAG values than healthy volunteers in NP, indicating an association between pain and IVD degeneration. gagCEST of lumbar IVDs is a powerful, non-invasive tool to investigate early disc degeneration, which we could demonstrate in the NP in our study collective.

关键词： Glycosaminoglycan Chemical Exchange Saturation Transfer Radiculopathy Intervertebral Disc Lumbar Spine Early Degeneration

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Quantitative multi-Layer Electromagnetic Induction Inversion and Full-Waveform Inversion of Crosshole Ground Penetrating Radar Data

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Journal of Earth Science 2015年第6期26卷 844-850页

作者： Jan van der Kruk Nils Gueting anja Klotzsche Guowei He Sebastian Rudolph Christian von Hebel Xi Yang lutz Weihermüller Achim mester Harry Vereecken Agrosphere (IBG-3) Forschungszentrum Jülich GmbH Centre for High-Performance Scientific Computing in Terrestrial Systems (TerrSys) British Geological Survey Environmenal Science Centre Key Worth Electronic Systems (ZEA-2) Forschungszentrum Jülich GmbH

Due to the recent system developments for the electromagnetic characterization of the subsurface, fast and easy acquisition is made feasible due to the fast measurement speed, easy coupling with GPS systems, and the availability of multi-channel electromagnetic induction（EmI） and ground penetrating radar（GPR） systems. moreover, the increasing computer power enables the use of accurate forward modeling programs in advanced inversion algorithms where no approximations are used and the full information content of the measured data can be exploited. Here, recent developments of large-scale quantitative EmI inversion and full-waveform GPR inversion are discussed that yield higher resolution of quantitative medium properties compared to conventional approaches. In both cases a detailed forward model is used in the inversion procedure that is based on maxwell＇s equations. The multi-channel EmI data that have different sensing depths for the different source-receiver offset are calibrated using a short electrical resistivity tomography（ERT） calibration line which makes it possible to invert for electrical conductivity changes with depth over large areas. The crosshole GPR full-waveform inversion yields significant higher resolution of the permittivity and conductivity images compared to ray-based inversion results.

关键词： ground penetrating radar electromagnetic induction full-waveform inversion.

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Implementation of the Flood Risk management Directive in Selected European Countries

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International Journal of Disaster Risk Science 2013年第3期4卷 115-125页

作者： Uwe müller Saxon State Agency for Environment Agriculture and GeologyDresdenSaxony 01109Germany

Flood events are a recurrent threat to economic developments and can jeopardize human existence. In order to reduce the flood risks in Europe on a sustainable basis, the European Union adopted the Flood Risk management Directive in 2007. The implementation of the directive in the national laws of all member states has laid the foundation for intergovernmental integrated flood risk management on an European scale. The following article is intended to compare and briefly assess the implementation process on inland waters at the technical level in selected European countries in the middle of the process. It covers the different basic structural, methodological, and data conditions for preparing the preliminary flood risk assessment, the flood hazard maps, the flood risk maps, and the flood risk management plans as a result of two EU projects. The technical differences in the various European countries need to be reduced in the next cycles of implementation of the Flood Risk management Directive.

关键词： flood inland preparing

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A NOVEL DESIGN OF COmPOSITE WATER TURBINE USING CFD

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Journal of Hydrodynamics 2012年第1期24卷 11-16页

作者： PIECHNA Janusz mller Norbert Turbomachinery Laboratory Department of Mechanical EngineeringMichigan State UniversityEast LansingUSA

This paper presents computational investigation of a novel design of composite material axial water turbine using Computational Fluid Dynamics（CFD）.Based on three-dimensional numerical flow analysis,the flow characteristics through the water turbine with nozzle,wheel and diffuser are *** extract power and torque of a composite water turbine at different rotating speeds were calculated and analyzed for a specific flow *** simulation results show that using nozzle and diffuser can increase the pressure drop across the turbine and extract more power from available water *** results provide a fundamental understanding of the composite water turbine,and this design and analysis method is used in the design process.

关键词： water turbine composite material Computational Fluid Dynamics(CFD) extracted power

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Surface morphology and impurity distribution of electron beam recrystallized silicon films on low cost substrates for solar cell absorber

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Rare metals 2006年第Z1期25卷 195-200页

作者： GROmBALL F müller J Department of mikrosystemtechnik Technische Universitt Hamburg-Harburg Hamburg 21073 Germany

A line shaped electron beam recrystallised polycrystalline silicon film on the low cost substrate was investigated for the use of the solar cell absorber. The applied EB energy density strongly influences the surface morphology of the film system. Lower EB energy density results in droplet morphology and the rougher SiO2 capping layer due to the low fluidity. With the energy increasing, the capping layer becomes smooth and continuous and less and small pinholes form in the silicon film. Tungstendisilicide (WSi2) is formed at the interface tungsten/silicon but also at the grain boundaries of the silicon. Because of the fast melting and cooling of the silicon film, the eutectic of silicon and tungstendisilicide mainly forms at the grain boundary of the primary silicon dendrites. The SEm-EDX analysis shows that there are no chlorine and hydrogen in the area surrounding a pinhole after recrystallization because of outgassing during the solidification.

关键词： polycrystalline silicon film solar cell recrystallization energy surface morphology outgassing

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Testing flexible polymer solar cells in near-space

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National Science Review 2023年第5期10卷 105-106页

作者： Peter müller-Buschbaum Department of Physics TUM School of Natural Sciencesand Heinz Maier-Leibnitz-Zentrum(MLZ)Technical University of Munich

Since the big success of the Vanguard1 mission,being the first solar-powered satellite,the use of solar cells in space developed very ***,conventional solar cell technologies for space are based on silicon and GaAs **...

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Biological consequences of global change for birds

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Integrative Zoology 2013年第2期8卷 136-144页

作者： Anders Pape mØller Department of Ecology Systematics and EvolutionUniversity Paris-SouthOrsay CedexFrance

Climate is currently changing at an unprecedented rate;so also human exploitation is rapidly changing the Earth for agriculture,forestry,fisheries and *** addition,pollution has affected even the most remote ecosystems,as has the omnipresence of humans,with consequences in particular for animals that keep a safe distance from potential predators,including human ***,all of these changes are occurring simultaneously,with increasing intensity,and further deterioration in both the short and the long-term is *** the consequences of these components of global change are relatively well studied on their own,the effects of their interactions,such as the combined effects of climate change and agriculture,or the combined effects of agriculture through nutrient leakage to freshwater and marine ecosystems and fisheries,and the effects of climate change and urbanization,are poorly ***,I provide a brief overview of the effects of climate change on phenology,diversity,abundance,interspecific interactions and population dynamics of birds.I address whether these effects of changing temperatures are direct,or indirect through effects of climate change on the phenology,distribution or abundance of food,parasites and ***,I review interactions between different components of global change.

关键词： climate change direct effects global change indirect effects interactions

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Use of the area of main influence to fix a relevant boundary for mining damages in Germany

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International Journal of mining Science and Technology 2018年第1期28卷 79-83页

作者： Denise müller Axel Preusse Faculty of Georesources and materials Engineering Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining RWTH Aachen University

In 2010, the fracking discussion in Germany caused a number of changes in German law, which came into force in *** the production of gas had to be *** the legislation amendment, the Subsidence-Area mining Regulation has been revised, *** changes expand the compensation of mining damages, especially to the extraction with drilling from the surface and underground *** the Subsidence-Area mining Regulation has been revised, the area of main influence(subsidence of 10 cm)remains to determine a relevant boundary for mining *** determination and prediction of this boundary above caverns are presented in this *** addition, further elements of ground movements and their relevance to mine damages are *** usage of the area of main influence to fix a relevant boundary for mining damages does not correspond to the relevant elements of ground movements.A limit for differences in subsidence(tilt) or horizontal changes in length should be preferred to describe the relevance of mining damages on ***, this paper outlines the meaning of using the area of main influence to fix a relevant boundary for mining damages.

关键词： Ground movements Area of main influence Boundary for mining damages Subsidence-area mining regulation Subsidence detection modeling above caverns

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managing stress granule disassembly with ubiquitin and its cousin

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3377-3378页

作者： Stefan müller Institute of Biochemistry II Gustav Embden ZentrumGoethe University FrankfurtFaculty of MedicineFrankfurtGermany

Recently,maxwell et al.1 revealed a critical function of ubiquitylation in stress granule(SG)disassembly upon recovery from heat *** are continuously exposed to endogenous or environmental *** stress endangers DNA integrity,whereas proteotoxic stress causes an imbalance in protein homeostasis(proteostasis).Genotoxic insults activate DNA damage response pathways that halt the cell-cycle progression and initiate DNA *** quality control(PQC)systems in turn safeguard the integrity of the proteome and prepare for the restart of cellular activities upon stress *** genome and proteome integrity pathways are orchestrated by ubiquitin signaling and the ubiquitin-proteasome system(UPS).

关键词： stress aging integrity

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Highly insulating thermoplastic blends comprising a styrenic copolymer for direct‐current power cable insulation

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High Voltage 2022年第2期7卷 251-259页

作者： Yingwei Ouyang Amir masoud Pourrahimi IdaÖstergren marcus mellqvist JakobÅnevall Azadeh Soroudi anja Lund Xiangdong Xu Thomas Gkourmpis Per‐Ola Hagstrand Christian müller Department of Chemistry and Chemical Engineering Chalmers University of TechnologyGöteborgSweden Department of Electrical Engineering Chalmers University of TechnologyGöteborgSweden Innovation&Technology Borealis ABStenungsundSweden

The impact of the composition of blends comprising low‐density polyethylene(LDPE),isotactic polypropylene(PP)and a styrenic copolymer additive on the thermomechanical properties as well as the direct‐current(DC)electrical and thermal conductivity is *** presence of 5 weight percent(wt%)of the styrenic copolymer strongly reduces the amount of PP that is needed to enhance the storage modulus above the melting temperature of LDPE from 40 to 24 wt%.At the same time,the copolymer improves the consistency of the thermomechanical properties of the resulting ternary *** both the DC electrical and thermal conductivity strongly decrease with PP content,the addition of the styrenic copolymer appears to have little influence on either ***,PP in combination with small amounts of a styrenic copolymer not only allows to reinforce LDPE at elevated temperatures but also functions as an electrical conductivity‐reducing additive,which makes such thermoplastic ternary formulations possible candidates for the insulation of high‐voltage power cables.

关键词： property. blends copolymer

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