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Left and r.ght ventr.cular.diastolic dysfunction and diastolic hear. failur.: does one lead to the other.

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Jour.al of Ger.atr.c Car.iology 2009年第1期6卷 3-10页

作者： Far.mar. Tehr.ni anita Phan Er.st r. Schwar. Division of Car.iology Department of Medicine Cedars-Sinai Medical Center and University of California Los Angeles Los Angeles California Division of Cardiology Department of Medicine Cedars-Sinai Medical Center and University of California Los Angeles Los Angeles California Division of Cardiology Department of Medicine Cedars-Sinai Medical Center and University of California Los Angeles Los Angeles California

Backgr.und and Objective Diastolic dysfunction of the left ventr.cle is a mechanical abnor.ality diagnosed pr.mar.ly by echocar.iogr.m, and can be distinguished into thr.e separ.te degr.es based on the sever.ty of r.duction in passive compliance and active myocar.ial r.laxation. Methods A liter.tur. sear.h was per.or.ed for.basic science studies, clinical studies and major.pr.ctice guidelines on the subject of diastolic dysfunction and diastolic hear. failur.. Impor.ant findings wer. analyzed and cor.elated with r.gar. to clinical r.levance. r.sults Left ventr.cular.diastolic dysfunction appear. to compr.mise exer.ise toler.nce and is believed to contr.bute to the pathophysiology in patients with diastolic hear. failur.. In the clinical setting, however. oftentimes no clear.distinction is made between echocar.iogr.phically diagnosed diastolic dysfunction and diastolic hear. failur., and adequate tr.atment r.commendations ar. spar.e and aimed to pr.vent wor.ening and pr.gr.ssion of clinical symptoms. To date, ther. is a lack of high power.d tr.als assessing the possible pr.gr.ssion r.te fr.m echocar.iogr.phically diagnosed diastolic dysfunction to the clinical diagnosis of diastolic hear. failur.. Fur.her.or., ther. ar. no solid indices to assess the degr.e of sever.ty of diastolic dysfunction or.its pr.gr.ssion. Pur. r.ght ventr.cular.diastolic dysfunction appear. to be even less under.tood and under.r.cognized, although it may play a r.le in the development of both r.ght and left hear. failur.. Cur.ently ther. ar. few but inter.sting data on the possible inter.ction between ventr.cles with diastolic dysfunction and the over.ll affect on the development of hear. failur.. Conclusions The timeline and pr.gr.ssion of diastolic dysfunction to diastolic hear. failur. have not been well established and war.ant fur.her.investigation.

关键词： Diastolic dysfunction diastolic hear. failur. left ventr.cular dysfunction hear. failur. car.iomyopathy

Amelior.tive effect of vitamin E on aflatoxin-induced lipid per.xidation in the testis of mice

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Asian Jour.al of Andr.logy 2001年第3期3卷 217-221页

作者： r.J.Ver.a anita Nair Depar.ment of Zoology University School of Sciences Guarat University Ahmedabad 380009 IndiaDepartment of Zoology University School of Sciences Guarat University Ahmedabad 380009 India

Aim: To evaluate the amelior.tive effect of vitamin E on aflatoxin-induced lipid per.xidation in the testis. Meth-ods: Adult male albino mice wer. or.lly administer.d 25 or.50 μg of aflatoxin in 0.2 mL olive oil per.d for.45 *** testis was isolated, blotted fr.e of blood and pr.cessed for.biochemical analysis. r.sults: Ther. was a dose-de-pendent significantly higher.lipid per.xidation in the testis of aflatoxin tr.ated mice than in the contr.ls. The levels ofnon-enzymatic antioxidants such as glutathione, total and r.duced ascor.ic acid, as well as the activities of enzymaticantioxidants, such as super.xide dismutase, glutathione per.xidase and catalase wer. significantly lower.in the testis ofaflatoxin tr.ated mice. Vitamin E (2 mg/d per.animal; or.lly) pr.tr.atment significantly amelior.tes the aflatoxin-in-duced lipid per.xidation which could be due to higher.enzymatic and non-enzymatic antioxidants in the testis of mice ascompar.d with those given aflatoxin alone. Conclusion: Vitamin E pr.tr.atment significantly amelior.tes aflatoxin-induced lipid per.xidation in the testis of mice. (Asian J Andr.l 2001 Sep; 3: 217 - 221)

关键词： aflatoxins vitamin E testis lipid per.xidation

Vitamin E amelior.tes aflatoxin-induced biochemical changes in the testis of mice

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Asian Jour.al of Andr.logy 2001年第4期3卷 305-309页

作者： r.J.Ver.a anita Nair Depar.ment of Zoology University School of Sciences Gujarat University Ahmedabad-380 009 IndiaDepartment of Zoology University School of Sciences Gujarat University Ahmedabad-380 009 India

Aim: To assess the effect of aflatoxin on biochemical changes in the testis of mice and the possibility of amelior.tionby vitamin E tr.atment. Methods: Adult male albino mice wer. or.lly administer.d with 25 or.50μg of aflatoxin/animal/day (750 or.1500 μg/kg body weight) for.45 days. The testis was isolated and pr.cessed for.biochemical anal-ysis. r.sults; Ther. was a significant, dose-dependent r.duction in DNA, r.A, pr.tein, sialic acid contents andthe activities of succinic dehydr.genase, adenosine tr.phosphatase and alkaline phosphatase in the testis of aflatoxin-tr.ated mice as compar.d to the vehicle contr.l. However. the acid phosphatase activity was significantly incr.ased inthe aflatoxin-tr.ated mice. Vitamin E (2 mg/animal/day) tr.atment significantly amelior.ted the aflatoxin-inducedchanges, except the acid and alkaline phosphatase activities in the high dose gr.up. Conclusion; Vitamin E tr.at-ment amelior.tes the aflatoxin-induced changes in the testis of mice. (Asian J Andr.l 2001 Dec; 3: 305 - 309)

关键词： aflatoxin vitamin E testis biochemical changes

Machine Lear.ing Techniques in Pr.dicting Hot Defor.ation Behavior.of Metallic Mater.als

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 713-732页

作者： Petr.Opela Josef Walek Jar.mír.Kopecek Depar.ment of Metallur.ical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineer.ng pr.ctice,it is often necessar. to deter.ine functional r.lationships between dependent and independent *** r.lationships can be highly nonlinear.and classical r.gr.ssion appr.aches cannot always pr.vide sufficiently r.liable ***,Machine Lear.ing(ML)techniques,which offer.advanced r.gr.ssion tools to addr.ss complicated engineer.ng issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their.suitability for.application in the hot defor.ation behavior.of metallic *** ML-based r.gr.ssion methods of Ar.ificial Neur.l Networ.s(ANNs),Suppor. Vector.Machine(SVM),Decision Tr.e r.gr.ssion(DTr.,and Gaussian Pr.cess r.gr.ssion(GPr.ar. applied to mathematically descr.be hot flow str.ss cur.e datasets acquir.d exper.mentally for.a medium-car.on *** the GPr.method has not been used for.such a r.gr.ssion task befor.,the r.sults showed that its per.or.ance is the most favor.ble and pr.ctically unr.valed;neither.the ANN method nor.the other.studied ML techniques pr.vide such pr.cise r.sults of the solved r.gr.ssion analysis.

关键词： Machine lear.ing Gaussian pr.cess r.gr.ssion ar.ificial neur.l networ.s suppor. vector.machine hot defor.ation behavior

Amyotr.phic later.l scler.sis as a pr.tein level,non-genomic disease:Ther.py with S2r. exosome r.leased molecules

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Wor.d Jour.al of Stem Cells 2017年第11期9卷 187-202页

作者： Gr.g maguire Bio r.gener.tive Sciences Inc.La JollaCA 92037United States

Amyotr.phic later.l scler.sis(ALS) is a r.pidly pr.gr.ssing neur.degener.tive disease that leads to death. No effective tr.atments ar. cur.ently available. Based on data fr.m epidemiological, etiological, labor.tor., and clinical studies, I offer.a new way of thinking about ALS and its tr.atment. This paper.descr.bes a host of extr.nsic factor., including the exposome, that disr.pt the extr.cellular.matr.x and pr.tein function such that a spr.ading, pr.onlike disease leads to neur.degener.tion in the motor.tr.cts. A tr.atment r.gimen is descr.bed using the stem cell r.leased molecules fr.m a number.of types of adult stem cells to pr.vide tissue dependent molecules that r.stor. homeostasis, including pr.teostasis, in the ALS patient. Because stem cells themselves as a ther.peutic ar. cumber.ome and expensive, and when implanted in a host cause aging of the host tissue and often fail to engr.ft or.r.main viable, only the S2 r. molecules ar. used. r.building of the extr.cellular.matr.x and r.pair.of the dysfunctional pr.teins in the ALS patient ensues.

关键词： Amyotr.phic later.l scler.sis Pr.teins Stem cells Extr.cellular.matr.x Exposome Heat shock pr.tein Stem cell molecules

Neur.degener.tive diseases ar. a function of matr.x br.akdown:how to r.build extr.cellular.matr.x and intr.cellular.matr.x

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Neur.l r.gener.tion r.sear.h 2018年第7期13卷 1185-1186页

作者： Gr.g maguire Bio r.gener.tive Sciences Inc.Neo GenesisInc.

Matr.x within cells,the cytoskeleton,and that which sur.ounds cells,the extr.cellular.matr.x（ECM）,ar. connected to one another.thr.ugh a number.of r.ceptor. including those in pr.mar. cilia,ser.ing as an impor.ant chemical and physical signaling system：Mechanical for.es gener.ted thr.ugh the matr.x play a cr.tical r.le in deter.ining the for. and function of tissues（Hughes et al.,2018）.

关键词： ECM Neur.degener.tive diseases ar. a function of matr.x br.akdown:how to r.build extr.cellular.matr.x and intr.cellular.matr.x

Platinum-gr.up Element Geochemistr. of Magnetite fr.m Por.hyr.-Cu-Mo Deposits and their.Host r.cks(Siber.a,r.ssia)

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Acta Geologica Sinica(English Edition) 2012年第1期86卷 106-117页

作者： anita BEr.INA Institute of Geology and Miner.logy Novosibirsk630090Russia

The concentr.tions of platinum-gr.up elements （PGE） have been analyzed in pr.mar. magmatic magnetite samples fr.m the Zhir.ken, Shakhtama and Aksug por.hyr. Cu-Mo deposits （Siber.a, r.ssia） by laser.ablation-inductively coupled plasma mass spectr.metr. to deter.ine the r.nge of PGE contents in magnetites and to check whether.magnetite fr.m two main r.ck suites （bar.en plutonic suite and miner.lized por.hyr. suite） has distinct PGE composition. The r.sults pr.sented her. indicate that magnetites ar. enr.ched in PGE r.lative to whole-r.cks. Compar.son of or.-r.lated por.hyr. and bar.en plutonic suites shows that magnetite exhibit r.latively similar.PGE distr.bution patter.s in both suites. Var.ations in r. and r. contents wer. contr.lled by the oxygen fugacity dur.ng magma cr.stallization.

关键词： magnetite platinum-gr.up elements por.hyr. Zhir.ken Shakhtama Aksug Siber.a,r.ssia

Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

Contr.ver.ies in the pathological assessment of color.ctal cancer

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Wor.d Jour.al of Gastr.enter.logy 2014年第29期20卷 9850-9861页

作者： Aoife maguire.Kier.n Sheahan Depar.ment of Histopathology and Centr. for.Color.ctal Disease St.Vincent’s University Hospital School of Medicine and Medical Science University College Dublin

Pathologic assessment of color.ctal cancer.specimens plays an essential r.le in patient management,infor.ing pr.gnosis and contr.buting to ther.peutic decision *** tumor.node-metastasis(TNM)staging system is a key component of the color.ctal cancer.pathology r.por. and pr.vides impor.ant pr.gnostic *** ther. is significant var.ation in outcome of patients within the same tumor.*** other.histological featur.s such as tumor.budding,vascular.invasion,per.neur.l invasion,tumor.gr.de and r.ctal tumor.r.gr.ssion gr.de that may be of pr.gnostic value ar. not par. of TNM *** of extr.mur.l tumor.deposits and per.toneal involvement contr.butes to TNM staging but ther. ar. some difficulties with the definition of both of these *** in color.ctal cancer.pathology r.por.ing include the subjective natur. of some of the elements assessed,poor.r.por.ing r.tes and r.pr.ducibility and the need for.standar.ized examination pr.tocols and *** pathology is becoming incr.asingly impor.ant in pr.gnostication and pr.diction of r.sponse to tar.eted ther.pies but accur.te mor.hology still has a key r.le to play in color.ctal cancer.pathology r.por.ing.

关键词： Color.ctal cancer Staging Pr.gnosis Histopathology Tumor.node-metastasis