Controversies in the pathological assessment of colorectal cancer

作     者：Aoife Maguire Kieran Sheahan 

作者机构：Department of Histopathology and Centre for Colorectal DiseaseSt.Vincent’s University Hospital School of Medicine and Medical ScienceUniversity College Dublin 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第29期

页      面：9850-9861页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Colorectal cancer Staging Prognosis Histopathology Tumor-node-metastasis 

摘      要：Pathologic assessment of colorectal cancer specimens plays an essential role in patient management,informing prognosis and contributing to therapeutic decision *** tumor-node-metastasis(TNM)staging system is a key component of the colorectal cancer pathology report and provides important prognostic *** there is significant variation in outcome of patients within the same tumor *** other histological features such as tumor budding,vascular invasion,perineural invasion,tumor grade and rectal tumor regression grade that may be of prognostic value are not part of TNM *** of extramural tumor deposits and peritoneal involvement contributes to TNM staging but there are some difficulties with the definition of both of these *** in colorectal cancer pathology reporting include the subjective nature of some of the elements assessed,poor reporting rates and reproducibility and the need for standardized examination protocols and *** pathology is becoming increasingly important in prognostication and prediction of response to targeted therapies but accurate morphology still has a key role to play in colorectal cancer pathology reporting.