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Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

Asian pacific Journal of Reproduction 2019年第4期8卷 141-147页

作者： Novita Eka Kusuma Wardani Respatiningrum Respatiningrum anis nur laili Dwi Yuni nur Hidayati Setyawati Soeharto Hidayat Sujuti Midwifery Master Program Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Midwifery Program Study of Bangkalan Midwifery Department of Health Polytechnic of Ministry of Health SurabayaEast JavaIndonesia Midwifery Program Health Polytechnic of Ministry of Health of TanjungpinangRiau ArchipelagoIndonesia Department of Microbiology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Department of Pharmacology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Program of Master of Biomedical Science Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia

Objective: To analyze the effects of subchronic cypermethrin on the ovary and endometrium as well as the involvement of apoptosis in the toxicity of cypermethrin. Methods: A total of 32 female Wistar rats were randomly divided into four groups, with 8 rats in each group. The control group received no treatment, and the other three groups received oral cypermethrin at 10, 15 or 20 mg/kg body weight for 28 days (sub-chronic). The granulosa cells were calculated histopathologically. The apoptotic index was determined by in situ technique. Histopathological examination was performed on the uterus and ovary. Results: There was no significant difference in the number of primary follicular granulosa cells between the treatment groups and the control group (P>0.05). However, the number of secondary and tertiary follicle granulosa cells in the treatment groups was significantly decreased compared to that of the control group (P all<0.05). The apoptotic index of primary follicular granulosa cells increased significantly in the groups treated with cypermethrin compared with the control group (P<0.05). The secondary, tertiary, and endometrial granulosa cell apoptosis index was significantly higher in all treatment groups compared to the control group (P<0.05). The higher the dose of cypermethrin was, the higher the apoptotic index of secondary, tertiary and endometrial granulosa cells was. There was a significant decrease in endometrial thickness in the three treatment groups compared to the control group (P<0.05). Thinning of the endometrial layer was seen in the cypermethrin exposure groups. Conclusions: Exposure to cypermethrin can suppress the number of secondary and tertiary follicular granulosa cells, and trigger thinning of the endometrium through induction of apoptosis.

关键词： Endocrine disruptor Pyrethroid pesticide Uterus Reproduction Apoptosis

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An assessment study of absorption effect:LED vs tungsten halogen lamp for noninvasive glucose detection

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 61-65页

作者： nur Ain Mohd Aziz Norhana Arsad P.Susthitha Menon Sahbudin Shaari Zalhan Md Yusof Abdur Rehman laili Institute of Microengineering and Nanoelectronics(IMEN) Dept.of ElectricalElectronic and System Engineering Faculty of Engineering and Built Environment The National University of MalaysiaBangiSelangor Department of Photonics MIMOS Berhad57000 Technology Park MalaysiaKuala LumpurMalaysia

Noninvasive gluoose monitoring development is critical for diabetic patient continuous ***,almost all the available devices are invasive and *** methods such as using spectroscopy have shown some good ***,the drawback was that the tungsten halogen lamps 1usage that is impractical if applied on human *** paper compared the light emitting diode(LED)to traditional tungsten halogen lamps as light source for glucose detection where the type of light source plays an important role in achieving a good spectrum *** concentration measurement has been developed as part of noninvasive technique using optical *** change and overlapping in tungsten halogen results need to replace it with a more convenient light source such as *** on the result obtained,the performance of LED for absorbance spectrum gives a signifcantly different and is directly proportional to the glucose *** result shows a linear trend and scucssully detects lowest at 60 to 160 mg/dL glucose concentration.

关键词： Tungsten halogen LED glucose rflectance absorbance spectrometer

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Efficacy of multigrain supplementation in type 2 diabetes mellitus:A pilot study protocol for a randomized intervention trial

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World Journal of Diabetes 2023年第5期14卷 606-616页

作者： nur anis Mohd Ariffin Mastura Mohd Sopian Lai Kuan Lee Food Technology Division School of Industrial TechnologyUniversiti Sains MalaysiaGelugor 11800Pulau PinangMalaysia Oncology and Radiological Sciences Cluster Advanced Medical and Dental InstituteUniversiti Sains MalaysiaBertam 13200Pulau PinangMalaysia

BACKGROUND Uncontrolled type 2 diabetes mellitus(T2DM)may lead to microvascular complications(nephropathy,retinopathy,and neuropathy)and cardiovascular *** beta-glucan content in grains has the potential to improve insulin sensitivity,lowering postprandial glucose response and reducing inflammation degrees.A proper combination of grains not only satisfies human body’s need,but also provides essential and reasonable nutritional ***,no trial has been conducted to evaluate the roles of multigrain in *** To determine the efficacy of multigrain supplementation among T2DM *** From October 2020 to June 2021,a total of 50 adults living with T2DM,who were receiving standard diabetes care at Day Care Clinic,were randomized into either a supplementation group or a control *** supplementation group received twice daily 30 g multigrain supplement(equivalent to 3.4 g beta-glucan)with standard medication for 12 wk,while the control group was prescribed with standard *** such as glycemic control(HbA1c,FPG,and HOMO-IR),cardiometabolic profile(lipid profile,renal function test,and liver function test),oxidative stress status,nutritional status,and quality of life(QoL)were assessed at two time points:Baseline and the end of the treatment period(week 12).RESULTS The primary outcomes were the mean difference of glycated haemoglobin(%),fasting plasma glucose,and serum insulin as intervention *** outcomes included the measurement of cardiometabolic profile,antioxidative and oxidative stress status,nutritional status indices,and *** outcomes involved the determination of safety and tolerability,and supplementation *** The present clinical trial will reveal the effectiveness of multigrain supplementation among T2DM patients for the improvement of diabetes management.

关键词： Beta-glucan Clinical trial Multigrain Type 2 diabetes mellitus Glycemic control

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Blockchain Governance: The Development and Application of a Framework for Waqf Institutions

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现代会计与审计:英文版 2023年第3期19卷 53-72页

作者： Khairil Faizal Khairi nur Hidayah laili Azuan Ahmad Universiti Sains Islam Malaysia NilaiMalaysia

The effectiveness of waqf administration is impeded by poor management of assets,opacity,and unstandardized *** is expected to solve these issues due to its ability to record and trace every transaction,allowing administrators to discharge their accountability to waqf *** there have been numerous proposals for waqf blockchain,there is no explicit framework for the governance of blockchain in waqf *** propose a governance of blockchain framework for waqf institutions based on IT governance dimensions and blockchain governance dimensions from the *** framework comprises three dimensions(formation and context,actors,and means of governance/decision making)that subsume eight sub-dimensions across three layers and three *** then apply the framework on a blockchain-based waqf organization to examine its *** framework is among the first to be designed for waqf institutions.

关键词： blockchain governance governance of blockchain framework waqf institutions

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