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Determining human-coronavirus protein-protein interaction using machine intelligence

Medicine in Novel Technology and Devices 2023年第2期18卷 123-142页

作者： Arijit Chakraborty Sajal Mitra Mainak Bhattacharjee Debashis De anindya j.pal Bachelor of Computer Application Department The Heritage AcademyKolkataIndia Department of Computer Science and Engineering Heritage Institute of TechnologyKolkataIndia Department of Biotechnology Heritage Institute of TechnologyKolkataIndia Department of Computer Science and Engineering Maulana Abul Kalam Azad University of TechnologyKolkataIndia University of Burdwan BurdwanIndia

The Severe Acute Respiratory Syndrome CoronaVirus 2(SARS-CoV-2)virus spread the novel CoronaVirus−19(nCoV-19)pandemic,resulting in millions of fatalities *** research demonstrated that the Protein-Protein Interaction(PPI)between SARS-CoV-2 and human proteins is accountable for viral ***,many of these PPIs are poorly understood and unexplored,necessitating a more in-depth investigation to find latent yet critical *** article elucidates the host-viral PPI through Machine Learning(ML)lenses and validates the biological significance of the same using web-based *** classifiers are designed based on comprehensive datasets with five sequence-based features of human proteins,namely Amino Acid Composition,Pseudo Amino Acid Composition,Conjoint Triad,Dipeptide Composition,and Normalized Auto Correlation.A majority voting rule-based ensemble method composed of the Random Forest Model(RFM),AdaBoost,and Bagging technique is proposed that delivers encouraging statistical performance compared to other models employed in this *** proposed ensemble model predicted a total of 111 possible SARS-CoV-2 human target proteins with a high likelihood factor≥70%,validated by utilizing Gene Ontology(GO)and KEGG pathway enrichment ***,this research can aid in a deeper understanding of the molecular mechanisms underlying viral pathogenesis and provide clues for developing more efficient anti-COVID medications.

关键词： Coronavirus Ensemble learning Machine intelligence Protein-protein interaction

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Structural and photoluminescence studies of Eu^(3+) doped zinc oxide nanorods prepared by precipitation method

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journal of Rare Earths 2013年第1期31卷 37-43页

作者： Partha P.pal j.Manam Department of Applied Physics Indian School of Mines

Abstract： Trivalent europium doped zinc oxide （ZnO：Eu3＋） nanocrystals were synthesized via room temperature chemical co-pre- cipitation and they were systematically characterized by means of X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR） and photoluminescence （PL） spectroscopy. The as-synthesized samples were found to have hexagonal wurtzite coexisted with the intermediate Zn5（OH）sC12·H2O phase, while the single hexagonal phase was facilitated due to the calcinations. The as obtained samples were broadly composed ofnanoflakes while the highly crystalline nanorods were formed due to low temperature annealing of the as-synthesized samples. The crystallite size of the nanoflakes and nanorods （40-90 nm） were extracted from the XRD pattern which was found to be consistent with scanning electron microscopy （SEM） measurements. The photoluminescence （PL） spectra of nanophosphors showed bright red and orange emissions at 618 and 594 nm respectively with efficient broad blue green emis- sion spectrum due to ZnO lattice. Further, a good energy transfer process from ZnO host to Eu3＋ was observed in PL emission and excitation spectra of Eu3＋ doped ZnO ions. In all, the present nanophosphors were found to have great potentiality for bio-appli- cations.

关键词： photoluminescence zinc oxide rare earth europium nanorods nanoflakes

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Creeping Tiger,Soaring Dragon:India,China and Competition in Information Technologies

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China & World Economy 2012年第6期20卷 1-28页

作者： anindya Chaudhuri National Institute of Science Technology & Development Studies

Although conventional international economic wisdom holds China ＇s hardware and India ＇s software industries to be equipotential, little attempt has been made to compare their information industries in an overarehing dynamic framework. Using a schema that links intellectual to financial value creation, it is found that China has systematically moved ahead in creating a self-supporting industrial and innovation ecosystem. Hardware enjoys higher barriers to entry, which the Chinese companies are increasingly reinforcing with intellectual property investments. In addition to being better integrated with the global economy, they are also buttressed by the huge domestic market. The overdependence of Indian firms on selling low-value services to a few countries and insulation from domestic demand make them vulnerable to emerging competition and international economic ill-winds. The two countries provide a study in contrast on the effects of divergent industrial strategies.

关键词： China India information technology innovation

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Land use effects on climate in China as simulated by a regional climate model

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Science China Earth Sciences 2007年第4期50卷 620-628页

作者： j.S.pal F.GIORGI The Abdus Salam International Center for Theoretical Physics Trieste 34100 Italy

A regional climate model (RegCM3) nested within ERA40 re-analyzed data is used to investigate the climate effects of land use change over China. Two 15-year simulations (1987―2001), one with current land use and the other with potential vegetation cover without human intervention, are conducted for a domain encompassing China. The climate impacts of land use change are assessed from the difference between the two simulations. Results show that the current land use (modified by anthropogenic ac- tivities) influences local climate as simulated by the model through the reinforcement of the monsoon circulation in both the winter and summer seasons and through changes of the surface energy budget. In winter, land use change leads to reduced precipitation and decreased surface air temperature south of the Yangtze River, and increased precipitation north of the Yangtze River. Land use change signifi- cantly affects summer climate in southern China, yielding increased precipitation over the region, de- creased temperature along the Yangtze River and increased temperature in the South China area (south-end of China). In summer, a reduction of precipitation over northern China and a temperature rise over Northwest China are also simulated. Both daily maximum and minimum temperatures are affected in the simulations. In general, the current land use in China leads to enhanced mean annual precipitation and decreased annual temperature over south China along with decreased precipitation over North China.

关键词： land use China simulation regional climate model regional climate change

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Nanostructured porous polyaniline(PANI)coated carbon cloth(CC)as electrodes for flexible supercapacitor device

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journal of Materials Science & Technology 2021年第29期88卷 168-182页

作者： Dinesh j.Ahirrao Ajay Kumar pal Vikalp Singh Neetu jha Department of Physics Institute of Chemical TechnologyMatunga(E)Mumbai400019India Department of Physics Ramniranjan Jhunjhunwala CollegeGhatkopar(W)Mumbai 400086India

Nanostructured porous polyaniline(PANI)has been synthesized and coated simultaneously on a highly flexible and conductive carbon cloth(CC)substrate using a simple in-situ chemical oxidative polymerization *** coated CC(PANI-CC)based flexible electrodes were further used for the fabrication of flexible supercapacitor *** the comparison purpose,pure PANI has also been synthesized and tested for its electrochemical *** energy storage capacity of PANI and PANI–CC composite was investigated using electrochemical techniques like CV,GCD,and EIS in a potential range from 0 to 0.8 V in 1 M H_(2)SO_(4)***-CC flexible electrodes exhibited the highest specific capacitance of 691 F/g;whereas,pure PANI could only achieve 575 F/g of specific capacitance at 1 A/*** also exhibited outstanding cyclic stability by recollecting 94%of its initial capacitance after 2000 GCD *** actual implementation,a flexible supercapacitor device has been fabricated using stainless steel sheets and PANI-CC flexile *** energy storage performance of the PANI-CC flexible supercapacitor device was tested at several bending angles,which resulted in 72%of capacitance retention at a maximum bending angle of 140°compared to the capacitance obtained at an angle 0°(flat state).PANI-CC exhibited improved electrochemical performance than pure PANI due to the synergistic effect between PANI and ***,CC helped in enhancing the conductivity and stability;whereas,PANI boosted the capacitance owing to its excellent porosity and fast pseudocapacitive charge storage response.

关键词： Polyaniline Carbon cloth Flexible supercapacitor Flexible electrode Composite

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A simplified approach to assess seismic stability of tailings dams

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journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1082-1090页

作者： Sanjay Nimbalkar V.S.Ramakrishna Annapareddy anindya Pain School of Civil and Environmental Engineering Faculty of Engineering and Information Technology University of Technology Sydney Geotechnical Engineering Group CSIR-Central Building Research Institute (CBRI)

In the zones of high seismic activity, tailings dam should be assessed for the stability against earthquake forces. In the present paper, a simplified method is proposed to compute the factor of safety of tailings dams. The strain-dependent dynamic properties are used to assess the stability of tailings dams under seismic conditions. The effect of foundation soil properties on the seismic stability of tailings dams is studied using the proposed method. For the given input parameters, the factor of safety for lowfrequency input motions is nearly 26% lower than that for high-frequency input excitations. The impedance ratio and the depth of foundation have significant effect on the seismic factor of safety of tailings dams. The results from the proposed method are well compared with the existing pseudo-static method of analysis. Tailings dams are vulnerable to damage for low-frequency input motions.

关键词： Tailings dam Horizontal slice method(HSM) Limit equilibrium Strain-dependent property Pseudo-static method

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Settling and spreading behaviour of particle clusters in quiescent liquids in confined vessels

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Particuology 2023年第12期83卷 91-100页

作者： Sayan pal Amol A.Kulkarni Chemical Engineering&Process Development Division CSIR-National Chemical LaboratoryPune411008India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India University College London Torrington PlaceLondonWC1E 7JEUK

Here we report experiments on particle cluster settling at high Reynolds number in quiescent liquid contained in a *** particles were observed to spread at the vessel bottom surface in a near-circular annular shape after settling irrespective of the shape of the vessel cross-section and particle shape,size,and *** of different parameters such as mass,type and aspect ratio of the particles,height,and viscosity of liquid was investigated on spreading *** of the hemispherical bottom cap of the cluster that bounces upon hitting the vessel bottom surface was found to be responsible for the final circular annular shape of the settled *** leakage from the cluster was seen in the form of a *** the liquid having viscosity beyond 100 cP,cluster breakage was observed that resulted in hindered settling and asymmetric shapes of finally settled *** observations are useful to understand the overall area over which settling and spreading of such clusters can be observed.

关键词： Particle cluster Temporal evolution Settling Spreading

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Spherical-earth finite element model of coseismic slip distribution during the 2010 Mentawai earthquake

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Geodesy and Geodynamics 2021年第2期12卷 155-164页

作者： anindya Sricandra Prasidya Hidayat Panuntun Muhammad Iqbal Taftazani Geomatics Laboratory Department of GeotechnologyVocational CollegeUniversitas Gadjah MadaIndonesia

The moment magnitude(MW)7.8 earthquake occurred along the Mentawai seismic region of Sunda Trench on 25 October 2010,which is classified as the tsunami *** GPS inversion results under the assumption of simple horizontal layered medium show that the slip near the trench is not apparent,which is inconsistent with our understanding of tsunami ***,we construct a spherical-earth finite element model(FEM)to investigate the coseismic slip distribution of the 2010 Mentawai earthquake by geometrically combining the subducting plate with a precise subduction *** FEM-based coseismic slip distribution shows that there are three major slip patches on the fault interface,one is located on the shallow region and the other two are located on the deeper part of the fault *** largest slip patch is located near the trench with the depth less than 10 km,and the maximum amplitude is about 12 *** significant near-trench slip is consistent with the tsunami earthquake studies.A more realistic domain of FEM is used to change the coseismic slip distribution,thus significantly improving the fitting degree of the data *** findings suggest that the FEM-derived Green's function is essential to image a more robust and realistic coseismic slip distribution of the large earthquake in the subduction zone.

关键词： The 2010 Mentawai earthquake Tsunami earthquake Finite element model

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Influence of A-site cation disorder on structural and magnetocaloric properties of Nd_(0.7–x)La_xSr_(0.3)MnO_3(x=0.0, 0.1, 0.2 & 0.3)

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journal of Rare Earths 2015年第10期33卷 1072-1080页

作者： Sudharshan Vadnala Prem pal Saket Asthana Department of Physics Indian Institute of Technology Hyderabad

In the present research, the influence of A-site ionic size disorder on structural, magnetic and magnetocaloric properties of Ndo.7_xtaxSr0.3MnO3 （for x=0.0, 0.1, 0.2 ＆ 0.3） compounds were investigated. These compounds were synthesized by solid state reaction route and crystallized in orthorhombic structure with Pnma space group. An average ionic radius 〈rA〉 increased with La-substitution which influenced the physical properties such as the magnetic entropy varying from 4.78 j/kg.K （for x-=0.0） to 3.55 j/kg.K （for x=0.3） and the maximum magnetization at 5 K changing from 3.92 μB （for x=0.0） to 3.59 μB （for x=0.3）. The change in maximum magnetic entropy decreased with increase of A-site average ionic radius. The decrease in magnetic entropy indicated the suppression of lattice disorder that influenced the spin-lattice coupling. The ferromagnetic transition temperature shifted toward room temperature with La substitution. As 〈rA〉 increased, the phase transition changed from first order （for x-=0.0） to second order （for x≥ 0.1） and the refrigeration capacity increased to a significant level. The modest change in magnetic entropy over a wide range of transition temperature might be useful for future active magnetic refrigeration technology.

关键词： manganites magnetocaloric effect relative cooling Curie temperature rare earths

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Fabrication of core-shell PLGA/PLA-pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs

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Particuology 2018年第5期16卷 169-176页

作者： Tanushree Basu Bonamali pal Satnam Singh School of Chemistry and Biochemistry Thapar lnstitute of Engineering and TechnologyPatiala 147004Punjablndia

Polylactic acid (PLA)and poly(lactic-co-glycolic)acid (PLGA)are two commonly applied biodegrad- able polymers for the preparation of nanocomposites used in drug-delivery ***,these polymers lack desirable attributes such as resistance to aggregation during long-term storage due to *** improve their efficacy,in this work,PLA and PLGA were encapsulated within a shell of poly(N-isopropylacrylamide)(pNIPAM)using a single emulsion technique followed by an aqueous free radical precipitation polymerisation process,yielding core-shell PLA/PLGA-pNIPAM nanocomposites. The nanocomposites were cbaracterised using zeta potential,dynamic light scattering,and transmission electron microscopy analyses and were further applied as a delivery system for ramipril,an antihypertensive *** drug-loaded PLGA-pNIPAM core-shell nanoparticles exhibited a higher drug content (91%)and entrapment efficiency (78%)than their PLA *** in vitro release study of the formulations at pH 7.3in phosphate-buffered saline indicated that PLGA was more efficient than PLA with a sustained release of 86% of ramipril from the polymer matrix within ***,to determine the release kinetics,the data were fitted to Korsmeyer-Peppas and Higuchi models;the release of ramipril from the polymer matrix followed zero-order rate kinetics and an anomalous (non-Fickian)diffusion mechanism.

关键词： Poly(lactic-co-glycolic)acid Polylactic acid Poly(N-isopropylacrylamide) Antihypertensive drug Entrapment efficiency Drug release

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