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Can Emax and platelet count truly differentiate between benign and malignant liver lesions?

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World Journal of Gastroenterology 2025年第3期31卷 120-122页

作者： Manjeet kumar Goyal Omesh Goyal Department of Gastroenterology and Human Nutrition Unit All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet *** notable findings,significant methodological and interpretative limitations are *** study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold *** nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with ***,the study's limitations,such as selection bias and confounding factors,are not adequately *** research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.

关键词： Emax Platelet count Benign liver lesions Malignant liver lesions Hepatocellular carcinoma Cirrhosis Diagnostic biomarkers Shear wave elastography Methodological limitations Clinical utility

Study of intermolecular interactions in binary mixtures of methyl acrylate with benzene and methyl substituted benzenes at different temperatures:An experimental and theoretical approach

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Chinese Journal of Chemical Engineering 2022年第4期35卷 212-238页

作者： anil kumar Nain Department of Chemistry Dyal Singh College(University of Delhi)New Delhi 110003India

The ultrasonic speeds,u and viscosities,ηof the binary mixtures of methyl acrylate with benzene,toluene,o-xylene,m-xylene,p-xylene,and mesitylene over the whole mole fraction range were measured at six different temperatures and at atmospheric *** the experimental data,the excess isentropic compressibility,κ_(s)^(E),excess ultrasonic speed,u^(E),excess molar isentropic compressibility,K_(s,m)^(E),excess specific impedance,Z^(E)and deviations in viscosity,Δηhave been *** partial molar isentropic compressions,K_(s,m,1) and K_(s,m,2),and excess partial molar isentropic compressions,K_(s,m,1)^(-E) and K_(s,m,2)^(-E) over the whole composition range,partial molar isentropic compressions,K_(s,m,1)^(-)and K_(s,m,2)^(-),and excesspartial molar isentropic compressions,K_(s,m,1)^(-E) and K_(s,m,2)^(-E)of the components at infinite dilution have also been *** results specified the existence of weak interactions between unlike molecules,and these interactions follow the order:benzene>toluene>p-xylene>m-xylene>o-xylene>mesityle *** magnitude of interactions was found to be dependent on the number and position of the methyl groups in these aromatic hydrocarbons.

关键词： Ultrasonic speed Viscosity Methyl acrylate Aromatic hydrocarbon Excess properties Intermolecular interactions

Congruent Feature Selection Method to Improve the Efficacy of Machine Learning-Based Classification in Medical Image Processing

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 357-384页

作者： Mohd Anjum Naoufel Kraiem Hong Min Ashit kumar Dutta Yousef Ibrahim Daradkeh Department of Computer Engineering Aligarh Muslim UniversityAligarh202002India College of Computer Science King Khalid UniversityAbha61413Saudi Arabia School of Computing Gachon UniversitySeongnam13120Republic of Korea Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Saudi Arabia Department of Computer Engineering and Information College of Engineering in Wadi AlddawasirPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia

Machine learning(ML)is increasingly applied for medical image processing with appropriate learning *** applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify specific flaws/diseases for *** primary concern of ML applications is the precise selection of flexible image features for pattern detection and region *** of the extracted image features are irrelevant and lead to an increase in computation ***,this article uses an analytical learning paradigm to design a Congruent Feature Selection Method to select the most relevant image *** process trains the learning paradigm using similarity and correlation-based features over different textural intensities and pixel *** similarity between the pixels over the various distribution patterns with high indexes is recommended for disease ***,the correlation based on intensity and distribution is analyzed to improve the feature selection ***,the more congruent pixels are sorted in the descending order of the selection,which identifies better regions than the ***,the learning paradigm is trained using intensity and region-based similarity to maximize the chances of ***,the probability of feature selection,regardless of the textures and medical image patterns,is *** process enhances the performance of ML applications for different medical image *** proposed method improves the accuracy,precision,and training rate by 13.19%,10.69%,and 11.06%,respectively,compared to other models for the selected *** mean error and selection time is also reduced by 12.56%and 13.56%,respectively,compared to the same models and dataset.

关键词： Computer vision feature selection machine learning region detection texture analysis image classification medical images

Antibiotic resistome of Salmonella typhi:molecular determinants for the emergence of drug resistance

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Frontiers of Medicine 2021年第5期15卷 693-703页

作者： Awanish kumar anil kumar Department of Biotechnology National Institute of TechnologyRaipur-492010(Chhattisgarh)India

Resistome is a cluster of microbial genes encoding proteins with necessary functions to resist the action of *** governs essential and separate biological functions to develop resistance against *** widespread clinical and nonclinical uses of antibiotics over the years have combined to select antibiotic-resistant determinants and develop resistome in *** present,the emergence of drug resistance because of resistome is a significant problem faced by clinicians for the treatment of Salmonella *** resistome is a dynamic and ever-expanding component in *** foundation of resistome in Salmonella is laid long before;therefore,the antibiotic resistome of Salmonella is reviewed,discussed,and *** have searched the literature using PubMed,MEDLINE,and Google Scholar with related key terms(resistome,Salmonella,antibiotics,drug resistance)and prepared this *** this review,we summarize the status of resistance against antibiotics in ***,highlight the seminal work in the resistome of *** and the genes involved in the antibiotic resistance,and discuss the various methods to identify *** resistome for the proactive identification of this infection and quick diagnosis of the disease.

关键词： S.typhi antibiotic resistance mechanism resistome identification methods

Cosmological Constant Dominated Transit Universe from the Early Deceleration Phase to the Current Acceleration Phase in Bianchi-V Spacetime

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Chinese Physics Letters 2012年第7期29卷 298-302页

作者： YADAV anil kumar Department of Physics Anand Engineering CollegeKeethamAgra-282007India

We present the transition of the universe from the early decelerating phase to the current accelerating phase with viscous fluid and time-dependent cosmological constant (A) as a source of matter in Bianchi- V *** study the transit behaviour of the universe,we assume the scale factor as an increasing function of time,which generates a time-dependent deceleration parameter (DP).The study revesls that the cosmological term does not change its fundamental nature for ε =const and ε =ε(t),where ε is the coefficient of bulk *** A(t)is found to be positive and is a decreasing function of *** same behavior was observed during recent supernovae *** physical behaviour of the universe is discussed in detail.

关键词： universe behaviour Phase

Anisotropic massive strings in the scalar-tensor theory of gravitation

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Research in Astronomy and Astrophysics 2013年第7期13卷 772-782页

作者： anil kumar Yadav Department of Physics Anand Engineering College

We present the model of an anisotropic universe with string fluid as the source of matter within the framework of the scalar-tensor theory of gravitation. An exact solution of field equations is obtained by applying Berman＇s law of variation to Hubble＇s parameter which yields a constant value of the deceleration parameter. The nature of classical potential is examined for the model under consideration. It has also been found that the massive strings dominate in the early universe and finally disap-pear from the universe. This is in agreement with current astronomical observations. The physical and dynamical properties of the model are also discussed.

关键词： early universe -- massive strings -- scalar-tensor theory -- classicalpotential

Bianchi-V string cosmological model and late time acceleration

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Research in Astronomy and Astrophysics 2012年第11期12卷 1467-1474页

作者： anil kumar Yadav Department of Physics Anand Engineering College

We have searched for the existence of the late time acceleration of the universe with string fluid as the source of matter in Bianchi-V space-time. To derive a deterministic solution, we choose the scale factor to be an increasing function of time that yields a time dependent deceleration parameter, representing a model which generates a universe showing a transition from an early decelerating phase to a recent accelerating phase. The study reveals that strings dominate the early universe and eventually disappear from the universe for sufficiently large times, i.e. in the present epoch. This picture is consistent with current astronomical observations. The physical behavior of the universe is discussed in detail.

关键词： early universe -- cosmological parameters

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

Insight into solute-solute and solute-solvent interactions of semicarbazide hydrochloride in water and D-glucose/D-sucrose+water solutions at temperatures(293.15 to 318.15)K

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3086-3095页

作者： Ankita Dinesh Chand anil kumar Nain Department of Chemistry Dyal Singh CollegeUniversity of DelhiNew Delhi 110003India Department of Chemistry University of DelhiDelhi 110007India Department of Chemistry Amity University Dubai CampusDubai International Academic CityDubaiUAE

The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates(Dglucose/D-sucrose)are investigated by using volumetric,viscometric and acoustic *** measurements of the densitiesρ,ultrasonic speeds u,and viscositiesη.of semicarbazide hydrochloride in 5% and 10%D-glucose/D-sucrose+water(w/w)solutions were carried out at temperatures(293.15-318.15)K and at pressure,p=101 *** apparent molar volumes,Vϕ,limiting apparent molar volumes,V°ϕ,apparent molar compressibilities,Ks,ϕ,limiting apparent molar compressibilities,K°s;ϕ,partial molar expansibilities,E°ϕ,transfer volumes,V°ϕ;tr and transfer compressibilities,K°s;ϕ;tr have been calculated from the experimental *** viscosity data were examined by using the Jones-Dole equation and the viscosity A and B coefficients were *** results are discussed in terms of solute-solute and solute-solvent interactions in these *** structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of Bcoefficient,dB/dT.

关键词： Density Ultrasonic speed Viscosity Semicarbazide hydrochloride Carbohydrates Solute-solvent interactions