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Journal of Mountain Science 2008年第1期5卷 84-90页

作者： anil kumar bisht Arvind Bhatt R.S.Rawal Uppeandra Dhar G.B.Pant Institute of Himalayan Environment and Development Kosi-Katarmal Almora-263 643 (Uttarakhand)India

Angelica glauca is one of the important medicinal plants and it is widely used by indigenous communities for different purposes. The present study analyzes variability in reproductive characters of A. glauca. The reproductive parts were found having significant positive correlation with altitude (e.g.,number of umbellets /umber r= 0.857,p<0.05; umbel diameter r=0.735,p<0.05).

关键词： Angelica glauca critically endangered Himalaya medicinal plant population reproductive potential

A Novel Deep Learning Based Healthcare Model for COVID-19 Pandemic Stress Analysis

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Computers, Materials & Continua 2022年第9期72卷 6029-6044页

作者： Ankur Dumka Parag Verma Rajesh Singh anil kumar bisht Divya Anand Hani Moaiteq Aljahdali Irene Delgado Noya Silvia Aparicio Obregon Computer Science and Engineering Women Institute of TechnologyUttarakhand-248007India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Research and Innovation Uttranchal UniversityDehradunUttrakhand248007India Department of Computer Science&IT MJP Rohilkhand UniversityBareilly236006UPIndia Computer Science and Engineering Lovely Professional UniversityPunjab144411India Higher Polytechnic School Universidad Europea del Atlántico39011SantanderSpain Faculty of Computing and Information Technology King Abdulaziz University37848JeddahSaudi Arabia Universidad Internacional Iberoamericana CampecheMexico Universidade Internacional do Cuanza Bairro Kaluanda EN 250CuitoBié.Angola

Coronavirus(COVID-19)has impacted nearly every person across the globe either in terms of losses of life or as of *** current coronavirus(COVID-19)pandemic is a rare/special situation where people can express their feelings on Internet-based social *** media is emerging as the biggest platform in recent years where people spend most of their time expressing themselves and their *** research is based on gathering data from Twitter and analyzing the behavior of the people during the COVID-19 *** research is based on the logic expressed by people in this perspective and emotions for the suffering of COVID-19 and *** this research,we have used a Long Short-Term Memory(LSTM)network model with Convolutional Neural Network using Keras python deep-learning library to determine whether social media platform users are depressed in terms of positive,negative,or neutral emotional out bust based on their Twitter *** results showed that the model has 88.14%accuracy(representation of the correct prediction over the test dataset)after 10 epochs which most tweets showed had neutral *** evaluation shows interesting results in positive(1),negative(–1),and neutral(0)emotions through different visualization.

关键词： COVID-19 lockdown stress analysis depression analysis sentiment analysis social media COVID-19 twitter dataset coronavirus

Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might Be Due to the Inhibition of Carbonic Anhydrase Enzyme:An in vivo and in silico Investigation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 62-68页

作者： Shikha Sharma Gaurav kumar Nitin kumar Neeraj K.Sethiya Dheeraj bisht Department of Pharmaceutical Sciences Lords UniversityAlwarRajasthan 301028India Navsahyadri Institute of Pharmacy NasrapurPuneMaharashtra 412213India Faculty of Pharmacy DIT UniversityMussoorie Diversion RoadDehradunUttarakhand 248009India Devsthali Vidyapeeth College of Pharmacy(Veer Madho Singh Bhandari Uttarakhand Technical University Dehradun)LalpurRudrapurUttarakhand 263148India

Background:Ayurvedic system of medicine is well established for prevention and treatment of renal *** are vast number of medicinal plants mentioned in Ayurvedic system of medicine,including Piper attenuatum Buch.-*** Miq.,which has been known to exhibit diuretic ***:To investigate possible mechanism and diuretic activity of ethanol extract of *** ***:Present study reports an in vivo diuretic activity of ethanol extracts of *** ***-four Sprague-Dawley male rats were deprived from food and water for 20 h,followed by being divided into four groups to receive normal saline,Furosemide,and two doses of the ethanol extract,***,the ethanol extract were subjected for prelimnary phytochemical screening test,and analytical investigation was performed via high-performance thin-layer chromatography(HPTLC),followed by effectiveness exploration of putative bioactive compounds from *** against human carbonic anhydrase(hCA)enzyme using molecular docking ***:During phytochemicals screening,several groups of compounds such as amides,terpenoids,proteins,flavonoids,and glycosides have been ***,HPTLC reveals presence of carbohydrates,proteins,amino acids,steroids,alkaloids,flavonoids,tannins,glycosides,and *** diuretic action was revealed for both 200 mg/kg bw and 400 mg/kg bw of ethanol extract of *** ***,molecular docking analysis demonstrated greater binding affinity of compounds such as Cepharadione A,Nor-cepharadione B,Galbelgin,Crotepoxide,and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms(a key biomarker for diuretic)and score is comparable with standard drug ***:It was concluded from the present studies that ethanol extract of *** leaves exhibits signifi-cant diuretic *** activity may be correlated due to the presence of Cepharadione A,Norcepharadion

关键词： Piper attenuatum Diuretic activity Phytochemicals In silico and molecular docking

Adaptive particle swarm optimized fuzzy algorithm to predict water table elevation

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第6期10卷 48-56页

作者： Dinesh C.S.bisht Shilpa Jain Pankaj kumar Srivastava Department of Mathematics Jaypee Institute of Information Technology Noida 201304 India School of Engineering and Technology The NorthCap University Gurugram 122017 India

This study helps to select the length for fuzzy sets in fuzzy time series *** order to examine the effect of intervals and evaluate the efficiency of the proposed algorithm,numerical data of water recharge and discharge are considered to predict water table elevation fluctuation(WTEF).Particle swarm optimization(PSO)is an influential tool to handle optimization of multi-model problems,whereas fuzzy logic can handle *** this paper,adaptive inertia weights are adopted rather than static inertia weights for PSO,which further improves efficiency of *** modified PSO is termed as adaptive particle swarm optimization(APSO).APSO optimizes the intervals and these intervals are further used to generate fuzzy sets for *** results indicate that the APSO performs better than PSO and genetic algorithm approaches for the same problem.

关键词： Swarm intelligence optimization fuzzy logic water table adaptive particle swarm optimization fuzzy inference system

Nanomaterial Based Biosensors for Detection of Viruses Including SARS-CoV-2:A Review

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Journal of Analysis and Testing 2021年第4期5卷 327-340页

作者： Ayushi bisht Abhishek Mishra Harender bisht R.M.Tripathi Amity Institute of Biotechnology Amity UniversityNoida 201303India Amity Institute of Nanotechnology Amity UniversityNoida 201303India Reliance Industries Limited MotikhavdiJamnagar 361140India

The COVID-19 outbreak led to an uncontrollable situation and was later declared a global ***-PCR is one of the reliable methods for the detection of COVID-19,but it requires transporting samples to sophisticated laboratories and takes a significant amount of time to amplify the viral ***,there is an urgent need for a large-scale,rapid,specific,and portable detection *** nanomaterials-based detection technology has been developed and it showed advancement over the conventional methods in selectivity and *** review aims at summarising some of the most promising nanomaterial-based sensing technologies for detecting *** possess unique physical,chemical,electrical and optical properties,which can be exploited for the application in ***,nanomaterials work on the same scale as biological processes and can be easily functionalized with substrates of *** devices do not require extraordinary sophistication and are suitable for use by common individuals without high-tech *** and colorimetric methods similar to glucometer and pregnancy test kits are discussed and reviewed as potential diagnostic devices for *** devices working on the principle of immune response and microarrays are also discussed as possible *** such as metal nanoparticles,graphene,quantum dots,and CNTs enhance the limit of detection and accuracy of the biosensors to give spontaneous *** challenges of industrial-scale production of these devices are also *** mass production is successfully developed,these sensors can ramp up the testing to provide the accurate number of people aff ected by the virus,which is extremely critical in today’s scenario.

关键词： SARS-CoV-2 Electrochemical sensors Nanomaterials Colorimetric detection Microarray-based sensors Impedimetric biosensors

Role of beneficial microbial gene pool in mitigating salt/nutrient stress of plants in saline soils through underground phytostimulating signalling molecules

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Pedosphere 2023年第1期33卷 153-171页

作者： Shalini TIWARI Barkha SHARMA Neha bisht Lakshmi TEWARI Department of Microbiology College of Basic Science&HumanitiesG.B.Pant University of Agriculture&TechnologyPantnagarUttarakhand 263145India

Soil salinity diminishes soil health and reduces crop yield,which is becoming a major global *** stress is one of the primary stresses,leading to several other secondary stresses that restrict plant growth and soil *** major secondary stresses induced in plants under saline-alkaline conditions include osmotic stress,nutrient limitation,and ionic stress,all of which negatively impact overall plant *** stressed conditions,certain beneficial soil microflora are known to have evolved phytostimulating mechanisms,such as the synthesis of osmoprotectants,siderophores,1-aminocyclopropane-1-carboxylic acid(ACC)deaminase activity,phosphate solubilization,and hormone production,which enhance plant growth and development while mitigating nutrient *** soil-borne bacterial species such as Bacillus,Pseudomonas,and Klebsiella and fungal strains such as Trichoderma,Aspergillus,Penicillium,Alternaria,and Fusarium also aid in reducing salinity ***-solubilizing microorganisms also assist in nutrient acquisition via both enzymatic and non-enzymatic *** the case of enzymatic processes,they produce different enzymes such as alkaline phosphatases and phytases,whereas non-enzymatic processes produce organic acids such as gluconic,citric,malic,and oxalic *** native halotolerant/halophilic soil microbial gene pool with multifunctional traits and stress-induced gene expression can be developed as suitable bio-inoculants to enhance stress tolerance and optimize plant growth in saline soils.

关键词： abiotic stress crop improvement gene expression halotolerant microbial diversity phosphate solubilization plant growth promoting traits soil health

Strongα-cut and associated membership-based modeling for fuzzy time series forecasting

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第1期12卷 53-72页

作者： Gunjan Goyal Dinesh C.S.bisht Department of Mathematics Jaypee Institute of Information Technology NoidaIndia

In this paper,a method is proposed to deal with factors affecting the fuzzy time series forecasting.A new fuzzification process is used by considering all the fuzzy sets with nonzero membership values corresponding to the data points.A strong alpha-cut based method is presented to select appropriate fuzzy logical relationships that carry importance in analyzing the trend of time ***,a unique defuzzification approach based on weights is proposed to get crisp *** obtained variation is finally converted to the forecasted *** presented method is tested on the benchmark enrolment dataset of Alabama University and seven datasets of the Taiwan Capitalization Weighted Stock *** comparing the results,it is observed that the presented method performs better than the existing ***,the statistical measures indicate the good forecasting results of the presented method.

关键词： Associated membership grade forecasting fuzzy logical relationship fuzzy time series strongα-cut

A relativistic model of stellar objects with core-crust-envelope division

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Research in Astronomy and Astrophysics 2021年第7期21卷 71-83页

作者： Ravindra K.bisht Satyanarayana Gedela Neeraj Pant Neeraj Tewari Department of Mathematics National Defence AcademyKhadakwaslaPune-411023India Department of Mathematics SSJ CampusKumaun UniversityAlmora-263601India Department of Physics Lajpat Rai CollegeGhaziabad-201005India

In this work, we present a cogent and physically well-behaved solution for neutron stars envisaged with a core layer having quark matter satisfying the MIT-bag equation of state(Eo S), meso layer with Bose-Einstein condensate(BEC) matter satisfying modified BEC Eo S and an envelope having neutron fluid and Coulomb liquids satisfying quadratic Eo S. All the required physical and geometrical parameters like gravitational potentials, pressures, radial velocity, anisotropy, adiabatic index, mass function, compactification factor, and gravitational and surface redshift functions show a feasible trend and are continuous with smooth variation throughout the interior and across the regions of the ***, causality condition, energy conditions, static stability criterion(using Tolman-OppenheimerVolkoff equation) and Herrera cracking stability criterion are met throughout the star. The approach seems to be resulting in more realistic and accurate modeling of stellar objects, particularly realized by us for X-ray binary stars 4 U 1608–52(M = 1.7 M_⊙, R = 9.5 km) and SAX J1808.4–3658(M = 1.2 M_⊙,R = 7.2 km). Furthermore, we have ascertained that the continuity of the stability factor in all three regions of the stars demand a smaller core. As the core region of the star increases, the stability factor becomes discontinuous at all the interfaces inside the star.

关键词： stars:interiors stars:neutron Galaxy:stellar content

Development of a novel stability indicating RP-HPLC method for quantification of Connexin43 mimetic peptide and determination of its degradation kinetics in biological fluids

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Journal of Pharmaceutical Analysis 2017年第6期7卷 365-373页

作者： Rohit bisht Ilva D. Rupenthal Sreevalsan Sreebhavan Jagdish K. Jaiswal Buchanan Ocular Therapeutics Unit(BOTU) Department of OphthalmologyNew Zealand National Eye CentreFaculty of Medical and Health SciencesUniversity of AucklandAuckland 1142New Zealand Auckland Cancer Society Research Centre Faculty of Medical and Health SciencesUniversity of AucklandAuckland 1142New Zealand

Connexin43 mimetic peptide （Cx43MP） has been intensively investigated for its therapeutic effect in the management of inflammatory eye conditions, spinal cord injury, wound healing and iscbemia-induced brain damage. Here, we report on a validated stability-indicating reversed-phase high performance liquid chromatography （RP-HPLC） method for the quantification of Cx43MP under stress conditions. These included exposure to acid/base, light, oxidation and high temperature. In addition, the degradation kinetics of the peptide were evaluated in bovine vitreous and drug-free human plasma at 37℃. Detection of Cx43MP was carried out at 214 nm with a retention time of 7.5 min. The method showed excellent linearity over the concentration range of 0.9-250μg/mL （R2a0.998）, and the limits of detection （LOD） and quantification （LOQ） were found to be 0.90 and 2.98 μg/mL, respectively. The accuracy of the method determined by the mean percentage recovery at 7.8, 62.5 and 250μg/mL was 96.79%, 98.25% and 99.06% with a RSD of〈 2.2%. Accelerated stability studies revealed that Cx43MP was more sensitive to basic conditions and completely degraded within 24 h at 37℃（0% recovery） and within 12 h at 80℃ （0.34% recovery）. Cx43MP was found to be more stable in bovine vitreous （t1/2 slow= 171.8 min） compared to human plasma （t1/2slow = 39.3 min） at 37℃ according to the two phase degradation kinetic model. These findings are important for further pre-clinical development of Cx43MP.

关键词： RP-HPLC determination biological fluids

Cr （Ⅲ） Removal from Synthetic Waste Water by Using Water Pond Mud

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Journal of Life Sciences 2010年第3期4卷 33-35页

作者： Ashok kumar Balwant Singh bisht Amitabh Talwar Manish kumar Lalit kumar Dept. of Biotechnology Himachal Institute of Life Science Paonta Sahib Sirmour 173025 （HP） India Dept. of Zoology/Entomology HNBGU （A Central University） Campus Badshahithaul Tehri 249199 （UK） India Dept. of Pharmaceutics Himachal Institute of Pharmacy Paonta Sahib Ditt-Sirmour 173025 （HP） India

The pollution of aquatic ecosystem by heavy metals has assumed serious proportions due to their toxicity and accumulative behavior. The toxicity metal is dependent on its chemical form and therefore removal of metal is more meaningful than the estimation of its concentrations. In this study, the batch experiments were carried out under 30℃ to study the effect of pH, initial Cr concentration, adsorbent dose and contact time on the removal of Cr （lII）. The maximum adsorption efficiency （99%） was observed when 1.5 g of pond mud was used for removal ofCr （Ⅲ） from test solution containing 150 mg·Cr / 100 ml. The optimal pH and contact time recorded during the study were 6 and 10.0, respectively.

关键词： Aquatic ecosystem toxicity water pond mud contact time adsorption.