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Potential of a mixture of eugenol and garlic tincture to improve performance and intestinal health in broilers under necrotic enteritis challenge

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Animal Nutrition 2022年第1期8卷 26-37页

作者： Alip kumar Nishchal k.sharma Sarbast k.kheravii Chake keerqin Catherine Ionescu Alexandra Blanchard Shu-Biao Wu School of Environmental and Rural Science University of New EnglandArmidaleNSW2351Australia ADMi Pancosma SA A-One Business CenterLa piece 3CH-1180RolleSwitzerland

Plant extracts(PE)are gaining increased attention as potential alternatives to in-feed antimicrobials(AM)due to their known antimicrobial *** study was conducted to examine the potential of PE,a microencapsulated product composed of eugenol and garlic tincture as an alternative to AM-agent on performance and intestinal health in broilers under necrotic enteritis(NE)challenge.A total of 960 dayold mixed-sex Cobb 500 chicks were randomly distributed to 48-floor pens with 6 treatments replicated 8 times with 20 birds *** 6 treatments were as follows:UC,unchallenged control;CC,challenged control;PE,challenged group plus PE;AM,challenged group plus AM;FAP,challenged group plus a full dose of AM with PE;HAP,challenged group plus a half dose of AM with PE in starter,grower and finisher *** in the challenged groups were inoculated with Eimeria *** d 9 and Clostridium perfringens on d *** body weight gain(BWG),feed intake(FI),feed conversion ratio(FCR),and livability of birds were compromised,and intestinal lesions and mortality were increased(P<0.05)by NE challenge,illustrating a successful clinical NE *** fed AM had higher BWG and FI,and lower FCR,mortality,and intestinal lesions compared to the CC group(P<0.05).Birds fed PE had improved FCR(P<0.05)and livability(5.8%)in an overall period compared to the CC *** d 16,PE supplementation reduced ileal lesion scores in only male birds(P<0.05).Birds fed PE had decreased Eimeria maxima and Eimeria acervulina oocyst counts in caecal content(P<0.05).Birds fed PE had decreased Eimeria brunetti and total oocyst counts in caecal content,and *** oocyst counts in ileal content in only female birds(P<0.05).On d 35,PE supplementation reduced variation of BW in both male and female birds and increased yellowness(b*value,14.4%)in the *** findings suggest the potential of PE supplementation in diets to improve the performance and intestinal health of birds under clinical NE a

关键词： Plant extract Performance Alternative to antimicrobials Clinical necrotic enteritis Broiler chicken

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Graphene-based flexible and wearable electronics

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Journal of Semiconductors 2018年第1期39卷 86-104页

作者： Tanmoy Das Bhupendra k.sharma Ajit k.katiyar Jong-Hyun Ahn School of Electrical and Electronic Engineering Yonsei University

Graphene with an exceptional combination of electronic, optical and outstanding mechanical features has been proved to lead a completely different kind of 2-D electronics. The most exciting feature of graphene is its ultra-thin thickness, that can be conformally contacted to any kind of rough surface without losing much of its transparency and conductivity. Graphene has been explored demonstrating various prototype flexible electronic applications, however, its potentiality has been proven wherever transparent conductive electrodes（TCEs） are needed in a flexible, stretchable format. Graphene-based TCEs in flexible electronic applications showed greatly superior performance over their conventionally available competitor indium tin oxide（ITO）. Moreover, enormous applications have been emerging, especially in wearable devices that can be potentially used in our daily life as well as in biomedical areas. However, the production of high-quality, defect-free large area graphene is still a challenge and the main hurdle in the commercialization of flexible and wearable products. The objective of the present review paper is to summarize the progress made so far in graphene-based flexible and wearable applications. The current developments including challenges and future perspectives arc also highlighted.

关键词： graphene flexible electronics wearable electronics transparent conductive electrode

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Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

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Frontiers of Environmental Science & Engineering 2019年第3期13卷 3-11页

作者： Virender k.sharma Xin Yu Thomas J.McDonald Chetan Jinadatha Dionysios D.Dionysiou Mingbao Feng Department of Environmental and Occupational Health School of Public Health Texas A&M University College Station TX 77843 USA Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China Central Texas Veterans Health Care System Temple TX 76504 USA College of Medicine Texas A&M Health Science Center Bryan TX 77807 USA Environmental Engineering and Science Program Department of Chemical and Environmental Engineering (DChEE) 705 Engineering Research Center University of Cincinnati Cincinnati OH 45221 USA

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after treatment with conventional disinfectants. Ultraviolet (UV) technology has been seen growth in application to disinfect the water. However, UV method alone is not adequate to degrade ARGs in water. Researchers are investigating the combination of UV with other oxidants (chlorine, hydrogen peroxide (H2O2), peroxymonosulfate (PMS), and photocatalysts) to harness the high reactivity of produced reactive species (C1-, C1O -, Cl2-,-OH, and SO4-_) in such processes with constituents of cell (e.g., deoxyribonucleic acid (DNA) and its components) in order to increase the degradation efficiency of ARGs. This paper briefly reviews the current status of different UV-based treatments (UV/chlorination, UV/H2O2, UV/PMS, and UV-photocatalysis) to degrade ARGs and to control horizontal gene transfer (HGT) in water. The review also provides discussion on the mechanism of degradation of ARGs and application of q-PCR and gel electrophoresis to obtain insights of the fate of ARGs during UV-based treatment processes.

关键词： Antibiotic resistance bacteria Advanced oxidation processes Disinfection Reactive chlorine species Sulfate radicals Reactive oxygen species

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Case Control Study of Post-endoscopic Variceal Ligation Bleeding Ulcers in Severe Liver Disease: Outcomes and Management

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 32-39页

作者： kapil D.Jamwal Rakhi Maiwall Manoj k.sharma Guresh kumar Shiv k.Sarin Department of Gastroenterology Artemis Hospital GurugramHaryanaIndia Department of Hepatology Institute of Liver and Biliary SciencesNew DelhiIndia Department of Gastroenterology Dharamshila Narayana Superspeciality HospitalNew DelhiIndia Department of Research and Biostatistics Institute of Liver and Biliary SciencesNew DelhiIndia

Background and Aims:The management of post-endoscopic variceal ligation(EVL)bleeding ulcers(PEBUs)is currently based on local expertise and patients liver disease *** present retrospective study investigated associations between the endoscopic morphology of PEBUs and patient ***:Patients underwent EVL(primary or secondary),from January 2015 to January 2018,in two tertiary care hospitals in India(ILBS New Delhi and Dharamshila Narayana New Delhi).Mortality rates were determined at post-EVL day five and week *** were typified based on Jamwal&Sarin classification system as follows:A,ulcer with active spurting;B,ulcer with ooze;C,ulcer base with visible vessel or clot;and D,clean or pigmented ***:Of 3854 EVL procedures,141(3.6%)patients developed PEBU,and 46/141(32.6%)suffered *** the former,the PEBU types A,B,C,and D accounted for 17.7,26.2,36.3,and 19.8%,*** those who died,39.1,30.4,21.7,and 8.8%had PEBU types A,B,C,and *** included transjugular intrahepatic portosystemic shunts(TIPS),esophageal self-expandable metal stent(SEMS),glue and sclerosant injection,Sengstaken-Blakemore tube placement and liver *** univariate analysis,no correlation with hepatic venous pressure gradient,TIPS placement,size of varices,or number of bands was *** Model for EndStage Liver Disease(MELD)-sodium score correlated positively with *** adjusting for MELD-sodium score,mortality was best predicted by type-A ulcer(p=0.024;OR 8.95,CI 1.34-59.72).Conclusions:PEBU occurred in 3.6%of a large EVL *** patients based on PEBU type can help predict outcomes,independent of the MELD-sodium *** PEBUs by endoscopic morphology may inform treatment strategies,and warrants further validation.

关键词： Post-endoscopic variceal ligation bleeding ulcers Severe liver disease Case control study Clinical outcomes

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Chemically modified silica gel with 1-{4-[(2-hydroxy-benzylidene)amino]phenyl}ethanone:Synthesis, characterization and application as an efficient and reusable solid phase extractant for selective removal of Zn(Ⅱ) from mycorrhizal treated fly-ash samples

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Journal of Environmental Sciences 2013年第6期25卷 1252-1261页

作者： R.k.sharma Aditi Puri anil kumar Alok Adholeya 2 Green Chemistry Network Centre Department of ChemistryUniversity of Delhi Biotechnology and Management of Bioresources Division The Energy and Resource Institute

1-{4-[（2-hydroxy-benzylidene）amino]phenyl}ethanone functionalized silica gel was synthesized and used as a highly efficient, selective and reusable solid phase extractant for separation and preconcentration of trace amount of Zn（II） from environmental matrices. The adsorbent was characterized by fourier transform infrared spectroscopy （FT-IR）, elemental analysis,~3C CPMAS NMR spectroscopy, scanning electron microscopy （SEM）, thermogravimetric analysis （TGA） and BET surface area analysis. The dependence of zinc extraction on various analytical parameters such as pH, type and amount of eluent, sample flow rate and interfering ions were investigated in detail. The material exhibited superior adsorption efficiency for Zn（II） with high metal loading capacity of 1.0 mmol/g under optimum conditions. After adsorption, the recovery （〉 98%） of metal ions was accomplished using 1.0 mol/L HNO3 as an eluent. The sorbent was also regenerated by microwave treatment in milder acidic environment （0.1 mol/L HNO3）. The lower detection limit and preconcentration factor of the present method were found out to be 0.04 ~tg/L and 312.5 respectively. The modified silica surface possessed excellent selectivity for the target analytes and the adsorption/desorption process remained effective for at least ten consecutive cycles. The optimized procedure was successfully implemented for the extraction of Zn（II） from mycorrhizal treated fly ash and pharmaceutical samples with reproducible results.

关键词： solid phase extraction silica gel preconcentration fly-ash zinc

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Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

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Traditional Medicine Research 2025年第1期10卷 12-26页

作者： Sanyam sharma Subh Naman Ashish Baldi Faculty of Pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India Faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

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Net energy,energy utilization,and nitrogen and energy balance affected by dietary pea supplementation in broilers

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Animal Nutrition 2021年第2期7卷 506-511页

作者： Nishchal k.sharma Zhibin Ban Hank L.Classen Huaming Yang Xiaogang Yan Mingan Choct Shu-Biao Wu School of Environmental and Rural Science University of New EnglandArmidaleNSW 2351Australia Laboratory of Animal Nutrition Metabolism Jilin Academy of Agricultural SciencesGongzhulingJilin 136100China Department of Animal and Poultry Science University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8Canada Office of the Pro Vice-Chancellor External Relations University of New EnglandArmidaleNSW 2351Australia

Pea starch consists predominantly of C-type of amylopectin chain which is more resistant to digestive enzymes than A-type of starch thus slowly digested in *** was hypothesized that the presence of slowly digested pea starch in broiler diets will increase net energy and the efficiency of energy utilization in *** experiments were performed to investigate starch digestibility of pea at different in-cubation times(in vitro study)and the effect of dietary pea on heat increment and net energy in broilers using an open-circuit respiratory calorimetry system(in vivo study).One-day-old Ross 308 male broilers were fed a common starter crumble from d 1 to 10 and standard grower diets *** d 21,birds were transferred to the chambers each housing 2 *** treatment was replicated 6 times with 2 identical runs of 3 replicates per treatment.A wheat-soybean meal-based diet was used as a control and the treatment diet contained 500 g of pea/kg *** vitro study showed that pellet processing increased(Pke,lower(P=0.020)body weight gain,but a similar(P>0.05)FCR compared to those offered the wheat-based *** energy(NE)and apparent metabolizable energy(AME)values were higher in the pea-based diet than in the wheat-based diet(P-0.037 for NE and P-0.018 for AME).Heat production,respiratory quotient,heat increment of feed,efficiency of utilization of gross energy for AME,and efficiency of utilization of AME for NE did not differ(P>0.05)between the 2 *** was no effect(P>0.05)of pea on the total tract di-gestibilities of dry matter,crude protein and ash,but the total tract digestibility of starch was higher(P-0.022)in the pea-based diet compared to the wheat-based *** study provides insight into the energy metabolism of broilers offered a pea-based diet and indicates that dieta

关键词： Slowly digested starch Pea Heat increment Net energy Broiler

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A transitioning universe with time varying G and decaying Λ

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Research in Astronomy and Astrophysics 2013年第5期13卷 501-508页

作者： anil kumar Yadav Amit sharma Department of Physics Anand Engineering College Department of Mathematics Anand Engineering College

We present a model of a universe that transitions from an early deceleration phase to the current acceleration phase under the framework of general relativity, in the presence of gravitational coupling G（t） and cosmological terms A（t）. Einstein＇s field equations have been solved by considering the time dependent deceleration parameter （DP） which renders the scale factor e = （thekt）1/m where m, n and k are positive con- stants. The cosmological term （A （t）） is found to be positive and a decreasing function of time, which supports the result obtained from observations of type Ia supernovae. The geometrical and kinematical features of the model are examined in detail.

关键词： early universe -- large scale structure of universe

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Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

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World Journal of Virology 2025年第1期14卷 108-117页

作者： Sanjay k Thakur anil k Sinha Santosh k.sharma Aarzoo Jahan Dinesh k Negi Ruchika Gupta Sompal Singh Regional Blood Transfusion Centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion Centre and Pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BACkGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood ***,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/*** highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations take place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIV,HBV,and HCV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card *** prevalence of HBV,HCV,HIV,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite Syphilis

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Tribology of enzymatically degraded cartilage mimicking early osteoarthritis

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Friction 2023年第9期11卷 1724-1740页

作者： ke REN Miguel Alejandro REINA MAHECHA Maike HÜBNER Zhiwei CUI Hans J.kAPER Hugo C.VAN DER VEEN Prashant k.sharma Department of Biomedical Engineering University Medical Centre GroningenUniversity of GroningenGroningen 9713AVthe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyEindhoven 5600MBthe Netherlands Department of Orthopedic Surgery University Medical Centre GroningenUniversity of GroningenGroningen 9700RBthe Netherlands

Healthy cartilage is a water-filled super lubricious *** type II provides it structural stability,and proteoglycans absorb water to keep the cartilage in a swollen condition,providing it the ability to creep and provide weeping ***(OA)is a degenerative and debilitating disorder of diarthrodial joints,where articular cartilage damage originates from enzymatic degradation and mechanical damage(wear).The objective of this research is to observe the level of cartilage damage present in knee arthroplasty patients and to understand the friction and creep behavior of enzymatically degraded bovine cartilage in ***(Lat)and medial(Med)condylar cartilages from OA patients undergoing total knee arthroplasty showed signs of enzymatic degradation and mechanical *** cartilages were exposed to collagenase III and chondroitinase ABC to degrade collagen and proteoglycans,*** loss of proteoglycans or collagen network and morphological changes were observed through histology and the atomic force microscope(AFM),respectively.A significant effect on creep due to enzymatic treatment was not *** the enzymatic treatment was found to significantly decrease the coefficient of friction(COF)at 4 N,while higher COF was shown from chondroitinase ABC degraded cartilage at 40 *** III treatment leads to the release of intact proteoglycans at the sliding interface,while chondroitinase ABC treatment leads to the loss of chondroitin sulfate(CS)from the *** ABC-digested bovine cartilage mimicked patient samples the best because of the similar distributions of proteoglycans,collagen network,and friction behavior.

关键词： lubrication cartilage boundary lubrication osteoarthritis(OA)

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