检索结果-南通市图书馆

Perturbations in th. earth.orm metabolite profile during a two-week exposure to metformin

Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.D.Gillis G.W.price S.O.Prash.r Department of Bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada Department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among th. most prescribed ph.rmaceuticals in many countries,and as a result h.s sh.wn up in biosolids derived from municipal wastewater treatment th.t are destined for land *** h.mans taking metformin,th. effects include reduced glucose uptake in th. intestine,a reduction in gluconeogenesis,increased oxidation of fatty acids,and reduced fatty acid *** effects of metformin on soil-dwelling organisms are not well *** study tested th. effects of metformin exposure(0,10,40,160,640μg g^(-1))on th. earth.orm(***)at four time points(6 h.2 d,7 d,and 14 d)using GC-MS to reveal sub-leth.l effects and elucidate potential modes of action for *** were no mortalities observed,and earth.orms exposed to th. h.gh.st concentrations(160 and 640μg g^(-1))gained weigh. relative to th. control on days 7 and *** reductions on day 7 were observed for glucose and malic acid(consistent with.a reduction in gluconeogenesis),and for palmitic and margaric acid(consistent with.increased oxidation and reduced synth.sis of fatty acids).Lactic acid ranked first and second among canonicals 1 and 2 respectively and led to significant differences in discriminant scores across concentration and *** levels increased to equal or greater th.n th. control on day 14,likely caused by reduced exposure as metformin is reported to be readily transformed by microorganisms under aerobic *** observations were consistent with.th. known effects of metformin in h.mans,and suggests th.t a similar mode of action exists in earth.orms.

关键词： Metabolites Toxicity Earth.orms Metformin GC-MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acetabular cup size trends in total h.p arth.oplasty

引用

World Journal of Orth.pedics 2024年第1期15卷 39-44页

作者： Daniel Patrick McKenna Alex price Timoth. McAleese Darren Dah.y Paul McKenna May Cleary Department of Trauma and Orth.paedics University Hospital WaterfordWaterford X91 ER8EIreland Department of Epidemiology and Public h.alth University College CorkCork T12 XF62Ireland

BACKGROUND Total h.p arth.oplasty(Th.)is a common procedure for end stage *** learning curve for Th. is complex and *** of th. most difficult skills to master is acetabular *** wish.to identify if experience in arth.oplasty leads to preservation of more bone *** To investigate if increasing surgeon experience will predict an ever decreasing acetabular cup *** A retrospective case series of four attending orth.paedic surgeons was *** uncemented elective total h.p arth.oplasties since appointment were selected for *** size of acetabular cup used was noted and logistic regression was used to identify if a trend to smaller cups *** A total of 1614 subjects were included with.a mean age of 64 *** cups were on average 0.18mm smaller per year(95%confidence interval-0.25 to-0.11,Ph.wed cup sizes to decrease 0.27 mm/year for surgeon A,0.02 mm/year for surgeon B,0.15 mm/year for surgeon C and 0.29 mm/year for surgeon *** of th. four surgeons h.d a more pronounced trend to smaller cups for male subjects th.n th.ir female *** We found increasing surgeon experience to be associated with.an ever-decreasing acetabular cup *** acetabular cup size may act as a surrogate marker of surgical proficiency by virtue of decreased acetabular reaming.

关键词： h.p Arth.oplasty Acetabulum Cup Learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于焊缝增强接头技术的模型参数

引用

钢结构(中英文) 2008年第5期 69-69页

作者： Sooyong Park Sangh.un Ch.i Norris Stubbs Robert Bolton angie h. price Ch.rles Sikorsky

基于整体无损伤评估方法,采用模型参数,定量评估了建设过程中焊缝增强接头技术的可行性。根据钢的屈服强度和焊缝中有效刚度的变化,改进了预测焊缝强度的表达式。通过模型参数的变化和系统识别技术,在27个焊缝区域,进行了局部刚度变化... 详细信息

基于整体无损伤评估方法,采用模型参数,定量评估了建设过程中焊缝增强接头技术的可行性。根据钢的屈服强度和焊缝中有效刚度的变化,改进了预测焊缝强度的表达式。通过模型参数的变化和系统识别技术,在27个焊缝区域,进行了局部刚度变化的无损测量试验。为了比较,传统的无损监测(NDT)方法、射线探伤以及破坏张拉试验均被用以评估无损强度预测程序的精度,从强度破坏模型和无损测量刚度变化焊接系统中所得到的预测强度与从破坏张拉试验中得到的结果也进行了比较。同时对该方法的适用范围进行了研究。

关键词：无损评估焊接模型参数强度预测

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Transcriptional reprogramming during h.man osteoclast differentiation identifies regulators of osteoclast activity

引用

Bone Research 2024年第1期12卷 180-198页

作者： Morten S.h.nsen Kaja Madsen Maria price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research.IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orth.pedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsch.s Zentrum Immunth.rapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enh.nced osteoclastogenesis and osteoclast activity contribute to th. development of osteoporosis,wh.ch.is ch.racterized by increased bone resorption and inadequate bone *** novel antiosteoporotic th.rapeutics are needed,understanding th. genetic regulation of h.man osteoclastogenesis could h.lp identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during h.man osteoclast *** were differentiated from CD14+monocytes from eigh. female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eigh. temporal patterns conserved across *** patterns revealed distinct molecular functions associated with.postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insigh. into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at th. monocyte stage,such.as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),th.t are predictive of th. resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and th.se receptors are associated with.bone mineral density SNPs,suggesting th.t th.y play a pivotal role in osteoclast differentiation and *** regulatory effects of th.ee differentially expressed G-protein coupled receptors were exemplified by in vitro ph.rmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enh.nced osteoclast formation,wh.le activating SSTR2 decreased th. resorptive activity of mature osteoclasts,and activating FFAR4 decreased both.th. number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Compreh.nsive Review on Ch.rging Topologies and Power Electronic Converter Solutions for Electric Veh.cles

引用

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 675-694页

作者： Abdelfatah.Ali h.ssam h.h.Mousa Mostafa F.Sh.aban Mah.r A.Azzouz Ah.ed S.A.Awad th. Department of Electrical Engineering American University of Sharjah26666 SharjahUnited Arab Emirates th. Department of Electrical Engineering South Valley University83523 QenaEgypt th. Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4 Canada Electrical Engineering Department Qatar UniversityDoha 2713Qatar Department of Electrical and Computer Engineering Sultan Qaboos UniversityMuscat123Oman

Electric veh.cles(EVs)are becoming more popular worldwide due to environmental concerns,fuel security,and price *** performance of EVs relies on th. energy stored in th.ir batteries,wh.ch.can be ch.rged using eith.r AC(slow)or DC(fast)***,EVs can also be used as mobile power storage devices using veh.cle-to-grid(V2G)*** electronic converters(PECs)h.ve a constructive role in EV applications,both.in ch.rging EVs and in ***,th.s paper compreh.nsively investigates th. state of th. art of EV ch.rging topologies and PEC solutions for EV *** examines PECs from th. point of view of th.ir classifications,configurations,control approach.s,and future research.prospects and th.ir impacts on power *** can be classified into various topologies:DC-DC converters,AC-DC converters,DC-AC converters,and AC-AC *** address th. limitations of traditional DC-DC converters such.as switch.ng losses,size,and h.gh.electromagnetic interference(EMI),resonant converters and multiport converters are being used in h.gh.voltage EV ***,power-train converters h.ve been modified for h.gh.efficiency and reliability in EV *** paper offers an overview of ch.rging topologies,PECs,ch.llenges with.solutions,and future trends in th. field of th. EV ch.rging station applications.

关键词： Ch.rging station ch.rging topology electric veh.cle power electronic converter veh.cle-to-grid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乐趣是健康生活的秘诀（英文）

引用

英语画刊(高中版) 2024年第1期 3-5页

作者： Cath.rine price

你每天都有在享受快乐吗?科学记者凯瑟琳·普莱斯认为:享乐不仅是一种快乐的体验,而且对你的健康和幸福也至关重要。在下面的演讲中,她提出了一个新的关于享乐的定义,并分享了一些简单而又可靠的将乐趣融入日常生活的方法。So in realit...

你每天都有在享受快乐吗?科学记者凯瑟琳·普莱斯认为:享乐不仅是一种快乐的体验,而且对你的健康和幸福也至关重要。在下面的演讲中,她提出了一个新的关于享乐的定义,并分享了一些简单而又可靠的将乐趣融入日常生活的方法。So in reality,fun is not just ligh.h.arted pleasure.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

h.man activity affects th. perception of risk by mule deer

引用

Current Zoology 2014年第6期60卷 693-699页

作者： Mary V. price Evelyn h. STROMBOM Daniel T. BLUMSTEIN Th. Rocky Mountain Biological Laboratory Crested Butte CO 81224 USA Sch.ol of Natural Resources and th. Environment University of Arizona Tucson AZ 85721 USA Department of Ecology and Evolutionary Biology University of California Los Angeles Los Angeles CA 90095-1606 USA

h.man activity h.s been sh.wn to influence h.w animals assess th. risk of predation, but we know little about th. spatial scale of such.impacts. We quantified h.w vigilance and fligh. beh.vior in mule deer Odocoileus h.mionus varied with.distance from an area of concentrated h.man activity--a subalpine field station. An observer walked trails at various distances away from th. station looking for deer. Upon encounter, th. observer walked toward th. focal animal and noted th. distance at wh.ch.it alerted and directed its attention to th. approach.ng h.man （Alert Distance; AD）, and th. distance at wh.ch.it fled （Fligh. Initiation Distance;. FID）. AD and FID both.increased nonlinearly with.distance from th. center of th. field station, reach.ng pla- teaus around 250 m and 750 m, respectively. Deer also tended to flee by stotting or running, rath.r th.n by walking, wh.n far from th. station but th.y walked away wh.n near th. station. Th.se results indicate th.t deer perceive lower risk near a focused area of h.man activity, and th.t vigilance and fligh. beh.viors respond on somewh.t different spatial scales. Th. concept of a spatial ＂h.man footprint＂ on beh.vior may be useful for understanding h.w h.man activities affect wildlife

关键词： Fligh. initiation distance Alert distance Predation risk assessment h.man disturbance Mule deer Odocoileush.mionus Vigilance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

霉菌毒素如何威胁家禽健康和生产性能

引用

国外畜牧学（猪与禽） 2024年第1期44卷 41-43页

作者： Kayla price Alexandra Weaver 蔡霞(译) 范美红(校) 李红(审) 不详

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影... 详细信息

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影响家禽的健康和生产性能。霉菌毒素污染是可控的,但必须采取从田间到农场的综合方法。

关键词：霉菌霉菌毒素家禽生产性能控制

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Preh.spital transdermal glyceryl trinitrate for ultra- acute isch.emic stroke: data from th. RIGh.- 2 randomised sh.m- controlled ambulance trial

引用

Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Ph.lip Appleton Lisa J Woodh.use Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timoth. J England Kailash.Krish.an Grant Mair Keith.W Muir Joh. Potter Ch.istoph.r I price Marc Randall Th.mpson G Robinson Ch.istine Roffe Else C Sandset Jeffrey L Saver Angela Sh.ne Aloysius Nirosh.n Siriwardena Joanna M Wardlaw Nikola Sprigg Ph.lip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied h.alth.esearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia Th. George Institute Ch.na at Peking University h.alth.Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of h.alth.and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service Nh. Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psych.logy University of GlasgowGlasgowUK Bob Ch.mpion Research.and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIh. Leicester Biomedical Research.Centre University of LeicesterLeicesterUK Stroke Research.in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research.and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Compreh.nsive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research.and Graduate Services University of NottinghamNottinghamUK Community and h.alth.Research.Unit University of LincolnLincolnUK

Background Th. effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome wh.n administered before h.spital admission in suspected stroke patients is ***,we assess th. safety and efficacy of GTN in th. prespecified subgroup of patients wh. h.d an isch.emic stroke with.n th. Rapid Intervention with.Glyceryl trinitrate in h.pertensive stroke Trial-2(RIGh.-2).Meth.ds RIGh.-2 was an ambulance-based multicentre sh.m-controlled blinded-endpoint study with.patients randomised with.n 4h.urs of *** primary outcome was a sh.ft in scores on th. modified Rankin scale(mRS)at day *** outcomes included death.a global analysis(Wei-Lach.n test)containing Barth.l Index,EuroQol-5D,mRS,teleph.ne interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Wh.tney difference(MWD)with.95%*** 597 of 1149(52%)patients h.d a final diagnosis of isch.emic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence th. primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death.or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,th.re were non-significant interactions suggesting GTN may be associated with.more death.and dependency in participants randomised with.n 1h.ur of symptom onset and in th.se with.more severe *** In patients wh. h.d an isch.emic stroke,ultra-acute administration of transdermal GTN in th. ambulance did not improve clinical outcomes in a population with.more clinical and radiological frailty th.n seen in previous in-h.spital *** IS ALREADY KNOWN ON Th.S TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with.less death.and dependency in th.se w

关键词： Glasgow nitrate random

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Root Growth.of Deep and Sh.llow Rooting Rice Cultivars in Compacted Paddy Soils on Subsequent Rice Growth

引用

Rice science 2023年第5期30卷 459-472,I0022-I0024页

作者： Md.Dh.n ISLAM Adam h.price Paul D.h.LLETT Sch.ol of Biological Sciences University of AberdeenSt Machar DrAberdeen AB243UUthe United Kingdom Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur-1706Bangladesh

Rice is often grown as multiple seasons in one year,alternating between flooded and upland systems.A major constraint,introduced from th. flooded system,is a plough.pan th.t may decrease rooting depth.and productivity of follow-on upland *** penetrating th. plough.pan under flooded rice system can leave a legacy of weaker root growth.*** rooting rice cultivars could h.ve a bigger impact,but no direct evidence is *** explore wh.th.r a deep rath.r th.n a sh.llow rooting rice cultivar grown in a flooded cropping cycle benefited deeper root growth.of follow-on rice in an upland,reduced tillage cropping cycle,a simulated flooded paddy in greenh.use was planted with.deep(Black Gora) and sh.llow(IR64) rooting cultivars and a plant-free *** plough.pans were made in between th. topsoil and subsoil to form different treatments with.no plough.pan(0.35 MPa),soft plough.pan(1.03 MPa) and h.rd plough.pan(1.70 MPa).After h.rvest of th.s ‘first season’ rice,th. soil was drained and undisturbed to simulate zero-tillage upland and planted rice cultivar BRRI Dh.n *** overall root length.density(RLD),root surface area,th. numbers of root tips and branch.ng of BRRI Dh.n 28 did not vary between plough.pan and no plough.pan *** with.th. sh.llow rooting rice genotype,th. deep rooting rice genotype as ‘first season’ crop produced 19% greater RLD,34% greater surface area and 29% more branch.ng of BRRI Dh.n 28 in th. *** th. topsoil,h.wever,BRRI Dh.n 28 h.d 28% greater RLD,35% greater surface area and 43% more branch.ng for th. sh.llow rath.r th.n deep rooting genotype planted in th. ‘first season’.Th. results suggested th.t rice cultivar selection for a paddy cycle affects root growth.of a follow-on rice crop grown under no-till,with.benefits to subsoil access from deep rooting cultivars and topsoil proliferation for sh.llow rooting cultivars.

关键词： plough.pan root growth biopores crop rotation Oryza sativa preceding crop zero-tillage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：