检索结果-南通市图书馆

Antiviral therapy in hepatitis C virus cirrhotic patients in compensated and decompensated condition

World Journal of Gastroenterology 2008年第42期14卷 6467-6472页

作者： angelo Iacobellis Antonio Ippolito angelo Andriulli Division of Gastroenterology "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo 71013 Italy

The main goals of treating cirrhotic patients with antiviral therapy are to attain sustained viral clearance(SVR),halt disease progression,and prevent re-infection of the liver ***,while the medical need is great,the use of interferon and ribavirin might expose these patients to severe treated-related side effects as a large proportion of them have pre-existing hematological *** have reviewed potential benefits and risks associated with antiviral drugs in patients with liver cirrhosis,due to hepatitis C virus(HCV) *** cases presenting with bridging fibrosis or cirrhosis,current regimens of antiviral therapy have attained a 44%-48% rate of *** cirrhotic patients with portal hypertension,the SVR rate was 22% overall,12.5% in patients with genotype 1,and 66.7% in those with genotypes 2 and 3 following therapy with low doses of either Peg-IFN alpha-2b and of *** patients with decompensated cirrhosis,full dosages of Peg-IFN alpha-2b and of ribavirin produced a SVR rate of 35% overall,16% in patients with genotype 1 and 4,and 59% in those with genotype 2 and *** of hematological cytokines will either ensure full course of treatment to be accomplished with and prevent development of treatment-associated side *** benefits after HCV eradication were partial recovery of liver metabolic activity,prevention of hepatitis C recurrence after transplantation,and removal of some patients from the waiting list for liver *** observations highlighted that therapy is inadvisable for individuals with poor hepatic reserve(Child-Pugh-Turcotte score ≥ 10).Although SVR rates are low indecompensated cirrhotics due to hepatitis C,these patients have the most to gain as successful antiviral therapy is potentially lifesaving.

关键词： Hepatitis C virus Cirrhosis Peg-interferon Ribavirin Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new algorithm for bank-failure mechanisms in 2D morphodynamic models with unstructured grids

引用

International Journal of Sediment Research 2015年第4期30卷 382-391页

作者： Stefania Evangelist Massimo Greco Michele Iervolino angelo Leopardi Andrea Vacca Andrea Vaccac a Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio Department of Civil Building and Environmental EngineeringUniversity of Naples "Federico 11" Department of Civil Engineering DesignBuilding and EnvironmentSecond University of Naples Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio

Bank failure is an important phenomenon in geomorphic *** the presence of river banks or steep bedforms,collapse mechanisms induced by the water-level rise deeply affect the bed evolution along with the sediment-transport *** this paper an algorithm capable of simulating such mechanisms in a two-dimensional two-phase morphodynamic model is presented.A mixed CellCentered and Node-Centered Finite-Volume discretization,which makes use of an unstructured triangular mesh and allows the slope in each cell to be univocally defined,is *** geo-failure operator guarantees that when in the cell the bed slope exceeds a critical angle,the corresponding bed material and pore water will become part of the bed transport and will then follow the dynamic equations of the two-phase *** algorithm effectiveness is shown by the numerical reproduction of some experimental tests from the literature.

关键词： unstructured grids critical angle bed evolution pore water

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

PHASE DIFFERENCE BETWEEN LOW-FREQUENCY OSCILLATIONS OF CEREBRAL DEOXY-AND OXY-HEMOGLOBIN CONCENTRATIONS DURING A MENTAL TASK

引用

Journal of Innovative Optical Health Sciences 2011年第2期4卷 151-158页

作者： angelo SASSAROLI FENG ZHENG MICHELE PIERRO PETER R.BERGETHON SERGIO FANTINI Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

Hemodynamic low-frequency(~0.1 Hz)spontaneous oscillations as detected in the brain by nearinfrared spectroscopy have potential applications in the study of brain activation,cerebral autoregulation,and functional *** this work,we have investigated the phase lag between oscillations of cerebral deoxy-and oxy-hemoglobin concentrations in the frequency range 0.05-0.10 Hz in a human subject during a mental workload *** have obtained a measure of such phase lag using two different methods:(1)phase synchronization analysis as used in the theory of chaotic oscillators and(2)a novel cross-correlation phasor *** two methods yielded comparable initial results of a larger phase lag between low-frequency oscillations of deoxy-and oxyhemoglobin concentrations during mental workload with respect to a control,rest condition.

关键词： Phase lag oxyhemoglobin deoxyhemoglobin phase synchronization cross-correlation phasor LFO

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Histopathology of hepatocellular carcinoma

引用

World Journal of Gastroenterology 2014年第43期20卷 15955-15964页

作者： Manuel Schlageter Luigi Maria Terracciano Salvatore D'angelo Paolo Sorrentino Department of Pathology University Hospital Basel Liver Unit Clinical and Experimental HepatologyS.G.Moscati General Hospital

Hepatocellular carcinoma(HCC)is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence *** etiology is usually linked to environmental,dietary or lifestyle *** most commonly arises in a cirrhotic liver but interestingly an increasing proportion of HCCs develop in the non-fibrotic or minimal fibrotic liver and a shift in the underlying etiology can be *** this process is yet to be completely understood,this changing scenario also has impact on the material seen by pathologists,presenting them with new diagnostic *** criteria for diagnosing classical,progressed HCC are well established and known,but with an increase in detection of small and early HCCs due to routine screening programs,the diagnosis of these small lesions in core needle biopsies poses a difficult *** lesions can be far more difficult to distinguish from one another than progressed HCC,which is usually a clear cut hematoxylin and eosin *** lesions thought to derive from progenitor cells have recently been reclassified in the *** review summarizes recent developments and tries to put new HCC biomarkers in context with the WHOs *** it also addresses the group of tumors known as combined hepatocellular-cholangiocellular carcinomas.

关键词： Histology Pathology Hepatocellular carinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bisacodyl plus split 2-L polyethylene glycol-citrate-simethicone improves quality of bowel preparation before screening colonoscopy

引用

World Journal of Gastroenterology 2013年第33期19卷 5493-5499页

作者： Flavio Valiante angelo Bellumat Manuela De Bona Michele De Boni Department of Gastroenterology and Digestive Endoscopy S Maria del Prato Hospital

AIM:To compare the bowel cleansing efficacy,tolerability and acceptability of split 2-L polyethylene glycol(PEG)-citrate-simethicone(PEG-CS)plus bisacodyl(BIS)vs 4-L PEG for fecal occult blood test-positive screening ***:This was a randomised,observer-blind comparative *** hundred and sixty-four subjects underwent screening colonoscopy(mean age 62.5±7.4years,male 61.7%).The primary objective of the study was to compare the bowel cleansing efficacy of the two ***:BIS plus PEG-CS:3 tablets of 5-mg BIS at 16:00,PEG-CS 1-L at 19:00 and 1-L at7:00,4-L PEG:3-L at 17:00,and 1-L at 7:*** was carried out after 11:00,at least 3 h after the completion of bowel *** cleansing was evaluated using the Harefield Cleansing ***:Bowel preparation was successful for 92.8%of subjects in the PEG-CS group and for 92.1%of subjects in the 4-L PEG(RR=1.01;95%CI:0.94-1.08).BIS+PEG-CS was better tolerated than 4-L PEG.A greater rate of patients in the BIS+PEG-CS group had no difficulty and/or were willing to repeat the same preparation compared to split-dose 4-L PEG *** in the BIS+PEG-CS group rated the prep as good or satisfactory in 90.6%as compared to 77%in the 4-L PEG(P=0.003).Subjects receiving BIS+PEGCS stated they fully adhered to instructions drinking all the 2-L solution in 97.1%compared with 87.3%in the4-L PEG(P=0.003).CONCLUSION:BIS plus split 2-L PEG-CS was as effective as but better tolerated and accepted than split4-L PEG for screening *** new procedure may increase the positive attitude and participation to colorectal cancer screening colonoscopy.

关键词： Colonoscopy Colon cleansing Bowel preparations Polyethylene glycol Simethicone Bisacodyl

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Imaging in liver transplantation

引用

World Journal of Gastroenterology 2009年第6期15卷 675-683页

作者： Settimo Caruso Roberto Miraglia Luigi Maruzzelli Salvatore Gruttadauria angelo Luca Bruno Gridelli Department of Diagnostic and Interventional Radiology Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IsMeTT)University of Pittsburgh Medical Center ItalyVia Tricomi 1Palermo 90127Italy Department of Transplantation Surgery Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IsMeTT) University of Pittsburgh Medical Center ItalyVia Tricomi 1 Palermo 90127Italy

The aim of this study was to illustrate the role of noninvasive imaging tools such as ultrasonography,multidetector row computed tomography,and magnetic resonance imaging in the evaluation of pediatric and adult liver recipients and potential liver donors,and in the detection of potential complications arising from liver transplantation.

关键词： Complications Liver donor Liver transplantation Magnetic resonance Multi detector computed tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein

引用

Virologica Sinica 2019年第2期34卷 211-221页

作者： Ayslan Castro Brant Vladimir Majerciak Miguel angelo Martins Moreira Zhi-Ming Zheng Tumor Virus RNA Biology Section RNA Biology Laboratory Center for Cancer Research National Cancer Institute NIH Frederick MD 21702 USA Genetics Post-Graduation Program Rio de Janeiro Federal University Rio de Janeiro Brazil Genetics Program Nacional Cancer Institute INCA Rio de Janeiro 20231-050 Brazil

Human papillomavirus 18(HPV18) E6 and E7 oncogenes are transcribed as a single bicistronic E6 E7 pre-mRNA. The E6 ORF region in the bicistronic E6 E7 pre-mRNA contains an intron. Splicing of this intron disrupts the E6 ORF integrity and produces a spliced E6*I RNA for efficient E7 translation. Here we report that the E6 intron has two overlapped branch point sequences(BPS) upstream of its 30 splice site, with an identical heptamer AACUAAC, for E6*I splicing. One heptamer has a branch site adenosine(underlined) at nt 384 and the other at nt 388. E6*I splicing efficiency correlates to the expression level of E6 and E7 proteins and depends on the selection of which branch site. In general, E6*I splicing prefers the 30 ss-proximal branch site at nt 388 over the distal branch site at nt 384. Inactivation of the nt 388 branch site was found to activate a cryptic acceptor site at nt 636 for aberrant RNA splicing. Together, these data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.

关键词： Human papillomavirus 18 (HPV18) HPV splicing Branch point E6,E7,E6 intron HPV oncogenes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genetic testing vs microforceps biopsy in pancreatic cysts:Systematic review and meta-analysis

引用

World Journal of Gastroenterology 2019年第26期25卷 3450-3467页

作者： Sandra Faias Luisa Pereira angelo Luis Paula Chaves Marilia Cravo Department of Gastroenterology Instituto Portugues de Oncologia de Lisboa de Francisco GentilEPELisboa 1099-023Portugal Faculdade de Ciencias da Seude Universidade da Beira InteriorCovilha 200-506Portugal GRUBI-Grupo de Revisoes Sistematicas Universidade da Beira InteriorCovilha 6200-506Portugal Centro de Matemática e Aplicacoes(CMA-UBI) Universidade da Beira InteriorCovilha 6200-506Portugal Centro de Investigacao em Ciencias da Saude(CICS-UBI) Universidade da Beira InteriorCovilha 6200-506Portugal Department of Pathology Instituto Portugues de Oncologia de Lisboa de Francisco GentilEPELisboa 1099-023Portugal Department of Gastroenterology Hospital Beatriz AngeloLoures 2674-514Portugal Faculdade de Medicina Universidade de LisboaLisboa 1099-023Portugal

BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic *** testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is *** To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for *** We performed a literature search in Medline,Scopus,and Web of Science for studies evaluating genetic testing of cystic fluid and microforceps biopsy of pancreatic cysts,with endoscopic ultrasound with fine-needle aspiration(EUSFNA)prior to surgery and surgical pathology as reference standard for *** evaluated the diagnostic accuracy for:1-benign cysts;2-mucinous low-risk cysts;3-high-risk cysts,and the diagnostic yield and rate of correctly identified cysts with microforceps biopsy and molecular *** also assessed publication bias,heterogeneity,and study *** Eight studies,including 1206 patients,of which 203(17%)referred for surgery who met the inclusion criteria were analyzed in the systematic review,and seven studies were included in the *** testing and microforceps biopsies were identical for diagnosis of benign *** analysis was superior for diagnosis of both low and high-risk mucinous cysts,with sensitivities of 0.89(95%CI:0.79-0.95)and 0.57(95%CI:0.42-0.71),specificities of 0.88(95%CI:0.75-0.95)and 0.88(95%CI:0.80-0.93)and AUC of 0.9555 and 0.92,*** diagnostic yield was higher in microforceps biopsies than in genetic analysis(0.73 vs 0.54,respectively)but the rates of correctly identified cysts were identical(0.73 with 95%CI:0.62-0.82 vs 0.71 with 95%CI:0.49-0.86,respectively).CONCLUSION Genetic testing and microforceps biopsies are useful second tests,with identical results in benign pancreatic *** analysis performs better for low-and high-risk cysts but has lower diagnos

关键词： Pancreatic cysts Endoscopic ultrasound Endoscopic ultrasound with fineneedle aspiration Genetic testing Microforceps biopsy Molecular analysis KRAS Carcinoembryonic antigen Cytology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geospatial web services pave new ways for server-based on-demand access and processing of Big Earth Data

引用

International Journal of Digital Earth 2018年第1期11卷 7-25页

作者： Julia Wagemann Oliver Clements Ramiro Marco Figuera angelo Pio Rossi Simone Mantovani Forecast Department European Centre for Medium-Range Weather ForecastsReadingUK Remote Sensing Group Plymouth Marine LaboratoryPlymouthUK Department of Physics and Earth Sciences Jacobs UniversityBremenGermany MEEO S.r.l. FerraraItaly

Big Earth Data has experienced a considerable increase in volume in recent years due to improved sensing technologies and improvement of numerical-weather prediction *** traditional geospatial data analysis workflow hinders the use of large volumes of geospatial data due to limited disc space and computing *** web service technologies bring new opportunities to access large volumes of Big Earth Data via the Internet and to process them at *** practical examples are presented from the marine,climate,planetary and earth observation science communities to show how the standard interface Web Coverage Service and its processing extension can be integrated into the traditional geospatial data *** service technologies offer a time-and cost-effective way to access multidimensional data in a user-tailored format and allow for rapid application development or time-series *** transport is minimised and enhanced processing capabilities are *** research is required to investigate web service implementations in an operational mode and large data centres have to become more progressive towards the adoption of geo-data standard *** the same time,data users have to become aware of the advantages of web services and be trained how to benefit from them most.

关键词： Geospatial web services interoperability Big Earth Data open data Open Geospatial Consortium(OGC)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly efficient and automated extraction of DNA from human remains using a modified EZ1 protocol

引用

Forensic Sciences Research 2021年第1期6卷 59-66页

作者： Anna Barbaro Sasha Samar Giacomo Falcone angelo La Marca Department of Forensic Genetics Studio Indagini Mediche E Forensi(SIMEF)Reggio CalabriaItaly

Bones and teeth often represent the only sources of DNA available for identifying human *** in bones and teeth is generally better preserved than that in soft tissues because of the presence of hard connective tissue with a high level of *** of the extensive mineralisation,the choice of an efficient DNA extraction procedure is important to minimise the sampling of a high level of minerals and to remove polymerase chain reaction(PCR)*** protocols are available for DNA extraction from bones and teeth as part of the Qiagen EZ1 DNA Investigator Kit using the EZ1 Advanced XL automated purification *** improve the efficiency of DNA extraction from skeletal remains,the present study focuses on a modification to these already available *** this study,different bones and teeth collected between 1 and 50 years after death were subjected to DNA extraction using the standard EZ1 protocol,a supplementary protocol,and a modified *** modified approach included a decalcification step,whereas the Qiagen protocols worked directly on non-decalcified *** all three procedures,150 mg samples were used for DNA *** evaluated the quantity of DNA recovered from samples,the presence of any PCR inhibitors co-extracted,the level of DNA degradation,the quality of short tandem repeat(STR)profiles,and the reproducibility of the modified *** compared with the other protocols,the modified protocol resulted in the best recovery of DNA that was free of PCR ***,the STR profiles were reliable and of high *** our opinion,the decalcification step increases DNA recovery by softening tissues,which allows lysis solutions to act more ***,the use of two lysis solutions and the variation added to the EZ1 purification step allow for DNA recovery with quality and quantity superior to those of the previously available Qiagen-based *** findings may be helpful solutions to t

关键词： Forensic sciences forensic genetics DNA extraction bone tooth EZ1 automation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：