Histopathology of hepatocellular carcinoma
Histopathology of hepatocellular carcinoma作者机构：Department of PathologyUniversity Hospital Basel Liver UnitClinical and Experimental HepatologyS.G.Moscati General Hospital
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第43期
页 面：15955-15964页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Histology Pathology Hepatocellular carinoma
摘 要：Hepatocellular carcinoma(HCC)is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence *** etiology is usually linked to environmental,dietary or lifestyle *** most commonly arises in a cirrhotic liver but interestingly an increasing proportion of HCCs develop in the non-fibrotic or minimal fibrotic liver and a shift in the underlying etiology can be *** this process is yet to be completely understood,this changing scenario also has impact on the material seen by pathologists,presenting them with new diagnostic *** criteria for diagnosing classical,progressed HCC are well established and known,but with an increase in detection of small and early HCCs due to routine screening programs,the diagnosis of these small lesions in core needle biopsies poses a difficult *** lesions can be far more difficult to distinguish from one another than progressed HCC,which is usually a clear cut hematoxylin and eosin *** lesions thought to derive from progenitor cells have recently been reclassified in the *** review summarizes recent developments and tries to put new HCC biomarkers in context with the WHOs *** it also addresses the group of tumors known as combined hepatocellular-cholangiocellular carcinomas.
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