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上海交通大学学报（医学版） 2010年第4期30卷 423-427页

作者：焦婷 Tingling Chang angelo a.caputo 上海交通大学医学院第九人民医院口腔修复科上海市口腔医学重点实验室上海200011 Division of Advanced Prostbodontic Biomaterial University of California-Los AngelesLos Angeles 90095-1668USA Biomaterials Science Section Division of Advanced ProsthodonticsBiomaterialsand Hospital DentistryUCLA School of DentistryLos Angeles 90095USA

目的利用光弹模型研究聚缩醛树脂义齿(隐形义齿)修复KennedyⅡ类牙列缺损的生物力学。方法建立下颌KennedyⅡ类牙列缺损((?)缺失)光弹模型,分别设计和制作聚缩醛树脂全隐形义齿、混合型隐形义齿和传统的金属支架可摘局部义齿。模拟双侧... 详细信息

目的利用光弹模型研究聚缩醛树脂义齿(隐形义齿)修复KennedyⅡ类牙列缺损的生物力学。方法建立下颌KennedyⅡ类牙列缺损((?)缺失)光弹模型,分别设计和制作聚缩醛树脂全隐形义齿、混合型隐形义齿和传统的金属支架可摘局部义齿。模拟双侧及单侧后牙加载,观察加载时三种义齿设计基牙和缺牙区牙槽嵴的载荷光弹图像,分别记录应力分布情况并加以分析和比较。结果三种义齿设计光弹模型应力分布分析显示,在单侧和双侧加载时,全隐形义齿基牙和缺牙区牙槽嵴承受压力最大,传统的金属支架可摘局部义齿(金属支架设计)承受压力沿基牙牙体长轴传导,基牙和剩余牙槽嵴承受压力最小且分布最均匀。结论对于KennedyⅡ类牙列缺损,全隐形义齿修复对基牙和剩余牙槽嵴损伤较大;而传统的金属支架可摘局部义齿使支持组织受力均匀、合理,应作为设计的首选。

关键词：聚缩醛树脂义齿光弹模型生物力学可摘局部义齿

Whole-eye transplantation: Current challenges and future perspectives

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World Journal of Transplantation 2024年第2期14卷 28-39页

作者： Anna Scarabosio Pier Luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati Leopoldo Spadea Glenda.caputo Pier Camillo Parodi Caterina Gagliano Jonathan M Winograd Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Plastic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye transplantation emerges as a frontier in ophthalmology,promising a transformative approach to irreversible *** advancements,formidable challenges *** of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell *** the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive,prompting the exploration of neurotrophic support and immunomodulatory *** tolerance,paramount for graft acceptance,confronts the distinc-tive immunogenicity of ocular tissues,driving research into targeted immunosup-pression *** and legal considerations underscore the necessity for stringent standards and ethical *** collaboration and ongoing research endeavors are imperative to navigate these ***,stem cell therapies,and precision immunomodulation represent promising avenues in this ***,the aim of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancements while delineating future directions for research and clinical *** concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalmic care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关键词： Eye Transplantation Optic nerve Nerve regeneration Immunological tolerance

Hot topics in pancreatic cancer management

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 121-126页

作者： Damiano caputo Department of General Surgery Fondazione Policlinico Universitario Campus Bio-MedicoRome 00128Italy General Surgery Research Unit University Campus Bio-Medico di RomaRome 00128Italy

Pancreatic ductal adenocarcinoma(PDAC)is a sneaky and lethal disease burdened by poor *** is often detected too late to be successfully cured,and it has been estimated that it will be a leading cause of cancer-related deaths in the near *** the last decade,multimodal treatments involving surgery,chemotherapy and radiotherapy have contributed to improving the prognosis of this disease;however,long-term results are still not *** morbidity and mortality rates remain high,and systemic treatments are burdened by toxicity in both neoadjuvant and adjuvant *** in technologies,targeted therapies,immunotherapy and PDAC microenvironment modulation strategies may represent useful potential weapons in the ***,in the fight against this dreadful disease,there is an urgent need for new,cheap and user-friendly tools for early *** this field,promising results have been found in nanotechnologies and“omics”analyses that search for new biomarkers to be used in primary and secondary ***,there are many issues that need to be solved before considering these tools in daily clinical *** editorial reported the state of the art of pancreatic cancer management.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Nanotechnology Neoadjuvant therapy Adjuvant therapy Omics

Osteopontin and the immune system:another brick in the wall

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Cellular & Molecular Immunology 2018年第4期15卷 405-407页

作者： Sara.caputo Matteo Bellone Cellular Immunology Unit Department of ImmunologyTransplantation and Infectious DiseasesSan Raffaele Scientific Institute20132 MilanItaly

The innate and adaptive arms of the immune system are finely tuned to efficiently react to either endogenous or exogenous noxiae that perturb the function of our tissues and organs,thus rapidly returning to homeostasis with minimal collateral *** molecular mechanisms by which this occurs have been only partially *** work by Kanayama et al.1 contributes to the building of this wall of knowledge by adding an important *** show that osteopontin(OPN),a phosphorylated protein of the extracellular matrix(ECM),has a dominant role in balancing lymphoid and myeloid cells during emergency granulopoiesis(that is,an increased cellular output from the bone marrow to meet the acute demand for the respective blood cell type).2 OPN that is produced and released by bone marrow(BM)stromal cells negatively impacts the pool size of hematopoietic stem cells(that is,Lin−Sca-1+c-kit+).

关键词： organs al. endogenous

Integrating beneficiaries into assessment of ecosystem services from managed forests at the Hubbard Brook Experimental Forest,USA

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Forest Ecosystems 2016年第4期3卷 243-257页

作者： Jesse caputo Colin M.Beier Valerie A.Luzadis Peter M.Groffman SUNY College of Environmental Science and Forestry Department of Forest and Natural Resources Management Syracuse NY 13210 USA Cary Institute of Ecosystem Studies Millbrook 12545 NY USA

Background：Forests contribute to human wellbeing through the provision of important ecosystem ***：In this study,we investigated how the perceived importance of ecosystem services may impact the overall benefit provided by managed watersheds at the Hubbard Brook Experimental Forest over a 45-year period,using standardized measures of service capacity weighted by service importance weights derived from a survey of ***：The capacity of watersheds to regulate water flow and quality was high in all watersheds throughout the study period,whereas cultural services such as scenic beauty declined after *** on greenhouse gas regulation depended on the efficiency with which harvested biomass was *** revealed that stakeholders placed high value on all ecosystem services,with regulating and cultural services seen as more important than provisioning *** service metrics were weighted by survey responses and aggregated into a single measure,total service provision followed the same overall trend as greenhouse gas *** biomass use was less efficient in terms of greenhouse gas emissions,harvesting resulted in an overall ＂ecosystem service debt＂;where use was more efficient,this ＂ecosystem service debt＂ was ***＇ educational backgrounds significantly affected overall assessment of service *** with college or university degrees incurred smaller ＂ecosystem service debts＂ and were less negatively affected by harvesting ***：This study highlights the importance of including empirical measures of beneficiary preference when attempting to quantify overall provision of ecosystem services to human beneficiaries over time.

关键词： Ecosystem services Forests Long-term ecological research Hubbard Brook Experimental Forest Regulating services

Southern East Siberia Pliocene-Quaternary faults:Database,analysis and inference

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Geoscience Frontiers 2014年第4期5卷 605-619页

作者： Oksana V.Lunina Riccardo caputo Anton A.Gladkov Andrey S.Gladkov Institute of the Earth's Crust Siberian Branch of Russian Academy of Sciences University of Ferrara Department of Physics and Earth SciencesVia Saragat 144122 FerraraItaly

This paper presents the first release of an Informational System（IS）devoted to the systematic collection of all available data relating to Pliocene-Quaternary faults in southern East Siberia,their critical analysis and their seismotectonic *** final goal of this project is to form a new base for improving the assessment of seismic hazard and other natural processes associated with crustal *** presented IS has been exploited to create a relational database of active and conditionally active faults in southern East Siberia（between 100°-114° E and 50°-57° N）whose central sector is characterized by the highly seismic Baikal rift *** information within the database for each fault segment is organized as distinct but intercorrelated sections（tables,texts and pictures,etc.）and can be easily visualized as HTML pages in offline *** preliminary version of the database distributed free on disk already highlights the general fault pattern showing that the Holocene and historical activity is quite uniform and dominated by NE-SW and nearly E-W trending faults;the former with a prevailing dip-slip normal kinematics,while the latter structures are left-lateral strike-slip and oblique-slip（with different proportion of left-lateral and normal fault slip components）.These faults are mainly concentrated along the borders of the rift basins and are the main sources of moderate-to-strong（M≥5.5）earthquakes on the southern sectors of East Siberia in recent *** a whole,based on analyzing the diverse fault kinematics and their variable spatial distribution with respect to the overall pattern of the tectonic structures formed and/or activated during the late Pliocene-Quaternary,we conclude they were generated under a regional stress field mainly characterized by a relatively uniform NW-SE tension,but strongly influenced by the irregular hard boundary of the old Siberian *** obtained inferences are in an agreement with the existing models

关键词： Pliocene-Quaternary faults Database Seismic hazard Tectonics Southern East Siberia

Shared(epi)genomic background connecting neurodegenerative diseases and type 2 diabetes

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World Journal of Diabetes 2020年第5期11卷 155-164页

作者： Valerio caputo Andrea Termine Claudia Strafella Emiliano Giardina Raffaella Cascella Department of Biomedicine and Prevention Tor Vergata UniversityRome 00133Italy Molecular Genetics Laboratory UILDM Santa Lucia FoundationRome 00142Italy Experimental and Behavioral Neurophysiology Laboratory Santa Lucia FoundationRome 00142Italy Department of Biomedical Sciences Catholic University Our Lady of Good CounselTirana 1000Albania

The progressive aging of populations has resulted in an increased prevalence of chronic pathologies,especially of metabolic,neurodegenerative and movement *** particular,type 2 diabetes(T2D),Alzheimer’s disease(AD)and Parkinson’s disease(PD)are among the most prevalent age-related,multifactorial pathologies that deserve particular attention,given their dramatic impact on patient quality of life,their economic and social burden as well the etiopathogenetic mechanisms,which may overlap in some ***,the existence of common triggering factors reflects the contribution of mutual genetic,epigenetic and environmental features in the etiopathogenetic mechanisms underlying T2D and AD/*** this subject,this review will summarize the shared(epi)genomic features that characterize these complex *** particular,genetic variants and gene expression profiles associated with T2D and AD/PD will be discussed as possible contributors to determine the susceptibility and progression to these ***,potential shared epigenetic modifications and factors among T2D,AD and PD will also be ***,this review shows that findings from genomic studies still deserves further research to evaluate and identify genetic factors that directly contribute to the shared ***,a common epigenetic background still needs to be investigated and *** evidences discussed in this review underline the importance of integrating largescale(epi)genomic data with additional molecular information and clinical and social background in order to finely dissect the complex etiopathogenic networks that build up the“disease interactome”characterizing T2D,AD and PD.

关键词： Type 2 diabetes Alzheimer’s disease Parkinson’s disease Metabolism Neurodegeneration Neuroinflammation Genetic variants Epigenomic background Disease interactome

Nanotechnology and pancreatic cancer management:State of the art and further perspectives

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 231-237页

作者： Damiano caputo Daniela Pozzi Tommaso Farolfi Roberto Passa Roberto Coppola Giulio Caracciolo Department of General Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of Molecular Medicine Sapienza University of RomeRome 00161Italy

Pancreatic ductal adenocarcinoma(PDAC)represents a leading cause of cancer death and is often diagnosticated too late to allow adequate *** of biomarkers have been discovered in lasts years but,to date,there is a lack of lowcost and non-invasive tools for PDAC early ***,drugs commonly used in PDAC treatment do not allow achieving long-term satisfying *** is gaining importance in both PDAC early detection and *** main implications of nanotechnology in cancer diagnosis lay in the ability that nanoparticles have on concentrate the alteration in human proteome caused by ***-enabled blood tests have been demonstrated to reach high rate of sensitivity(up to 85%)and specificity(up to 100%).In the field of cancer therapy nanoparticles can be used as nanocarriers able to reach specific tumour’s cells and selectively release the drug they contain into them.A literature review was carried out with the aim to assess the state of the art and highlight the future perspectives of nanotechnology in PDAC early detection and therapy.

关键词： Pancreatic ductal adenocarcinoma Biomarkers Nanotechnology Nanoparticles Protein corona Early detection

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel

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Advances in Chemical Engineering and Science 2013年第3期3卷 189-194页

作者： Giuseppe caputo Dipartimento di IngegneriaIndustriale Universitàdeglistudi di Salerno Fisciano Italy

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35℃ and 45℃ and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

关键词： Silica Aerogel Adsorption Domperidone Drug Delivery Systems Adsorption Mechanisms