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Brain Urea as a Potential Biomarker of Neoplasm Progression

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Journal of Biosciences and Medicines 2024年第4期12卷 1-13页

作者： Larisa Mikhailovna Obukhova Elena Ivanovna Erlykina Igor Aleksandrovich Medyanik Artem Sergeevich Grishin angelina Mikhailovna Shutova Federal State Budgetary Educational Institution of Higher Education The &#8220Privolzhsky Research Medical University&#8221 of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia National Research Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod Russia

Metabolic reprogramming is a key feature driving oncogenesis in cancers. Recent studies have revealed that protein metabolism is largely altered in gliomas facilitating its malignant growth. Urea is the end product of nitrogen metabolism which is mainly produced by arginase. The interdependence of arginase and other biochemical mechanisms triggered scientific research interest. This research aimed to investigate the relationships between the urea as the main parameter of protein metabolism and glioma progression. It was also the most pronounced relationship between urea and the level of the nuclear protein Ki-67 as a marker of proliferative activity and O-6-methylguanine-DNA methyltransferase (MGMT), which performs DNA repair. Postoperative material from 20 patients with gliomas of different grades of anaplasia was analyzed.

关键词： Glioma Peritumoral Zone Urea Gliomal Molecular Genetic Markers Ki-67 MGMT

Increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovуeva Shaza S.Issa Aysilu I.Mullagulova angelina A.Titova Yana O.Mukhamedshina Anna V.Timofeeva Alexander M.Aimaletdinov Islam R.Nigmetzyanov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(HexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of HexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-HEXA-HEXB express the functionally active HexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

LVMH路威酪轩集团董事会主席兼CEO 伯纳德·阿尔诺:我们的每项计划都着眼于未来

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商业周刊（中文版） 2024年第12期 42-49页

作者： BRAD STONE angelina RASCOUET RUVEN AFANADOR(摄影) Jeannette Neumann Natalie Wong Daniela Wei Shirley Zhao 杨飞(译) 不详

LVMH路威酪轩集团已将全球众多奢侈品牌收入囊中,如今又成为2024年巴黎奥运会的最大赞助商。阿尔诺认为,该集团作为法国文化旗手,有责任让奥运会取得成功每周六早上,伯纳德·阿尔诺(BernardArnault)都会在副手、保镖和子女轮流担当的随... 详细信息

LVMH路威酪轩集团已将全球众多奢侈品牌收入囊中,如今又成为2024年巴黎奥运会的最大赞助商。阿尔诺认为,该集团作为法国文化旗手,有责任让奥运会取得成功每周六早上,伯纳德·阿尔诺(BernardArnault)都会在副手、保镖和子女轮流担当的随从陪同下,花几个小时的时间巡查他供奉着手袋、时装、珠宝和昂贵手表的时尚神殿。

关键词：集团董事会奢侈品牌阿尔诺奥运会伯纳德 CEO 赞助商

Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair

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Neural Regeneration Research 2017年第6期12卷 886-889页

作者： angelina Angelova Borislav Angelov Institut Galien Paris-Sud CNRS UMR 8612 University of Paris-Sud Université Paris-Saclay Lab Ex LERMIT Institute of Physics ELI Beamlines Academy of Sciences of the Czech Republic

Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor（BDNF） and its high-affinity tropomyosin-related kinase receptor（Trk B） present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB（c AMP response element-binding protein） has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at（i） neurotrophic protein regulation in the central and peripheral nervous systems, and（ii） diminishment of the production of reactive oxygen species（ROS） and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines.

关键词： neuronal synaptic repair neurotrophic neurotrophin mitochondria CREB biodegradable endogenous aiming

On the possible orbital motion of Sgr A* in the smooth potential of the Milky Way

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Research in Astronomy and Astrophysics 2020年第12期20卷 383-390页

作者： Igor’I.Nikiforov angelina V.Veselova St.Petersburg State University Universitetskij Prospekt 28Staryj PeterhofSt.Petersburg 198504Russia

The modern accuracy of measurements allows the residual/peculiar(Galactocentric) velocity of the supermassive black hole(SMBH) in our Galaxy, Sgr A*, on the order of several kilometers per *** integrate possible orbits of the SMBH along with the surrounding nuclear stellar cluster(NSC) for a barred model of the Galaxy using modern constraints on the components of the SMBH Galactocentric velocity. Is is shown that the range of oscillations of the SMBH + NSC in a regular Galactic field in the plane of the Galaxy allowed by these constraints strongly depends on the set of central components of the Galactic potential. If the central components are represented only by a bulge/bar, for a point estimate of the SMBH Galactocentric velocity, the oscillation amplitude does not exceed 7 pc in the case that a classical bulge is present and reaches 25 pc if there is no bulge;with SMBH velocity components within the 2σ significance level, the amplitude can reach 15 and 50 pc, respectively. However, when taking into account the nuclear stellar disk(NSD), even in the absence of a bulge, the oscillation amplitude is only 5 pc for the point estimate of the SMBH velocity, and 10 pc for the 2σ significance level. Thus, the possible oscillations of the SMBH + NSC complex from the confirmed components of the Galaxy’s potential are mostly limited by the NSD, and even taking into account the uncertainty of the mass of the latter, the oscillation amplitude can hardly exceed 13 pc = 6′.

关键词： Galaxy:center Galaxy:fundamental parameters Galaxy:kinematics and dynamics

A pancreatic player in dementia:pathological role for islet amyloid polypeptide accumulation in the brain

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Neural Regeneration Research 2023年第10期18卷 2141-2146页

作者： angelina S.Bortoletto Ronald J.Parchem Center for Cell and Gene Therapy Stem Cell and Regenerative Medicine CenterDepartment of NeuroscienceDepartment of Molecular and Cellular BiologyTranslational Biology and Molecular Medicine ProgramMedical Scientist Training ProgramBaylor College of MedicineHoustonTXUSA

Type 2 diabetes mellitus patients have a markedly higher risk of developing *** multiple factors contribute to this predisposition,one of these involves the increased secretion of amylin,or islet amyloid polypeptide,that accompanies the pathophysiology of type 2 diabetes *** amyloid polypeptide accumulation has undoubtedly been implicated in various forms of dementia,including Alzheimer’s disease and vascular dementia,but the exact mechanisms underlying islet amyloid polypeptide’s causative role in dementia are *** this review,we have summarized the literature supporting the various mechanisms by which islet amyloid polypeptide accumulation may cause neuronal damage,ultimately leading to the clinical symptoms of *** discuss the evidence for islet amyloid polypeptide deposition in the brain,islet amyloid polypeptide interaction with other amyloids implicated in neurodegeneration,neuroinflammation caused by islet amyloid polypeptide deposition,vascular damage induced by islet amyloid polypeptide accumulation,and islet amyloid polypeptide-induced *** are very few therapies approved for the treatment of dementia,and of these,clinical responses have been controversial at ***,investigating new,targetable pathways is vital for identifying novel therapeutic strategies for treating *** such,we conclude this review by discussing islet amyloid polypeptide accumulation as a potential therapeutic target not only in treating type 2 diabetes mellitus but as a future target in treating or even preventing dementia associated with type 2 diabetes mellitus.

关键词： Alzheimer’s disease amylin amyloid dementia diabetes human islet amyloid polypeptide islet amyloid polypeptide protofibrils type 2 diabetes mellitus vascular dementia

Segments of spiral arms of the Galaxy traced by classical Cepheids:effects of age heterogeneity

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Research in Astronomy and Astrophysics 2020年第12期20卷 357-366页

作者： angelina V.Veselova Igor’I.Nikiforov Department of Celestial Mechanics Saint Petersburg State UniversityUniversitetskij Prospekt 28Staryj PeterhofSaint Petersburg198504 Russia

We investigated the dependence of the parameters of the segments of spiral arms of the Galaxy on the age of classical *** catalog of Cepheids(Mel’nik et al.)was divided into two samples—relatively young(P>9d)and relatively old(P<9d)*** parameters of the spiral structure were determined both for two samples separately and jointly for the combination of two systems of segments traced by young and old *** most of the segments,their parameters for young and old objects differ *** into account the difference between the two segment systems,we obtained the estimate R0 equal to 7.23^+0.19/-0.18 kpc,which in the modern Large Magellanic Cloud(LMC)calibration corresponds to the value of R0=8.08^+0.2/-10.20|stat.^+0.38/-0.36|*** is shown that the displacement between the segments is not reduced to the effect of differential rotation *** interpret this displacement for objects of Perseus and Sagittarius-2 segments,we carried out a dynamic modeling of the change in the position of the segment points when moving in the smooth gravitational field of the *** the angular velocity of rotation of the spiral pattern Ωp=25.2±0.5 km s 1 kpc 1(Dambis et al.)the observed displacement between segments on young and old objects can be explained by the amplitude of spiral perturbations of the radial velocity of u=10±1.5 km s *** the constructed double system of spiral segments,it is demonstrated that the assumption of constancy of the pitch angles within each segment and the assumption that the pole of the spiral pattern is in the direction of the nominal center of the Galaxy do not contradict the data within the range of uncertainty.

关键词： Galaxy:fundamental parameters Galaxy:structure

Emotional intelligence in professional nursing practice:A concept review using Rodgers's evolutionary analysis approach

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International Journal of Nursing Sciences 2018年第2期5卷 126-130页

作者： angelina E.Raghubir Faculty of Health Sciences School of NursingUniversity of OttawaCanada

Background:Knowledge around emotional intelligence originated in the 1990s from research regarding thoughts,emotions and *** concept of emotional intelligence has evolved over the last 25 years;however,the understanding and use is still *** this,emotional intelligence has been a widely-considered concept within professions such as business,management,education,and within the last 10 years has gained traction within nursing *** and objectives:The aim of this concept review is to clarify the understanding of the concept emotional intelligence,what attributes signify emotional intelligence,what are its antecedents,consequences,related terms and implications to advance nursing ***:A computerized search was guided by Rodger's evolutional concept *** courses included:CINAHL,PyschINFO,Scopus,EMBASE and ProQuest,focusing on articles published in Canada and the United Stated during ***:A total of 23 articles from various bodies of disciplines were included in this integrative concept *** analysis reveals that there are many inconsistencies regarding the description of emotional intelligence,however,four common attributes were discovered:self-awareness,self-management,social awareness and social/relationship *** attributes facilitate the emotional well-being among advance practice nurses and enhances the ability to practice in a way that will benefit patients,families,colleagues and advance practice nurses as working professionals and as ***:The integration of emotional intelligence is supported within several disciplines as there is consensus on the impact that emotional intelligence has on job satisfaction,stress level,burnout and helps to facilitate a positive *** to advance practice nursing,emotional intelligence is a concept that may be central to nursing practice as it has the potential to impact the quality of patient care and outcomes,decision-ma

关键词： Emotional intelligence Concept analysis Nursing

NGR-tagged nano-gold： A new CD13-selective carrier for cytokine delivery to tumors

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Nano Research 2016年第5期9卷 1393-1408页

作者： Flavio Curnis Martina Fiocch angelina Sacchi Alessandro Gori Anna Gasparri Angelo Corti Division of Experimental Oncology IRCCS San Raffaele Scientific Institute Milan 20132 Italy Istituto di Chimica del Riconoscimento Molecolare CNR Milan 20131 Italy Vita Salute San Raffaele University Milan 20132 Italy

Colloidal gold （Au）, a well-tolerated several applications in nanomedicine. nanomaterial, is currently exploited for We show that gold nanoparticles tagged with a novel tumor-homing peptide containing Asn-Gly-Arg （NGR）, a ligand of CD13 expressed by the tumor neovasculature, can be exploited as carriers for cytokine delivery to tumors. Biochemical and functional studies showed that the NGR molecular scaffoldflinker used for gold functionalization is critical for CD13 recognition. Using fibrosarcorna-bearing mice, NGR-tagged nanodrugs could deliver extremely low, yet pharmacologically active doses of tumor necrosis factor （TNF）, an anticancer cytokine, to tumors with no evidence of toxicity. Mechanistic studies confirmed that CD13 targeting was a primary mechanism of drug delivery and excluded a major role of integrin targeting consequent to NGR deamidation, a degradation reaction that generates the isoAsp-Gly-Arg （isoDGR） integrin ligand. NGR-tagged gold nanoparticles can be used, in principle, as a novel platform for single- or multi-cytokine delivery to tumor endothelial cells for cancer therapy.

关键词： Asn-Gly-Arg (NGR) isoAsp-Gly-Arg (isoDGR) CD13 integrin tumor necrosis factor albumin gold nanoparticles