Effects of Estradiol on 5-HTsA and 5-HT2c Receptor Immunolabeling in Rat Hippocampus
Effects of Estradiol on 5-HTsA and 5-HT2c Receptor Immunolabeling in Rat Hippocampus作者机构：Facultad de Quimica Universidad A utonoma de Querotaro Centro Universitario Queretaro 76010 Mexico Facultad de Ciencias Naturales Universidad Autonoma de Queretaro Campus Juriquilla Juriquilla Queretaro 76230 Mexico Department of Cellular and Molecular Neurobiology Instituto de Neurobiologia Universidad Nacional Autonoma de Mexico Campus Juriquilla Juriquilla Queretaro 76230 Mexico
出 版 物：《Journal of Life Sciences》 (生命科学（英文版）)
年 卷 期：2011年第5卷第11期
页 面：884-889页
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0906[农学-兽医学] 09[农学]
主 题：Serotonin receptor 5-HTsA 5-HT2c hippocampus estradiol progesterone
摘 要：Steroid hormones participate in the modulation of serotonergic transmission, including the regulation of synthetic and metabolic enzyme production, as well as receptor and transporter activity. The changes of 5-HT5A and 5-HT2c immunolabeling induced by steroids in the hippocampus ofovariectomized rats were studied in this work. Densitometric analysis in rat hippocampi were carried out for adjacent brain coronal immunolabeled sections after treatment with subcutaneous injections of vehicle, estradiol, progesterone or the combination of both steroids in ovariectomized rats. Exposure to estradiol and the combination of estradiol and progesterone significantly reduced the 5-HT5A-like immunosignal in the CA 1 region while progesterone did not induce changes. On the other hand, exposure to the combination of estradiol and progesterone or estradiol alone increased the 5-HT2c immunosignal in the same region. These results indicate that estradiol is involved in the discrete regulation of serotonin receptors 5-HT5A and 5-HT2c in rat hippocampus.
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