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A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling

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Bioactive Materials 2023年第1期19卷 167-178页

作者： Alexander Stahl Dake Hao Janos barrera Dominic Henn Sien Lin Seyedsina Moeinzadeh Sungwoo Kim William Maloney Geoffrey Gurtner Aijun Wang Yunzhi Peter Yang Department of Orthopaedic Surgery Stanford University240 Pasteur DriveStanfordCA94304USA Department of Chemistry Stanford University121 Mudd BuildingStanfordCA94305USA Department of Surgery School of MedicineUniversity of California DavisSacramentoCA95817USA Institute for Pediatric Regenerative Medicine Shriners Hospitals for ChildrenSacramentoCA95817USA Department of Surgery Stanford University300 Pasteur DriveStanfordCA94305USA Department of Biomedical Engineering University of California DavisDavisCA95616USA Department of Materials Science and Engineering Stanford University496 Lomita MallStanfordCA94305USA Department of Bioengineering Stanford University443 Via OrtegaStanfordCA4305USA

Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative *** different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts,it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular *** size of pores within implanted biomaterials has shown significant effects on macrophage polarization,which has been further confirmed as necessary for efficient vascular formation and ***,we developed biodegradable,autoclavable synthetic vascular grafts from a new polyurethane elastomer and tailored the grafts’interconnected pore sizes to promote macrophage populations with a pro-regenerative phenotype and improve vascular regeneration and patency *** synthetic vascular grafts showed similar mechanical properties to native blood vessels,encouraged macrophage populations with varying M2 to M1 phenotypic expression,and maintained patency and vascular regeneration in a one-month rat carotid interposition model and in a four-month rat aortic interposition *** innovative bioactive synthetic vascular graft holds promise to treat clinical vascular diseases.

关键词： Vascular graft Vascular compliance Pore size Macrophage polarization Vascular remodeling

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固相萃取和气相色谱-质谱分析酚类化合物应用简报

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环境化学 2003年第2期22卷 196-199页

作者： angelica A Reese Harry Prest AgilentTechnologies Inc.91BlueRavineRoadFolsomAgilentTechnologiesInc.1601CallfomlaAvePaloAlto CA95630USACA94304USA

固相萃取为分析水中痕量化合物提供了简便的分析方法 .高分子树脂如聚苯乙烯二乙烯基苯比常用的十八烷基和类似的硅胶基体的固相萃取吸附剂好 ,特别是对极性较大的化合物 .最近 ,安捷伦科技扩展了所提供的固相萃取产品 ,包括了聚苯乙烯... 详细信息

固相萃取为分析水中痕量化合物提供了简便的分析方法 .高分子树脂如聚苯乙烯二乙烯基苯比常用的十八烷基和类似的硅胶基体的固相萃取吸附剂好 ,特别是对极性较大的化合物 .最近 ,安捷伦科技扩展了所提供的固相萃取产品 ,包括了聚苯乙烯二乙烯基苯固相萃取材料AccuBondⅡ ENV小柱 ,专门用于环境应用 .本文用以前介绍的保留时间锁定气相色谱 /质谱分析方法[1 ] ,使用这种聚苯乙烯二乙烯基苯固相萃取材料对水中浓度为1 0 μg·l- 1 的选定酚类分析能达到的准确度和精密度进行了初步论证 .固相萃取过程快速 ,缩短干燥时间 ,且只需要两种回收率指示物 (Surrogates) .小柱经优化设计 ,提高了酚类化合物的回收率 ,而其它小柱的回收率通常很低且不重复 .苯酚的回收率超过 70 % ,其它酚类化合物的回收率超过 90 % .精密度大于 5 % ,以平均绝对偏差表示的准确度 (以百分数表示 )除了 2 环己基 2 4 二硝基酚之外 ,都大于 8% .样品萃取速率高 (2 0— 2 5ml·min- 1 ) ,萃取 1L样品不到

关键词：固相萃取气相色谱-质谱分析酚类化合物痕量分析

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Effects of "Candidatus Liberibacter solanacearum"(haplotype B)on Bactericera cockerelli fitness and vitellogenesis

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Insect Science 2020年第1期27卷 58-68页

作者： angelica Albuquerque Tomilhero Frias Freddy Ibanez Azucena Mendoza William Mario de Carvalho Nunes Cecilia Tamborindeguy Department of Entomology Texas A&M University412 Heep CenterCollege StationTexasUSA DEM-Depto.de Agronomia Nucleo de Pesquisa em Biotecnologia AplicadaMaringaBrazil

"Candidatus Liberibacter solanacearum"(Lso)are phloem-restricted and unculturable Gram-negative *** five haplotypes have been identified worldwide;but only haplotypes A and B are associated with the vector Bactericera cockerelli(Sulc.)in the *** studies showed that Lso-infection reduces *** reproductive output and that Lso haplotype B is more pathogenic than Lso haplotype *** understand the interaction of Lso haplotype B and ***,the fitness of Lso-free and Lso B-infected insects,and the expression of vitellogenin(5cKg7-like),a gene involved directly in the insect reproduction were *** differences in the number of eggs oviposited,and the total number of progeny nymphs and adults were found among crosses of insects with or without *** differences in sex proportions were found between Lso B-infected and Lso-free crosses:a higher proportion of Fi adult females were obtained from Lso B-infected mothers.A significant reduction of BcVgl-like was observed in crosses performed with Lso B-infected females compared to the Lso-free *** female cohorts of different age,a significant reduction of BcVgl-like expression was measured in 7-d-old Lso B-infected females(virgin and mated)compared with 7-d-old Lso-free females(virgin and mated),*** reduction of BcVgl-like transcript was associated with a lower number of developing oocytes observed in female5s reproductive ***,this study represents the first step to understand the interaction of Lso B with ***,highlighting the effect of Lso B infection on egg production,BcVgl-like expression,and oocyte development.

关键词： feminization insect-pathogen interaction oviposition psyllids reproduction vitellogenesis

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Evaluation of the Anti-Trypanosoma cruzi Effects of the Antipsychotic Drug Levomepromazine

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International Journal of Clinical Medicine 2012年第5期3卷 344-351页

作者： Inga Eva Stik Lange Elisabeth Mieko Furusho Pral anahi Magdaleno Ariel Mariano Silber Departamento de Parasitologia Instituto de CienciasUniversidade de Sao PauloSao PauloBrazil

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a relevant parasitic disease in the Americas. Current chemotherapy relies on Nifurtimox and Benznidazole, which present serious drawbacks, including high toxicity, low efficiency and the emergence of resistant strains. In the present work, the perspectives of levomepromazine, a tri-cyclic compound belonging to the family of phenotiazines with well-known properties as antipsychotics were evaluated as a potential anti-T. cruzi drug. We show that this drug is able to inhibit the proliferation of epimastigotes (IC50 = 0.41 ± 0.01 mM) and to interfere with the infection of the host cells (IC50 = 0.34 ± 0.01 mM). Interestingly, the treatment with levomepromazine affected the ability of metabolites such as glucose, proline and glutamate to fuel the recovery of epi-mastigotes after being submitted to metabolic stress. These findings prompt levomepromazine as a promising leader drug to obtain new trypanocidal activities.

关键词： Chagas Disease Phenothiazines Trypanothione Reductase Amino Acid Metabolism Chemotherapy

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Modelling marine DOC degradation time scales

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National Science Review 2018年第4期5卷 468-474页

作者： Luca Polimene Richard B.Rivkin Ya-Wei Luo Eun Young Kwon Marion Gehlen M.angelica Pe?a Nannan Wang Yantao Liang Hermanni Kaartokallio Nianzhi Jiao Plymouth Marine Laboratory Department of Ocean Sciences Memorial University of Newfoundland State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen University Center for Climate Physics Institute for Basic ScienceSouth Korea Laboratoire des Sciences du Climat et de l'Environnement Institut Pierre Simon LaplaceCEA-CNRS-UVSQ Institute of Ocean Sciences Fisheries and Oceans Canada Key Laboratory of Biofuels Shandong Provincial Key Laboratory of Energy Genetics Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences Finnish Environment Institute Marine Research Centre

INTRODUCTION Marine dissolved organic carbon(DOC)is formed of a large number of highly diverse *** on the environmental conditions,a fraction of these molecules may become progressively resistant to bacterial degradation and accumulate in the ocean for extended time *** longlived DOC(the so-called recalcitrant DOC,RDOC)is thought to play an

关键词： DOC Modelling marine DOC degradation time scales

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Relationship between ovarian cancer stem cells,epithelial mesenchymal transition and tumour recurrence

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Cancer Drug Resistance 2019年第4期2卷 1127-1135页

作者： Monica angelica Amaya Padilla Mudra Binju Graeme Wan Yohan Suryo Rahmanto Pritinder Kaur Yu Yu School of Pharmacy&Biomedical Science Curtin UniversityCurtin Health Innovative Research InstitutePerthWA 6102Australia Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medical InstitutionsBaltimoreMD 21231USA Department of Pathology Johns Hopkins Medical InstitutionsBaltimoreMD 21205USA Division of Obstetrics&Gynaecology University of Western Australia Medical SchoolWA 6009Australia

Investigating the biological processes that occur to enable recurrence and the development of chemoresistance in ovarian cancer is critical to the research and development of improved treatment options for *** lethality of ovarian cancer is largely attributed to the recurrence of disease with acquired *** stem cells are likely to be critical in ovarian cancer progression,contributing to tumour malignancy,metastasis and recurrence by persisting in the body despite treatment with anti-cancer ***,cancer stem cells are capable of mediating epithelial-to-mesenchymal transition traits and secrete extracellular vesicles to acquire therapy resistance and disease *** attributes merit in depth research to provide insight into the biological role of ovarian cancer stem cells in disease progression and chemotherapy response,leading to the development of improved biomarkers and innovative therapeutic approaches.

关键词： Ovarian cancer stem cells chemoresistance platinum resistance recurrence epithelial-to-mesenchymal transition extracellular vesicles

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Coping Immigrants M6xico-United States as an Agent of Change： From Risk to Protection Factors~

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Psychology Research 2011年第5期1卷 318-327页

作者： angelica Ojeda Garcia Alma Polo Velazquez Universidad Iberoamericana Mexico City Mexico

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Construction and Characterization of an Ultrasonic Array Using Different Backing Materials to Evaluate Crosstalk

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材料科学与工程（中英文B版） 2013年第8期3卷 493-497页

作者： Israel Sanchez Dominguez Pedro acevedo Contla Polytechnic University of Madrid School of lndustrial Engineering Madrid 28001 Spain National Autonomous University of Mexico Institute of Research in Applied Mathematics and Systems Mexico City 04510Mexico

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C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.Smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay acevedo-acevedo Yifeng Gao Michelle A.Reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

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Effects of Silicon Nanoparticles on the Transient Liquid Phase Bonding of 304 Stainless Steel

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Journal of Materials Science & Technology 2014年第3期30卷 259-262页

作者： H.M.Hdz-García A.I.Martinez R.Mu?oz-Arroyo J.L.acevedo-Dávila F.García-Vázquez F.A.Reyes-Valdes Corporación Mexicana de Investigación en Materiales S.A.de C.V. Ciencia y Tecnología No.790 Fracc.Saltillo 400 Saltillo Coah.CP.25290 Mexico Centro de Investigación y de Estudios Avanzados del IPN Carr.Mty-Saltillo km.13 Ramos Arizpe Coah.CP.25900 Mexico

Transient liquid phase （TLP） bonding of 304 stainless steel with nickel based filler metal, BNi-9, was performed to study the influence of silicon nanoparticles （NPs） on the mechanical and structural properties of the bonding area. It was found that silicon NPs act as a melting point depressant in the brazing process; the formation of silicon TLP induces the dissolution of elements of the metal filler and promotes a uniform distribution in the bonding area. Silicon NPs induce the development of smaller eutectic structures in the melting zone; it has been related to microhardness measurements, which are lower when the silicon NPs are used in the brazing process.

关键词： Brazing Nanoparticles Silicon Stainless steel

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