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A case of biliary gastric fistula following percutaneous radiofrequency thermal ablation of hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第5期13卷 804-805页

作者： angela Falco Dante Orlando Roberto Sciarra Luciano Sergiacomo Department of Internal Medicine "S. Massimo" Civil HospitalPenneItaly Department of Radiology "S. Massimo" Civil Hospital Penne Italy

Percutaneous radiofrequency thermal ablation （RFA） is an effective and safe therapeutic modality in the management of liver malignancies, performed with ultrasound guidance. Potential complications of RFA include liver abscess, ascites, pleural effusion, skin burn, hypoxemia, pneumothorax, subcapsular hematoma, hemoperitoneum, liver failure, tumour seeding, biliary lesions. Here we describe for the first time a case of biliary gastric fistula occurred in a 66-year old man with a Child＇s class A alcoholic liver cirrhosis as a complication of RFA of a large hepatocellular carcinoma lesion in the nl segment. In the light of this case, RFA with injection of saline between the liver and adjacent gastrointestinal tract, as well as laparoscopic RFA, ethanol injection （PEI）, or other techniques such as chemoembolization, appear to be more indicated than percutaneous RFA for large lesions close to the gastrointestinal tract.

关键词： Radiofrequency thermal ablation Hepatocellular carcinoma Biliary gastric fistula Complications

A High Order Sharp-Interface Method with Local Time Stepping for Compressible Multiphase Flows

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Communications in Computational Physics 2011年第1期9卷 205-230页

作者： angela Ferrari Claus-Dieter Munz Bernhard Weigand Institute of Aerodynamics and Gasdynamics University of StuttgartPfaffenwaldring 21D-70569 StuttgartGermany Institute of Aerospace Thermodynamics University of StuttgartPfaffenwaldring 31D-70569 StuttgartGermany

In this paper,a new sharp-interface approach to simulate compressible multiphase flows is *** new scheme consists of a high order WENO finite volume scheme for solving the Euler equations coupled with a high order pathconservative discontinuous Galerkin finite element scheme to evolve an indicator function that tracks the material *** the interface our method applies ghost cells to compute the numerical flux,as the ghost fluid ***,unlike the original ghost fluid scheme of Fedkiw et al.[15],the state of the ghost fluid is derived from an approximate-state Riemann solver,similar to the approach proposed in[25],but based on a much simpler *** formulation leads only to one single scalar nonlinear algebraic equation that has to be solved at the interface,instead of the system used in[25].Away from the interface,we use the new general Osher-type flux recently proposed by Dumbser and Toro[13],which is a simple but complete Riemann solver,applicable to general hyperbolic conservation *** time integration is performed using a fully-discrete one-step scheme,based on the approaches recently proposed in[5,7].This allows us to evolve the system also with time-accurate local time *** to the sub-cell resolution and the subsequent more restrictive time-step constraint of the DG scheme,a local evolution for the indicator function is applied,which is matched with the finite volume scheme for the solution of the Euler equations that runs with a larger time *** use of a locally optimal time step avoids the introduction of excessive numerical diffusion in the finite volume *** different fluids have been used,namely an ideal gas and a weakly compressible fluid modeled by the Tait *** tests have been computed to assess the accuracy and the performance of the new high order scheme.A verification of our algorithm has been carefully carried out using exact solutions as well as a comparison with other numerical re

关键词： Sharp interface capturing compressible multiphase flows one-step time-integration time-accurate local time stepping modified ghost fluid method WENO schemes discontinuous Galerkin methods

Unhealthy aging? Featuring older people in television food commercials in China

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International Journal of Nursing Sciences 2020年第S1期7卷 67-73页

作者： Wen Jiao angela Wen-Yu Chang Department of Communication Faculty of Social SciencesUniversity of MacaoChina

Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a *** study aimed to investigate how older people are portrayed in televised food commercials from the approach of a healthy aging perspective in contemporary Chinese ***:All televised advertising in the Ad Topic archive were screened against inclusion and exclusion criteria,and a total of 164 commercials from the years of 2016-2019 that portrayed Chinese older people were *** association between the main older characters with the product categories,healthy *** foods,use of health claims,sex,type of spokesperson,companions,and tones and manners were included in the ***:Older people more frequently appeared in unhealthy food products than in healthy food *** claims involving older adults were portrayed adequately,whereas nursing professions as companions of older adults were *** advertising that delivered happy,caring,or warm tones was overwhelmingly ***,the advertising messages circulated in China represent a binary stereotype model of images of older adults'characteristics that reflect ageist and the so-called agelessism,referring to the new application of the look from the approach of social psychology and marketing ***:This study examined aging discrimination reflected in *** exploring the impact of a crisis remain *** is needed to improve the accuracy of advertised healthy older adults and normal aging.

关键词： Advertising Aged Ageism China Food Healthy aging Marketing Stereotypes

Functional diversity in an Andean subparamo affected by wildfire in Colombia

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Plant Diversity 2023年第4期45卷 385-396页

作者： Korina Ocampo-Zuleta angela Parrado-Rosselli Instituto de Ciencias Ambientales y Evolutivas.Facultad de Ciencias.Universidad Austral de Chile.Campus Isla Teja 5090000 ValdiviaChile Programa de Doctorado en Ciencias Mencion Ecología y Evolucion Escuela de GraduadosFacultad de CienciasUniversidad Austral de ChileValdiviaChile Jardín Botanico de Bogota Jose Celestino Mutis Subdireccion CientíficaLínea de Investigacion en Restauracion Ecologica111071BogotaColombia Facultad del Medio Ambiente y Recursos Naturales Universidad Distrital Francisco Jose de CaldasSede Vivero111711BogotaColombia

Recently,the Andean subparamo in Colombia has experienced severe wildfires,but little is known about the functional composition of recovering or not after a ***,we examined the functional community composition subparamo affected byfire in *** documented how functional traits changed 31 months after the disturbance and compared them with an unburned *** sampled from one to two years after the fire every four months,then registered all recruits in 1655m *** individuals were classified into strategy functional groups based on the traits of persistence and *** first group was stem type and regeneration mechanism(seedling and resprout),and the second was fruit type and dispersal *** investigated the degree to which functional diversity changes plant communities over time(woody and non-woody),and we compared it with an unburned *** most relevant results showed that resprouts and seed regenerated increased post-fire time and significant differences between sampling *** anemochory is the most relevant dispersal mode that indicates the community capacity to colonize the new gaps opened by the fire *** discuss how wildfire appears to be a triggering factor for persistence and dispersal strategy groups in subparamo burned given their characteristics of tolerance to *** this reason,a greater functional divergence between the ecosystems studied post-fire recovery has been related to higher levels of biodiversity at the landscape scale due to the high degree of endemism and significant differences in species composition between paramos.

关键词： Subparamo Cerro aguanoso Dispersal mode Functional traits Postfire regeneration

Combination therapy of dabrafenib plus trametinib in patients with BRAF^(V600E)-mutated biliary tract cancer

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 506-507页

作者： Alessandro Rizzo angela Dalia Ricci Giovanni Brandi Division of Oncology Azienda Ospedaliero-Universitaria di Bolognavia Albertoni 15BolognaItaly

To the Editor: In the last decade, next-generation sequencing(NGS)-based molecular profiling has shed light on the molecular landscape of biliary tract cancer(BTC), revealing the presence of several potentially actionable mutations [1]. According to Clinical ***, there are at least 40 phase I to IV ongoing trials aimed at evaluating the role of targeted treatments in BTC, as monotherapy or in combination with other anticancer agents [2]. Early encouraging results have been observed with therapies targeting IDH mutations, FGFR fusions, HER family and, more recently, BRAF mutations [3].

关键词： BRAF cancer Clinical

Lithium:from mood stabilizer to putative cognitive enhancer

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Neural Regeneration Research 2016年第8期11卷 1234-1235页

作者： Adele Quartini angela Iannitelli Giuseppe Bersani Department of Medical-Surgical Sciences and Biotechnologies Faculty of Pharmacy and Medicine-"Sapienza" University of RomeDSM ASL/LT-Unit of Psychiatry"A.Fiorini" Hospital

The monovalent cation lithium,whose introduction in psychiatry dates back at the end of the 1940s,remains the first-line agent in the management of patients with bipolar disorder（BD）.It is effective in the treatment of moderate-to-severe acute mania,prophylactic for recurrent manic and depressive episodes,and reduces the risk of suicide.

关键词： lithium stabilizer enhancer mania bipolar moderate neurotrophic putative boost cortex

Mutations of the AAAS gene in an Indian family with Allgrove's syndrome

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World Journal of Gastroenterology 2006年第29期12卷 4764-4766页

作者： Ashis Mukhopadhya Sumita Danda angela Huebner Ashok Chacko Department of Gastrointestinal Sciences Christian Medical College VelloreIndia Children's Hospital Technical University Dresden Germany

The triple A or AIIgrove＇s syndrome is an autosomal recessive disorder characterized by the triad of achalasia cardia, alacrima and ACTH resistant adrenocortical insufficiency. Mutations of the Achalasia-AddisonianismAlacrima-Syndrome （AAAS） gene on chromosome 12q13 are associated with this syndrome. We report an Indian family where two siblings were homozygous for a known mutation of the AAAS gene and presented with the classical triad of symptoms. The mother and the brother were heterozygous and asymptomatic. The affected siblings had iron deficiency anemia and the younger sister had pes cavus and palmoplantar keratosis. Neurological symptoms were absent in both affected children. Recognition of this syndrome can lead to early treatment of adrenal insufficency and genetic counselling.

关键词： Allgrove's syndrome Triple A syndrome Autosomal recessive Genetic mutation India

Mitochondrial transcription factor A （TFAM）： one actor for different roles

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Frontiers in Biology 2012年第1期7卷 30-39页

作者： angela M. S. LEZZA Department of Biochemistry and Molecular Biology ＇E. Quagliariello University of Bari Aldo Moro Bari Italy

Mitochondrial Transcription Factor A （TFAM） is a nuclear-encoded factor present in mitochondria from allkinds of animals, even with a homologous form in yeast, which has strongly and progressively gained an eminent relevance in the regulation of mitochondrial DNA （mtDNA） functions. This is due to the various functions performed by the protein, which cover a very wide scenario including： replication, transcription, maintenance and eventually repair of mtDNA molecules. In consideration of so many different roles it plays, it can be understood there is a deep interest in its regulation of expression and activity as well as its eventual involvement in pathologies related to a decreased functionality/presence of the mitochondrial genome and the consequences of TFAM induced overexpression.

关键词： TFAM mtDNA transcription replication and maintenance

Rebuilding trust in proton pump inhibitor therapy

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World Journal of Gastroenterology 2022年第24期28卷 2667-2679页

作者： Alla Turshudzhyan Sonia Samuel angela Tawfik Micheal Tadros Department of Medicine University of ConnecticutFarmingtonCT 06030United States Department of Medicine Albany Medical CollegeAlbanyNY 12208United States Guilderland High School Guilderland CenterAlbanyNY 12085United States Department of Gastroenterology and Hepatology Albany Medical CollegeAlbanyNY 12208United States

Introduction of proton pump inhibitor(PPI)therapy into clinical practice has revolutionized treatment approach to acid-related *** its clinical success came a widespread use of PPI ***,several studies found that PPIs were oftentimes overprescribed in primary care and emergency setting,likely attributed to seemingly low side-effect profile and physicians having low threshold to initiate ***,now there is a growing concern over PPI side-effect profile among both patients and *** would like to bring more awareness to the currently available guidelines on PPI use,discuss clinical indications for PPIs and the evidence behind the reported *** hope that increased awareness of proper PPI use will make the initiation or continuation of therapy a well informed and an evidence-based decision between patient and *** also hope that discussing evidence behind the reported side-effect profile will help clarify the growing concerns over PPI therapy.

关键词： Proton pump inhibitor Side-effects Gastro-esophageal reflux disease Therapy