检索结果-南通市图书馆

Multi-level governance through adaptive co-management:conflict resolution in a Brazilian state park

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2014年第1期3卷 201-213页

作者： Barbara Schroter Karla Sessin-Dilascio Claas meyer Bettina Matzdorf Claudia Sattler angela meyer Gregor Giersch Camila Jerico-Daminello Lukas Wortmann Leibniz Centre for Agricultural Landscape Research(ZALF) Institute of Socio-EconomicsEberswalder Straβe 8415374 MünchebergGermany Instituto de Eletrotecnica e Energia(IEE)da Universidade de São Paulo(USP) Servico Tecnico AcademicoSecretaria de Pos GraduacaoAvenida Professor Luciano Gualberto1289Cidade Universitaria05508-010 Sao PauloSPBrazil Organisation for International Dialogue and Conflict Management(IDC) Kaiserstrasse 50/6Vienna 1070Austria

Introduction:Communities situated in protected areas generate conflicts among park administrators,residents and *** they stay or should they go?This article presents a positive example of a community existing in a state *** study describes the community’s governance process as well as how the park administration and the community solve the conflicts that arise and achieve a method of co-management in a multi-level governance ***:The analysis is based on the Management and Transition Framework(MTF).We used a case study approach and collected data via document study,participatory observation and qualitative ***:We find that the agreed system of community-based co-management has improved the implementation and enforcement of the state park’s rules through negotiation and communication mechanisms in the park *** relative success is due to the construction of social capital,equality and ***:For state parks in similar situations,the findings suggest that:1)a community should have at least a minimal level of self-organization;2)the empowerment of the community in the decision-making process is useful;3)the park administration should gain the trust of the residents;and 4)the effective management of ecosystem services can create a win-win situation for the community as well as the park.

关键词： Management of ecosystem services Social capital Protected areas Communities Latin America

Understanding activity of butyrate at a cellular level

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty angela S.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

维普期刊数据库

Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

维普期刊数据库

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

维普期刊数据库

Role of lipid rafts in liver health and disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第20期17卷 2520-2535页

作者： angela Dolganiuc Department of Medicine University of Massachusetts Medical School

Liver diseases are an increasingly common cause of morbidity and mortality; new approaches for investigation of mechanisms of liver diseases and identification of therapeutic targets are emergent. Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver cells, parenchymal and non-parenchymal; more importantly, LRs are active participants in multiple physiological and pathological conditions in individual types of liver cells. This article aims to review experimental-based evidence with regard to LRs in the liver, from the perspective of the liver as a whole organ composed of a multitude of cell types. We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases.

关键词： Hepatocytes Stellate cells Kupffer cells Endothelial cells Signaling Therapeutic Viral HepatitisC virus Metabolism

A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2019年第1期6卷 3-4页

作者： Jianbin Wang angela Wu School of Life Sciences Tsinghua University Division of Life Science Hong Kong University of Science and Technology Department of Chemical and Biological Engineering Hong Kong University of Science and Technology

Today, many next-generation sequencing (NGS) methods, technologies and platforms have been developed that allow users to produce Tera base pairs of data in less than one day or ultralong reads covering multiple genes. By far the most popular NGS approach to date is cyclic sequencing-by-synthesis (SBS),whereby each DNA template’s complementary strand is synthesized by DNA polymerase and, as the new strand grows base by base, the identity of each

关键词： A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

In vitro and in vivo models of acute alcohol exposure

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第10期15卷 1168-1177页

作者： angela Dolganiuc Gyongyi Szabo Department of Medicine University of Massachusetts Medical School 364 Plantation Street Worcester MA 01605-2324 United States

Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifi es their suitability for biomedical research.

关键词： Models Acute alcohol abuse Human Nonhuman Progress

Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 299-300页

作者： angela M.Otto Munich Institute of BioEngineering Technical University of Munich85748 GarchingGermany

Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of glucose availability in ***,a small metabolite of the glycolytic pathway,dihydroxyacetone phosphate,has been identified by Sabatini and his coworkers,who show how mTORC1-activity is regulated in glucose-starved and replenished cancer cells.

关键词： metabolism cancer mTORC1

How Africa Is Promoting Agricultural Innovations and Technologies amidst the COVID-19 Pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2020年第10期13卷 1345-1346页

作者： angela Joseph Fernando Consultant-The Alliance of Bioversity International and CIAT Km 17 Recta Cali-PalmiraApartado Aéreo 6713763537 CaliColombia

The COVID-19 pandemic has left an indelible mark on Africa's Agribusiness *** of households whose livelihoods depend on farming are facing a huge food *** mitigate these effects,the African Agricultural Technology Foundation(AATF)gathered a panel of renowned agricultural experts through an interactive webinar themed"Promotion of Agricultural Technologies and Innovations for Agri-Business Resilience in Africa in the Wake of COVID-19",the first in a series of several interactive seminars to be held virtually until the end of December *** seminars will focus on several topics specific to agricultural transformation,which revolve around smallholder farmers in Sub-Saharan Africa(SSA)and aim to help them come out of the cataclysmic effect of COVID-19 and recover their business and livelihoods.

关键词： Agricultural Africa interactive