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Renal-function change after transjugular intra-hepatic portosystemic shunt placement and its relationship with survival:a single-center experience

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Gastroenterology Report 2021年第4期9卷 306-312,I0001,I0002页

作者： Min lang angela l.lang Brian Q.Tsui Weiping Wang Brian K.Erly Bo Shen Baljendra Kapoor Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Anesthesia Critical Careand Pain ManagementMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Radiology UCLA Medical CenterLos AngelesCAUSA Department of Radiology Mayo ClinicJacksonvilleFLUSA Colorado School of Public Health AuroraColoradoUSA The Inflammatory Bowel Disease Center at Columbia Columbia University Irving Medical CenterNew YorkNYUSA Division of Vascular and Interventional Radiology Imaging InstituteCleveland ClinicClevelandOHUSA

Background:The effect of transjugular intra-hepatic portosystemic shunt(TIPS)placement on renal function and the correlation of post-TIPS Cr with mortality remain *** study aimed to assess the effect of TIPS placement on renal function and to examine the relationship between post-TIPS Cr and mortality ***:A total of 593 patients who underwent de novo TIPS placement between 2004 and 2017 at a single institution were included in the *** pre-TIPS Cr level(T0;within 7 days before TIPS placement)and post-TIPS Cr levels,at 1–2 days(T1),5–12 days(T2),and 15–40 days(T3),were *** of Cr change after TIPS placement and the 1-year mortality rate were analysed using multivariable linear-regression and Cox proportional-hazards models,***:Overall,21.4%of patients(n=127)had elevated baseline Cr(≤1.5 mg/dl;mean,2.5161.49 mg/dl)and 78.6%(n=466)had normal baseline Cr(l;mean,0.9260.26 mg/dl).Patients with elevated pre-TIPS Cr demonstrated a decrease in post-TIPS Cr(difference,-0.60 mg/dl),whereas patients with normal baseline Cr exhibited no change(difference,l).The 30-day,90-day,and 1-year mortality rates were 13%,20%,and 32%,*** bleeding as a TIPS-placement indication(hazard ratio=1.731;P=0.036),higher T0 Cr(hazard ratio=1.834;P=0.012),and higher T3 Cr(hazard ratio=3.524;Plity ***:TIPS placement improved renal function in patients with baseline renal dysfunction and the post-TIPS Cr level was a strong predictor of 1-year mortality risk.

关键词： TIPS transjugular intra-hepatic portosystemic shunt portal hypertension renal function renal failure mortality

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Purinergic signaling systems across comparative models of spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 2391-2398页

作者： Eva E.Stefanova angela l.Scott Department of Pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Within the last several decades,the scientific community has made substantial progress in elucidating the complex pathophysiology underlying spinal cord ***,despite the many advances using conventional mammalian models,both cellular and axonal regeneration following spinal cord injury have remained out of *** this sense,turning to non-mammalian,regenerative species presents a unique opportunity to identify pro-regenerative cues and chara cterize a spinal cord microenvironment permissive to *** the signaling pathways hypothesized to be dysregulated during spinal cord injury is the purinergic signaling *** addition to its well-known role as energy currency in cells,ATP and its metabolites are small molecule neurotransmitte rs that mediate many diverse cellular processes within the central nervous *** our unde rstanding of the roles of the purinergic system following spinal cord injury is limited,this signaling pathway has been implicated in all injury-induced secondary processes,including cellular death,inflammation,reactive gliosis,and neural *** that the purinergic system is also evolutionarily conserved between mammalian and non-mammalian species,comparisons of these roles may provide important insights into conditions responsible for recovery ***,we compare the secondary processes between key model species and the influence of purinergic signaling in each *** our understanding of this signaling system and pro-regenerative conditions continues to evolve,so does the potential for the development of novel therapeutic interventions for spinal cord injury.

关键词： cell death differenriation glia inflammation neurogenesis proliferation purinergic signaling reactive gliosis regeneration spinal cord injury teleost

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New generations of dihydropyridines for treatment of hypertension

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Journal of Geriatric Cardiology 2017年第1期14卷 67-72页

作者： angela l Wang Costantino Iadecola Gang Wang Premed Program Washington University in St. Louis St. Louis MO USA Feil Brain and Mind Research Institute Weill Cornell Medicine New York NY USA

Since the calcium channel blocker （CCB） has become one of the most prescribed agents for antihypertensive monotherapy in the world, this brief review will focus on the recent research and development of the dihydropyridine （DHP） CCB, addressing pharmacological mecha- nisms for the clinical efficacy of the third and fourth generations of the DHP CCBs, especially on their possible central mechanisms underlying lowering blood pressure.

关键词： Central nervous system Dihydropyridine Hypertension Voltage-gated calcium channel blocker

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Economic optimization of resource-constrained project scheduling:a two-phase metaheuristic approach

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 481-494页

作者： angela H.l.CHEN Chiuh-Cheng CHYU Department of Industrial Engineering and Management Yuan Ze University Department of Finance Nanya Institute of Technology

This paper deals with the problem of project scheduling subject to multiple execution modes with non-renewable resources, and a model that handles some of monetary issues in real world *** objective is to schedule the activities to maximize the expected net present value(NPV) of the project, taking into account the activity costs, the activity durations, and the cash flows generated by successfully completing an *** to the combinatorial nature of this problem, the current study develops a hybrid of branch-and-bound procedure and memetic algorithm to enhance both mode assignment and activity *** for the makespan minimization problem have been made through a set of benchmark problem *** performance is rated on the maximization of the project NPV and computational results show that the two-phase hybrid metaheuristic performs competitively for all instances of different problem sizes.

关键词： Memetic algorithm(MA) Branch and bound(B&B) algorithm Net present value(NPV) Project scheduling problem

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A quaternion-based simulation of multirotor dynamics

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International Journal of Modeling, Simulation, and Scientific Computing 2015年第1期6卷 145-162页

作者： Valeria Artale Cristina l.R.Milazzo angela Ricciardello Kore University of Enna Faculty of Engineering and Architecture Cittadella Universitaria 94100EnnaItaly

The main problem addressed in this paper is the quaternion-based trajectory control of a microcopter consisting of six rotors with three pairs of counter-rotating fixed-pitch blades,known as *** the hypothesis of rigid body condition is assumed,the Newton–Euler equations describe the translational and rotational motion of the *** standard Euler-angle parametrization of three-dimensional rotations contains singular points in the coordinate space that can cause failure of both dynamical model and *** order to avoid singularities,all the rotations of the microcopter are thus parametrized in terms of quaternions and an original proportional derivative(PD)regulator is proposed in order to control the dynamical *** simulations will be performed on symmetrical flight configuration,proving the reliability of the proposed PD control technique.

关键词： Newton-Euler equation quaternion UAV control

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Context-dependent insect predation pressure on an avian ectoparasite

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Insect Science 2023年第6期30卷 1784-1797页

作者： angela Salido Jesús Veiga Joaquín luis Reyes-lópez Francisco Valera Department of Botany Ecology and Plant PhysiologyUniversity of CórdobaCórdobaSpain Departamento de Ecología Funcional y Evolutiva Estación Experimental de ZonasÁridas(EEZA-CSIC)AlmeríaSpain Department of Parasitology University of GranadaGranadaSpain MEMEG Department of BiologyLund UniversityLundSweden

Context dependence arises when ecological relationships vary with the conditions under which they are observed. Context dependence of interactions involving parasites is poorly known, even if it is key to understanding host–parasite relationships and food web dynamics. This paper investigates to which extent predation pressure on an avian ectoparasite (Carnus hemapterus) is context-dependent. Based on a predator-exclusion experiment, predation pressure on C. hemapterus pupae in the host's nest for 3 years, and its variation between habitat types are quantified. Variation in precipitation and normalized difference vegetation index (NDVI) is also explored as a likely cause of context dependency. We hypothesize that predation pressure should fluctuate with such surrogates of food availability, so that inter-annual and intra-annual differences may emerge. The number of nests with significant reduction of pupae varied widely among years ranging from 24% to 75%. However, average pupae reduction in nests where a significant reduction occurred did not vary between years. No differences in predation rates between habitat types were detected. Precipitation and NDVI varied widely between years and NDVI was consistently lower around nests on cliffs than around nests on trees and farmhouses. Parallels were found between variation in predation pressure and precipitation/NDVI at a wide scale (highest predation the driest year, and much lower the 2 rainier ones), but not at the nest scale. This paper shows clear context-dependent insect predation pressure on an ectoparasite under natural conditions, and that such interaction changes in signs rather than magnitude between years. The causes for these variations require longer-term studies and/or well-designed, large-scale experiments.

关键词： ants arid areas Carnus hemapterus consumer-resource interaction ecosys-tem productivity predator-parasite rainfall

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Prickly pairs: the proportion of spinescent species does not differ between islands and mainlands

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Journal of Plant Ecology 2019年第6期12卷 941-948页

作者： Floret l.Meredith Marianne l.Tindall Frank A.Hemmings angela T.Moles Evolution and Ecology Research Centre School of BiologicalEarth and Environmental SciencesUNSW AustraliaSydneyNSW 2052Australia John T.Waterhouse Herbarium School of BiologyEarth and Environmental SciencesUNSW AustraliaSydneyNSW 2052Australia

Aims Organisms on islands are thought to escape biotic pressure and lose defensive ***,broadscale,evidence-based tests of this idea are *** this study,we asked:(i)whether the proportion of spinescent plant species differed between islands and mainlands and(ii)whether the proportion of spinescent species increased with increasing island area and with decreasing island distance to *** We compiled species lists for 18 island–mainland pairs around *** classified 1129 plant species as spinescent or nonspinescent using published species *** Findings There was no significant difference between the proportion of spinescent species found on islands and on *** of spinescent species were not significantly related to island area or distance to *** results suggest that spinescence is just as important to island plants as it is to mainland plants,even for plants inhabiting small or distal *** is unexpected,given prevailing thought and previous work on island–mainland *** study demonstrates the importance of testing well-accepted yet untested ideas.

关键词： herbivory island biogeography theory physical defence plant community plant defence prickles thorns

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Management of cytomegalovirus corneal endotheliitis

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Eye and Vision 2021年第1期8卷 18-30页

作者： angela H.Y.Wong Wee Nie Kua Alvin l.Young Kelvin H.Wan Department of Ophthalmology Tuen Mun HospitalHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina

Background:Cytomegalovirus(CMV)can manifest as corneal endotheliitis in immunocompetent *** diagnosis is prudent to prevent endothelial cell loss,which could ultimately lead to corneal *** DNA was first detected in an eye with corneal endotheliitis in 2006;since then,clinical evidence from numerous case reports and case series have *** text:In this narrative review,we identified several drugs,including ganciclovir,valganciclovir,and their combination in oral,intravenous,intravitreal,and topical forms in different concentrations,together with the judicious use of topical steroids,have reported variable *** has yet to be any prospective comparative study evaluating the efficacy and safety of these assorted forms of treatment;clinical evidence is based on case reports and case *** endotheliitis presenting with corneal edema can masquerade as other corneal diseases and thus poses a great challenge especially in post-keratoplasty *** awareness is needed before and after keratoplasty to start prompt prophylaxis and ***:There is no consensus on the management of CMV *** studies are much needed to elucidate the optimal treatment modality,regime,and duration in the treatment and prophylaxis of CMV endotheliitis.

关键词： Cytomegalovirus CMV Endotheliitis Keratoplasty Corneal transplant Cornea

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The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design

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Journal of Sport and Health Science 2021年第4期10卷 499-506页

作者： Kimberley l.Way angela S.lee Stephen M.Twigg Nathan A.Johnson Faculty of Medicine and Health Discipline of Exercise and Sports ScienceUniversity of SydneyLidcombeNSW 2141Australia Charles Perkins Centre University of SydneyCamperdownNSW 2006Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia Faculty of Medicine and Health Central Clinical SchoolUniversity of SydneyCamperdownNSW 2006Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia

Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this *** aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with ***,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic ***,the effect of HIIE on the aforementioned outcomes in people with diabetes is not *** purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned ***:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over *** participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 ***:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON *** was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for *** all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of

关键词： Augmentation index Central systolic blood pressure Diabetes High-intensity interval exercise

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Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease

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World Journal of Gastroenterology 2021年第42期27卷 7350-7361页

作者： David Bernstein Nitzan Roth angela Kim Marica Epstein David Hirschwerk Charlotte l Kvasnovsky Sanjaya K Satapathy Department of Medicine/Hepatology Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious Diseases Department of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical Center Zucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States

BACKGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.

关键词： COVID-19 liver enzymes Outcomes Predictors

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