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Alternative feedstock for the production of activated carbon with ZnCl_(2):Forestry residue biomass and waste wood

Carbon Resources Conversion 2022年第4期5卷 299-309页

作者： Dominik Bosch Jan OBack David Gurtner Sara Giberti angela hofmann Anke Bockreis Josef Ressel Centre for Production of Activated Carbon from Municipal Residues Department of EnvironmentalProcess and Energy EngineeringMCI–The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Unit of Environmental Engineering Department for InfrastructureUniversity of InnsbruckTechnikerstrasse 136020 InnsbruckAustria Department of Environmental Process and Energy EngineeringMCI–The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Institute for Chemical and Energy Engineering BOKU-University of Natural Resources and Life ScienceGregor-Mendel-Strasse 331160 ViennaAustria Department of Civil ChemicalEnvironmentaland Materials EngineeringUniversit`a di BolognaVia Zamboni 3340126 BolognaItaly

In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw *** with important wood industries offer two potentially underestimated resource types:forestry residue biomass(FRB)and waste wood(WW).Although these materials are widely available(approx.130 mio.m3a-1 FRB,approx.50 ***^(-1) WW in the EU),they are mostly valorised through energy production,as they are high in ashes and may be contaminated with organics and heavy *** this study,both FRB and WW were treated via one-step pyrolysis for AC ***_(2) was applied as activating agent at pyrolysis temperatures varying from 400 to 600℃ and residence times between 1 and 3 ***,76 samples were prepared and characterized thoroughly via elemental analysis,N_(2)/CO_(2) ad/-desorption,thermogravimetric analysis(TGA),scanning electron microscopy(SEM),and infrared spectroscopy(FTIR).The produced carbons showed specific surface areas of up to 1430 m2g􀀀1 and a pore size distribution with a micropore share of up to 80%.The presence of oxygen-containing functional groups was confirmed via *** feedstock contamination can be mitigated,as minerals and heavy metals could be leached out(up to-99.15%)by an additional wash step and organic contamination undergoes thermal cracking during *** presented study could be a next step in upcycling considerable waste streams from the wood sector through localised and non-fossil-based AC production.

关键词： Sustainable resources Waste wood Forestry residue Activated carbon Chemical activation Pyrolysis Porosity Functionalized surface

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Corrigendum to“Alternative feedstock for the production of activated carbon with ZnCl2:Forestry residue biomass and waste wood”[Carbon ***.5(2022)299-309]

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Carbon Resources Conversion 2023年第1期6卷 65-66页

作者： Dominik Bosch Jan O.Back David Gurtner Sara Giberti angela hofmann Anke Bockreis Josef Ressel Centre for Production of Activated Carbon from Municipal Residues Department of EnvironmentalProcess and Energy EngineeringMCI-The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Unit of Environmental Engineering Department for InfrastructureUniversity of InnsbruckTechnikerstrasse 136020 InnsbruckAustria Department of Environmental Process and Energy EngineeringMCI-The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Institute for Chemical and Energy Engineering BOKU-University of Natural Resources and Life ScienceGregor-Mendel-Strasse 331160 ViennaAustria Department of Civil ChemicalEnvironmentaland Materials EngineeringUniversit`a di BolognaVia Zamboni 3340126 BolognaItaly

The authors regret that there was a mix-up in the illustrations during the approval *** is the correct image for Fig.4:The authors would like to apologise for any inconvenience caused.

关键词： approval process. residue

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Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty angela S.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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Development of a sample preparation approach to measure the size of nanoparticle aggregates by electron microscopy

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Particuology 2019年第4期17卷 49-57页

作者： Agnieszka Dudkiewicz angela Lehner Qasim Chaudhry Kristian Molhave Guenter Allmaier Karen Tiede Alistair B.A. Boxall Peter hofmann John Lewis The Food and Environment Research Agency Sand Hutton York Y041 1LZ UK Department of Environment The University of York Heslington York YO10 5DD UK National Centre for Food Manufacturing The University of Lincoln Holbeach PE12 7AG UK Research Group Bio- and Polymer Analysis Institute of Chemical Technologies and Analytics TU Wien (Vienna University of Technology) Getreidemarkt 9 A-1060 Vienna Austria University of Chester Parkgate Road Chester CH1 4BJ UK Department of Micro and Nanotechnology Technical University of Denmark DTU Bldg 345b Lyngby 2800 Denmark Research Centre for Global Food Security and Ecosystems University of Hohenheim Wollgrasweg 43 70155 Stuttgart Germany Department of Geoinformatics - Z.GIS University of Salzburg Schillerstr. 30 A-5020 Salzburg Austria

Electron microscopy (EM) is widely used for nanoparticle (NP) sizing. Following an initial assessment of two sample preparation protocols described in the current literature as"unperturbed", we found that neither could accurately measure the size of NPs featuring a broad size distribution, e.g., aggregates. Because many real-world NP samples consist of aggregates, this finding was of considerable concern. The data showed that the protocols introduced errors into the measurement by either inducing agglomeration artefacts or providing a skewed size distribution towards small particles (skewing artefact). The focus of this work was to develop and apply a mathematical refinement to correct the skewing artefact. This refinement provided a much improved agreement between EM and a reference methodology, when applied to the measurement of synthetic amorphous silica NPs. Further investigation, highlighted the influence of NP chemistry on the refinement. This study emphasised the urgent need for greater and more detailed consideration regarding the sample preparation of NP aggregates to routinely achieve accurate measurements by EM. This study also provided a novel refinement solution applicable to the size characterisation of silica and c让rate-coated gold NPs featuring broad size distributions. With further research, this approach could be extended to other NP types.

关键词： Nanoparticles Aggregates Measurement Electron microscopy Sample preparation Artefacts

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Role of lipid rafts in liver health and disease

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World Journal of Gastroenterology 2011年第20期17卷 2520-2535页

作者： angela Dolganiuc Department of Medicine University of Massachusetts Medical School

Liver diseases are an increasingly common cause of morbidity and mortality; new approaches for investigation of mechanisms of liver diseases and identification of therapeutic targets are emergent. Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver cells, parenchymal and non-parenchymal; more importantly, LRs are active participants in multiple physiological and pathological conditions in individual types of liver cells. This article aims to review experimental-based evidence with regard to LRs in the liver, from the perspective of the liver as a whole organ composed of a multitude of cell types. We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases.

关键词： Hepatocytes Stellate cells Kupffer cells Endothelial cells Signaling Therapeutic Viral HepatitisC virus Metabolism

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A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

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National Science Review 2019年第1期6卷 3-4页

作者： Jianbin Wang angela Wu School of Life Sciences Tsinghua University Division of Life Science Hong Kong University of Science and Technology Department of Chemical and Biological Engineering Hong Kong University of Science and Technology

Today, many next-generation sequencing (NGS) methods, technologies and platforms have been developed that allow users to produce Tera base pairs of data in less than one day or ultralong reads covering multiple genes. By far the most popular NGS approach to date is cyclic sequencing-by-synthesis (SBS),whereby each DNA template’s complementary strand is synthesized by DNA polymerase and, as the new strand grows base by base, the identity of each

关键词： A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

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Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

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Signal Transduction and Targeted Therapy 2020年第1期5卷 299-300页

作者： angela M.Otto Munich Institute of BioEngineering Technical University of Munich85748 GarchingGermany

Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of glucose availability in ***,a small metabolite of the glycolytic pathway,dihydroxyacetone phosphate,has been identified by Sabatini and his coworkers,who show how mTORC1-activity is regulated in glucose-starved and replenished cancer cells.

关键词： metabolism cancer mTORC1

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How Africa Is Promoting Agricultural Innovations and Technologies amidst the COVID-19 Pandemic

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Molecular Plant 2020年第10期13卷 1345-1346页

作者： angela Joseph Fernando Consultant-The Alliance of Bioversity International and CIAT Km 17 Recta Cali-PalmiraApartado Aéreo 6713763537 CaliColombia

The COVID-19 pandemic has left an indelible mark on Africa's Agribusiness *** of households whose livelihoods depend on farming are facing a huge food *** mitigate these effects,the African Agricultural Technology Foundation(AATF)gathered a panel of renowned agricultural experts through an interactive webinar themed"Promotion of Agricultural Technologies and Innovations for Agri-Business Resilience in Africa in the Wake of COVID-19",the first in a series of several interactive seminars to be held virtually until the end of December *** seminars will focus on several topics specific to agricultural transformation,which revolve around smallholder farmers in Sub-Saharan Africa(SSA)and aim to help them come out of the cataclysmic effect of COVID-19 and recover their business and livelihoods.

关键词： Agricultural Africa interactive

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