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World Journal of Gastroenterology 2007年第5期13卷 804-805页

作者： angela Falco Dante Orlando Roberto Sciarra Luciano Sergiacomo Department of Internal Medicine "S. Massimo" Civil HospitalPenneItaly Department of Radiology "S. Massimo" Civil Hospital Penne Italy

Percutaneous radiofrequency thermal ablation （RFA） is an effective and safe therapeutic modality in the management of liver malignancies, performed with ultrasound guidance. Potential complications of RFA include liver abscess, ascites, pleural effusion, skin burn, hypoxemia, pneumothorax, subcapsular hematoma, hemoperitoneum, liver failure, tumour seeding, biliary lesions. Here we describe for the first time a case of biliary gastric fistula occurred in a 66-year old man with a Child＇s class A alcoholic liver cirrhosis as a complication of RFA of a large hepatocellular carcinoma lesion in the nl segment. In the light of this case, RFA with injection of saline between the liver and adjacent gastrointestinal tract, as well as laparoscopic RFA, ethanol injection （PEI）, or other techniques such as chemoembolization, appear to be more indicated than percutaneous RFA for large lesions close to the gastrointestinal tract.

关键词： Radiofrequency thermal ablation Hepatocellular carcinoma Biliary gastric fistula Complications

Unleashing strategies to mitigate methane emissions in rice fields and livestock systems

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Molecular Plant 2024年第12期17卷 1787-1790页

作者： Ezhilmathi angela Joseph Fernando Michael Selvaraj Jacobo Arango The Alliance of Bioversity International and International Center for Tropical Agriculture(CIAT) Km 17 Recta Cali-PalmiraApartado Aereo 6713763537 CaliColombia

The intense heatwaves of 2023 and 2024 underscored the serious health,food security,and well-being risks posed by extreme heat,emphasizing the urgent need to curb greenhouse gas(GHG)emissions,especially methane(CH_(4)),which is 28 times more potent than carbon dioxide and primarily emitted through agriculture,fossil fuels,and waste(*** Protection Agency,2024).Cattle alone contribute approximately 231 billion pounds of CH_(4)annually,and rice cultivation is expected to increase by 9.9 billion tonnes by 2050(*** Protection Agency,2020).To effectively address this challenge,it is essential to balance microbial processes involved in CH_(4)production with sustainable agricultural practices—such as cultivating low-emission rice varieties,leveraging methanotrophs,and adopting efficient,low-methane livestock diets—as highlighted by the American Academy of Microbiology’s Microbes&Climate Change colloquium(2022).Achieving the COP28 Global CH_(4)Pledge’s 30%reduction goal by 2030 necessitates prioritizing these strategies.

关键词： methane annually livestock

Combination therapy of dabrafenib plus trametinib in patients with BRAF^(V600E)-mutated biliary tract cancer

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 506-507页

作者： Alessandro Rizzo angela Dalia Ricci Giovanni Brandi Division of Oncology Azienda Ospedaliero-Universitaria di Bolognavia Albertoni 15BolognaItaly

To the Editor: In the last decade, next-generation sequencing(NGS)-based molecular profiling has shed light on the molecular landscape of biliary tract cancer(BTC), revealing the presence of several potentially actionable mutations [1]. According to Clinical ***, there are at least 40 phase I to IV ongoing trials aimed at evaluating the role of targeted treatments in BTC, as monotherapy or in combination with other anticancer agents [2]. Early encouraging results have been observed with therapies targeting IDH mutations, FGFR fusions, HER family and, more recently, BRAF mutations [3].

关键词： BRAF cancer Clinical

Functional diversity in an Andean subparamo affected by wildfire in Colombia

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Plant Diversity 2023年第4期45卷 385-396页

作者： Korina Ocampo-Zuleta angela Parrado-Rosselli Instituto de Ciencias Ambientales y Evolutivas.Facultad de Ciencias.Universidad Austral de Chile.Campus Isla Teja 5090000 ValdiviaChile Programa de Doctorado en Ciencias Mencion Ecología y Evolucion Escuela de GraduadosFacultad de CienciasUniversidad Austral de ChileValdiviaChile Jardín Botanico de Bogota Jose Celestino Mutis Subdireccion CientíficaLínea de Investigacion en Restauracion Ecologica111071BogotaColombia Facultad del Medio Ambiente y Recursos Naturales Universidad Distrital Francisco Jose de CaldasSede Vivero111711BogotaColombia

Recently,the Andean subparamo in Colombia has experienced severe wildfires,but little is known about the functional composition of recovering or not after a ***,we examined the functional community composition subparamo affected byfire in *** documented how functional traits changed 31 months after the disturbance and compared them with an unburned *** sampled from one to two years after the fire every four months,then registered all recruits in 1655m *** individuals were classified into strategy functional groups based on the traits of persistence and *** first group was stem type and regeneration mechanism(seedling and resprout),and the second was fruit type and dispersal *** investigated the degree to which functional diversity changes plant communities over time(woody and non-woody),and we compared it with an unburned *** most relevant results showed that resprouts and seed regenerated increased post-fire time and significant differences between sampling *** anemochory is the most relevant dispersal mode that indicates the community capacity to colonize the new gaps opened by the fire *** discuss how wildfire appears to be a triggering factor for persistence and dispersal strategy groups in subparamo burned given their characteristics of tolerance to *** this reason,a greater functional divergence between the ecosystems studied post-fire recovery has been related to higher levels of biodiversity at the landscape scale due to the high degree of endemism and significant differences in species composition between paramos.

关键词： Subparamo Cerro aguanoso Dispersal mode Functional traits Postfire regeneration

Lithium:from mood stabilizer to putative cognitive enhancer

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Neural Regeneration Research 2016年第8期11卷 1234-1235页

作者： Adele Quartini angela Iannitelli Giuseppe Bersani Department of Medical-Surgical Sciences and Biotechnologies Faculty of Pharmacy and Medicine-"Sapienza" University of RomeDSM ASL/LT-Unit of Psychiatry"A.Fiorini" Hospital

The monovalent cation lithium,whose introduction in psychiatry dates back at the end of the 1940s,remains the first-line agent in the management of patients with bipolar disorder（BD）.It is effective in the treatment of moderate-to-severe acute mania,prophylactic for recurrent manic and depressive episodes,and reduces the risk of suicide.

关键词： lithium stabilizer enhancer mania bipolar moderate neurotrophic putative boost cortex

Mutations of the AAAS gene in an Indian family with Allgrove's syndrome

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World Journal of Gastroenterology 2006年第29期12卷 4764-4766页

作者： Ashis Mukhopadhya Sumita Danda angela Huebner Ashok Chacko Department of Gastrointestinal Sciences Christian Medical College VelloreIndia Children's Hospital Technical University Dresden Germany

The triple A or AIIgrove＇s syndrome is an autosomal recessive disorder characterized by the triad of achalasia cardia, alacrima and ACTH resistant adrenocortical insufficiency. Mutations of the Achalasia-AddisonianismAlacrima-Syndrome （AAAS） gene on chromosome 12q13 are associated with this syndrome. We report an Indian family where two siblings were homozygous for a known mutation of the AAAS gene and presented with the classical triad of symptoms. The mother and the brother were heterozygous and asymptomatic. The affected siblings had iron deficiency anemia and the younger sister had pes cavus and palmoplantar keratosis. Neurological symptoms were absent in both affected children. Recognition of this syndrome can lead to early treatment of adrenal insufficency and genetic counselling.

关键词： Allgrove's syndrome Triple A syndrome Autosomal recessive Genetic mutation India

Mitochondrial transcription factor A （TFAM）： one actor for different roles

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Frontiers in Biology 2012年第1期7卷 30-39页

作者： angela M. S. LEZZA Department of Biochemistry and Molecular Biology ＇E. Quagliariello University of Bari Aldo Moro Bari Italy

Mitochondrial Transcription Factor A （TFAM） is a nuclear-encoded factor present in mitochondria from allkinds of animals, even with a homologous form in yeast, which has strongly and progressively gained an eminent relevance in the regulation of mitochondrial DNA （mtDNA） functions. This is due to the various functions performed by the protein, which cover a very wide scenario including： replication, transcription, maintenance and eventually repair of mtDNA molecules. In consideration of so many different roles it plays, it can be understood there is a deep interest in its regulation of expression and activity as well as its eventual involvement in pathologies related to a decreased functionality/presence of the mitochondrial genome and the consequences of TFAM induced overexpression.

关键词： TFAM mtDNA transcription replication and maintenance

Rebuilding trust in proton pump inhibitor therapy

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World Journal of Gastroenterology 2022年第24期28卷 2667-2679页

作者： Alla Turshudzhyan Sonia Samuel angela Tawfik Micheal Tadros Department of Medicine University of ConnecticutFarmingtonCT 06030United States Department of Medicine Albany Medical CollegeAlbanyNY 12208United States Guilderland High School Guilderland CenterAlbanyNY 12085United States Department of Gastroenterology and Hepatology Albany Medical CollegeAlbanyNY 12208United States

Introduction of proton pump inhibitor(PPI)therapy into clinical practice has revolutionized treatment approach to acid-related *** its clinical success came a widespread use of PPI ***,several studies found that PPIs were oftentimes overprescribed in primary care and emergency setting,likely attributed to seemingly low side-effect profile and physicians having low threshold to initiate ***,now there is a growing concern over PPI side-effect profile among both patients and *** would like to bring more awareness to the currently available guidelines on PPI use,discuss clinical indications for PPIs and the evidence behind the reported *** hope that increased awareness of proper PPI use will make the initiation or continuation of therapy a well informed and an evidence-based decision between patient and *** also hope that discussing evidence behind the reported side-effect profile will help clarify the growing concerns over PPI therapy.

关键词： Proton pump inhibitor Side-effects Gastro-esophageal reflux disease Therapy

Phenotypic ASCOD characterisations of ischaemic stroke in the young at an urban tertiary care centre

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Stroke & Vascular Neurology 2018年第4期3卷 209-214页

作者： angela Liu Mohsen Pirastehfar Daohai Yu Guillermo Linares Department of Neurology Washington University in St LouisSaint LouisMissouriUSA Department of Vascular Neurology UC San DiegoLa JollaCaliforniaUSA Department of Clinical Sciences Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPennsylvaniaUSA Department of Stroke and Neurocritical Care University of Vermont College of MedicineBurlingtonVermontUSA

Background and purpose Stroke in young individuals is a serious public health *** study aimed to characterise the various phenotypes of ischaemic stroke in a young urban population(≤50 years old)using the ASCOD classification system,which assigns a score to five stroke categories:atherosclerosis,small vessel disease(SVD),cardioembolism,other and *** each category,a numerical score represents the degree of causality attributed to the *** This retrospective study cohort was composed of patients from an urban tertiary care academic *** were selected by searching Get With the Guidelines database for adults≤50 years old with ischaemic *** study sample included 175 ischaemic strokes in 157 patients,with 16 subjects *** retrospective chart review,each stroke was scored according to the ASCOD classification *** logistic regression analyses were performed to explore each ASCOD category’s association with causal risk *** Of possible causal mechanisms,defined as receiving a grade 1 or 2,a cardiovascular aetiology was most prevalent(25.7%),followed by SVD(22.3%),and closely by atherosclerosis(21.1%).Of general phenotypes,defined as receiving a grade 1 or 2 or 3,atherosclerosis was the most prevalent(51.4%),followed by SVD(47.4%),cardioembolism(42.3%)and other(35.4%).31.6%of all strokes were of unclear *** between 45 and 50 years old were more likely to develop a cardioembolic or SVD stroke when compared with subjects<45 years *** This study took a novel approach to ASCOD phenotyping,allowing several observations:(1)In patients with advanced atherosclerosis receiving the score A1,the vast majority had systemic atherosclerosis in multiple vascular territories;(2)the cardiac score C2(6),defined as a radiographic pattern highly suggestive of a central embolic source,may overestimate the prevalence of true cardiac disease;(3)incidental laboratory findings may detec

关键词： ASCO character category

The number of alignments between two DNA sequences

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International Journal of Biomathematics 2016年第4期9卷 75-80页

作者： Helena Andrade Juan J. Nieto angela Torres Departamento de Andlisis Matemdtico Facultad de Matemdticas Universidad de Santiago de Compostela Spain Department of Mathematics Faculty of ScienceKing Abdulaziz University Jeddah 21589 Saudi Arabia Departamento de Psiquiatrla Radiologla y Salud Publica Facultad de Medicina Universidad de Santiago de Compostela Spain

We consider two DNA sequences and compare both sequences. One of the crucial issues in bioinformatics is to measure the similarity of two DNA sequences. To this purpose one has to consider different alignments between both sequences. The number of alignments grows very rapidly with the length of the sequences. In this paper we give exact, explicit and computable formulas for the number of different possible alignments and for some classes of reduced alignments. We provide a new insight into the theory of DNA sequence alignment.

关键词： DNA sequence alignment difference equation.