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Detection of Progesterone Receptor as a Method of Diagnosing Mammary Cancer in Female Dogs

Open Journal of Veterinary Medicine 2024年第8期14卷 217-227页

作者： José de Jesús Vázquez Pérez angel ramses figueroa hernandez Jorge Peregrina Sandoval Guillermo Nolasco Rodríguez Manuel Rosales Cortés Department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico Department of Cellular and Molecular Biology University Center for Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico

Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most common neoplastic disease in canines in Veterinary Medicine. Aim: Relate the expression of the receptor to progesterone (PR) with the tumor stage of canine mammary carcinoma. Material and Methods: Analytical-cross-sectional study, samples of paraffinized tumor tissue obtained from 30 canine patients with breast cancer were used. The expression of PR was performed by immunohistochemical labeling, using murine anti-PR (anti-PR Biocare brand). A descriptive analysis was carried out with the results using the SPSS program. Results: The predominant histological subtype of breast cancer was tubular carcinoma with 12 patients, followed by papillary cystic carcinoma with 6 patients, solid carcinoma 5, carcinosarcoma 4 and comedocarcinoma 3. There was a significant trend between breast cancer subtypes, histological grade G1. Among the histopathological findings, the degree of invasion is related to the presence of tumor cells in adjacent lymph nodes, which is why it is a prognostic indicator. The expression of PR in the tumor tissue samples it was 42.8% positive versus 57.14% negative, of which 75% correspond to G1, 8.3% to G2 and 16.6% to G3. With respect to the relationship of the expression of PR vs type of tumor, it was found that 50% correspond to tubular carcinoma, 33.3% to papillary cystic carcinoma, 8.3% to solid carcinoma and 8.3% to comedocarcinoma. Conclusion: The hormone receptor was negative in more than half of the patients and histological grade is significantly associated with tumor subtypes, this study emphasizes the need to introduce receptor testing into our routine clinical practice to offer the best treatment for breast cancer.

关键词： Cancer Mammary Gland Progesterone Immunohistochemistry Progesterone Membrane Receptor Component 1 (PGRMC 1)

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Clinical Parameters of Metabolic Control (HbA_(1c)) and Deterioration of Peripheral Arterial Perfusion in Type 2 Diabetes

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Journal of Diabetes Mellitus 2017年第1期7卷 31-39页

作者： Made Lourdes Zuniga-Martinez Yolanda Teran-figueroa Laura Escarlet Guerrero-Cruz angel Antonio Vertiz-hernandez Academic Coordination Altiplano Region Autonomous University of San Luis PotosiSan Luis PotosiMexico Faculty of Nursing and Nutrition Autonomous University of San Luis PotosiSan Luis PotosiMexico

Objective: To determine the relationship between clinical parameters (HbA1c) whit metabolic control and deterioration of peripheral arterial perfusion in diabetic patients. Methodology: 108 medical records of patients with type 2 diabetes mellitus were evaluated. We obtained averages of: blood glucose (162.3 ± 73.10 mg/dl), glycated hemoglobin (HbA1c = 7.64% ± 1.77%), cholesterol (189.28 ± 35.25 mg/dl), triglycerides (189.11 ± 87.76 mg/dl), Systolic Blood Pressure (SBP = 119.69 ± 14.95 mmHg), Diastolic Blood Pressure (DBP = 77.15 ± 9.55 mmHg) and Media Blood Pressure (MBP = 91.36 ± 9.89 mmHg). We correlated variable HbA1c with vascular injury symptomatology. Results: Correlation was found between sensitivity dysfunction and HbA1c with a statistical significance of p = 0.01, and a correlation Kendal coefficient w = 0.01, any other parameter of metabolic control was not correlated with symptoms of vascular injury. Conclusion: It is remarkable that the sensitivity dysfunction is a symptom of poorly vascularized lower extremities caused for both functional impairment and structural changes in diabetic patients’ peripheral nerves, even in the preclinical stage of vascular disease. The HbA1c could also be investigated as a likely sensitivity dysfunction biomarker in DM due to the correlation presented in this study but more studies must be realized.

关键词： Protein Glycation Vascular Disease HbA_(1c) Type 2 Diabetes Mellitus

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Recurrent and Invasive Primary Squamous Cell Carcinoma of the Chest Wall: A Case Report

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Surgical Science 2020年第8期11卷 209-215页

作者： Corona figueroa Alejandro angel García Rodríguez Francisco Mario Lorenzo Silva José Manuel Corona Padilla Alejandro Arnulfo Mancera Steiner Carlos González Chávez Alberto Manuel General Surgery Service Hospital Espa&ntilde ol de México México City México Oncology Surgery Service Hospital Espa&ntilde ol de México México City México Thoracic Surgery Service Hospital Espa&ntilde ol de México México City México Plastic Surgery Service Hospital Espa&ntilde ol de México México City México

Squamous cell carcinoma is a type of skin cancer with abnormal proliferation of keratinocytes. Its incidence reaches approximately 20% of cases of non-melanoma skin cancer, which has increased in recent decades due to growth in life expectancy, increased sun exposure, the use of tanning beds and improved detection of this type of tumors. We present a patient who was diagnosed with a squamous cell skin carcinoma in the chest wall, treated initially with surgical resection. A few years recurred in the same place, so the patient received radiotherapy with poor response. Ultimately a new surgical approach was performed with a wide margin resection by a multidisciplinary surgical team. Multidisciplinary management in this type of procedure is important so that the long-term result is optimal for the patient.

关键词： Squamous Cell Carcinoma Skin Cancer Chest Wall Tumor Oncological Sternectomy

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Analysis of Querétaro-Celaya Highway Applying Queueing Theory

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Journal of Traffic and Transportation Engineering 2018年第2期6卷 97-107页

作者： Gabriel Guzmán-Sáenz Salvador Hernández-González JoséAlfredo Jiménez-García Vicente figueroa-Fernández Miguel angel Melchor-Navarro Tecnológico Nacional de México en Minatitlán Minatitlán City96848Mexico Tecnológico Nacional de México en Celaya Celaya City38010Mexico

Querétaro-Celaya highway is the obligatory road to the center of Mexico;the establishment of new companies in the area has generated the need to study the dynamics of the vehicular flow that transits this *** that the flow of traffic on a highway is a stochastic phenomenon,it is necessary to apply tools that take into account the randomness of the system to measure *** theory models capture the random nature of the phenomenon and provide direct information about the relationship between the variables of the *** this work,the flow of vehicles on the Querétaro-Celaya highway is analyzed with a macroscopic approach and using analytical models of queueing theory;it is concluded that currently the flow on this road is *** method is an alternative for institutions that do not have specialized packages to carry out studies of this nature.

关键词： Traffic flow fundamental diagram queueing theory cycle time

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