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Cardiovascular risk factors and frontotemporal dementia: a case–control study

Translational Neurodegeneration 2014年第1期3卷 98-103页

作者： angel golimstok Nuria Cámpora Juan I Rojas María C Fernandez Cristina Elizondo Enrique Soriano Edgardo Cristiano Cognitive and Behavior Unit Department of NeurologyHospital Italiano de Buenos AiresPerón 42721411 Buenos AiresArgentina Department of Neurology Hospital Italiano de Buenos AiresBuenos AiresArgentina Epidemiology Department Hospital Italiano de Buenos AiresBuenos AiresArgentina

Cardiovascular risk factors(CRF)were widely described as related to *** are very few studies regarding this association in *** objective of the study was to compare the frequency of CRF in our population with FTD and controls.100 consecutive subjects with FTD diagnosis according to Lund-Manchester clinical criteria and 200 controls matched by age and sex were included between January 2003 to February 2007 at the Cognitive and Behavior Unit of Hospital Italiano de Buenos *** evaluation,laboratory tests,brain images(CT/MRI),neuropsychological and neuropsychiatric assessment were *** regression analysis was performed to analyze the association in CRF between FTD patients *** mean age in FTD was 69.7±0.9 vs.70.1±0.8 in controls(p 0.12).No difference in gender was observed between cases and *** differences were identified between patients and controls regarding hypertension(HTA)(65%vs.67,3%p 0.44);dyslipidemia(57%vs.54.7%p 0.74);obesity(39%vs.27.6%p 0.14)and hypothyroidism(26%vs.17.1%p 0.1).A significant difference was observed for Diabetes Mellitus(39%vs.22.6%p 0.001).In our population,Diabetes Mellitus was associated as an independent risk factor for *** our knowledge this is the first report in which CRF were evaluated prospectively in FTD *** studies are needed to confirm this finding in larger populations.

关键词： Cardiovascular risk factors Frontotemporal dementia Dementia FTD Diabetes DBT DM

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