Cardiovascular risk factors and frontotemporal dementia: a case–control study
作者机构：Cognitive and Behavior UnitDepartment of NeurologyHospital Italiano de Buenos AiresPerón 42721411 Buenos AiresArgentina Department of NeurologyHospital Italiano de Buenos AiresBuenos AiresArgentina Epidemiology DepartmentHospital Italiano de Buenos AiresBuenos AiresArgentina
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2014年第3卷第1期
页 面：98-103页
学科分类：0710[理学-生物学] 0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 1009[医学-特种医学] 10[医学]
基 金：Novartis Avanir Bayer Biogen Merck Teva
主 题：Cardiovascular risk factors Frontotemporal dementia Dementia FTD Diabetes DBT DM
摘 要：Cardiovascular risk factors(CRF)were widely described as related to *** are very few studies regarding this association in *** objective of the study was to compare the frequency of CRF in our population with FTD and controls.100 consecutive subjects with FTD diagnosis according to Lund-Manchester clinical criteria and 200 controls matched by age and sex were included between January 2003 to February 2007 at the Cognitive and Behavior Unit of Hospital Italiano de Buenos *** evaluation,laboratory tests,brain images(CT/MRI),neuropsychological and neuropsychiatric assessment were *** regression analysis was performed to analyze the association in CRF between FTD patients *** mean age in FTD was 69.7±0.9 vs.70.1±0.8 in controls(p 0.12).No difference in gender was observed between cases and *** differences were identified between patients and controls regarding hypertension(HTA)(65%vs.67,3%p 0.44);dyslipidemia(57%vs.54.7%p 0.74);obesity(39%vs.27.6%p 0.14)and hypothyroidism(26%vs.17.1%p 0.1).A significant difference was observed for Diabetes Mellitus(39%vs.22.6%p 0.001).In our population,Diabetes Mellitus was associated as an independent risk factor for *** our knowledge this is the first report in which CRF were evaluated prospectively in FTD *** studies are needed to confirm this finding in larger populations.
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