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Open Journal of Urology 2024年第8期14卷 447-457页

作者： Abdul-Jalilu Mohammed Muntaka Edwin Mwintiereh Ta-ang Yenli Francis Atindaana Abantanga Department of Surgery School of Medicine University for Development Studies Tamale Ghana Department of Surgery Tamale Teaching Hospital Tamale Ghana

Background: Benign prostatic hyperplasia (BPH) is the proliferation of the stromal and epithelial cells of the prostate gland, resulting in an increase in its size. This may result in obstruction of the lower urinary tract causing storage and voiding symptoms. Methods: This was a prospective cross-sectional study from August 2020 to July 2021, to evaluate the characteristic of patients presenting to the Tamale Teaching Hospital with lower urinary tract symptoms secondary to BPH. Results: The median age at presentation with LUTS secondary to BPH is 68.88 ± 11.10 years with an average prostate volume of 70 g. The average time of presentation to the hospital is 5 months, mostly with moderate to severe symptoms. Correlation between Prostate volume (PV) and age yielded a positive relationship;however, this was not statistically significant, (r = 0.028, p-value = 0.747). There was a significant positive relationship between PV and the IPSS score, (r = 0.334, p-value Conclusion: Our patients with symptomatic BPH present at age 60 years and above, with nearly all of them presenting with moderate to severe LUTS.

关键词： Benign Prostate Hyperplasia Lower Urinary Tract Symptoms Sociodemographic Characteristics

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基于六维语义空间的自动驾驶风险评估研究

通信学报 2024年第1期45卷 77-93页

作者：陈亚男李昂吴丹南京邮电大学通信与信息工程学院江苏南京210003 南京邮电大学空天地海通信技术一体化研究院江苏南京210003 陆军工程大学通信工程学院江苏南京210007

针对自动驾驶中风险要素提取不充分、风险场景评估鲁棒性低等问题,提出一种基于六维语义空间的风险评估框架,包括基于六维语义空间的风险要素提取和基于知识图谱的风险场景评估。前者构建六维语义空间并将RGB和红外数据映射其中,利用模... 详细信息

针对自动驾驶中风险要素提取不充分、风险场景评估鲁棒性低等问题,提出一种基于六维语义空间的风险评估框架,包括基于六维语义空间的风险要素提取和基于知识图谱的风险场景评估。前者构建六维语义空间并将RGB和红外数据映射其中,利用模态间的关联提取丰富的数据特征,以获得显在和潜在的风险要素。后者通过语义角色标注和实体融合将风险要素凝练为知识图谱,并联合节点补全和风险等级函数设计知识图谱推理方法,实现准确的风险评估。仿真结果表明,较现有的MSMatch和iSQRT-COV-Net方法,所提方法在准确率、漏/虚警率和处理时间上均有优势。

关键词：六维语义空间知识图谱风险要素风险评估自动驾驶汽车

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan ang Guo Sijo Mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations

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Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima Ricardo gutiérrez-Garcia David Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients

Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages

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Chinese Journal of Natural Medicines 2018年第11期16卷 856-865页

作者： ROSA MARTHA Pérez-gutiérrez SUSANA GABRIELA Enriquez-Alvirde Research Laboratory of Natural Products School of Chemical Engineering and Extractive Industries National Polytechnic Institute

The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products(AGEs) in vitro. Bioactivity-guided fractionation of chloroform extract from Hylocereus undatus afforded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12-en-28-oic acid(1) and 3β, 6β, 19α, 22α-tetrahydroxy-urs-12-en-28-oic acid(2), as well as four known triterpenes 2α, 3β, 23-tetrahydroxy-urs-11-en-28-oic acid(3), 3β-acetoxy-28-hydroxyolean-12-ene(4), 3β, 16α-dihidroxyolean-12-ene(5) and 3β-acetoxy-olean-12-ene(6). Our results revealed that triterpenes 1–3 were able to inhibit the formation of AGEs in all tested assays. The data indicated that the triterpenes had inhibitory activity at the múltiple stages of glycation and that there might be a high potential for decreasing protein oxidation and protein glycation that can enhance glycative stress in diabetic complications.

关键词： Hylocereus undatus Advanced glycation end product Triterpenes

Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVILLANO Javier PRECIADO-GARBAYO Jorge SEVIL Francisco gutiErrez Juan JMARTiNEZ Sonia MARTiN-LOPEZ Miguel GONZALEZ-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics Labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

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儒家教育主体间性思想及其当代启示

江汉论坛 2024年第7期 85-90页

作者：涂一昂湖北省社会科学院马克思主义研究所湖北武汉430077

在儒家教育主体间性思想中,人作为主体从不孤立存在,而是借助“仁”的情感价值牵引,在“礼”的交往规则调适下,与其他主体或认知对象共同构成一个相互尊重、共生共存的道德认知关系网络,达到万物并育、和合统一。透过其中蕴含的交互伦... 详细信息

在儒家教育主体间性思想中,人作为主体从不孤立存在,而是借助“仁”的情感价值牵引,在“礼”的交往规则调适下,与其他主体或认知对象共同构成一个相互尊重、共生共存的道德认知关系网络,达到万物并育、和合统一。透过其中蕴含的交互伦理性和人文性,我们可以一窥中华民族独特深厚的精神气质和德性基质,在现实中可用以完善教育理念、重塑教育伦理和充盈教育生态。在“两个结合”的不断引领之下,这种主体间性思想亦能迸发更多的理论潜力,开拓更广阔的应用空间。

关键词：主体间性儒家思想教育主体马克思主义

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吉金藏礼:浅谈中国古代礼祭文化与社会中的青铜器

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艺术品鉴 2024年第6期 92-97页

作者： Marian ang 不详

青铜器是中国文明起源的重要标志,跨越三千年,象征中国从原始时代迈向文明。本文趁“天人之际”开拍期间,研究古代青铜器在礼制和日常生活中扮演的角色。“青铜的耐用性使其成为中国早期艺术所有历史和现代理解的中心”。——克雷格·... 详细信息

青铜器是中国文明起源的重要标志,跨越三千年,象征中国从原始时代迈向文明。本文趁“天人之际”开拍期间,研究古代青铜器在礼制和日常生活中扮演的角色。“青铜的耐用性使其成为中国早期艺术所有历史和现代理解的中心”。——克雷格·克鲁纳斯。

关键词：古代青铜器吉金中国文明起源天人之际克雷格文化与社会耐用性礼制

Characteristics and close-range exploration methods of near- Earth asteroid 2016HO_(3)

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Astronomical Techniques and Instruments 2024年第1期1卷 42-51页

作者： He Zhang Fei Li Linzhi Meng Fuming Zeng Xiaoyu Jia Yu’ang Liu Beijing Institute of Spacecraft System Engineering Beijing 100094China

The characteristics of asteroids are vital parameters for planning asteroid exploration *** characteristics have been explored in close range for some typical asteroids,and are summarized in the *** allows estimates of the characteristics of asteroid 2016HO_(3),the target of the first Chinese asteroid exploration mission,Tianwen *** obtain 80 characteristic parameters in 9 categories and analyze their impacts on the *** comparing three close-range exploration modes,we provide advantages and disadvantages of each,and propose suitable methods for the exploration of 2016HO_(3).Owing to the weak gravity and small size of 2016HO_(3),a combination of multiple hovering positions and active orbiting is recommended for scientific exploration.

关键词： Near-Earth asteroid 2016HO_(3) Tianwen 2 Close-range exploration Characteristics

A 256 Gb/s electronic−photonic monolithically integrated transceiver in 45 nm CMOS

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Journal of Semiconductors 2024年第7期45卷 7-10页

作者： ang Li Qianli Ma Yujun Xie Yongliang Xiong Yingjie Ma Han Liu Ye Jin Menghan Yang Guike Li Haoran Yin Minye Zhu Yang Qu Peng Wang Daofa Wang Wei Li Liyuan Liu Nan Qi Ming Li Key Laboratory of Optoelectronic Materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

With the explosive development of artificial intelligence(AI),machine learning(ML),and high-performance comput-ing(HPC),the ever-growing data movement is asking for high density interconnects with higher bandwidth(BW),lower power and lower latency[1−3].The optical I/O leverages silicon photonic(SiPh)technology to enable high-density large-scale integrated photonics.

关键词： Gb/s transceiver monolithic