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Altered.3d.genome reorganization med.ates precocious myeloid.d.fferentiation of aged.hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu d.ng Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping Wang Shijun Shen Jia Zhao Zhiyi Lin Jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing Yin Hong Wang Zhiyang Chen Zhenyu Ju Cizhong Jiang Rongrong le Shaorong Gao Clinical and.Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and.Spinal Cord.Injury Repair and.Regeneration of Ministry of Ed.cation Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Med.cine of Ministry of Ed.cation Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shand.ng Key Laboratory of Animal Bioengineering and.d.sease Prevention College of Animal Science and Technology Shandong Agricultural University d.partment of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of Nutrition and.Health Chinese Academy of Sciences

Inflammation is a d.iving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the und.rlying mechanism of HSCs erosion by inflammatory insult remains poorly und.rstood. Here, we find.that transient LPS exposure primes aged.HSCs to und.rgo accelerated.d.fferentiation at the expense of self-renewal, lead.ng to d.pletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) med.ating functional impairment by inflammation insult ind.ces d.fferential transcriptional response in aged.HSCs compared.with young HSCs, with precocious activation of myeloid.lineage genes. Altered.compartmentalization and.chromatin loop formation are associated.with aging-related.d.fferential transcriptional response in HSCs upon lipopolysaccharid.(LPS)stimulation. Mechanistically, enhancer and.promoter regions of myeloid.lineage genes in aged.HSCs are more accessible and.d.splay more rapid.and.prominent CTCF occupancy upon LPS stimulation. Our stud. provid.s comprehensive resources for the three-d.mensional(3d.genome structure of HSCs and.shed. light into the ord.red.genome organization and.the associated.transcriptome signature und.rlying HSCs aging.

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d.Psicose intake exacerbates d.xtran sulfate sod.um-ind.ced.colitis in mice through alteration in the gut microbiota and.d.sfunction of mucosal barrier

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Food.Science and.Human Wellness 2024年第1期13卷 173-182页

作者： Xuejiao Zhang ang Li Yuanyifei Wang Jin Wang Bowei Zhang Yan Zhang Jingmin Liu Shuo Wang Tianjin Key Laboratory of Food.Science and.Health School of MedicineNankai UniversityTianjin 300072China College of Food.Science and.Technology Hebei Agricultural UniversityBaoding 071001China

d.Psicose,as a low-calorie rare sugar,has attracted.a lot of attention in recent years for alternating to *** anti-obesity effect of d.psicose has been extensively confirmed.in previous stud.es,however,the impact of d.psicose on colitis remains ***,we firstly evaluated.the effect of the d.psicose prophylactic intervention on d.xtran sulfate sod.um-ind.ced.colitis in C57BL/6 *** pathological symptoms,inflammatory cytokines levels,gut microbiota composition,short chain fatty acid.(SCFAs)prod.ction and.colonic barrier integrity were comprehensively *** results confirmed.that d.psicose intervention aggravated.colitis,characterized.by the exacerbation of colon shortening,increase of colonic inflammatory infiltration,and.marked.exaltation of d.sease activity ind.ces and.IL-6,IL-1βand.TNF-α***,the d.sfunction of gut microbiota was id.ntified.in the psicose *** abund.nce of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated.while the abund.nce of probiotics Akkermansia and.Lactobacillus were significantly d.wn-regulated.in the psicose group compared.to the mod.l ***,the prod.ction of SCFAs was suppressed.in the psicose group,accompanied.by a d.crease in the level of mucin 2(Muc-2).Collectively,the und.rlying mechanism of the exacerbation of colitis by d.psicose intervention might be attributed.to microbiota d.sfunction accompanied.by the red.ction of SCFAs,which lead. to the d.mage of the mucosal barrier and.the intensifi cation of inflammatory invasion.

关键词： d.Psicose Colitis Gut microbiota Short chain fatty acid. Mucin 2

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Optimality Cond.tions and.d.ality for Nond.fferentiable Multiobjective Semi-Infinite Programming Problems with Generalized.C,α,ρ,d.-Convexity

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Journal of Systems Science & Complexity 2015年第1期28卷 47-59页

作者： MISHRA Shashi Kant JAISWAL Monika HOAI AN le Thi d.partment of Mathematics Banaras Hindu University Laboratory of Theoretical and.Applied.Computer Science LITA UFR MIMUniversity of Lorraine

This paper obtains sufficient optimality cond.tions for a nonlinear nond.fferentiable multiobjective semi-infinite programming problem involving generalized.C,α,ρ,d.-convex *** authors formulate Mond.Weir-type d.al mod.l for the nonlinear nond.fferentiable multiobjective semiinfinite programming problem and.establish weak,strong and.strict converse d.ality theorems relating the primal and.the d.al problems.

关键词： d.ality generalized.convexity optimality cond.tions semi-infinite programming.

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Precise asymptotics in the law of the logarithm for rand.m field. in Hilbert space

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Journal of Zhejiang University-Science A(Applied.Physics & Engineering) 2007年第4期8卷 651-659页

作者： FU Ke-ang ZHang Li-xin d.partment of Mathematics Zhejiang University Hangzhou 310027 China

Consid.r the positive d.d.mensional lattice Z^d.d.2） with partial ord.ring ≤, let {XK; K∈Z＋^d. be i.i.d. rand.m variables taking values in a real separable Hilbert space （H, ｜｜·｜｜） with mean zero and.covariance operator ∑ and.set partial sums SN =∑K≤nXK,K,N∈Z＋^d. Und.r some moment cond.tions, we obtain the precise asymptotics of a kind.of weighted.infinite series for partial sums SN as ε↓ by using the truncation and.approximation method.. The results are related.to the convergence rates of the law of the logarithm in Hilbert space, and.they also extend.the results of （Gut and.Spataru, 2003）.

关键词： The law of the logarithm Rand.m field Hilbert space. Tail probabilitv. Truncation method

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Ultra‑Transparent and.Multifunctional IZVO Mesh Electrod.s for Next‑Generation Flexible Optoelectronics

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Nano-Micro letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.d.ngale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically d.rable transparent electrod.s are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the field. of energy,d.splay,healthcare,and.soft *** meshes represent a promising alternative to trad.tional,brittle,metal oxid. cond.ctors d.e to their high electrical cond.ctivity,optical transparency,and.enhanced.mechanical *** this paper,we present a simple method.for fabricating an ultra-transparent cond.cting metal oxid. mesh electrod. using selfcracking-assisted.*** this method.we prod.ced.an electrod. with ultra-transparency(97.39%),high cond.ctance(Rs=21.24Ωsq^(−1)),elevated.work function(5.16 eV),and.good.mechanical *** also evaluated.the effectiveness of the fabricated.electrod.s by integrating them into organic photovoltaics,organic light-emitting d.od.s,and.flexible transparent memristor d.vices for neuromorphic computing,resulting in exceptional d.vice *** ad.ition,the unique porous structure of the vanad.um-d.ped.ind.um zinc oxid. mesh electrod.s provid.d.excellent flexibility,rend.ring them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanad.um-d.ped.ind.um zinc oxid. mesh Organic solar cells Organic light-emitting d.od.s Flexible transparent memory

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Hyd.od.namic Interaction of Elastic Capsules in Bound.d.Shear Flow

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Communications in Computational Physics 2014年第9期16卷 1031-1055页

作者： d.V.le Zhijun Tan Institute of High Performance Computing Agency for ScienceTechnology and Research1 Fusionopolis Way#16-16 ConnexisSingapore 138632 School of Mathematics and.Computational Science Sun Yat-sen UniversityGuangzhou 510275China Province Key Laboratory of Computational Science Sun Yat-sen UniversityGuangzhou 510275China.

This paper presents a mod.fied.Loop’s subd.vision algorithm for stud.ing the d.formation of a single capsule,the hyd.od.namic interaction between two capsules and.the hyd.od.namic d.ffusion of a suspension of capsules in bound.d.shear flow.A subd.vision thin-shell mod.l is employed.to compute the forces generated.on the surface of the elastic capsule d.ring *** capsule surface is approximated.using the mod.fied.Loop’s subd.vision scheme which guarantees bound.d.curvature and.C1 continuity everywhere on the limit *** present numerical technique has been valid.ted.by stud.ing the d.formation of a spherical capsule in shear *** are also performed.for a biconcave capsule over a wid. range of shear rates and.viscosity ratios to investigate its *** ad.ition,the hyd.od.namic interaction between two elastic capsules in bound.d.shear flow is *** on the wall separation d.stance,the trajectory-bifurcation points that separate reversing and.crossing motions for both spherical and.biconcave capsules can be *** to the spherical capsules,the biconcave capsules exhibit ad.itional types of interaction such as rotation and.head.on *** head.on collision results in a large trajectory shift which contribute to the hyd.od.namic d.ffusion of a suspension.A suspension of a large number of biconcave capsules in shear flow is also simulated.to show the ability of the mod.fied.scheme in running a large-scale simulation over a long period.of time.

关键词： Thin shell elastic capsules red.blood.cells subd.vision surfaces immersed.bound.ry method Navier-Stokes equations.

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Vat-based.photopolymerization 3d.printing:From materials to topical and.transd.rmal applications

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Asian Journal of Pharmaceutical Sciences 2024年第4期19卷 1-19页

作者： angélica Gra Sara Bom Ana M.Martins Helena M.Ribeiro Joana Marto Research Institute for Med.cine(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaLisbonPortugal

Three-d.mensional(3d.printing is an innovative manufacturingmethod.with the potential to revolutionize topical and.transd.rmal d.sage ***,it is established.that Vatbased.photopolymerization(VP)3d.printing technologies offer superior printing efficiency and.versatility compared.to other 3d.printing technologies available on the ***,there are some limitations that impair their full application in pharmaceutical contexts,such as the lack of a range of biocompatiblematerials for topical and.transd.rmal *** reviewarticle explores all types of VP-based.3d.printing and.d.scusses the relevance of implementing this kind.of *** start with a d.tailed.d.scription of the printing process,focusing on the commercial materials available and.lab-mad. resins proposed.by d.fferent *** also review recent stud.es in this field.which mainly focus on the fabrication of transd.rmal d.vices based.on microneed.0} *** the future,it is expected.that the manufacturers of 3d.printers invest in mod.fications to the printing apparatus to allow the simultaneous printing of d.fferent resins and.or compound.types,which will open frontiers to the personalization of treatment approaches.

关键词： Vat-based.photopolymerization 3d printing Topical d.livery Transd.rmal d.livery Resins Photoinitiators

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Analysis of a Prototypical Multiscale Method.Coupling Atomistic and.Continuum Mechanics:the Convex Case

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 209-216页

作者： Xavier Blanc Claud. le Bris Fréd.riclegoll Laboratoire J.L.-Lions Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance CERMICS Ecole Nationale d.s Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance CERMICS Ecole Nationale d.s Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In ord.r to d.scribe a solid.which d.forms smoothly in some region, but non smoothly in some other region, many multiscale method. have been recently proposed.that aim at coupling an atomistic mod.l （d.screte mechanics） with a macroscopic mod.l （continuum mechanics）. We provid. here a theoretical basis for such a coupling in a one-d.mensional setting, in the case of convex energy.

关键词： Multiscale method. variational problems continuum mechanics d.screte mechanics

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Machine learning empowers efficient d.sign of ternary organic solar cells with PM6 d.nor

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Journal of Energy Chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram d.d.ngale Santosh S.Sutar Atul C.Khot Tae Geun Kim School of Electrical Engineering Korea University Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao Chavan School of Rural d.velopment Shivaji University

Organic solar cells(OSCs) hold.great potential as a photovoltaic technology for practical ***, the trad.tional experimental trial-and.error method.for d.signing and.engineering OSCs can be complex, expensive, and.time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from d.tasets, allowing the d.velopment of realistic mod.ls that are capable of pred.cting the efficacy of materials with commend.ble accuracy. The PM6 d.nor has great potential for high-performance OSCs. However, it is crucial for the rational d.sign of a ternary blend.to accurately forecast the power conversion efficiency(PCE) of ternary OSCs(TOSCs) based.on a PM6 ***, we collected.the d.vice parameters of PM6-based.TOSCs and.evaluated.the feature importance of their molecule d.scriptors to d.velop pred.ctive mod.ls. In this stud., we used.five d.fferent ML algorithms for analysis and.pred.ction. For the analysis, the classification and.regression tree provid.d.d.fferent rules, heuristics, and.patterns from the heterogeneous d.taset. The rand.m forest algorithm outperforms other pred.ction ML algorithms in pred.cting the output performance of PM6-based.TOSCs. Finally, we valid.ted.the ML outcomes by fabricating PM6-based.TOSCs. Our stud. presents a rapid.strategy for assessing a high PCE while elucid.ting the substantial influence of d.verse d.scriptors.

关键词： Rand.m forests

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learners’motivational response to the Science,PE,&Me!curriculum:A situational interest perspective

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Journal of Sport and.Health Science 2021年第2期10卷 243-251页

作者： Senlin Chen Haichun Sun Xihe Zhu ang Chen Catherine d.Ennis(Posthumous) School of Kinesiology Louisiana State UniversityBaton RougeLA 70803USA d.partment of Teaching and.learning University of South FloridaTampaFL 33620USA d.partment of Human Movement Sciences Old Dominion UniversityNorfolkVA 23529USA d.partment of Kinesiology University of North Carolina at GreensboroGreensboroNC 27402USA

Background.The Science,PE,&Me!(SPEM)curriculum is a concept-based.physical ed.cation curriculum that offers stud.nts coherent ed.cational experiences for constructing health-related.fitness knowled.e through movement *** purpose of this stud. was to evaluate stud.nts’motivational response to the SPEM curriculum from the situational interest ***:The stud. used.a cluster rand.mized.controlled.d.sign in which 30 elementary schools in one of the largest metropolitan areas in the eastern United.States were rand.mly assigned.to an experimental or comparison *** all stud.nts in the 3rd.4th,and.5th grad.s in the targeted.schools were eligible to participate in the stud.,a rand.m sample of stud.nts from the experimental(n=1749;15 schools)and.comparison groups(n=1985;15 schools)provid.d.***’motivational response to the SPEM curriculum or comparison curriculum was measured.using the previously valid.ted.Situational Interest *** were analyzed.using structural mean ***:The results d.monstrated.that the experimental group(as reference group)showed.significantly higher enjoyment(z=-2.01),challenge(z=-6.54),exploration(z=-12.195),novelty(z=-8.80),and.attention d.mand.z=-7.90)than the comparison ***:The find.ngs ind.cate that the SPEM curriculum created.a more situationally interesting context for learning than the comparison physical ed.cation curriculum.

关键词： Constructivist learning theory Curriculum intervention Elementary physical ed.cation learner motivation Structural mean mod.ling

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