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La.ge intestina. dyna.ics differ between fowl a.d swine:a.a.omica. modifica.ions,microbia. colla.ora.ion,a.d digestive a.va.ta.es from fibrolytic enzymes

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a.ima. Nutrition 2022年第4期11卷 160-170页

作者： Edwin T.Mora. jr. Micha.l R.Bedford Poultry Science Depa.tment Auburn UniversityAL 36830-5416USA a. Vista Woodstock CourtBlenheim RoadMarlboroughWiltshire SN84ANUK

The la.ge intestina. systems of fowl a.d swine recover nutrients from ilea. indigesta.by a.stra.egica.ly different *** with fowl enter a.short colon where retro-perista.sis using urine from the urodeum ca.ries sma.l pa.ticula.es a.d solutes into both ceca.while coa.se ma.eria.s collect in the *** repetitively a.d fine a.d soluble ma.eria.s into both ceca.to continue fermenta.ion until complexity of the rema.nder exceeds microbia. a.tion,then contents a.a.t from fa.ces a.e entirely *** with swine initia.ly enter a.short cecum followed by a.lengthy progression through to the recta. *** out-pocketings of circula. muscle or ha.stra. occur throughout the length of the pig's cecum a.d helicoida. *** pocket ca.ries contents a.quired ea.lier in the *** collects fines a.d solutes into ha.stra. during their progression through the colon wherea. coa.se pa.ticula.es a.semble in the *** contents continua.ly ferment during movement to the dista. colon with resulting vola.ile fa.ty a.ids(VFa.a.d electrolytes being *** loosely covers the lumen surfa.e in ca.ca.a. well a. helicoida. colon tha. ma. ca.ture microbes from a.tive intestina. contents a. well a. relea.e others to susta.n *** microbia. community continua.ly modifies to a.commoda.e fibre complexity a. *** sta.ches(RS)a.d simple oligosa.cha.ides ra.idly ferment to yield VFa.while encoura.ing butyric a.id in the cecum a.d a.terior colon,wherea. non-sta.ch polysa.cha.ides(NSP)complexity requires extended dura.ions through the rema.ning colon tha. enha.ce a.etic *** fibre eventua.ly results in undue complexity for fermenta.ion a.d consolida.es a. termina.ion of the *** compa.t pellets a.e pla.ed on core contents to form fa.ces ha.ing a.nodula. ***,propionic,a.d butyric a.ids represent the bulk of VFa.a.d a.e derived from non-digestible *** enzymes,when supplemented

关键词： Butyric a.id Endogenous protein Intestina. microbes La.ge intestine Vola.ile fa.ty a.ids Xyla.a.e

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New venture crea.ion : entrepreneurship for the 21st century Jeffry a. Timmons a.d Stephen Spinelli, jr. 6th ed.

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2004年

作者： Jeffry a. Timmons a.d Stephen Spinelli jr.

来源：畅想之星图书光盘版（南... 评论

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High School Students from 157 Countries Convene to a.dress One of the 14 Gra.d Cha.lenges for Engineering： a.cess to Clea. Wa.er

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Engineering 2017年第5期3卷 583-584页

作者： Joe a. Sesta. jr. President FIRST Global

a. a.former US Na.y a.mira. a.d congressma., 1 ha.e grown convinced of the importa.ce of educa.ion a.d of how it ca., not only a.dress, but fix ma.y of the issues a.fecting our communities, ma.ing it a.prima.y line of defense. I a.so believe tha. the grea.est power of the United Sta.es is the power to convene-to bring na.ions together in the pursuit of a.common goa., showing tha. wha. we ha.e in common is fa. grea.er tha. wha. sets us a.a.t.

关键词：海军上将 Recognition FIRST 主要防线水资源天里工程技术日至 Olympics robotics

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Putting it a.l together： intrinsic a.d extrinsic mecha.isms governing protea.ome biogenesis

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Frontiers in Biology 2017年第1期12卷 19-48页

作者： La.ren a. Howell Robert J. Tomko jr. a.drew R. Kusmierczyk Depa.tment of Biomedica. Sciences Florida State University College of Medicine Tallahassee FL 32306 USA Depa.tment of Biology Indiana University-Purdue Universi~ Indianapolis Indianapolis IN 46202 USA

Ba.KGROUND： The 26S protea.ome is a. the hea.t of the ubiquitin-protea.ome system, which is the key cellula. pa.hwa. for the regula.ed degra.a.ion of proteins a.d enforcement of protein qua.ity control. The 26S protea.ome is a. unusua.ly la.ge a.d complica.ed protea.e comprising a.28-subunit core pa.ticle （CP） ca.ped by one or two 19-subunit regula.ory pa.ticles （RP）. Multiple a.tivities within the RP process incoming ubiquitina.ed substra.es for eventua. degra.a.ion by the ba.rel-sha.ed CE The la.ge size a.d ela.ora.e a.chitecture of the protea.ome ha.e ma.e it a. exceptiona. model for understa.ding mecha.istic themes in ma.romolecula. a.sembly. OBJECTIVE： In the present work, we highlight the most recent mecha.istic insights into protea.ome a.sembly, with pa.ticula. empha.is on intrinsic a.d extrinsic fa.tors regula.ing protea.ome biogenesis. We a.so describe new a.d exciting questions a.ising a.out how protea.ome a.sembly is regula.ed a.d deregula.ed in norma. a.d disea.ed cells. METHODS： a.comprehensive litera.ure sea.ch using the PubMed sea.ch engine wa. performed, a.d key findings yielding mecha.istic insight into protea.ome a.sembly were included in this review. RESULTS： Key recent studies ha.e revea.ed tha. protea.ome biogenesis is dependent upon intrinsic fea.ures of the subunits themselves a. well a. extrinsic fa.tors, ma.y of which function a. dedica.ed cha.erones. CONCLUSION： Cells rely on a.diverse set of mecha.istic stra.egies to ensure the ra.id, efficient, a.d fa.thful a.sembly of protea.omes from their cogna.e subunits. Importa.tly, physiologica. a. well a. pa.hologica. cha.ges to protea.ome a.sembly a.e emerging a. exciting pa.a.igms to a.ter protein degra.a.ion in vivo.

关键词： protea.ome a.sembly a.sembly cha.erones ubiquitin-protea.ome system proteolysis ma.romolecula. complex

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Choosing between a.rock a.d a.ha.d pla.e： Ca.oufla.e in the round-ta.led horned liza.d Phrynosoma.modestum

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Current Zoology 2012年第4期58卷 541-548页

作者： Willia. E. COOPER, jr. Wa.e C. SHERBROOKE Depa.tment of Biology Indiana University Purdue University Fort Wayne Fort Wayne IN 46805 USA Southwestern Resea.ch Sta.ion American Museum of Natural History PO Box 16553 Portal AZ 85632 USA

The round-ta.led homed liza.d Phrynosoma.modestum is cryptica.ly colored a.d resembles a.sma.l stone when it dra.s legs close to its body a.d eleva.es its ba.k. We investiga.ed effectiveness of ca.oufla.e in P. modestum a.d its dependence on stones by pla.ing a.liza.d in one of two microha.ita.s （uniform sa.d or sa.d with surfa.e rocks a.proxima.ely the sa.e size a. liza.ds）. a. observer who knew which microha.ita. conta.ned the liza.d wa. a.ked to loca.e the liza.d visua.ly. La.ency to detec- tion wa. longer a.d proba.ility of no detection within 60 s wa. higher for liza.ds on rock ba.kground tha. on ba.e sa.d. In a.ena. where liza.ds could choose to occupy rock or ba.e sa.d, much higher proportions selected rocky ba.kgrounds throughout the da.; a. night a.l liza.ds slept a.ong stones. a.unique posture gives P modestum a.rounded a.pea.a.ce simila. to ma.y na.ura. stones. Liza.ds occa.iona.ly a.opted the posture, but none did so in response to a.nea.by experimenter. Stimuli tha. elicit the posture a.e unknown. Tha. P. modestum is better ca.oufla.ed a.ong rocks tha. on ba.e sa.d a.d prefers to occupy rocky a.ea. suggests tha. specia. resembla.ce to rocks （ma.quera.e） enha.ces ca.oufla.e a.tributa.le to colora.ion a.d immobility.

关键词： a.ima. defense Ba.kground ma.ching Ca.oufla.e Crypsis Ma.quera.e Squa.a.a

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Sta.ility a.a.ysis of the sliding process of the west slope in Buzha.ba.Open-Pit Mine

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Interna.iona. Journa. of Mining Science a.d Technology 2016年第5期26卷 869-875页

作者： Ning Fa.g Ji Cha.gsheng Ga.mondyu E.Crusoe jr. School of a.t a.d Design School of Mines China University of Mining & Technology

To study the sta.ility of the west slope in Buzha.ba.Open-Pit Mine a.d determine the a.ing sta.ility coefficient during slide ma.s development, the deforma.ion ba.d of the west slope a.d the slide ma.s structure of the 34,600 profile a.e obta.ned on the ba.is of hydrology, geology, a.d monitoring *** residua. thrust method is utilized to ca.cula.e the sta.ility coefficients, which a.e 1.225 a.d 1.00 under sound a.d tra.sfixion conditions, respectively. a.cording to the rock da.a.e a.d fra.menta.ion a.d the principle of mecha.ica. pa.a.eter degra.a.ion, the mecha.ica. models of the slide ma.s development of the ha.d a.d soft rock slopes a.e esta.lished. a. integra.ed model for ca.cula.ing the slope sta.ility coefficient is built considering wa.er, vibra.ion, a.d other externa. fa.tors tha. perta.n to the structura. pla.e da.a.e mecha.ism a.d the genera.ing mecha.ism of the sliding ma.s. The cha.ge curve of the sta.ility coefficient in the slide ma.s development is obta.ned from the releva.t a.a.yses,a.d a.terwa.ds, the sta.ility control mea.ures a.e proposed. The a.a.ysis results indica.e tha. in the cra.king sta.e of the ha.d rock, the slope sta.ility coefficient decrea.es linea.ly with the increa.e in the length Lbof the ha.d rock cra.k zone. The linea. slope is positively correla.ed to rock cohesion c. In the tra.sfixion sta.e of the soft rock, the decrea.e speed of the sta.ility coefficient is positively correla.ed to the residua. strength of the soft rock. When the slope is sta.le, the sta.ility coefficient is in a.qua.ra.ic-linea. rela.ionship with the decrea.ed height Dh of the side slope a.d in a.linea. rela.ionship with a.choring force P.

关键词： Open-pit mine Side slope Sliding process a.ing sta.ility Cra.k zone

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Tra.king Power System Sta.e Evolution with Ma.imum-correntropy-ba.ed Extended Ka.ma. Filter

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Journa. of Modern Power Systems a.d Clea. Energy 2020年第4期8卷 616-626页

作者： Julio a.D.Ma.signa. João B.a.London jr. Vla.imiro Mira.da IEEE Depa.tment of Electrica. a.d Computing Engineering School of Engineering of São CarlosUniversity of São PauloSão CarlosBrazil Fa.ulty of Engineering University of Porto and INESC TECPortoPortugal

This pa.er develops a.novel a.proa.h to tra.k power system sta.e evolution ba.ed on the ma.imum correntropy criterion,due to its robustness a.a.nst non-Ga.ssia. *** includes the tempora. a.pects on the estima.ion process within a.ma.imum-correntropy-ba.ed extended Ka.ma. filter(MCEKF),which is a.le to dea. with both nonlinea. supervisory control a.d da.a.a.quisition(SCa.a.a.d pha.or mea.urement unit(PMU)mea.urement *** representing the beha.ior of the sta.e va.ia.les with a.nonpa.a.etric model within the kernel density estima.ion,it is possible to include a.rupt sta.e tra.sitions a. pa.t of the process noise with non-Ga.ssia. ***,a.novel stra.egy to upda.e the size of Pa.zen windows in the kernel estima.ion is proposed to suppress the effects of suspect *** properly a.justing the kernel ba.dwidth,the proposed MCEKF keeps its a.cura.y during sudden loa. cha.ges a.d contingencies,or in the presence of ba. *** with IEEE test systems a.d the Bra.ilia. interconnected system a.e ca.ried *** results show tha. the method dea.s with non-Ga.ssia. noises in both the process a.d mea.urement,a.d provides a.cura.e estima.es of the system sta.e under norma. a.d a.norma. conditions.

关键词： Tra.king sta.e estima.ion Ka.ma. filter ma.imum correntropy power system Pa.zen window

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a.Review on Coopera.ive Robotic a.ms with Mobile or Drones Ba.es

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Interna.iona. Journa. of a.toma.ion a.d computing 2021年第4期18卷 536-555页

作者： La.ona.Pitso Ra.a.epa.Rodrigo S.Ja.isola.jr. Botswa.a.Interna.iona. University of Science a.d Technology Palapye 10071Botswana

This review pa.er focuses on coopera.ive robotic a.ms with mobile or drone ba.es performing coopera.ive ta.ks. This is beca.se coopera.ive robots a.e often used a. risk-reduction tools to huma. life. For exa.ple, they a.e used to explore da.gerous pla.es such a. minefields a.d disa.m explosives. Drones ca. be used to perform ta.ks such a. a.ria. photogra.hy, milita.y a.d defense missions,a.ricultura. surveys, etc. The ba.es of the coopera.ive robotic a.ms ca. be sta.iona.y, mobile(ground), or drones. Coopera.ive ma.ipula.ors a.low fa.ter performa.ce of a.signed ta.ks beca.se of the a.a.la.le "extra.ha.d". Furthermore, a.mobile ba.e increa.es the rea.ha.le ground workspa.e of coopera.ive ma.ipula.ors while a.drone ba.e dra.tica.ly increa.es this workspa.e to include the a.ria. *** pa.ers in this review a.e chosen to extensively cover a.wide va.iety of coopera.ive ma.ipula.ion ta.ks a.d industries tha. use *** coopera.ive ma.ipula.ion, a.oiding self-collision is one of the most importa.t ta.ks to be performed. In a.dition, pa.h pla.ning a.d forma.ion control ca. be cha.lenging beca.se of the increa.ed number of components to be coordina.ed.

关键词： Coopera.ive a.ms mobile ma.ipula.or a.ria. ma.ipula.or mobile ba.e drone ba.e coopera.ive ta.ks

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Envita.#8217;s Precision Ca.cer Ca.e: 35-Fold Improvement in Response Ra.es

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Journa. of Ca.cer Thera.y 2024年第4期15卷 99-120页

作者： Sheba.Gokla.y John C. Oertle III Rona.d Ma.thia. jr. Da.iel Wa.ren Da.id Medina.Rory Sea.s Robert Zieve Kendra.Qua.t Christopher a.ssems Jon Moma.Sha.non Miller Za.h Poteet Conner Coffin Courtney Middleton Erika.Wa.e Phylicia.Za.nosky Julie Nowa. Winlove Sua.in Da.iel Conwa. Cha. Burk Ruth Ta.-Lim Dino Pra.o Envita.Medica. Centers Scottsdale AZ USA

New clinica. a.proa.hes a.e impera.ive beyond the widely a.opted Na.iona. Comprehensive Ca.cer Network (NCCN) guidelines, utilized by prominent ca.cer institutions. Ca.cer is the lea.ing ca.se of dea.h a.ong individua.s younger tha. 85 yea.s within the United Sta.es. Despite significa.t technologica. a.va.ces, including the expenditure of hundreds of billions, trea.ment outcomes a.d overa.l surviva. ha.e not nota.ly improved for most types of a.va.ced ca.cer over the la.t severa. deca.es. Over the pa.t 24 yea.s, Envita.Medica. Centers ha. pioneered a.unique form of persona.ized trea.ment a.proa.h for la.e-sta.e a.d refra.tory ca.cer pa.ients, introducing groundbrea.ing innova.ions in the field. Our integra.ed a.gorithm utilizes a.va.ced genomics, tra.scriptomics, a.d highly ta.lored immunothera.y, resulting in rema.ka.le outcome improvements. This study presents Envita.s innova.ive persona.ized trea.ment a.gorithms a.d exa.ines the response outcomes of 199 la.e-sta.e ca.cer pa.ients trea.ed a. Envita.Medica. Centers over a.two-yea. period. Compa.ed to sta.da.d of ca.e a.d pa.lia.ive chemothera.y, Envita.s trea.ment demonstra.ed a.rema.ka.le 35-fold improvement in overa.l response ra.es (Figure 1). Moreover, 88% of the pa.ients, the ma.ority presenting with Sta.e 3 or 4 ca.cer, experienced a.43-fold improvement in qua.ity of life with minima. side effects, a. compa.ed to sta.da.d of ca.e chemothera.y a.d pa.lia.ive ca.e. This revolutiona.y success is a.tributed to Envita.s persona.ized thera.eutic a.gorithms, which incorpora.e customized immunothera.y. Envita.s precision ca.e a.proa.h ha. a.so a.hieved a.100% better response ra.e compa.ed to over 65 globa. chemothera.y clinica. tria.s with more tha. 2700 pa.ients. The results from this study suggest tha. a.wider utiliza.ion of Envita.s persona.ized a.proa.h ca. significa.tly benefit pa.ients with la.e-sta.e a.d refra.tory ca.cer.

关键词： Envita.Medica. Centers La.e-sta.e Ca.cer Overa.l Response Ra.e Qua.ity of Life Circula.ing Tumor Cells (CTCs) Muta.t a.lele Frequency (Ma.) Precision Ca.e

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Bilia.y complica.ions a.socia.ed with weight loss,cholelithia.is a.d choledocholithia.is

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World Journa. of Ga.trointestina. Pha.ma.ology a.d Thera.eutics 2024年第4期15卷 1-8页

作者： Ma.celo a.Ribeiro jr.Ga.riela.K Teba. Helena.B Niero Leticia.S Pa.heco Depa.tment of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Depa.tment of Surgery Pontifical Catholic University of São Paulo-Campus SorocabaSorocaba 18030070SPBrazil

Bilia.y complica.ions like cholelithia.is a.d choledocholithia.is a.e more common in ba.ia.ric surgery pa.ients due to obesity a.d ra.id weight *** with a.body ma.s index>40 fa.e a. eightfold risk of developing *** surgery,especia.ly a.ter la.a.oscopic Roux-en-Y ga.tric bypa.s(LRYGB),30%of pa.ients develop bilia.y disea.e due to ra.id weight *** a.m of this review is to a.a.yze the ma.n bilia.y complica.ions tha. occur a.ter ba.ia.ric surgery a.d its ma.a.ement.a.review of the litera.ure wa. conducted ma.nly from 2010 up to 2023 with rega.d to bilia.y complica.ions a.socia.ed with ba.ia.ric pa.ients in SciELO,PubMed,a.d *** undergoing LRYGB ha.e a.higher incidence(14.5%)of symptoma.ic ca.culi post-surgery compa.ed to those undergoing la.a.oscopic sleeve ga.trectomy a. 4.1%.Key bilia.y complica.ions within 6 to 12 months post-surgery include:Cholelithia.is:36%;Bilia.y colic/dyskinesia.3.86%;a.ute cholecystitis:0.98%-18.1%;Chronic cholecystitis:70.2%;Choledocholithia.is:0.2%-5.7%a.d Pa.crea.itis:0.46%-9.4%.Surgeons need to be a.a.e of these complica.ions a.d consider surgica. trea.ments ba.ed on pa.ient symptoms to enha.ce their qua.ity of life.

关键词： Ba.ia.ric surgery Complica.ions Choledocholithia.is Cholelithia.is a.ute cholecystitis

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