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A Meshless LBIE/LRBF Method for Solving the Nonlinear fisher Equation: Application to Bone Healing

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Computer Modeling in Engineering & Sciences 2015年第6期105卷 87-122页

作者： K.N.Grivas M.G.Vavva E.J.Sellountos d.I.Fotiadis d.Polyzos department of Mechanical Engineering and Aeronautics University of PatrasPatrasGreece Instituto Seperior Tecnico CEMAT LisbonPortugal department of Materials Science and Engineering University of Ioannina

A simple Local Boundary Integral Equation(LBIE)method for solving the fisher nonlinear transient diffusion equation in two dimensions(2d)is *** method utilizes,for its meshless implementation,randomly distributed nodal points in the interior domain and nodal points corresponding to a Boundary Element Method(BEM)mesh,at the global *** interpolation of the interior and boundary potentials is accomplished using a Local Radial Basis Functions(LRBF)*** the nodes of global boundary the potentials and their fluxes are treated as independent *** the local boundaries,potential fluxes are avoided by using the Laplacian companion *** gradients are accurately evaluated without RBFs via a LBIE,valid for gradient of *** is treated using the Newton-Raphson *** accuracy of the proposed methodology is demonstrated through representative numerical *** equation is solved here via the LBIE/LRBF method in order to predict cell proliferation during bone *** concentrations and their gradients are numerically evaluated in a 2d model of fractured *** results are demonstrated and discussed.

关键词： fisher equation Local Boundary Integral Equation Method LBIE Local Radial Basis Functions Bone healing

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卒中治疗专业学术圆桌会议临床前推荐更新版

国际脑血管病杂志 2009年第8期17卷 561-567页

作者： Marc fisher Giora Feuerstein david W. Howells Patricia d. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) From the department of Neurology University of Massachusetts Medical School Worcester Mass Wyeth Pharmaceuticals National Stroke Research Institute & University of Melbourne Melbourne Australia department of Medicine department of Anesthesiology University of Oregon Health Sciences Center Portland Ore department of Neurology Baylor College of Medicine department of Neurology University of Texas Houston Medical School Houston Tex department of Radiology. Harvard Medical School. Cambridge Mass 不详

首份卒中治疗专业学术圆桌会议（Stroke Yherapy Academic Industry Roundtable，STAIR）推荐于1999年出版，旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的，但并未得到严格的遵循和验证。为了更好... 详细信息

首份卒中治疗专业学术圆桌会议（Stroke Yherapy Academic Industry Roundtable，STAIR）推荐于1999年出版，旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的，但并未得到严格的遵循和验证。为了更好地向临床转化，有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议，即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括：高质量科学研究的基本原则应消除随机和评价偏倚，预先确定纳入和排除标准，计算合适的效能和样本量，并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后，在雌性、高龄动物和伴有合并症（如高血压、糖尿病和高胆固醇血症）的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性，但遵循这些推荐有望提高成功的机会。

关键词：临床前卒中模型治疗

dIOXIN FORMATION ANd SUPPRESSION IN IRON ORE SINTERING IN THE UK STEEL INdUSTRY

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DIOXIN FORMATION AND SUPPRESSION IN IRON ORE SINTERING IN TH...

针灸治疗慢性头痛的初级保健:大样本、实用的随机试验

International Symposium on Global Environment and Steel Industry(ISES’03)

作者： david R.Anderson Raymond.fisher derek Hemfrey Trevor A.T.Fray Corus R D＆T Rotherham UK Corus R D＆T Rotherham UK Corus Strip Products UK Port Talbot UK Corus Construction and Industrial Scunthorpe UK

＜正＞Corus UK has developed technology to reduce the formation and emission of dioxins from iron ore sintering. Extensive measurements have shown that emissions from the main waste gas stacks of the five UK sinter plants were in the concentration range 0.28 to 4.4 ng I-TEQ/Nm3 from 94 measurements. The overall mean was 1.19 ng I-TEQ/Nm3 which is slightly above the achievable release limit of 1 ng I-TEQ/Nm3 specified by the UK Environment Agency for new plant. Fundamental studies concluded that dioxins are most likely formed within the sinter bed, ahead of the flame-front. Suppression trials have been successful when urea was added to the raw sinter mix prior to the strand, with at least 50% reduction in dioxin emissions. Urea addition appears to offer cost-effective dioxin suppression and trials are continuing to confirm the long-term viability of the technique.

关键词： dioxins Iron ore sintering Formation Suppression

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英国医学杂志中文版 2005年第2期8卷 89-92页

作者： andrew J Vickers Rebecca W Rees Catherine E Zollman Rob McCarney Claire Smith Nadia Ellis Peter fisher Robbert Van Haselen 宋军 Integrative Medicine ServiceBiostatistics Service Memorial Sloan-Kettering Cancer Center1275 York AvenueNYNY 10021 assistant attending research methodologist Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre)Social Science Research Unit Institute of EducationLondon WC1H 0NS research officer MontpelierHealth Centre department of Psychological MedicineImperial College London London W2 1PD research officer Academic RheumatologyWeston Education Centre King's CollegeLondon SE5 9RJ senior trials coordinator department of Health and Social SciencesCoventry University Coventry CV1 5FB lecturer Royal London Homeopathic HospitalLondon W1W 5PB director of research Royal London Homeopathic Hospital London W1W 5PB deputy director of research

目的与“不用针灸”对比,确定“使用针灸”的治疗方法对慢性头痛患者的头痛、健康状况及无病时间的影响。设计随机对照试验。试验场所英格兰和威尔士的开业医生诊所。受试对象 401位慢性头痛患者,主要是偏头痛患者。干预患... 详细信息

目的与“不用针灸”对比,确定“使用针灸”的治疗方法对慢性头痛患者的头痛、健康状况及无病时间的影响。设计随机对照试验。试验场所英格兰和威尔士的开业医生诊所。受试对象 401位慢性头痛患者,主要是偏头痛患者。干预患者被随机分配进入针灸治疗组(在 3个月内接受12次针灸治疗)和对照组(接受常规治疗)。主要结果测定指标治疗前、治疗后3个月及12个月对头痛积分,SF-36健康状况及用药量进行评估。每3个月对治疗方法作1次评估。头痛积分即判定疗效的主要终点指标。结果针灸组治疗后12个月的头痛积分(针灸组161例患者,平均头痛积分为16．2,标准差 13．7,比治疗前减少34％)比对照组低(对照组140 例患者,平均头痛积分为22．3,标准差17．0,比治疗前减少16％)。两种方法调整后的差异为4．6 (95％可信区间为2．2-7．0;P=0．0002)。对于包含缺失数据的灵敏度分析,该结果也是肯定的。针灸组的患者每年少头痛22(8-38)天。尽管达到统计学差异的项目仅有生理功能、精力和健康改变等,SF-36的资料也有利于针灸组。与对照组相比,针灸组的患者减少了15％的服药量(P=0．02), 减少了25％的就诊量(P=0．10),同时减少15％的病休时间(P=0．2)。结论针灸在初级保健中用于治疗慢性头痛, 特别是偏头痛,可以产生与临床相关的持久益处。应当考虑扩大英国国家医疗保险体系中针灸治疗的范围。

关键词：慢性头痛针灸治疗初级保健随机试验大样本 SF-36 随机对照试验医疗保险体系治疗方法健康状况偏头痛患者灵敏度分析统计学差异对照组治疗前开业医生受试对象常规治疗随机分配测定指标终点指标可信区间

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培育强竞争力型小麦品种的潜力

麦类文摘 1995年第4期 6-7页

作者： d.Lemerle R.Cousens B.Verbeek J.A.fisher 李保庆澳大利亚新南威尔士州农业研究所

一年生黑麦草(Lolium rigidum 瑞士黑麦草)是南澳大利亚小麦田的一种主要杂草。近二三十年来选择性除草剂已被广泛用来减少其造成的小麦产量损失。利用除草剂防除杂草使得小麦育种者可以选育收获指数较高的品种,这类品种在纯作时产量较... 详细信息

一年生黑麦草(Lolium rigidum 瑞士黑麦草)是南澳大利亚小麦田的一种主要杂草。近二三十年来选择性除草剂已被广泛用来减少其造成的小麦产量损失。利用除草剂防除杂草使得小麦育种者可以选育收获指数较高的品种,这类品种在纯作时产量较高,通常表现矮秆、分蘖力低和直立习性(donald和 Hamblin 1976),它们的丰产性对除草剂的依赖程度可能更甚于较老的品种类型。近年来杂草对除草剂抗性的广泛发展。

关键词：小麦品种竞争力一年生黑麦草除草剂抗性小麦基因型小麦田选择性除草剂南澳大利亚品种类型防除杂草

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d型多流道传递式(MCTd)挤出机

橡塑技术与装备 2001年第6期27卷 37-38,45页

作者： Florian W.fisher 姚琳

介绍了d型多流道传递式（MCTd）挤出机的原理、性能，并总结了该挤出机的优点，展望了该机的发展前景。

关键词：橡胶加工传递式 d型多流道挤出机 MCTd 性能

一个美国人在阿里巴巴总部实习的感受(英文)

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大学英语 2015年第9期 51-53页

作者： Jonathan fisher 张露茜上海理工大学外语学院

Working as an intern at a large tech company in Silicon Valley is an eye-opening *** as an intern at one of the most successful tech companies in the world in China is beyond ***’s a similar world filled with investo... 详细信息

关键词：英语教学教学方法课堂教学英语翻译大学英语

Increased vitamin d is associated with decline of naive, but accumulation of effector, Cd8 T cells during early aging

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Advances in Aging Research 2013年第2期2卷 72-80页

作者： Yong Gil Hwang Hui-Chen Hsu Fei Chu Lim Qi Wu PingAr Yang Gordon fisher Gary RHunter John dMountz University of Alabama at Birmingham Division of Clinical Immunology and RheumatologyBirminghamALUSA department of Human Studies University of Alabama at BirminghamBirminghamALUSA Birmingham VA Medical Center BirminghamALUSA

Given the protective roles of 25-hydroxyvitamin d (25(OH)d or vitamin d) in musculoskeletal health and the potential beneficial effects of vitamin d supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin d has been widely advocated. Of note, Cd8 T cells have the highest levels of the vitamin d receptor compared with other major immune cells. The effects of vitamin d on Cd8 T cells during aging, however, remain unclear. This study determined the relationship between vitamin d levels and Cd8 T cell status in 34 healthy female subjects (all >60 years old). The Cd8 T-cell phenotype was defined by the surface expression of Cd28 and Cd95. The low-25(OH)d serum groups (≤30 ng/ml) had higher percentages of Cd28+Cd95–Cd8+ (na?ve) T cells and lower percentages of Cd28+Cd95+Cd8+ (effector) T cells. By contrast, subjects with high levels of 25(OH)d had very low percentages of na?ve Cd8 T cells but very high percentages of effector Cd8 T cells. There was a significant inverse correlation between 25(OH)d levels and the frequency of na?ve Cd8 T cells. The results show that higher levels of vitamin d are correlated with decreased frequencies of na?ve Cd8 T cells during early aging, suggesting that higher levels of 25(OH)d accelerate Cd8 T cell senescence. These results warrant further evaluation of the effects of vitamin d supplementation in immune aging.

关键词： Naive Cd8 Immunosenescence Vitamin d Human

Lineage structure of the human antibody repertoire in response to influenza vaccination

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医用生物力学 2013年第S1期28卷 36-37页

作者： Ning Jiang Jiankui He Joshua A.Weinstein Lolita Penland Sanae Sasaki Xiao-Song He Patrick C.Wilson Harry B.Greenberg Mark M.davis daniel S.fisher Stephen R.Quake department of Biomedical Engineering the University of Texas at AustinAustinTXUSA department of Bioengineering Stanford University School of MedicineStanfordCaliforniaUSA Biophysics Graduate Program Stanford UniversityStanfordCaliforniaUSA department of Immunology and Microbiology Stanford University School of MedicineStanfordCaliforniaUSA VA Palo Alto Health Care System Palo AltoCaliforniaUSA department of Medicine Stanford University School of MedicineStanfordCaliforniaUSA department of Medicine University of Chicago Pritzker School of MedicineChicagoIllinoisUSA Howard Hughes Medical Institute department of Applied Physics Stanford UniversityStanfordCaliforniaUSA department of Biology Stanford UniversityStanfordCaliforniaUSA

The adaptive immune system produces a large and diverse set of antibodies,each with an individual evolutionary and clonal *** so called"antibody repertoire"protects each individual against insults such as infection and cancer,and responds to vaccination with B cell proliferation in response to the antigenic *** and antigen-specific FACSbased analysis have given us much insight on how the immune system generates the complex and diverse immune response required to protect the body from the wide variety of potential ***,these methods have not been sufficient to make global and unbiased characterizations of the clonal structure of the immune system of a particular individual。

关键词： vaccination clonal antigenic diverse insight stimulation evolutionary immunized protect vaccine