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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo andres-Leon Laura Carmen Terron-Camero Blanca cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

The Effect of Brain Gym on Global Cognitive Function of Institutionalized Older People

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International Journal of Mental Health Promotion 2022年第3期24卷 375-383页

作者： Araceli cano-Estrada Araceli Jimenez-Mendoza Denny Contreras-Guerrero Mario Hernandes-Alejandro andres Salas-Casas Escuela Superior de Tlahuelilpan Universidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico Escuela Nacional de Enfermería y Obstetricia.Universidad Nacional Autónoma de México Mexico CityMéxico Departomento de Bioingenieria Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politecnico Nacional(UPIBIIPN)Mexico CityMexico Instituto de Ciencias de la Salud.Universidad Autónoma del Estado de Hidalgo.Pachuca Hidalgo.México.Scuela Superior de TlahuelilpanUniversidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico

Cognitive function of older adults is influenced by several factors such as age,sex,education,and physical activity so that it can impact the decrease in progressive cognitive *** is necessary to implement cognitive training in old people’s care to prevent or delay the onset of age-related cognitive *** gym is a series of simple motion exercises and is an alternative therapy that stimulates the *** study aims to evaluate the effect of brain gym as a cognitive training intervention on global cognitive functioning of institutionalized older *** study is a non-randomized quasi-experimental one using pre-and post-test control group *** participants of the study were 65 years old or older who had been part of gerontological centers from a local *** were divided into two groups:control and intervention,each one with 15 ***-Mental State Examination was applied to the sample before and after the cognitive *** brain gym training consists of bi-weekly group meeting for 12 weeks,lasting 50 min *** treated group had a significantly better global cognitive ***(memory),orientation and language skills were the domains with the most significant changes(p<0.05).On the other hand,no significant changes were found in the participants of control groups during post *** results suggest that cognitive training based in brain gym improves global cognitive function of institutionalized older people lease type your abstract *** of a research paper is typically 200 to 400 words in length,and 150 to 300 words for a review *** shall be running continuously(not structured)and shall not include reference *** that appear only once in the abstract should be defined in *** abbreviations appear more than once,the full definitions should be provided first before they can be used elsewhere.

关键词： Cognitive function brain gymnastic older people gerontological center physical activity

Use of simulated sunlight radiation and hydrogen peroxide in azithromycin removal from aqueous solutions:Optimization&mineralization analysis

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Emerging Contaminants 2020年第1期6卷 53-61页

作者： Pablo andres cano Marcela Jaramillo-Baquero Henry Zúniga-Benítez Yudy A.Londono Gustavo A.Penuela Facultad de Ingeniería Tecnologico de Antioquia Institucion UniversitariaCalle 78B#72A-220MedellínColombia Departamento de Ingeniería Química Facultad de IngenieríaUniversidad de Antioquia UdeACalle 70#52-21MedellínColombia Grupo GDCON Facultad de IngenieríaSede de Investigacion Universitaria(SIU)Universidad de Antioquia UdeACalle 70#52-21MedellínColombia

Azithromycin(AZT)is a broad-spectrum antibiotic from the group of macrolides that acts against several Gram-positive and Gram-negative bacteria,which has promoted its use in the treatment of different respiratory and sexually transmitted ***,its presence in environmental matrices and in the effluents of conventional wastewater treatment plants has been evidenced in recent years,which reflects the need to develop new treatment alternatives that allow its total removal and minimize the eventual adverse effects,selection of resistant bacterial strains,associated with its presence in water *** sunlight radiation and H2O2 were used to remove AZT from water assessing the effects of operational parameters like the solution initial pH and the peroxide *** indicate that hydroxyl free radical is the main responsible for pollutant removal but acidic solution conditions and larger H2O2 doses negatively affect OHgeneration under the evaluated experimental *** removal was almost complete after 120 min of *** addition,reduction of the organic carbon content in the treated samples was^50.0%;and a significant increase of nitrates concentration in solution was evidenced.

关键词： Advanced oxidation Antibiotics Azithromycin Hydrogen peroxide Sunlight Wastewater treatment

Mixing Efficiency across Rayleigh-Taylor and Richtmeyer-Meshkov Fronts

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Open Journal of Fluid Dynamics 2015年第2期5卷 145-150页

作者： Jose Manuel Redondo Pilar Lopez Gonzalez-Nieto Jose Leandro cano German andres Garzon Applied Physics Department Politecnica University of Catalu&#241 a (UPC) Barcelona Spain Applied Mathematics Department Complutense University of Madrid (UCM) Madrid Spain Earth Physics Astronomy and Astrophsics II Department Complutense University of Madrid (UCM) Madrid Spain

Mixing generated by gravitational acceleration and the role of local turbulence measured through multifractal methods is examined in numerical experiments of Rayleigh-Taylor and Richtmyer-Meshkov driven front occurring at density interfaces. The global advance of the fronts is compared with laboratory experiments and Nusselt and Sherwood numbers are calculated in both large eddy simulation (LES) and kinematic simulation KS models. In this experimental method, the mixing processes are generated by the evolution of a discrete set of forced turbulent plumes. We describe the corresponding qualitative results and the quantitative conclusions based on measures of the density field and of the height of the fluid layers. We present an experimental analysis to characterize the partial mixing process. The conclusions of this analysis are related to the mixing efficiency and the height of the final mixed layer as functions of the Atwood number, which ranges from 9.8 × 10−3 to 1.34 × 10−1.

关键词： Rayleigh-Taylor Instability Richtmyer-Meshkov Instability Mixing Efficiency Front Evolution Fractal Dimension

Clinical features and radiological manifestations of COVID-19 disease

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World Journal of Radiology 2020年第11期12卷 247-260页

作者： Pedro Landete Carlos andres Quezada Loaiza Beatriz Aldave-Orzaiz Susana Hernandez Muniz Antonio Maldonado Enrique Zamora Allan Charles Sam Cerna Elia del Cerro Raquel cano Alonso Felipe Counago Department of Pulmonology H.U.La PrincesaMadrid 28006Spain Department of Pulmonology H.12 de OctubreMadrid 28041Spain Department of Radiologist H.U.La PrincesaMadrid 28006Spain Department of Radiation Oncology Hospital Universitario Quironsalud MadridMadrid 28223Spain Department of Pulmonology Hospital MD Anderson Madrid.EspanaMadrid 28033Spain Department of Diagnostic Imaging Hospital Universitario Quiron MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzUniversidad Europea de MadridMadrid 28028Spain

Coronavirus disease 2019(COVID-19)was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province(China).Coronavirus is a family of single-stranded RNA *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted from person to *** asymptomatic individuals can transmit the virus,symptomatic patients are more *** incubation period ranges from 3-7 d and symptoms are mainly respiratory,including pneumonia or pulmonary embolism in severe *** serum levels of interleukins(IL)-2,IL-6,IL-7 indicate the presence of cytokine release syndrome,which is associated with disease *** disease has three main phases:Viral infection,pulmonary involvement,and *** date,no treatment has proved to be safe or *** X-ray and computed tomography(CT)are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia,follow-up,and detection of *** main radiological findings are ground-glass opacification and areas of *** long-term clinical course is unknown,although some patients may develop pulmonary *** emission tomography-computed tomography(PETCT)is useful to assess pulmonary involvement,to define the affected areas,and to assess treatment *** pathophysiology and clinical course of COVID-19 infection remain poorly ***,patterns detected on CT and PETCT may help to diagnose and guide *** this mini review,we analyze the clinical manifestations and radiological findings of COVID-19 infection.

关键词： COVID-19 Coronavirus Natural history Clinical features Pathogenesis Radiology images