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A fifteen-year review of skin allergy testing in Irish patients with symptomatic rhinitis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 338-343页

作者： andreea nae K.Hinchion I.J.Keogh Department of Otolaryngology Head and Neck Surgery University College Hospital GalwayIreland School of Medicine National University of Ireland GalwayGalwayIreland

Objective:Our objective was to review skin prick allergy testing(SPAT)results in patients with symptomatic rhinitis in an Irish ***:A fifteen-year retrospective review of our database of symptomatic patients with rhinitis was *** patients who had SPAT performed during this interval were *** was analysed in terms of demographics and dominant ***:1158 patients were included.617 Females vs 541 *** range five to eighty-five years *** age thirty-four years.49%of our patients tested positive to at least one *** most common allergens were dust mites(23%)and timothy grass(22%).Patients born during the Irish pollen season(April-July)were between 5 and 7 times more likely to be sensitive to timothy and ryegrass pollens compared to others tested.241 patients had both SPAT and serum allergen specific IgE testing(SASIgET)performed;positive results were consistent between both ***:Results demonstrated that half of our patients with symptomatic rhinitis had allergen *** mites and grass were the main allergens in our *** nurse led clinic has allowed efficient patient education and the development of a unique Irish SPAT *** a patient with a known allergy test result it is not indicated.

关键词： Allergic rhinitis Skin prick allergy test Dust mites Grass allergy Rhinosinusitis Allergen specific IgE

Utility of CT and MRI in assessment of mandibular involvement in oral cavity cancer

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 71-75页

作者： andreea nae Gerard O'Leary Linda Feeley Cassie Fives Brendan Fitzgerald Elena Chiriac Patrick Sheahan ENT Department South Infirmary-Victoria University HospitalCorkIreland ENT Department University Hospital Galway Newcastle RoadGalwaypost code H91YR71Ireland Radiology Department South Infirmary-Victoria University HospitalCorkIreland

Objective:Oral cavity squamous cell carcinoma (SCC) may present with early invasion of mandibular *** planning of surgery is essential considering patient's postoperative quality of *** purpose was to evaluate the efficacy of computer tomography scan (CT) and magnetic resonance imaging (MRI) in detecting mandibular bone involvement in oral ***:A retrospective study was conducted on 98 patients with SCC of floor of mouth,lower alveolus and retromolar trigone operated on with curative *** CT and MRI scans were re-reviewed by a consultant radiologist and original histology slides were rereviewed by 3 ***:Forty-five patients were included in the final *** CT and MRI had a sensitivity of 100% and a specificity of 72%.Conclusion:The results suggest that combined CT and MRI have diagnostic utility in detecting mandibular invasion by oral cancer,but with a significant false positive rate.

关键词： Oral cavity SCC CT MRI Mandibular invasion Diagnostic accuracy

Growth of silicon nanowires in aqueous solution under atmospheric pressure

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Nano Research 2014年第6期7卷 898-902页

作者： nae-Man Park Chel-Jong Choi Components and Materials Laboratory Electronics and Telecommunications Research Institute (ETRI) 161 Gajeong-dong Yuseong-gu Daejeon 305-700 Republic of Korea School of Semiconductor and Chemical Engineering Semiconductor Physics Research Center Chonbuk National University 664-14 Deokjin-dong Deokjin-gu Jeonju 561-756 Republic of Korea

A new method for growing silicon nanowires is presented. They were grown in an aqueous solution at a temperature of 85℃ under atmospheric pressure by using sodium methylsiliconate as a water-soluble silicon precursor. The structure, morphology, and composition of the as-grown nanowires were characterized by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectrometry. It was also confirmed by X-ray powder diffraction and Raman spectroscopy that the silicon nanowire has a hexagonal structure. It was possible to grow the crystalline silicon nanowires at low temperature under atmospheric pressure because potassium iodide, which was used as a gold etchant, sufficiently increased the surface energy and reactivity of gold as a metal catalyst for the reaction of the Si precursor even at low temperature.

关键词： Silicon nanowire solution process metal catalyst hexagonal crystalline phase

Transparent, stretchable, and rapid-response humidity sensor for body-attachable wearable electronics

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Nano Research 2017年第6期10卷 2021-2033页

作者： Tran Quang Trung Le Thai Duy Subramanian Ramasundaram nae-Eung Lee School of Advanced Materials Science & Engineering Sungkyunkwan University (SKKU) Suwon Kyunggi-do 16419 Republic of Korea Center for Water Resource Cycle Research Korea Institute of Science and Technology Hwarang-ro 14 gil Seongbuk-gu Seoul 02793 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) SKKU Suwon Kyunggi-do 16419 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) SKKU Suwon Kyunggi-do 16419 Republic of Korea

Stretchable and conformal humidity sensors that can be attached to the human body for continuously monitoring the humidity of the environment around the human body or the moisture level of the human skin can play an important role in electronic skin and personal healthcare applications. However, most stretchable humidity sensors are based on the geometric engineering of non-stretchable components and only a few detailed studies are available on stretchable humidity sensors under applied mechanical deformations. In this paper, we propose a transparent, stretchable humidity sensor with a simple fabrication process, having intrinsically stretchable components that provide high stretchability, sensitivity, and stability along with fast response and relaxation time. Composed of reduced graphene oxide-polyurethane composites and an elastomeric conductive electrode, this device exhibits impressive response and relaxation time as fast as 3.5 and 7 s, respectively. The responsivity and the response and relaxation time of the device in the presence of humidity remain almost unchanged under stretching up to a strain of 60% and after 10,000 stretching cycles at a 40% strain. Further, these stretchable humidity sensors can be easily and conformally attached to a finger for monitoring the humidity levels of the environment around the human body, wet objects, or human skin.

关键词： transparent stretchablehumidity sensor reduced graphene oxide wearable electronics body-attachable intrinsically stretchable components

Case report of a healthy,elderly man with long-term high titers for anti-acetylcholine receptor antibody without myasthenia gravis

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Neural Regeneration Research 2010年第23期5卷 1832-1835页

作者： Jin Jun LUO nae J. Dun Department of Neurology Temple University School of Medicine Philadelphia PA 19140 USA Department of Pharmacology Temple University School of Medicine Philadelphia PA 19140 USA

Anti-acetylcholine receptor antibodies （AAR） are considered pathognomonic and pathogenetic for myasthenia gravis （MG）. AAR detection confirms clinical diagnosis of MG. However, AAR is rarely detected in patients without MG. The underlying pathophysiological mechanisms in a normal subject without MG have not been adequately addressed in previous studies. The present study reports on a case study of a healthy, elderly man with high AAR titers for 14 years. Pathophysiological mechanisms could be due to AAR heterogeneity in specificity, affinity, and multiform, and to muscle variability in response to AAR.

关键词： myasthenia gravis anti-acetylcholine receptor antibody false-positive antibody autoimmune disorder

Effect of Pore Size on the Nucleate Pool Boiling of Structured Enhanced Tubes

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Journal of Thermal Science 2000年第3期9卷 230-235页

作者： nae－HyunKim Jong－WonKim 等 DepartmentofMechanicalEngineering UniversityofInchonInchonKorea

In this study, pool boiling test results are provided for the structured enhanced tubes having pores with connecting gaps. The surface geometly of the present tube is similar to that of Turbo-B. Three tubes with different pore size (0.20 mm, 0.23 mm and 0.27 mm) were manufactured and tested using R-11, R-123 and R-134a. The pore size which yields the maximum heat transfer coefficient varied depending on the refrigerant. For R-134a, the maximum heat transfer coefficient was obtained for the tube having 0.27 nun pore size. For R-11 and R- 123, the optimum pore size was 0.23 mm. One novel feature of the present tubes is that their boiling curves do not show a cross-over characteristic, which existing pored tubes do. The connecting gaps of the present tube are believed to serve an additional route for the liquid supply and delay the dry-out of the tunnel. The present tubes yield the heat transfer coefficients approximately equal to those of the existing pored enhanced tubes. At the heat flux 40 kW/m2 and saturation temperature 4.4° C, the heat transfer coefficients of the present tubes are 6.5 times larger for R-11, 6.0 times larger for R-123 and 5.0 times larger for R-134a than that of the smooth tube

关键词： structured enhanced tube pore gap nucleate pool boiling R-11 R-123 R-134a.

Development of a Powder Extruder System for Dual-pore Tissue-engineering Scaffold Fabrication

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Journal of Bionic Engineering 2019年第4期16卷 686-695页

作者： nae-Un Kang Myoung Wha Hong Young Yul Kim Young-Sam Cho Seung-Jae Lee Department of Mechanical Design Engineering College of EngineeringWonkwang University460 Iksandae-roIks an Jeonbuk570-749Republic of Korea Department of Orthopedics Daejeon StMary's HospitalCatholic University of Korea64Daeheung-i Jung-guDaejeon301-723Republic of Korea

In this study,we developed a powder extruder system that can extrude and deposit powder mixtures to overcome the reported limitations of conventional dualpore scaffold manufacturing *** evaluate the extrusion and deposition capability of the powder extruder system,3D tissue-engineering scaffolds with dual-pore characteristics were fabricated with a PCL/PEO/NaCl(polycaprolactone/polyethylene oxide/sodium chloride)powder *** addition,to evaluate the fabricated scaffolds,their compressive modulus,morphology,and in-vitro cell activity were ***,it was confirmed that the proposed powder extruder system can fabricate dual-pore scaffolds with well-interconnected pores as well as arbitrary 3D shapes shown by the fabrication of a 3D femur-shape scaffold similar to the femur *** results of the cell proliferation and Cell Counting Kit-8(CCK-8)assays,DNA content analysis and viability assays confirm that the dual-pore scaffold fabricated by the powder extruder system improves cell attachment,proliferation,and viability.

关键词： dual-pore scaffold powder extruder system polycaprolactone 3D tissue-engineering scaffold

Analytic design of information granulation-based fuzzy radial basis function neural networks with the aid of multiobjective particle swarm optimization

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International Journal of Intelligent Computing and Cybernetics 2012年第1期5卷 4-35页

作者： Byoung-Jun Park Jeoung-nae Choi Wook-Dong Kim Sung-Kwun Oh IT Convergence Technology Research Laboratory Electronics and Telecommunications Research Institute(ETRI)DaejeonSouth Korea Research Institute KDT Co.LtdBucheong-siSouth Korea Department of Electrical Engineering The University of SuwonHwaseong-siSouth Korea

Purpose–The purpose of this paper is to consider the concept of Fuzzy Radial Basis Function Neural Networks with Information Granulation(IG-FRBFNN)and their optimization realized by means of the Multiobjective Particle Swarm Optimization(MOPSO).Design/methodology/approach–In fuzzy modeling,complexity,interpretability(or simplicity)as well as accuracy of the obtained model are essential design *** the performance of the IG-RBFNN model is directly affected by some parameters,such as the fuzzification coefficient used in the FCM,the number of rules and the orders of the polynomials in the consequent parts of the rules,the authors carry out both structural as well as parametric optimization of the network.A multi-objective Particle Swarm Optimization using Crowding Distance(MOPSO-CD)as well as O/WLS learning-based optimization are exploited to carry out the structural and parametric optimization of the model,respectively,while the optimization is of multiobjective character as it is aimed at the simultaneous minimization of complexity and maximization of ***–The performance of the proposed model is illustrated with the aid of three *** proposed optimization method leads to an accurate and highly interpretable fuzzy ***/value–A MOPSO-CD as well as O/WLS learning-based optimization are exploited,respectively,to carry out the structural and parametric optimization of the *** a result,the proposed methodology is interesting for designing an accurate and highly interpretable fuzzy model.

关键词： Modelling Optimization techniques Neural nets Design calculations Fuzzy c-means clustering Multi-objective particle swarm optimization Information granulation-based fuzzy radial basis function neural network Ordinary least squaresmethod Weighted least square method

Second to fourth digit ratio： a predictor of adult lung function

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Asian Journal of Andrology 2014年第1期16卷 140-145页

作者： I-nae Park Ho-Kee Yum Sang Chul Lee Jin Kyu Oh Tae Beom Kim Department of Pulmonology Inje University Seoul Paik Hospital Seoul Korea Department of Urology Gachon University Gil Hospital Incheon Korea

Sex and sex hormones play a major role in lung physiology. It has been proposed that the ratio of the second to fourth digits （digit ratio） is correlated with fetal sex hormones. We therefore hypothesized that digit ratio might help predict lung function. We investigated the relationship between digit ratio and pulmonary function test （PFT） findings. A total of 245 South Korean patients （162 male, 83 female） aged from 34 to 90 years who were hospitalized for urological surgery were prospectively enrolled. Before administering the PFTs, the lengths of the second and fourth digits of the right hand were measured by a single investigator using a digital Vernier caliper. In males （n = 162）, univariate and multivariate analysis using linear regression models showed that digit ratio was a significant predictive factor of forced vital capacity （FVC） and forced expiratory volume in I second （FEV1）（FVC： r = 0.156, P = 0.047; FEVI： r = 0.160, P = 0.042）. In male ever-smokers （n = 69）, lung functions （FVC and FEV1） were correlated with smoking exposure rather than digit ratio. In female never-smokers （n = 83）, lung functions （FEV1 and FEVI/FVC ratio） were positively correlated with digit ratio on univariate analysis （FEVI： r = 0.242, P = 0.027; FEVI/FVC ratio： r = 0.245, P = 0.026）. Patients with lower digit ratios tend to have decreased lung function. These results suggest that digit ratio is a predictor of airway function.

关键词： airway function digit ratio sex hormone