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Atypical hematological manifestation of celiac disease:A case report of aplastic anemia in a 2-year-old child and review of the literature

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Pediatric Investigation 2021年第2期5卷 159-162页

作者： Thea von Graffenried Mattia Rizzi Michel Russo andreas nydegger Simon Kayemba-Kay’s Pediatric Gastroenterology Unit Department of PediatricsUniversity of LausanneCentre Hospitalier Universitaire VaudoisLausanneSwitzerland Hemato-Oncology Unit Department of PediatricsUniversity of LausanneSwitzerland Department of Pediatrics Centre Hospitalier du Valais RomandSionSwitzerland Department of Pediatrics Centre Hospitalier des Pays de MorlaixFrance

Introduction Celiac disease typically presents with symptoms of malabsorption,but extraintestinal manifestations are increasingly *** anemia as the mode of celiac disease presentation is extremely rare in *** presentation We report a 2-year-old boy who presented with loose stools,loss of appetite,and bicytopenia with severe aregenerative normocytic ***,including bone marrow aspirate and biopsy,revealed aplastic *** for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies.A duodenal biopsy confirmed the histologic features of celiac *** child received a packed red cell transfusion and was started on a gluten-free diet,with a very good prognosis and normalization of both his blood and histological *** the best of our knowledge,our report is the sixth pediatric case in the *** Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.

关键词： Aplastic anemia Celiac disease Child Gluten-free diet

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Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children

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World Journal of Gastroenterology 2017年第20期23卷 3643-3654页

作者： Francois-Pierre Martin Ming-Ming Su Guo-Xiang Xie Seu Ping Guiraud Martin Kussmann Jean-Philippe Godin Wei Jia andreas nydegger NestléInstitute of Health Sciences University of Hawaii Cancer Center Metabo-Profile Biotechnology(Shanghai)Co. Ltd. The Liggins Institute The University of Auckland NestléResearch Center Division of Pediatric Gastroenterology University of Lausanne

AIMTo identify metabolic signatures in urine samples from healthy and inflammatory bowel disease(IBD)*** applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry(MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year(baseline,6 and 12 mo),and 27age-and gender-matched healthy *** metabolic profiles of IBD children differ significantly from healthy *** metabolic differences encompass central energy metabolism,amino acids,bile acids and gut microbial *** particular,levels of pyroglutamic acid,glutamic acid,glycine and cysteine,were significantly higher in IBD children in the course of the *** suggests that glutathione cannot be optimally synthesized and *** alterations of the enterohepatic circulation of bile acids in pediatric IBD patients is known,we show here that non-invasive urinary bile acid profiling can assess those altered hepatic and intestinal barrier *** present study shows how non-invasive sampling of urine followed by targeted MS-based metabonomic analysis can elucidate and monitor the metabolic status of children with different GI health/disease status.

关键词：小儿科新陈代谢显型生长煽动性的肠疾病 Crohns 疾病 Ulcerative 大肠炎

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