Atypical hematological manifestation of celiac disease:A case report of aplastic anemia in a 2-year-old child and review of the literature

作     者：Thea von Graffenried Mattia Rizzi Michel Russo Andreas Nydegger Simon Kayemba-Kay’s Thea von Graffenried;Mattia Rizzi;Michel Russo;Andreas Nydegger;Simon Kayemba-Kay's

作者机构：Pediatric Gastroenterology UnitDepartment of PediatricsUniversity of LausanneCentre Hospitalier Universitaire VaudoisLausanneSwitzerland Hemato-Oncology UnitDepartment of PediatricsUniversity of LausanneSwitzerland Department of PediatricsCentre Hospitalier du Valais RomandSionSwitzerland Department of PediatricsCentre Hospitalier des Pays de MorlaixFrance 

出 版 物：《Pediatric Investigation》 (儿科学研究（英文）)

年 卷 期：2021年第5卷第2期

页      面：159-162页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Aplastic anemia Celiac disease Child Gluten-free diet 

摘      要：Introduction Celiac disease typically presents with symptoms of malabsorption,but extraintestinal manifestations are increasingly *** anemia as the mode of celiac disease presentation is extremely rare in *** presentation We report a 2-year-old boy who presented with loose stools,loss of appetite,and bicytopenia with severe aregenerative normocytic ***,including bone marrow aspirate and biopsy,revealed aplastic *** for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies.A duodenal biopsy confirmed the histologic features of celiac *** child received a packed red cell transfusion and was started on a gluten-free diet,with a very good prognosis and normalization of both his blood and histological *** the best of our knowledge,our report is the sixth pediatric case in the *** Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.