检索结果-南通市图书馆

WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma:Role of Calculus bovis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 130-133页

作者： Tryfonas Mpektsis Anastasios Manolakis andreas Kapsoritakis Department of Gastroenterology University Hospital of LarisaLarisa 41100Greece

Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and *** date,definitive treatment options include either surgical excision or ablation of the affected *** increasing research on several pathways that could be involved in the progression of HCC,new elements within these pathways emerge as potential targets for novel *** WNT/β-catenin pathway favors the presence of M2 tumor-associated macrophages which in turn promote tumor growth and *** inhibition of this pathway is considered a good candidate for such targeted therapeutic ***,as Huang et al show in their recently published article,Calculus bovis which is used in traditional Chinese medicine can exert an inhibitory effect on theβ-catenin pathway and become a potential candidate for targeted pharmacotherapy against liver cancer.

关键词： Hepatocellular carcinoma Calculus bovis WNT/β-catenin pathway Tumorassociated macrophages

The interaction between a shaped charge jet and a single moving plate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 1-13页

作者： andreas Helte Jonas Lundgren Jonas Candle FOI WeaponsProtection and SecuritySE-16490StockholmSweden

Reactive armour is a very efficient add-on armour against shaped charge *** reactive armour consists of one or several plates that are accelerated by an *** but less violent acceleration of plates can also be achieved in a completely inert reactive *** be efficient against elongated jets,the motion of the plates needs to be inclined against the jet such that a sliding contact between the jet and the plates is *** sliding contact causes a deflection and thinning of the *** certain circumstances,the contact will become unstable,leading to severe disturbances on the *** disturbances will drastically reduce the jet penetration performance and it is therefore of interest to study the conditions that leads to an unstable *** studies on the interaction between shaped charge jets and flyer plates have shown that it is mainly the forward moving plate in an explosive reactive armour that is effective in disturbing the *** is usually attributed to the higher plate-to-jet mass flux ratio involved in the collision of the forward moving plate compared to the backward moving *** slow moving plates,as occurs in inert reactive armour,the difference in mass flux for the forward and backward moving plate is much lesser,and it is therefore of interest to study if other factors than the mass flux influences on the protection *** this work,experiments have been performed where a plate is accelerated along its length,interacting with a shaped charge jet that is fired at an oblique angle to the plate’s normal,either against or along the plate’s *** arrangement corresponds to a jet interacting with a flyer plate from a reactive armour,with the exception that the collision velocity is the same for both types of obliquities in these *** experiments show that disturbances on the jet are different in the two cases even though the collision velocities are the *** simulatio

关键词： Reactive armour Flyer plate Shaped charge jet

Small scale adeno-associated virusvector production for preclinical gene delivery based on chloroform precipitation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 99-100页

作者： Marcus Davidsson andreas Heuer Molecular Neuromodulation Department of Experimental Medical SciencesLund UniversityLundSweden Behavioural Neuroscience Laboratory Department of Experimental Medical SciencesLund UniversityLundSweden

Gene therapy aims to introduce genetic information into a cell-type of interest to replace,correct,silence,or modify defective *** therapy in its broadest sense can theoretically prevent,halt,or cure any condition that affects *** addition to that,the introduction and/or manipulation of genes is one of the major research areas in biological sciences,aimed to deepen our knowledge on how biological systems *** advances have made it possible to induce changes ranging from manipulations of large stretches of the genome to the change of single *** gold-standard vehicles to bring this genetic information into the target cells are viral vectors.

关键词： replace Small mankind

Synthesis and Crystal Structure of an Anionic Linear Trinuclear Copper(Ⅱ) Complex Containing 2-Thenoyltrifluoroacetonato and Acetato Ligands

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2014年第1期33卷 19-26页

作者： LOGANATHAN Nagarajan ROODT andreas Department of Chemistry University of the Free State

A novel anionic trinuclear linear copper（II） complex {[Et3NH][Cul.5（CH3COO）- （TTA）3] } 2 （1, TTA = 2-thenoyltrifluoroacetonate） has been synthesized in a direct reaction involving copper（]l） acetate monohydrate, TTA and excess triethylamine base in dichloromethane solvent. Green colored X-ray quality crystals of 1 were grown from n-hexane solvent at room temperature. The data were collected at 100 K. Compound I crystallizes in the monoclinic P21/n space group （a = 11.2141（8）, b = 19.0965（13）, c = 17.3680（14） A, β = 90.225（2）°, V= 3719.3（5） A3, Mr = 1840.14, Dc = 1.643 Mg/m3, F（000） = 1866, μ = 1.129 mm^-1 and Z = 2）. The asymmetric unit of 1 contains two copper atoms, one of which lies on a crystallographic inversion center with 50% occupancy.

关键词： copper crystals acetate monoclinic 1,3-diketonates

Current treatment of ulcerative colitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第27期17卷 3204-3212页

作者： Johannes Meier andreas Sturm Department of Hepatology and Gastroenterology Charité-Universittsmedizin Berlin Campus Virchow Clinic13353 BerlinGermany

Ulcerative colitis (UC) is a chronic disease featuring re- current inflammation of the colonic mucosa. The goal of medical treatment is to rapidly induce a steroid-free remission while at the same time preventing complica- tions of the disease itself and its treatment. The choice of treatment depends on severity, localization and the course of the disease. For proctitis, topical therapy with 5-aminosalicylic acid (5-ASA) compounds is used. More extensive or severe disease should be treated with oral and local 5-ASA compounds and corticosteroids to induce remission. Patients who do not respond to this treatment require hospitalization. Intravenous steroids or, when refractory, calcineurin inhibitors (cyclosporine, tacrolimus), tumor necrosis factor-α antibodies (infliximab) or immunomodulators (azathioprine, 6-mercaptopurine) are then called for. Indications for emergency surgery include refractory toxic megacolon, perforation, and continuous severe colorectal bleeding. Close collaboration between gastroenterologist and surgeon is mandatory in order not to delay surgical therapy when needed. This article is intended to give a general, practice-orientated overview of the key issues in ulcerative colitis treatment. Recommendations are based on published consensus guidelines derived from national and international guidelines on the treatment of ulcerative colitis.

关键词： Ulcerative colitis Inflammatory bowel disease Medical management Diagnosis Azathioprine TNF-α blocker

Calculating pH-dependent free energy of proteins by using Monte Carlo protonation probabilities of ionizable residues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2012年第3期3卷 230-238页

作者： Qiang Huang andreas Herrmann State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200433China Department of Biology Molecular BiophysicsHumboldt University of Berlin10115 BerlinGermany

Protein folding,stability,and function are usually in-fluenced by *** free energy plays a fundamental role in analysis of such pH-dependent ***-trostatics-based theoretical framework using dielectric solvent continuum model and solving Poisson-Boltzm-ann equation numerically has been shown to be very successful in understanding the pH-dependent ***,in this approach the exact computation of pH-dependent free energy becomes impractical for proteins possessing more than several tens of ioni-zable sites(e.g.>30),because exact evaluation of the partition function requires a summation over a vast number of possible protonation *** we present a method which computes the free energy us-ing the average energy and the protonation probabili-ties of ionizable sites obtained by the well-established Monte Carlo sampling *** key feature is to calculate the entropy by using the protonation *** used this method to examine a well-studied protein(lysozyme)and produced results which agree very well with the exact *** to the optimum pH of maximal stability of proteins and pro-tein-DNA interactions have also resulted in good agreement with experimental *** examples recommend our method for application to the elucidation of the pH-dependent properties of proteins.

关键词： protein protonation protein electrostatics pH-dependent free energy Poisson-Boltzmann equation Monte Carlo simulation

A Comprehensive Numerical Investigation on the Mechanical Properties of Hetero-Junction Carbon Nanotubes

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2015年第8期64卷 215-230页

作者： Ali Ghavamian andreas chsner School of Engineering Griffith University Gold Coast Campus

A set of forty-three hetero-junction CNTs, made of forty-four homogeneous carbon nanotubes of different chiralities and configurations with all possible hetero-connection types, were numerically simulated, based on the finite element method in a commercial finite element software and their Young's and shear moduli, and critical buckling loads were obtained and evaluated under the tensile, torsional and buckling loads with an assumption of linear elastic deformation and also compared with each other. The comparison of the linear elastic behavior of hetero-junction CNTs and their corresponding fundamental tubes revealed that the size, type of the connection, and the bending angle in the structure of hetero-junction CNTs considerably influences the mechanical properties of these hetero-structures. It was also discovered that the Stone-Wales defect leads to lower elastic and torsional strength of hetero-junction CNTs when compared to homogeneous CNTs. However, the buckling strength of the hetero-junction CNTs was found to lie in the range of the buckling strength of their corresponding fundamental tubes. It was also determined that the shear modulus of hetero-junction carbon nanotubes generally tends to be closer to the shear modulus of their wider fundamental tubes while critical buckling loads of these heterostructures seem to be closer to critical buckling loads of their thinner fundamental tubes. The evaluation of the elastic properties of hetero-junction carbon nanotubes showed that among the hetero-junction models, those with armchair-armchair and zigzag-zigzag kinks have the highest elastic modulus while the models with armchair-zigzag connections show the lowest elastic stiffness. The results from torsion tests also revealed the fact that zigzag-zigzag and armchair-zigzag hetero-junction carbon nanotubes have the highest and the lowest shear modulus, respectively. Finally, it was observed that the highest critical buckling loads belong to armchair-armchair heter

关键词： finite element method carbon nanotube hetero-junct

Is the Prform of phytochrome biologically active in the nucleus?

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第4期14卷 535-537页

作者： Jigang Li andreas Hlitbrunner State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agicultural UniversityBeijing 100193China Institute of Biology I Faculty of Biology and Signalling Research Centres BIOSS and CIBSSUniversity of Freiburg79104 FreiburgGermany

The sessile nature of plants has promoted the evolution of a wide range of mechanisms that enable plants to adapt to the changing *** particular,the light environment is highly dynamic and,therefore,plants have evolved several families of photoreceptors to detect almost all facets of light,such as quality,quantity,direction,and *** are red(R)and far-red(FR)light photoreceptors in plants that play fundamental roles in modulating adaptive growth of plants in response to their changing light environment(Li et al.,2011).In the model plant Arabidopsis thaliana there are five phytochrome photoreceptors,named phytochrome A(phyA)to *** is photolabile,whereas phyB to phyE are *** and phyB,the two most abundant phytochromes,account for-95% of total phytochrome proteins in etiolated Arabidopsis seedlings and play the most important role in regulating seedling photomorphogenesis(Li et al.,2011).

关键词： photoreceptor environment. Arabidopsis

Abandoned Altitudes? Decrease and Expansion of Grassland in the Hinterland of Popayán, Southern Colombian Andes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2015年第1期12卷 123-133页

作者： andreas Haller Oliver Bender Institute of Geography University of Innsbruck Institute for Interdisciplinary Mountain Research Austrian Academy of Sciences Technikerstrasse 21a 6020 InnsbruckAustria

Due to their ecological disadvantages, many mountain regions have experienced land-use abandonment and shrub encroachment on former grassland at higher altitudinal zones--especially during recent decades of urbanization. But does this trend also apply to the hinterland of urban settlements？ By using the Southern Colombian example of Popay^n, a medium-sized city located in the Northern Andes, we can show that the landscape changes observed between 1989 and 2010 can hardly be related to agricultural abandonment. Hypsometric variations of land-cover change indicate that, until 2001, woods or shrubland expanded faster at the lower altitudinal range adjacent to the city than at the more remote higher zones. In contrast, after 2001 grassland areas increased on former woods or shrnbland at all altitudinal belts. Both periods thus present developments that can be interpreted as the result of land-use expansion below 2000 m asl and land-use persistence in the tierrafrla of the mountain city＇s hinterland.

关键词： Land-cover change Land-use change Rural-urban linkages Northern Andes