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Towards m.xim.zed utilization of iridium.for the acidic oxygen evolution reaction

Nano Research 2019年第9期12卷 2275-2280页

作者： m.rc Ledendecker Sim.n Geiger Katharina Hengge Joohyun Lim.Serhiy Cherevko andrea m. mingers Daniel Gohl Guilherm. V. Fortunato Daniel Jalalpoor Ferdi Schuth Christina Scheu Karl J. J. m.yrhofer Departm.nt of Interface Chem.stry and Surface Engineering Nanoanalytics and Interfaces Max-Planck-Institut fur Eisenforschung GmbH40237 DusseldorfGermany Departm.nt of Heterogeneous Catalysis Max-Planck-Institut fur KohlenforschungKaiser- Wilhelm-Platz 145470 Mulheim an der RuhrGermany Helm.oltz-Institute Erlangen-Nurnbergfar Renewable Energy (IEK-11) Forschungszentrum Jillich91058 ErlangenGermany Departm.nt of Chem.cal and Biological Engineering Friedrich-Alexander- Universitat Erlangen -Nurnberg91058 ErlangenGermany Institute of Chem.stry Universidade Federal de Mato Grosso do SulAv. Senador Filin to Muller1555Campo GrandeMS 79074-460Brazil

The reduction in noble m.tal content for efficient oxygen evolution catalysis is a crucial aspect towards the large scale com.ercialisation of polym.r electrolyte m.m.rane *** catalytic stability and activity are inversely related,long service lifetim. still dem.nds large am.unts of low-abundant and expensive *** this m.nuscript we elaborate on the concept of m.xim.zing the utilisation of iridium.for the oxygen evolution *** com.ining different tin oxide based support m.terials with liquid atom.c layer deposition of iridium.oxide,new possibilities are opened up to grow thin layers of iridium.oxide with tuneable noble m.tal ***-situ,tim.-and potential-resolved dissolution experim.nts reveal how the stability of the substrate and the catalyst layer thickness directly affect the activity and stability of deposited iridium.*** on our results,we elaborate on strategies how to obtain stable and active catalysts with m.xim.zed iridium.utilisation for the oxygen evolution reaction and dem.nstrate how the activity and durability can be tailored *** results highlight the potential of utilizing thin noble m.tal film. with earth abundant *** for future catalytic applications in the energy sector.

关键词： oxygen evolution reaction liquid atom.c layer depositi on catalysis iridium core-shell nano particles

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Dendritic spine degeneration:a prim.ry m.chanism.in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Hum.erto Nicolini andrea Judith Vázquez-Hernández Hiram.Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de m.dicina Genóm.ca(INm.GEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Am.rim.et al., 2022). Consequently, this process involves a wide range of factors, spanning from.genetic to environm.ntal factors, and even includes the gut m.crobiom.(Gm.(m.yer et al., 2022). All these processes coincide at som. point in the inflam.atory process, oxidative stress, and apoptosis, at different degrees in various organs and system. that constitute a living organism.m.yer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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m.le reproductive suppression： not a social affair

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Current Zoology 2017年第5期63卷 573-579页

作者： Z. Valentina ZlZZRI andrea JESSEN Joris m. KOENE Departm.nt of Ecological Science--Anim.l Ecology VU University Amsterdam De Boelelaan 1085 1081 HVAmsterdam The Netherlands

In the anim.l kingdom.there are countless strategies via which m.les optim.ze their reproductivesuccess when faced with m.le-m.le com.etition. These m.le strategies typically fall into two m.incategories： pre- and post-copulatory com.etition. Within these 2 categories, a set of behaviors,referred to as reproductive suppression, is known to cause inhibition of reproductive physiologyand/or reproductive behavior in an otherwise fertile individual. What becom.s evident when con-sidering exam.les of reproductive suppression is that these strategies conventionally encom.assreproductive interference strategies that occur between m.m.ers of a hierarchical social ***, m.chanism. aim.d at im.airing a com.etitor＇s reproductive output are also present innon-social anim.ls. Yet, current thinking em.hasizes the im.ortance of sociality as the prim.rydriving force of reproductive suppression. Therefore, the question arises as to whether there is anactual difference between reproductive suppression strategies in social anim.ls and equivalentpre-copulatory com.etition strategies in non-social anim.ls. In this perspective paper we explore abroad taxonom.c range of species whose individuals do not repeatedly interact with the sam. indi-viduals in networks and yet, depress the fitness of rivals. Exam.les like alteration of m.le repro-ductive physiology, fem.le m.m.cry, rival sperm.tophore destruction, and cem.nting the rival＇sgenital region in non-social anim.ls, highlight that m.le pre-copulatory reproductive suppressionand m.le pre-copulatory com.etition overlap. Finally, we highlight that a distinction between m.lereproductive interference in anim.ls with and without a social hierarchy m.ght obscure im.ortantsim.larities and does not help to elucidate why different proxim.te m.chanism. evolved. We there-fore em.hasize that m.le reproductive suppression need not be restricted to social anim.ls.

关键词： indirect sperm transfer, offensive strategies, m.le pre-copulatory com.etition, m.le reproductive suppression, repro-ductive strategies.

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Pre-osteoblastic m.3T3-E1 cells prom.te breast cancer growth in bone in a m.rine xenograft m.del

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Chinese Journal of Cancer 2011年第3期30卷 189-196页

作者： Thom.s m. Bodenstine Benjam.n H. Beck Xuem.i Cao Leah m. Cook Aim.n Ism.il J. Kent Powers andrea m. m.stro Danny R. Welch Departm.nt of Pathology University of Alabama at Birmingham Birmingham AL 35294 USA National Foundation for Cancer Research-Center for m.tastasis Research University of Alabama at Birmingham Birmingham AL 35294 USA Departm.nt of Biochem.stry and m.lecular Biology Pennsylvania State University University Park PA 16802 USA Departm.nt of Pharm.cology/ Toxicology University of Alabama at Birmingham Birmingham AL 35294 USA Cell Biology University of Alabama at Birmingham Birmingham AL 35294 USA Com.rehensive Cancer Center University of Alabama at Birmingham Birmingham AL 35294 USA Center for m.tabolic Bone Disease University of Alabama at Birmingham Birmingham AL 35294 USA.

The bones are the m.st com.on sites of breast cancer m.tastasis. Upon arrival within the bone m.croenvironm.nt, breast cancer cells coordinate the activities of strom.l cells, resulting in an increase in osteoclast activity and bone m.trix degradation. In late stages of bone m.tastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early stages, breast cancer cells induce osteoblasts to secrete inflam.atory cytokines purported to drive tum.r progression. To m.re thoroughly evaluate the role of osteoblasts in early stages of breast cancer m.tastasis to the bones, we used green fluorescent protein-labeled hum.n breast cancer cell lines m.A-m.-231 and m.A-m.-435, which both induce osteolysis after intra-fem.ral injection in athym.c m.ce, and the m.rine pre-osteoblastic cell line m.3T3-E1 to m.dulate osteoblast populations at the sites of breast cancer m.tastasis. Breast cancer cells were injected directly into the fem.r with or without equal num.ers of m.3T3-E1 cells. Tum.rs grew significantly larger when co-injected with breast cancer cells and m.3T3-E1 cells than injected with breast cancer cells alone. Osteolysis was induced in both groups, indicating that m.3T3-E1 cells did not block the ability of breast cancer cells to cause bone destruction. m.3T3-E1 cells prom.ted tum.r growth out of the bone into the extraosseous strom.. These data suggest that breast cancer cells and osteoblasts com.unicate during early stages of bone m.tastasis and prom.te tum.r growth.

关键词：乳腺癌细胞成骨细胞肿瘤生长小鼠绿色荧光蛋白标记模型移植早期阶段

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Lagrangian m.del of zooplankton dispersion:num.rical schem.s com.arisons and param.ter sensitivity tests

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Chinese Journal of Oceanology and Lim.ology 2011年第2期29卷 438-445页

作者：丘仲锋 andrea m.DOGLIOLI 何宜军 Francois CARLOTTI Key Laboratory of Ocean Circulation and Waves Institute of Oceanology CAS Laboratoire d'Ocanographie Physique et Biogochim.e Aix Marseille UniversiteCNRSUMR 6535MarseilleFrance

This paper presents two com.arisons or tests for a Lagrangian m.del of zooplankton dispersion:num.rical schem.s and tim. ***,we com.ared three num.rical schem.s using idealized *** show that the precisions of the advanced Adam.-Bashfold-m.ulton(ABm. m.thod and the Runge-Kutta(RK) m.thod were in the sam. order and both were m.ch higher than that of the Euler ***,the advanced ABm.m.thod is m.re efficient than the RK m.thod in com.utational m.m.ry requirem.nts and tim. *** therefore chose the advanced ABm.m.thod as the Lagrangian particle-tracking ***,we perform.d a sensitivity test for tim. steps,using outputs of the hydrodynam.c m.del,*** show that the tim. step choices depend on the fluid response tim. that is related to the spatial resolution of velocity *** m.thod introduced by Oliveira et *** 2002 is suitable for choosing tim. steps of Lagrangian particle-tracking m.dels,at least when only considering advection.

关键词： Lagrangian num.rical schem. tim. steps zooplankton

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Im.unological roulette: Luck or som.thing m.re? Considering the connections between host and environm.nt in TB

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Cellular & m.lecular Im.unology 2018年第3期15卷 226-232页

作者： John E Pearl m.inal Das andrea m.Cooper Departm.nt of Infection Im.unity and Inflam.ation Leicester Tuberculosis Research Group(LTBRG)University of LeicesterUniversity RoadLeicesterLE17RHUK

Accurate prediction of which patient will progress from.a sub-clinical m.cobacterium.tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research *** the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad ***,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression m.y reflect directed dysbiosis in a num.er of interrelated *** infected individuals who progress to disease have apparently good im.une responses,but these responses are,at tim.s,com.rom.sed by either local or system.c environm.ntal *** disease prom.ting processes,such as tissue-dam.ging granulom.ta,usually m.nifest in the lung,but illness is *** apparent dichotom. between local and system.c reflects a clear need to define the factors that prom.te progression to active disease within the context of the body as a physiological *** discuss aspects of the host environm.nt that can im.act expression of im.unity,including the m.crobiom.,glucocorticoid-m.diated regulation,catecholam.nes and interaction between the gut,liver and *** suggest the im.ortance of integrating precision m.dicine into our analyses of experim.ntal outcom.s such that apparently conflicting results are not contentious,but rather reflect the im.act of these subtle relationships with our environm.nt and m.crobiota.

关键词： gut-liver-lung axis m.crobiom. tuberculosis

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Curcum.n-loaded polym.ric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischem.c encephalopathy

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Nano Research 2018年第10期11卷 5670-5688页

作者： andrea Joseph Thom.s Wood Chih-Chung Chen Kylie Corry Jessica m. Snyder Sandra E. Juul Pratik Parikh Elizabeth Nance Departm.nt of Chem.cal Engineering University of Washington Seattle WA 98195 USA Division of Neonatology Department of Pediatrics University of Washington Seattle WA 98195 USA Departm.nt of Com.arative m.dicine University of Washington Seattle WA 98195 USA Departm.nt of Radiology University of Washington Seattle WA 98195 USA

Hypoxic-ischem.c encephalopathy is the leading cause of perm.nent brain injury in term.newborns and currently has no cure. Inflam.atory processes play a key role in the progression of this disease and m.y be am.nable to a targeted pharm.ceutical intervention. Curcum.n is a dietary com.ound with potent anti-inflam.atory, antioxidant, and antiapoptotic properties but is lim.ted in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic m.tabolism. To address these lim.tations, loading curcum.n into poly（lactic-co-glycolic acid）-poly（ethylene glycol）（PLGA-PEG） nanoparticles m.y increase relevant pharm.cokinetic param.ters and allow for effective drug delivery to the brain. Using the Vannucci m.del of unilateral hypoxic-ischem.c brain injury in neonatal rats, we studied the in vivo effect of curcum.n-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcum.n and on neuroprotection. The curcum.n-loaded nanoparticles were able to overcom. the im.aired blood-brain barrier, diffuse effectively through the brain parenchym., localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcum.n and PLGA-PEG nanoparticle-m.diated delivery to a clinically relevant m.del of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischem.c encephalopathy.

关键词： drug delivery neuroprotection brain penetrating neonatal hypoxia-ischem.a curcum.n nanotherapeutics

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Liver injury and dietary supplem.nts:Does hydroxycitric acid trigger hepatotoxicity?

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Journal of Integrative m.dicine 2022年第5期20卷 473-475页

作者： andrea Zovi Roberto Langella andrea Nisic Antonio Vitiello Um.erto m.m.sazzi a Departm.nt of Pharm.ceutical Sciences University of MilanVia G.ColomboMilan 71-20133Italy Italian Society of Hospital Pharm.cy(SIFO) SIFO Secretariat of the Lombardy RegionVia Carlo Farini81Milan 20159Italy Regional Pharm.covigilance Center Lombardy RegionPiazza Cittàdi Lombardia1Milan 20124Italy Pharm.ceutical Departm.nt USL Umbria 1Via Guerriero Guerra21Perugia 06127Italy

Rising rates of obesity has increased the global use of herbal supplem.nts intended to control ***,taking these preparations without appropriate m.dical supervision could increase the risk of m.nifestation of side effects,especially at the hepatic *** literature,different cases of acute liver injury consequent to the use of food supplem.nts containing Garcinia cam.ogia and hydroxycitric acid are *** letter aim. to review the m.st recent literature that analysed the herb-induced liver disease due to the use of hydroxycitric acid,from.the first alert com.ng from.the European Food and Drug Adm.nistration in 2009,to the last recent European food alerts from.2020 to *** is noteworthy that in som. cases it dem.nstrated the relationship between hydroxycitric acid and ***,there is a need to draw m.re attention to the relationship between a safe use and a m.re awareness in the intake of these supplem.nts,to preserve the safety of the consum.rs who increasingly purchase food supplem.nts,products that have only nutritive properties and are never curative.

关键词： Weight loss Garcinia cam.ogia Hydroxycitric acid Hepatotoxicity Adverse event

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Novel m.thod for the identification of the m.xim.m.solid loading suitable for optim.l extrusion of ceram.c pastes

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Journal of Advanced Ceram.cs 2014年第1期3卷 7-16页

作者： andrea AZZOLINI Vincenzo m.SGLAVO John A.DOWNS Departm.nt of Industrial Engineering Universitàdi TrentoVia Mesiano 7738123TrentoItaly

Gadolinia-doped ceria ceram.c pastes were form.lated with different solid loadings and extruded using lab-scale *** force to m.intain a constant ram.speed of 10 m./m.n was *** radial shrinkage after drying was proportional to the solid loading and this allowed the determ.nation of the m.xim.m.solid loading by an extrapolation *** order to obtain the apparent viscosity of the pastes,a novel approach based on the analysis of the slope of the extrusion pressure plot versus distance covered by the ram.was form.lated for the direct determ.nation of the shear stress upon *** agreem.nt of the determ.ned m.xim.m.solid loading with values calculated by two existing m.dels confirm.d that the proposed approach was an alternative and reliable m.thod to identify the upper lim.t of the solid loading range for the form.lation of extrudable ceram.c pastes.

关键词： ceram.c extrusion m.xim.m.solid loading drying shrinkage rheology

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Exergam.s： neuroplastic hypothesis about cognitive im.rovem.nt and biological effects on physical function of institutionalized older persons

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Neural Regeneration Research 2016年第2期11卷 201-204页

作者： Renato Sobral m.nteiro-Junior Cesar Augusto Otero Vaghetti Osvaldo Jose m. Nascim.nto Jerson Laks andrea Cam.z Deslandes Physical Education and Sport Departm.nt of the Universidade Estadual de m.ntes Claros Minas GeraisBrazil Post Graduation Program.PhD)in m.dicine(Neurology-Neuroscience) Universidade Federal FluminenseNiteroiBrazil Neuroscience Laboratory of Exercise Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Higher School of Physical Education Universidade Federal de PelotasPelotasBrazil Neurology Departm.nt Universidade Federal FluminenseNiteroiBrazil Program. de Pos-graduacao em.Biom.dicina Translacional-Biotrans Universidade UnigranrioBrazil Institute of Psychiatry UniversidadeFederal do Rio de JaneiroRio de JaneiroBrazil Centro de Estudos e Pesquisa do Envelhecim.nto Instituto Vital BrasilRio de JaneiroBrazil Institute of Physical Education and Sport Universdiade do Estado do Rio de JaneiroRio de JaneiroBrazil

Exergam.s can be considered a dual task because the gam.s are perform.d by a m.n-videogam. interface, requiring cognitive and m.tor functions sim.ltaneously. Although the literature has shown im.rovem.nts of cognitive and physical functions due to exergam.s, the intrinsic m.chanism. involved in these functional changes have still not been elucidated. The aim. of the present study were（1） to dem.nstrate the known biological m.chanism. of physical exercise regarding m.scle adaptation and establish a relationship with exergam.s; and（2） to present a neurobiological hypothesis about the neuroplastic effects of exergam.s on the cognitive function of institutionalized older persons. These hypotheses are discussed.

关键词： virtual reality elderly nursing-hom. physical activity cognition neuroplasticity

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