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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte andrea Z.LaCroix Eleanor M.Simonsick Steven P.Hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology Mortality

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Uveal melanoma:Recent advances in immunotherapy

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World Journal of Clinical Oncology 2024年第1期15卷 23-31页

作者： Francesco Saverio Sorrentino Francesco De Rosa Patrick Di Terlizzi Giacomo Toneatto andrea Gabai Lucia Finocchio Carlo Salati Leopoldo Spadea Marco Zeppieri Department of Surgical Sciences Unit of OphthalmologyOspedale MaggioreBologna 40100Italy Department of Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

Uveal melanoma(UM)is the most common primary intraocular cancer in *** incidence in Europe and the United States is 6-7 per million population per *** most primary UMs can be successfully treated and locally controlled by irradiation therapy or local tumor resection,up to 50%of UM patients develop metastases that usually involve the liver and are fatal within 1 *** date,chemotherapy and targeted treatments only obtain minimal responses in patients with metastatic UM,which is still characterized by poor *** standard therapeutic approaches for its prevention or treatment have been *** application of immunotherapy agents,such as immune checkpoint inhibitors that are effective in cutaneous melanoma,has shown limited effects in the treatment of ocular *** is due to UM’s distinct genetics,natural history,and complex interaction with the immune *** cutaneous melanomas characterized mainly by BRAF or NRAS mutations,UMs are usually triggered by a mutation in GNAQ or *** a result,more effective immunotherapeutic approaches,such as cancer vaccines,adoptive cell transfer,and other new molecules are currently being *** this review,we examine novel immunotherapeutic strategies in clinical and preclinical studies and highlight the latest insight in immunotherapy and the development of tailored treatment of UM.

关键词： Uveal melanoma Immunotherapy Ocular oncology Tumor Metastatic disease Genetic mutations

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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini andrea Minervini Sergio Serni Francesco Sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

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The Path Less Traveled

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Beijing Review 2024年第10期67卷 48-48页

作者： andrea Rafai East China Normal University in Shanghai

As a big country,China's economic A and political influence is felt around the ***,in recent years,its influence in the realms of education and culture has been growing *** Confucius Institute,offering free language classes,has gained increasing popularity in both Hungary and *** offering opportunities to learn Chinese language and traditional arts such as painting,and hosting events to celebrate China's holidays,like the Lantern Festival and Mid-Autumn Festival,Confucius institutes bring Chinese culture closer to interested learners,serving as bridges between *** own interest in China grew through participation in these classes and events.

关键词： offering bridges closer

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Geophysical evidence of a large occurrence of mud volcanoes associated with gas plumbing system in the Ross Sea(Antarctica)

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Geoscience Frontiers 2024年第1期15卷 304-324页

作者： Martina Busetti Riccardo Geletti Dario Civile Chiara Sauli Giuseppe Brancatelli Edy Forlin Daniela Accettella Lorenza Barro Savonuzzi Laura De Santis Aldo Vesnaver andrea Cova National Institute of Oceanography and Applied Geophysics–OGS Borgo Grotta Gigante 42/c34010 SgonicoTriesteItaly

Seafloor and buried reliefs occur along continental margin of the Ross Sea(Antarctica).These features are several kilometres wide and tens of metres high,exhibiting cone or flat-top dome *** studies have proposed a volcanic or glacial origin for these formations,but these hypotheses do not account for all the available *** this study,we use morpho-bathymetric data,intermediate resolution multichannel seismic and high resolution chirp profiles,as well as magnetic lines to investigate these clusters of *** employing targeted processing techniques to enhance the geophysical characterization of the seafloor and buried reliefs,and to understand the underlying geological features,we propose that the reliefs are mud *** of these formations appear to be associated with a plumbing system,as indicated by acoustic anomalies linked to sediment containing *** formations are likely fed by clayey source rocks of Miocene ***,other reliefs might be the result of mud mobilisation caused by gravity instability and fluid overpressure.

关键词： Ross Sea Antarctica Mud volcanoes Gas plumbing system Gas hydrate Bottom Simulating Reflector

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A Wild Trek Through History

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Beijing Review 2024年第36期67卷 48-48页

作者： andrea Rafai East China Normal University in Shanghai

Have you ever imagined what it would be like to climb the Great LWall of China?Everyoneknows the Great Wall is long,but just how long is it?Stretching along approximately 21,196 km,its sheer scale is mind-boggling,especially considering that it was built without modern industry or *** fact that this architectural wonder still stands today,and is likely to continue to be there for generations to come,is a testament to human ingenuity.

关键词： technology. architectural likely

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Pediatric flexible flatfoot: Does obesity influence the outcomes of arthroereisis?

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World Journal of Orthopedics 2024年第9期15卷 850-857页

作者： Luca Monestier Giacomo Riva Mahfuz Latiff Luca Marciandi Elisa Bozzi Alessandra Pelozzi andrea Pautasso Giorgio Pilato Michele Francesco Surace Fabio D'Angelo Division of Orthopedics and Traumatology ASST Sette LaghiVarese 21100LombardyItaly Residency Program in Orthopedics and Trauma Department of Biotechnologies and Life SciencesUniversity of InsubriaVarese 21100LombardyItaly Interdisciplinary Research Centre for Pathology and Surgery of the Musculoskeletal System Department of Biotechnology and Life SciencesUniversity of InsubriaVarese 21100LombardyItaly Division of Orthopedics and Traumatology Ospedale di CittiglioASST Sette LaghiVarese 21100LombardyItaly

BACKGROUND Childhood obesity has emerged in the last decades as an important public health problem *** relationships between obesity and flatfoot have been shown,no studies have investigated the influence of obesity on arthroereisis *** To evaluate correlations between childhood overweight/obesity and clinical and radiographic outcomes after subtalar arthroereisis with self-locking *** This retrospective study included one hundred and sixty-nine pediatric patients(10-14 years old)who underwent subtalar arthroereisis(PEEK PitStop®device)for severe flexible *** criteria were additional procedures,revision of previous corrective surgeries,rigid flatfoot with severe deformity,and neurologi-cal or post-traumatic ***/postoperative European Foot and Ankle Society(EFAS)and visual analogue scale(VAS)scores were determined;radiographic assessment was conducted on weight-bearing foot X-rays:Kite angle,first metatarsal-talus angle,Meary angle,calcaneal pitch angle and lateral talo-calcaneal angle were *** EFAS and VAS scores improved post-operatively in the whole *** seven cases with complications were *** assessment revealed an improvement in all *** analysis demonstrated that the impact of obesity was significant on arthroereisis outcomes:Relationships were reported between BMI and postoperative EFAS/VAS scores,postoperative calcaneal pitch angle,Kite angle,Meary angle and talo-first meta-tarsal *** Although arthroereisis represents a very effective and valid treatment for flatfoot both in normal weight and obese children,obesity significantly influences clinical and radiographic outcomes of arthroereisis,and obese children tend to perceive more pain and discomfort.

关键词： Pediatric flatfoot Obesity Subtalar Arthroereisis Outcomes

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Design of Off-statistics Axial-flow Fans by Means of Vortex Law Optimization

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Journal of Thermal Science 2014年第6期23卷 505-515页

作者： andrea Lazari andrea Cattanei DIME-Università degli Studi di Genova Via Montallegro 1I-16145 GenovaItaly Presently with FPZ S.p.A. Via Fratelli Cervi16I-20863ConcorezzoItaly

Off-statistics input data sets are common in axial-flow fans design and may easily result in some violation of the requirements of a good aerodynamic blade *** order to circumvent this problem,in the present paper,a solution to the radial equilibrium equation is found which minimizes the outlet kinetic energy and fulfills the aerodynamic constraints,thus ensuring that the resulting blade has acceptable aerodynamic *** presented method is based on the optimization of a three-parameters vortex law and of the meridional channel *** aerodynamic quantities to be employed as constraints are individuated and their suitable ranges of variation are *** method is validated by means of a design with critical input data values and CFD ***,by means of systematic computations with different input data sets,some correlations and charts are obtained which are analogous to classic correlations based on statistical investigations on existing *** new correlations help size a fan of given characteristics as well as study the feasibility of a given design.

关键词： axial flow fan statistical correlations optimum design feasibility study

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Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis

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World Journal of Virology 2024年第4期13卷 120-134页

作者： Mutali Musa Babatunde Ismail Bale Ayuba Suleman Gladness Aluyi-Osa Ekele Chukwuyem FabianaD’Esposito Caterina Gagliano Antonio Longo andrea Russo Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser Centre LtdBenin 300105Nigeria Department of Ophthalmology Centre for Sight Africa LtdNkpor 434212Nigeria Imperial College Ophthalmic Research Group Unit Imperial CollegeLondon NW15QHUnited Kingdom GENOFTA srl Via A.Balsamo93Naples 80065Italy Department of Medicine and Surgery University of Enna"Kore"Catania 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Ophthalmology University Hospital of CataniaCatania 95123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

BACKGROUND Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology,including viral *** can be acute or chronic,selflimiting,or needing medical *** To review possible viral agents crucial for accurate differential diagnosis in cases of *** The PubMed database was searched for records relating to viral *** search string generated was“("virally"[All Fields]OR"virals"[All Fields]OR"virology"[MeSH Terms]OR"virology"[All Fields]OR"viral"[All Fields])AND"Blepharoconjunctivitis"[All Fields]".RESULTS A total of 24 publications were generated from the search *** lists from each relevant article were also searched for more information and included in this *** etiologies such as adenovirus,herpes simplex virus(HSV),varicella-zoster virus(VZV),and Epstein-Barr virus(EBV)are frequently *** infections manifest with follicular conjunctivitis and preauricular lymphadenopathy,often presenting as epidemic *** and VZV infections can result in herpetic keratitis and may exhibit characteristic dendritic corneal ***,although less common,can cause unilateral or bilateral follicular conjunctivitis,particularly in immunocompromised *** potential viral agents,such as enteroviruses and molluscum contagiosum virus,should also be considered,especially in pediatric *** Prompt recognition of these viral etiologies is essential for appropriate management and prevention of ***,a thorough understanding of the clinical presentation,epidemiology,and diagnostic modalities is crucial for accurate identification and management of viral blepharoconjunctivitis.

关键词： Viral Blepharoconjunctivitis Herpes simplex virus Varicella-Zoster Epstein-Barr

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Physical insights into trapping effects on vertical GaN-on-Si trench MOSFETs from TCAD

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Journal of Semiconductors 2024年第3期45卷 45-52页

作者： NicolòZagni Manuel Fregolent andrea Del Fiol Davide Favero Francesco Bergamin Giovanni Verzellesi Carlo De Santi Gaudenzio Meneghesso Enrico Zanoni Christian Huber Matteo Meneghini Paolo Pavan Department of Engineering“Enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy Department of Information Engineering University of PadovaPadova 35131Italy Department of Sciences and Methods for Engineering(DISMI) University of Modena and Reggio EmiliaReggio Emilia 42122Italy EN&TECH Center University of Modena and Reggio EmiliaReggio Emilia 42122Italy Advanced Technologies and Micro Systems Department Robert Bosch GmbHRenningen 71272Germany

Vertical GaN power MOSFET is a novel technology that offers great potential for power switching *** still in an early development phase,vertical GaN devices are yet to be fully optimized and require careful studies to foster their *** this work,we report on the physical insights into device performance improvements obtained during the development of vertical GaN-on-Si trench MOSFETs(TMOS’s)provided by TCAD simulations,enhancing the dependability of the adopted process optimization ***,two different TMOS devices are compared in terms of transfer-curve hysteresis(H)and subthreshold slope(SS),showing a≈75%H reduction along with a≈30%SS *** allow attributing the achieved improvements to a decrease in the border and interface traps,respectively.A sensitivity analysis is also carried out,allowing to quantify the additional trap density reduction required to minimize both figures of merit.

关键词： vertical GaN trench MOSFET SiO_(2) interface traps border traps hysteresis BTI

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