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Preoperative Intra-Aortic Balloon Counterpulsation in Coronary Artery Bypass Graft Patients with Severe Left Ventricular Dysfunction

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World Journal of Cardiovascular Diseases 2016年第10期6卷 321-328页

作者： andrea cristina oliveira freitas Danilo B. Gurian Wladmir F. Saporito Leandro N. Machado Louise Horiuti Adilson C. Pires Rua Dr. Henrique Calderazzo Sao Paulo Brazil

Background: The intra-aortic balloon pumping (IABP) is the most used ventricular mechanical assist device. In recent years, the preoperative use in patients with severe ventricular dysfunction presents itself as a great benefic strategy to the postoperative recovery. This paper aim is to evaluate the IABP post-operative benefit in patients with severe ventricular dysfunction. Methods: From January 2011 to March 2016, 125 patients underwent a coronary artery bypass graft (CABG) with cardiopulmonary bypass and preoperative IABP in Teaching Hospital of the ABC Medical School and Hospital Estadual Mario Covas. The inclusion criteria were the presence of severe ischemic cardiomyopathy with left ventricular ejection fraction (LVEF) less than or equal to 40%, estimated by Doppler echocardiography using the Simpson method. The preoperative LVEF was 30.25% ± 8.53% and the diastolic diameter of the left ventricle (LVDD) 67.75 ± 16.37 mm. IABP was installed approximately 15 hours before the surgery. Results: The patients required the IABP for 2.4 ± 1.58 days, and vasoactive drugs, 4.8 ± 2.12 days. We performed 3.2 ± 1.9 grafts per patient and the total length of stay was 07 ± 5.52 days. Cardiopulmonary bypass time was 67 ± 10.95 minutes and anoxia time, 46.4 ± 10.06 minutes. Twelve patients (9.6%) had pneumonia and four (3.2%), atrial fibrillation. We observed a LVDD reduction to 63 ± 16.26 (p = 0.068) and LVEF enhancement to 36.50 ± 16.86 (p = 0.144). The data were analyzed statistically according to the Wilcoxon test. There were no deaths. Conclusion: The initial experience of the authors with the preoperative IABP in patients with severe left ventricular dysfunction suggests great benefit in post-operative recovery with im-provement of LVEF and reduction of LVDD.

关键词： Intra-Aortic Balloon Pumping Left Ventricular Dysfunction Coronary Artery Bypass Graft

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nunes Pamela Castro-e-Souza Anselmo Alves de oliveira Bruno de freitas Camilo Gislaine cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to ***:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training

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Current Zoology 2024年第1期70卷 1-12页

作者： Lucia V.Sommaro Juan J.Martinez Marina B.Chiappero andrea R.Steinmann cristina N.Gardenal JoséW.Priotto Laboratorio de Ecologia Evolutiva y Biogeografia Instituto de Ecorregiones Andinas(INECoA)Universidad Nacional de Jujuy-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)San Salvador de JujuyJujuyArgentina Instituto de Diversidad y Ecologia Animal(IDEA) Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)and Universidad Nacionalde CordobaCordobaArgentina Catedra de Genética de Poblaciones y Evolucion Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaCordobaArgentina Grupo de Investigaciones en Ecologia Poblacional y Comportamental(GIEPCO) Instituto de Ciencias de la TierraBiodiversidad y Ambiente(ICBiA)Universidad Nacional de Rio Cuarto-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Rio CuartoCordobaArgentina

The sex-biased dispersal and kinship dynamics are important factors shaping the spatial distribution of individuals and are key parameters affecting a variety of ecological and evolutionary ***,we studied the spatial distribution of related individuals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal *** sampling was carried out from spring 2005 to winter 2006 in field borders of intensively managed *** data from 346 individuals with 9 microsatellites showed spatial genetic structure was weak for males,but not for *** results indicate a complex spatial kinship dynamic of related females across all ***,contrary to our expectations,dispersal distances decrease with the increase of the population ***,male dispersal distances were greater when population abundance increased and thus the availability of active *** disperse greater distances to mate and sire offspring with distant females as a possible inbreeding avoidance *** study shows that *** is capable of much greater scattering distances than previously reported and that dispersal occurs fluidly and without barriers across the *** indirect benefit of dispersal on individual fitness could be related to relaxing the competition in the natal area and increasing the mating *** study highlights the value of combining genetic relatedness,fieldwork observations,and behavioral data to estimate dispersal at a fine geographical scale.

关键词： dispersal distances kinship dynamics microsatellite small mammals spatial autocorrelation

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Effect of Soybean Cultivars on the Nutrients and Consumer Acceptance of Soymilk

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Food and Nutrition Sciences 2024年第8期15卷 807-826页

作者： Ilana Felberg Mercedes Concórdia Carrão-Panizzi Rosires Deliza Sidinéa Cordeiro de freitas Manuela cristina Pessanha de Araujo Santiago Marilia Penteado Stephan Monalisa Santana Coelho de Jesus Elisabeth Borges Gonçalves Rosemar Antoniassi Embrapa Food Technology Rio de Janeiro Brazil Embrapa Wheat Passo Fundo Brazil

Soymilk is one of the most available beverages, an alternative to dairy milk and is recognized for its nutritional value. The nutritional quality, the presence of anti-nutritional factors, isoflavones and sensory acceptability of soymilk depended on the soybean variety as well as the processing conditions. The soymilks from conventional and specialty Brazilian soybean cultivars were compared regarding the composition and consumer acceptance. There were significant differences on the protein, oil, sugars, isoflavones, presence of anti-nutritional factors (phytate and trypsin inhibitor activity) and NSI (nitrogen solubility index) among cultivars and soymilks and for sensory acceptance of soymilks. The preference mapping and cluster analysis identified three different segments of consumers. The soymilk from the conventional cultivar BRS284 achieved higher and similar acceptance score for the three consumer’s segments while the lipoxygenase free cultivars (BRS213 and BRS257) and specialty cultivar BRS216 showed higher score for two segments of consumers. The sensory evaluation of soymilk from different soybean cultivars could improve consumer uptake.

关键词： Preference Mapping Cluster Analysis Protein Phytate

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Triassic actinopterygian fishes:the recovery after the end-Permian crisis

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Integrative Zoology 2014年第4期9卷 394-411页

作者： andrea TINTORI TomažHITIJ Dayong JIANG cristina LOMBARDO Zuoyu SUN Department of Earth Sciences‘A.Desio’ Universitàdegli Studi di MilanoMilanoItaly Dental School Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia Department of Geology and Geological Museum Beijing UniversityBeijingChina

In the last 15 years,the discovery of several new actinopterygian fish faunas from the Early and Middle Triassic of the Tethys,cast new light on the timing,speed and range of their recovery after the end-Permian *** addition to several new taxa having been described,the stratigraphical and geographical record of many others have been greatly *** fact,most of the new fossiliferous sites are in southern China,thus at the Eastern end of the Tethys,and furthermore a few are somewhat older(Chaohu,Panxian,Luoping)than the major classical Western Tethys sites(Monte San Giorgio).Following these new finds,it is possible to have a better definition of the Triassic recovery ***,after a quite short phase till the end of the Smithian(Olenekian,Early Triassic)in which a rather consistent fauna was present all around the Pangea coasts,a major radiation occurred in the Early-Middle Anisian after the new Middle Triassic fish fauna already appeared in the late Early Triassic,thus occuring well before what was previously supposed from the Alps ***,the new assemblages from southern China point to an early broader differentiation among the basal neopterygians rather than in the‘subholosteans’,the group that was then dominant in the Western Tethys since the Late Ani*** stands that during the Norian a new basal neopterygian radiation gave rise to several new branches that dominated the remaining part of the Mesozoic.

关键词： Actinopterygians biodiversity predation stratigraphy Triassic recovery

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Perinatal variation and covariation of oxidative status and telomere length in yellow-legged gull chicks

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Current Zoology 2019年第5期65卷 509-516页

作者： Marco PAROLINI cristina Daniela POSSENTI andrea ROMANO Manuela CAPRIOLI Diego RUBOLINI Nicola SAINO Department of Environmental Science and Policy University of MilanMilanItaly Department of Ecology and Evolution University of LausanneBuilding BiophoreLausanneSwitzerland

The perinatal period is critical to survival and performance of many *** birds,rapid postnatal growth and sudden exposure to aerial oxygen around hatching markedly affect the chick redox status,with potentially negative consequences on physiology mediated by oxidative *** addition,telomere length(TL)undergoes reduction during birds’early life,partly depending on oxidative ***,relatively few studies have focused specifically on the changes in oxidative status and TL that occur immediately after *** this study of the yellow-legged gull Larus michahellis,we found that chicks undergo a marked increase in plasma total antioxidant capacity and a marked decrease in the concentration of pro-oxidant molecules during the first days after *** addition,TL in erythrocytes decreased by 1 standard deviation over the 4days *** mass and tarsus length covaried with total antioxidant capacity and concentration of pro-oxidants in a complex way,that partly depended on sex and laying order,suggesting that oxidative status can affect ***,TL positively covaried with the concentration of pro-oxidant molecules,possibly because retention of high concentrations of pro-oxidant molecules results from mechanisms of prevention of their negative effects,including reduction in ***,this study shows that chicks undergo marked variation in oxidative status,which predicts growth and subsequent TL,prompting for more studies of the perinatal changes in the critical posthatching stages.

关键词： early-life period oxidative status telomeres yellow-legged gull

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An integrated approach to investigate climate-driven rockfall occurrence in high alpine slopes: the Bessanese glacial basin, Western Italian Alps

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Journal of Mountain Science 2020年第11期17卷 2591-2610页

作者： VIANI cristina CHIARLE Marta PARANUNZIO Roberta MERLONE andrea MUSACCHIO Chiara COPPA Graziano NIGRELLI Guido Department of Earth Sciences University of Torino10125 TorinoItaly Research Institute for Geo-Hydrological Protection Italian National Research Council10135 TorinoItaly Institute of Atmospheric Sciences and Climate Italian National Research Council10133 TorinoItaly National Institute of Metrological Research 10135 TorinoItaly

Rockfalls are one of the most common instability processes in high *** represent a relevant issue,both for the risks they represent for(infra)structures and frequentation,and for their potential role as terrestrial indicators of climate *** study aims to contribute to the growing topic of the relationship between climate change and slope instability at the basin *** selected study area is the Bessanese glacial basin(Western Italian Alps)which,since 2016,has been specifically equipped,monitored and investigated for this *** order to provide a broader context for the interpretation of the recent rockfall events and associated climate conditions,a cross-temporal and integrated approach has been *** this purpose,geomorphological investigations(last 100 years),local climate(last 30 years)and near-surface rock/air temperatures analyses,have been carried *** research outcomes show that rockfalls occurred in two different geomorphological positions:on rock slopes in permafrost condition,facing from NW to NE and/or along the glacier margins,on rock slopes uncovered by the ice in the last *** thaw of the active layer and/or glacier debutressing can be deemed responsible for slope failure *** regard to timing,almost all dated rock falls occurred in *** the July events,initiation may have been caused by a combination of rapid snow melt and enhanced seasonal thaw of the active layer due to anomalous high temperatures,and *** events are,instead,associated with a significant positive temperature anomaly on the quarterly scale,and they can be ascribed to the rapid and/or in depth thaw of the permafrost active *** to our findings,we can expect that in the Bessanese glacierized basin,as in similar high mountain areas,climate change will cause an increase of slope instability in the *** fasten knowledge deepening,we highlight the need for a growth of a network of high elevation

关键词： Rockfalls Climate change Air and rock temperature Periglacial environment Western Italian Alps

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A New Perleidiform(Actinopterygii,Osteichthyes)from the Middle Anisian(Middle Triassic)of Yunnan,South China

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Acta Geologica Sinica(English Edition) 2009年第3期83卷 460-470页

作者： SUN Zuoyu andrea TINTORI JIANG Dayong cristina LOMBARDO Marco RUSCONI HAO Weicheng SUN Yuanlin Department of Geology and Geological Museum Peking University Beijing 100871 China Dipartimento di Scienze della Terra ＇A. Desio ＇ Universita degli Studi di Milano via Mangiagalli 34 1- 20133 Milano Italy

Two complete specimens from the Pelsonian （Middle Anisian, Middle Triassic） of Luoping, Yunnan Province, South China are referred to a new actinopterygian genus, Luopingichthys gen. nov., and ascribed to the perleidiform family Polzbergidae based especially on a typical synapomorphy of a peculiar premaxillary-maxillary complex, i.e., the fusion between premaxillary and maxillary along the antero-dorsal margin of the maxillary. The new taxon differs from other deep-bodied representatives of the family, Felberia and Stoppania, in its fusiform or deep fusiform body shape; sickle-shaped preopercular with short infraorbital process; lack of modified scales at the base of the anal fin; the short-based dorsal fin; scarcely ornamented scales; and thin anterior teeth. Based on a redescription of the holotype of the taxon Ctenognathichthys hattichi from the Middle Triassic （Ladinian） Prosanto Formation, Canton Graubiinden, eastern Switzerland, the only known specimen, which shows the same fusion between premaxillary and maxillary, the systematic position of the species is clarified and the taxon is proposed to be a further representative of the family Polzbergidae, and is transferred to the new genus.

关键词： actinopterygian new taxon Perleidiformes Middle Triassic Anisian Yunnan China

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Immune response against HBsAg vaccine

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World Journal of Gastroenterology 1998年第6期4卷 9-11页

作者： Maria cristina Honorati and andrea Facchini

ＨｅｐａｔｉｔｉｓＢｖｉｒｕｓ（ＨＢＶ）ｉｓａｈｅｐａｄｎａｖｉｒｕｓｗｈｉｃｈｃａｎｃａｕｓｅｓｙｓｔｅｍｉｃｉｎｆｅｃｔｉｏｎａｎｄｈｅｐａｔｏｃｅｌｕｌａｒｄａｍａｇｅｉｎｈｕｍａｎｓ．Ｉｎｆｅｃｔｉｏｎｉｓａ... 详细信息

ＨｅｐａｔｉｔｉｓＢｖｉｒｕｓ（ＨＢＶ）ｉｓａｈｅｐａｄｎａｖｉｒｕｓｗｈｉｃｈｃａｎｃａｕｓｅｓｙｓｔｅｍｉｃｉｎｆｅｃｔｉｏｎａｎｄｈｅｐａｔｏｃｅｌｕｌａｒｄａｍａｇｅｉｎｈｕｍａｎｓ．Ｉｎｆｅｃｔｉｏｎｉｓａｃｑｕｉｒｅｄｔｈｒｏｕｇｈｃｏｎ...

关键词： rHBsAg hepatitis B vaccines vaccination

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SmartFlare^(TM) is a reliable method for assessing mRNA expression in single neural stem cells

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World Journal of Stem Cells 2021年第12期13卷 1918-1927页

作者： andrea Diana Maria Dolores Setzu Zaal Kokaia Roxana Nat cristina Maxia Daniela Murtas Department of Biomedical Sciences University of CagliariMonserrato 09042CagliariItaly Laboratory of Stem Cells&Restorative Neurology Lund Stem Cell CenterLund UniversityLund SE-22184LundSweden Institute of Neuroscience Medical University of InnsbruckInnsbruck 6020Austria

BACKGROUND One of the most challenging tasks of modern biology concerns the real-time tracking and quantification of mRNA expression in living *** this matter,a novel platform called SmartFlare^(TM) has taken advantage of fluorophore-linked nanoconstructs for targeting RNA *** fluorescence emission does not account for the spatial mRNA distribution,NanoFlare technology has grown a range of theranostic applications starting from detecting biomarkers related to diseases,such as cancer,neurodegenerative pathologies or embryonic developmental *** To investigate the potential of SmartFlare^(TM) in determining time-dependent mRNA expression of prominin 1(CD133)and octamer-binding transcription factor 4(OCT4)in single living cells through *** Brain fragments from the striatum of aborted human fetuses aged 8 wk postconception were processed to obtain *** the in vitro differentiation,neurospheres were gently dissociated with Accutase *** cells were resuspended in a basic medium enriched with fetal bovine serum,plated on poly-L-lysine-coated glass coverslips,and grown in a lapse of time from 1 to 4 *** cell mRNA detection was performed using SmartFlare^(TM) probes(CD133,Oct4,Actin,and Scramble).All the samples were incubated at 37°C for 24 *** nuclear staining,Hoechst 33342 was ***^(TM) CD133-and OCT4-specific fluorescence signal was assessed using a semiquantitative visual approach,taking into account the fluorescence intensity and the number of labeled *** In agreement with previous PCR experiments,a unique expression trend was observed for CD133 and OCT4 genes until 7 d in vitro(DIV).Fluorescence resulted in a mixture of diffuse cytoplasmic and spotted-like pattern,also detectable in the contacting neural *** 15 to 30 DIV,only few cells showed a scattered fluorescent pattern,in line with the differentiation progression and coherent with mRNA downregulation of

关键词： mRNA detection SmartFlareTM NanoFlare Live staining Nanotechnology Neural stem cell genes

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